WO2002000932A3 - Diagnose von bedeutenden genetischen parametern innerhalb des mhc - Google Patents

Diagnose von bedeutenden genetischen parametern innerhalb des mhc Download PDF

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Publication number
WO2002000932A3
WO2002000932A3 PCT/IB2001/001501 IB0101501W WO0200932A3 WO 2002000932 A3 WO2002000932 A3 WO 2002000932A3 IB 0101501 W IB0101501 W IB 0101501W WO 0200932 A3 WO0200932 A3 WO 0200932A3
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WO
WIPO (PCT)
Prior art keywords
mhc
diagnosis
genetic parameters
known genetic
probes
Prior art date
Application number
PCT/IB2001/001501
Other languages
English (en)
French (fr)
Other versions
WO2002000932A2 (de
Inventor
Alexander Olek
Christian Piepenbrock
Kurt Berlin
Original Assignee
Epigenomics Ag
Alexander Olek
Christian Piepenbrock
Kurt Berlin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epigenomics Ag, Alexander Olek, Christian Piepenbrock, Kurt Berlin filed Critical Epigenomics Ag
Priority to AU2001277653A priority Critical patent/AU2001277653A1/en
Priority to JP2002506246A priority patent/JP2004511217A/ja
Priority to EP01955494A priority patent/EP1358351A2/de
Publication of WO2002000932A2 publication Critical patent/WO2002000932A2/de
Publication of WO2002000932A3 publication Critical patent/WO2002000932A3/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Die vorliegende Erfindung beschreibt Nukleinsäuren zur Diagnose von einem Satz genetischer Parameter innerhalb des Major Histocompatibility Complexes (MHC), umfassend einen mindestens 20 Basenpaare langen revers komplementären oder identischen Abschnitt einer chemisch vorbehandelten genomischen DNA sowie einen Satz Oligomersonden (Oligonukleotide und/oder PNA-Oligomere), die zur Detektion des Cytosin-Metylierungszustandes in Nukleinsäuren dienen. Diese Sonden sind für die Diagnose von genetischen Parametern innerhalb des MHC besonders geeignet.
PCT/IB2001/001501 2000-06-30 2001-06-29 Diagnose von bedeutenden genetischen parametern innerhalb des mhc WO2002000932A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2001277653A AU2001277653A1 (en) 2000-06-30 2001-06-29 Diagnosis of known genetic parameters within the MHC
JP2002506246A JP2004511217A (ja) 2000-06-30 2001-06-29 組織適合性の大複合体内の遺伝的主要パラメーターによる診断
EP01955494A EP1358351A2 (de) 2000-06-30 2001-06-29 Diagnose von bedeutenden genetischen parametern innerhalb des mhc

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10032529A DE10032529A1 (de) 2000-06-30 2000-06-30 Diagnose von bedeutenden genetischen Parametern innerhalb des Major Histocompatibility Complex (MHC)
DE10032529.7 2000-06-30

Publications (2)

Publication Number Publication Date
WO2002000932A2 WO2002000932A2 (de) 2002-01-03
WO2002000932A3 true WO2002000932A3 (de) 2003-09-04

Family

ID=7647778

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/001501 WO2002000932A2 (de) 2000-06-30 2001-06-29 Diagnose von bedeutenden genetischen parametern innerhalb des mhc

Country Status (6)

Country Link
US (1) US20030186277A1 (de)
EP (1) EP1358351A2 (de)
JP (1) JP2004511217A (de)
AU (1) AU2001277653A1 (de)
DE (1) DE10032529A1 (de)
WO (1) WO2002000932A2 (de)

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Publication number Priority date Publication date Assignee Title
ES2391949T3 (es) 2002-12-23 2012-12-03 Immunex Corporation Ácidos nucleicos, proteínas y anticuerpos BTL-II
US20060183128A1 (en) * 2003-08-12 2006-08-17 Epigenomics Ag Methods and compositions for differentiating tissues for cell types using epigenetic markers
US7388127B2 (en) * 2004-02-24 2008-06-17 Korea Research Institute Of Bioscience And Biotechnology Multiple stress-inducible peroxidase promoter derived from Ipomoea batatas
US7932027B2 (en) 2005-02-16 2011-04-26 Epigenomics Ag Method for determining the methylation pattern of a polynucleic acid
WO2006088978A1 (en) 2005-02-16 2006-08-24 Epigenomics, Inc. Method for determining the methylation pattern of a polynucleic acid
ATE547537T1 (de) 2005-04-15 2012-03-15 Epigenomics Ag Verfahren zur bestimmung der dna-methylierung in blut- oder urinproben
WO2006111586A2 (es) * 2005-04-20 2006-10-26 Proyecto De Biomedicina Cima, S.L. Procedimiento para la determinación in vitro del grado de metilación del promotor de line-1
US8084734B2 (en) * 2006-05-26 2011-12-27 The George Washington University Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays
KR100862599B1 (ko) * 2007-08-13 2008-10-09 인제대학교 산학협력단 고구마 유래 식물 조직배양세포 고발현 프로모터 및 이를포함하는 식물 조직배양세포 고발현 벡터
WO2009108917A2 (en) * 2008-02-29 2009-09-03 Oncomethylome Sciences, S.A. Markers for improved detection of breast cancer
WO2010065916A1 (en) * 2008-12-04 2010-06-10 Rush University Medical Center Dna methylation based test for monitoring efficacy of treatment
US8110796B2 (en) 2009-01-17 2012-02-07 The George Washington University Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays
US9490113B2 (en) * 2009-04-07 2016-11-08 The George Washington University Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry
US9938580B2 (en) 2012-03-14 2018-04-10 Ruprecht-Karls-Universität Heidelberg Epigenetic signatures as marker for cardiomyopathies and myocardial insufficiencies
US9840742B2 (en) * 2014-06-16 2017-12-12 JBS Science Inc. Detection of hepatitis B virus (HBV) DNA and methylated HBV DNA in urine of patients with HBV-associated hepatocellular carcinoma
AU2016287499B2 (en) 2015-06-29 2022-08-04 Caris Science, Inc. Therapeutic oligonucleotides
WO2023159138A2 (en) * 2022-02-17 2023-08-24 Northwestern University Use of dinucleotide repeat rnas to treat cancer

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US5650277A (en) * 1992-07-02 1997-07-22 Diagenetics Ltd. Method of determining the presence and quantifying the number of di- and trinucleotide repeats
US5605798A (en) * 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
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Also Published As

Publication number Publication date
JP2004511217A (ja) 2004-04-15
EP1358351A2 (de) 2003-11-05
DE10032529A1 (de) 2002-02-07
WO2002000932A2 (de) 2002-01-03
AU2001277653A1 (en) 2002-01-08
US20030186277A1 (en) 2003-10-02

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