WO2002018631A3 - Diagnose von bestehenden erkrankungen oder der prädisposition für bestimmte erkrankungen - Google Patents

Diagnose von bestehenden erkrankungen oder der prädisposition für bestimmte erkrankungen Download PDF

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Publication number
WO2002018631A3
WO2002018631A3 PCT/EP2001/010073 EP0110073W WO0218631A3 WO 2002018631 A3 WO2002018631 A3 WO 2002018631A3 EP 0110073 W EP0110073 W EP 0110073W WO 0218631 A3 WO0218631 A3 WO 0218631A3
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WO
WIPO (PCT)
Prior art keywords
illnesses
predisposition
diagnosis
certain
probes
Prior art date
Application number
PCT/EP2001/010073
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English (en)
French (fr)
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WO2002018631A2 (de
Inventor
Alexander Olek
Christian Piepenbrock
Kurt Berlin
Original Assignee
Epigenomics Ag
Alexander Olek
Christian Piepenbrock
Kurt Berlin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epigenomics Ag, Alexander Olek, Christian Piepenbrock, Kurt Berlin filed Critical Epigenomics Ag
Priority to AU2002212187A priority Critical patent/AU2002212187A1/en
Priority to US10/363,483 priority patent/US20050064401A1/en
Priority to JP2002522536A priority patent/JP2005512499A/ja
Priority to EP01980314A priority patent/EP1373564A2/de
Publication of WO2002018631A2 publication Critical patent/WO2002018631A2/de
Publication of WO2002018631A3 publication Critical patent/WO2002018631A3/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Die vorliegende Erfindung beschreibt einen Satz von Oligomersonden (Oligonukleotiden und/oder PNA-Oligomeren), die zur Detektion des Cytosinmethylierungszustandes in Nukleinsäuren dienen. Diese Sonden sind für die Diagnose von bestehenden Erkrankungen durch Analyse eines Satzes genetischer und/oder epigenetischer Parameter besonders geeignet.
PCT/EP2001/010073 2000-09-01 2001-09-01 Diagnose von bestehenden erkrankungen oder der prädisposition für bestimmte erkrankungen WO2002018631A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2002212187A AU2002212187A1 (en) 2000-09-01 2001-09-01 Diagnosis of illnesses or predisposition to certain illnesses
US10/363,483 US20050064401A1 (en) 2000-09-01 2001-09-01 Diagnosis of illnesses or predisposition to certain illnesses
JP2002522536A JP2005512499A (ja) 2000-09-01 2001-09-01 進行中の疾病または特定の疾病の発病素質の診断
EP01980314A EP1373564A2 (de) 2000-09-01 2001-09-01 Diagnose von bestehenden erkrankungen oder der prädisposition für bestimmte erkrankungen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10043826.1 2000-09-01
DE10043826 2000-09-01

Publications (2)

Publication Number Publication Date
WO2002018631A2 WO2002018631A2 (de) 2002-03-07
WO2002018631A3 true WO2002018631A3 (de) 2003-10-16

Family

ID=7655132

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/010073 WO2002018631A2 (de) 2000-09-01 2001-09-01 Diagnose von bestehenden erkrankungen oder der prädisposition für bestimmte erkrankungen

Country Status (5)

Country Link
US (1) US20050064401A1 (de)
EP (1) EP1373564A2 (de)
JP (1) JP2005512499A (de)
AU (1) AU2002212187A1 (de)
WO (1) WO2002018631A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8871732B2 (en) 2002-12-23 2014-10-28 Dynavax Technologies Corporation Immunostimulatory sequence oligonucleotides and methods of using the same

