WO2002000928A3 - Diagnose von mit dem immunsystem assoziierten krankheiten durch bestimmung der cytosin-methylierung - Google Patents

Diagnose von mit dem immunsystem assoziierten krankheiten durch bestimmung der cytosin-methylierung Download PDF

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Publication number
WO2002000928A3
WO2002000928A3 PCT/EP2001/007537 EP0107537W WO0200928A3 WO 2002000928 A3 WO2002000928 A3 WO 2002000928A3 EP 0107537 W EP0107537 W EP 0107537W WO 0200928 A3 WO0200928 A3 WO 0200928A3
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WO
WIPO (PCT)
Prior art keywords
immune system
diagnosis
diseases associated
cytosine methylation
genes associated
Prior art date
Application number
PCT/EP2001/007537
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English (en)
French (fr)
Other versions
WO2002000928A2 (de
Inventor
Alexander Olek
Christian Piepenbrock
Kurt Berlin
Original Assignee
Epigenomics Ag
Alexander Olek
Christian Piepenbrock
Kurt Berlin
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Filing date
Publication date
Priority claimed from DE10032529A external-priority patent/DE10032529A1/de
Application filed by Epigenomics Ag, Alexander Olek, Christian Piepenbrock, Kurt Berlin filed Critical Epigenomics Ag
Priority to EP01967115A priority Critical patent/EP1294951A2/de
Priority to AU2001287575A priority patent/AU2001287575A1/en
Publication of WO2002000928A2 publication Critical patent/WO2002000928A2/de
Publication of WO2002000928A3 publication Critical patent/WO2002000928A3/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/125—Bisulfite(s)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

Die vorliegende Erfindung betrifft die chemisch modifizierte genomische Sequenzen von mit dem Immunsystem assoziierten Genen, gegen die Sequenz gerichtete Oligonukleotide und/oder PNA-Oligomere zur Detektion des Cytosin-Methylierungszustandes von mit dem Immunsystem assoziierten Genen sowie ein Verfahren zur Ermittlung von genetischen und/oder epigenetischen Parametern von mit dem Immunsystem assoziierten Genen.
PCT/EP2001/007537 2000-06-30 2001-07-02 Diagnose von mit dem immunsystem assoziierten krankheiten durch bestimmung der cytosin-methylierung WO2002000928A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01967115A EP1294951A2 (de) 2000-06-30 2001-07-02 Diagnose von mit dem immunsystem assoziierten krankheiten
AU2001287575A AU2001287575A1 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with the immune system by determining cytosine methylation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10032529A DE10032529A1 (de) 2000-06-30 2000-06-30 Diagnose von bedeutenden genetischen Parametern innerhalb des Major Histocompatibility Complex (MHC)
DE10032529.7 2000-06-30
DE10043826 2000-09-01
DE10043826.1 2000-09-01

Publications (2)

Publication Number Publication Date
WO2002000928A2 WO2002000928A2 (de) 2002-01-03
WO2002000928A3 true WO2002000928A3 (de) 2002-08-01

Family

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Family Applications (8)

Application Number Title Priority Date Filing Date
PCT/EP2001/007471 WO2002002807A2 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with cell signalling
PCT/EP2001/007470 WO2002002806A2 (en) 2000-06-30 2001-06-29 Method and nucleic acids for analysing the methylation of genes implicated in pharmacogenomics
PCT/EP2001/007472 WO2002000926A2 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with signal transduction
PCT/EP2001/007538 WO2002002808A2 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the analysis of astrocytomas
PCT/EP2001/007539 WO2002000705A2 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the differentiation of astrocytoma, oligoastrocytoma and oligodendroglioma tumor cells
PCT/EP2001/007540 WO2002002809A2 (en) 2000-06-30 2001-07-02 Diagnosis of behavioural disorders, neurological disorders and cancer
PCT/EP2001/007537 WO2002000928A2 (de) 2000-06-30 2001-07-02 Diagnose von mit dem immunsystem assoziierten krankheiten durch bestimmung der cytosin-methylierung
PCT/EP2001/007536 WO2002000927A2 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with development by means of assessing their methylation status

Family Applications Before (6)

Application Number Title Priority Date Filing Date
PCT/EP2001/007471 WO2002002807A2 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with cell signalling
PCT/EP2001/007470 WO2002002806A2 (en) 2000-06-30 2001-06-29 Method and nucleic acids for analysing the methylation of genes implicated in pharmacogenomics
PCT/EP2001/007472 WO2002000926A2 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with signal transduction
PCT/EP2001/007538 WO2002002808A2 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the analysis of astrocytomas
PCT/EP2001/007539 WO2002000705A2 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the differentiation of astrocytoma, oligoastrocytoma and oligodendroglioma tumor cells
PCT/EP2001/007540 WO2002002809A2 (en) 2000-06-30 2001-07-02 Diagnosis of behavioural disorders, neurological disorders and cancer

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/007536 WO2002000927A2 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with development by means of assessing their methylation status

Country Status (5)

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US (5) US20040023230A1 (de)
EP (9) EP1294947A2 (de)
JP (1) JP2004501666A (de)
AU (8) AU2001277521A1 (de)
WO (8) WO2002002807A2 (de)

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