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US6727230B1 (en) * 1994-03-25 2004-04-27 Coley Pharmaceutical Group, Inc. Immune stimulation by phosphorothioate oligonucleotide analogs
US20030026782A1 (en) * 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US6207646B1 (en) * 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
EP0855184A1 (de) * 1997-01-23 1998-07-29 Grayson B. Dr. Lipford Pharmazeutisches Präparat das ein Polynukleotid und ein Antigen enthält, insbesondere zur Impfung
US6406705B1 (en) * 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
US6693086B1 (en) * 1998-06-25 2004-02-17 National Jewish Medical And Research Center Systemic immune activation method using nucleic acid-lipid complexes
US20030022854A1 (en) 1998-06-25 2003-01-30 Dow Steven W. Vaccines using nucleic acid-lipid complexes
US7585847B2 (en) * 2000-02-03 2009-09-08 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for the treatment of asthma and allergy
US20040131628A1 (en) * 2000-03-08 2004-07-08 Bratzler Robert L. Nucleic acids for the treatment of disorders associated with microorganisms
KR100917101B1 (ko) * 2000-08-04 2009-09-15 도요 보세키 가부시키가이샤 플렉시블 금속적층체 및 그 제조방법
US20040053880A1 (en) * 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7576066B2 (en) * 2002-07-03 2009-08-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7569553B2 (en) * 2002-07-03 2009-08-04 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7605138B2 (en) * 2002-07-03 2009-10-20 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7807803B2 (en) * 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
AU2003257587A1 (en) * 2002-08-23 2004-03-11 Japan As Represented By President Of National Cancer Center Method of evaluating degree of canceration of human-origin specimen
PT2241325E (pt) * 2002-10-29 2012-04-12 Coley Pharm Gmbh Utilização de oligonucleótidos cpg no tratamento de infecção com vírus da hepatite c
WO2004053104A2 (en) * 2002-12-11 2004-06-24 Coley Pharmaceutical Group, Inc. 5’ cpg nucleic acids and methods of use
EP1992635B1 (de) * 2002-12-23 2012-02-08 Dynavax Technologies Corporation Immunstimulierende Sequenz-Oligonukleotide und Verwendungsverfahren dafür
EP1608403A2 (de) * 2003-04-02 2005-12-28 Coley Pharmaceutical Group, Ltd. Immunostimulatorische nukleinsäure öl-in-wasser emulsionen zur topischen anwendung
US20050013812A1 (en) * 2003-07-14 2005-01-20 Dow Steven W. Vaccines using pattern recognition receptor-ligand:lipid complexes
KR100558851B1 (ko) * 2004-01-08 2006-03-10 학교법인연세대학교 면역조절능력이 증가된 ＣｐＧ 올리고데옥시뉴클레오티드변형체
CA2649777C (en) * 2006-04-17 2018-08-14 Epigenomics Ag Methods and nucleic acids for the detection of colorectal cell proliferative disorders
US8084734B2 (en) * 2006-05-26 2011-12-27 The George Washington University Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays
EP2302069A1 (de) * 2007-12-11 2011-03-30 Epigenomics AG Verfahren und Nukleinsäuren für Analysen von Zellwucher-Störungen
EP2677041A3 (de) * 2008-02-19 2014-04-09 MDxHealth SA Detektion und Prognose von Lungenkrebs
US20110195412A1 (en) * 2008-09-05 2011-08-11 James Timmons Predictive Biomarkers for Response to Exercise
US8110796B2 (en) 2009-01-17 2012-02-07 The George Washington University Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays
WO2010089538A2 (en) * 2009-02-03 2010-08-12 Oncomethylome Sciences Sa Methods of detecting colorectal cancer
US9490113B2 (en) * 2009-04-07 2016-11-08 The George Washington University Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry
WO2010149782A1 (en) * 2009-06-26 2010-12-29 Epigenomics Ag Methods and nucleic acids for analysis of bladder cell proliferative disorders
EP2707506B1 (de) * 2011-05-12 2018-07-11 The Johns Hopkins University Verfahren zum nachweis von krebs durch allgemeinen stabilitätsverlust epigenetischer domänen und zusammensetzungen dafür
GB201121924D0 (en) * 2011-12-20 2012-02-01 Fahy Gurteen Labs Ltd Detection of breast cancer
CN113981057A (zh) * 2014-12-12 2022-01-28 精密科学公司 用于进行甲基化检测测定的组合物和方法
WO2016094839A2 (en) * 2014-12-12 2016-06-16 Exact Sciences Corporation Compositions and methods for performing methylation detection assays
DE102015009187B3 (de) * 2015-07-16 2016-10-13 Dimo Dietrich Verfahren zur Bestimmung einer Mutation in genomischer DNA, Verwendung des Verfahrens und Kit zur Durchführung des Verfahrens
HUE059194T2 (hu) 2016-12-16 2022-10-28 Eurofins Genomics Europe Sequencing GmbH Epigenetikai markerek és a kapcsolódó eljárások, valamint eszközök a petefészekrák kimutatására és kezelésére
CN112195243A (zh) * 2020-09-22 2021-01-08 北京华大吉比爱生物技术有限公司 一种检测多基因甲基化的试剂盒及其应用

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8871732B2 (en) 2002-12-23 2014-10-28 Dynavax Technologies Corporation Immunostimulatory sequence oligonucleotides and methods of using the same
US9422564B2 (en) 2002-12-23 2016-08-23 Dynavax Technologies Corporation Immunostimulatory sequence oligonucleotides and methods of using the same

Also Published As

Publication number Publication date
US20050064401A1 (en) 2005-03-24
AU2002212187A1 (en) 2002-03-13
JP2005512499A (ja) 2005-05-12
WO2002018631A2 (de) 2002-03-07
EP1373564A2 (de) 2004-01-02

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