AU2001287575A1 - Diagnosis of diseases associated with the immune system by determining cytosine methylation - Google Patents

Diagnosis of diseases associated with the immune system by determining cytosine methylation

Info

Publication number
AU2001287575A1
AU2001287575A1 AU2001287575A AU8757501A AU2001287575A1 AU 2001287575 A1 AU2001287575 A1 AU 2001287575A1 AU 2001287575 A AU2001287575 A AU 2001287575A AU 8757501 A AU8757501 A AU 8757501A AU 2001287575 A1 AU2001287575 A1 AU 2001287575A1
Authority
AU
Australia
Prior art keywords
diagnosis
immune system
diseases associated
cytosine methylation
determining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001287575A
Inventor
Kurt Berlin
Alexander Olek
Christian Piepenbrock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epigenomics AG
Original Assignee
Epigenomics AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10032529A external-priority patent/DE10032529A1/en
Application filed by Epigenomics AG filed Critical Epigenomics AG
Publication of AU2001287575A1 publication Critical patent/AU2001287575A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/125—Bisulfite(s)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
AU2001287575A 2000-06-30 2001-07-02 Diagnosis of diseases associated with the immune system by determining cytosine methylation Abandoned AU2001287575A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10032529A DE10032529A1 (en) 2000-06-30 2000-06-30 Diagnosis of major genetic parameters within the Major Histocompatibility Complex (MHC)
DE10032529.7 2000-06-30
DE10043826 2000-09-01
DE10043826.1 2000-09-01
PCT/EP2001/007537 WO2002000928A2 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with the immune system by determining cytosine methylation

Publications (1)

Publication Number Publication Date
AU2001287575A1 true AU2001287575A1 (en) 2002-01-08

Family

ID=26006285

Family Applications (8)

Application Number Title Priority Date Filing Date
AU2001277521A Abandoned AU2001277521A1 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with cell signalling
AU2001289617A Abandoned AU2001289617A1 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with signal transduction
AU2001276371A Abandoned AU2001276371A1 (en) 2000-06-30 2001-06-29 Method and nucleic acids for analysing the methylation of genes implicated pharmacogenomics
AU2001279707A Abandoned AU2001279707A1 (en) 2000-06-30 2001-07-02 Diagnosis of behavioural disorders, neurological disorders and cancer
AU2001283915A Abandoned AU2001283915A1 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with development by means of assessing their methylation status
AU2001283916A Abandoned AU2001283916A1 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the analysis of astrocytomas
AU2001287576A Abandoned AU2001287576A1 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the differentiation of astrocytoma, oligoastrocytoma and oligodendroglioma tumor cells
AU2001287575A Abandoned AU2001287575A1 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with the immune system by determining cytosine methylation

Family Applications Before (7)

Application Number Title Priority Date Filing Date
AU2001277521A Abandoned AU2001277521A1 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with cell signalling
AU2001289617A Abandoned AU2001289617A1 (en) 2000-06-30 2001-06-29 Diagnosis of diseases associated with signal transduction
AU2001276371A Abandoned AU2001276371A1 (en) 2000-06-30 2001-06-29 Method and nucleic acids for analysing the methylation of genes implicated pharmacogenomics
AU2001279707A Abandoned AU2001279707A1 (en) 2000-06-30 2001-07-02 Diagnosis of behavioural disorders, neurological disorders and cancer
AU2001283915A Abandoned AU2001283915A1 (en) 2000-06-30 2001-07-02 Diagnosis of diseases associated with development by means of assessing their methylation status
AU2001283916A Abandoned AU2001283916A1 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the analysis of astrocytomas
AU2001287576A Abandoned AU2001287576A1 (en) 2000-06-30 2001-07-02 Method and nucleic acids for the differentiation of astrocytoma, oligoastrocytoma and oligodendroglioma tumor cells

Country Status (5)

Country Link
US (5) US20040023230A1 (en)
EP (9) EP1294947A2 (en)
JP (1) JP2004501666A (en)
AU (8) AU2001277521A1 (en)
WO (8) WO2002002807A2 (en)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9806954A (en) 1997-01-14 2000-03-21 Human Genome Sciences Inc Tumor necrosis factor 6a and 6b receptors
US7285267B2 (en) 1997-01-14 2007-10-23 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6α & 6β
US6818404B2 (en) 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7611869B2 (en) * 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) * 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
AU2001275663A1 (en) 2000-04-06 2001-10-23 Epigenomics Ag Diagnosis of diseases associated with DNA replication by assessing DNA methylation
AU2001281311A1 (en) * 2000-07-10 2002-01-21 Epigenx Pharmaceutical, Inc. Detecting methylated cytosine in polynucleotides
JP2002034575A (en) * 2000-07-28 2002-02-05 Shiseido Co Ltd Human type ii 5 alpha-reductase promoter gene and its use
DE10054974A1 (en) * 2000-11-06 2002-06-06 Epigenomics Ag Diagnosis of diseases associated with Cdk4
DE10061338A1 (en) * 2000-12-06 2002-06-20 Epigenomics Ag Diagnosis of diseases associated with angiogenesis
US6756200B2 (en) * 2001-01-26 2004-06-29 The Johns Hopkins University School Of Medicine Aberrantly methylated genes as markers of breast malignancy
EP1410304A2 (en) * 2001-03-26 2004-04-21 Epigenomics AG Method for epigenetic feature selection
WO2002083921A2 (en) 2001-04-10 2002-10-24 Agensys, Inc. Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
DE10128508A1 (en) 2001-06-14 2003-02-06 Epigenomics Ag Methods and nucleic acids for the differentiation of prostate tumors
US7432050B2 (en) 2001-10-05 2008-10-07 Case Western Reserve University Methods and compositions for detecting colon cancers
US20110151438A9 (en) 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
WO2003062441A1 (en) * 2002-01-18 2003-07-31 Genzyme Corporation Methods for fetal dna detection and allele quantitation
EP1470255A2 (en) * 2002-01-30 2004-10-27 Epigenomics AG Identification of cell differentiation states based on methylation patterns
EP1340818A1 (en) * 2002-02-27 2003-09-03 Epigenomics AG Method and nucleic acids for the analysis of a colon cell proliferative disorder
EP1497462A4 (en) 2002-03-07 2007-11-07 Univ Johns Hopkins Med Genomic screen for epigenetically silenced genes associated with cancer
US20040053880A1 (en) 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7807803B2 (en) 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
JP2005532067A (en) * 2002-07-03 2005-10-27 コーリー ファーマシューティカル グループ，インコーポレイテッド Nucleic acid composition for stimulating immune response
US7605138B2 (en) * 2002-07-03 2009-10-20 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US20040029128A1 (en) * 2002-08-08 2004-02-12 Epigenomics, Inc. Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the calcitonin gene
ATE437962T1 (en) 2002-10-01 2009-08-15 Epigenomics Ag METHOD FOR THE TREATMENT OF PROLIFERATIVE DISEASES OF BREAST CELLS
ATE462017T1 (en) * 2002-12-02 2010-04-15 Illumina Cambridge Ltd DETERMINATION OF METHYLATION OF NUCLEIC ACID SEQUENCES
WO2004087044A2 (en) * 2002-12-20 2004-10-14 Bioseek, Inc. Drug target
ITRM20030149A1 (en) 2003-04-02 2004-10-03 Giuliani Spa ANTISENSE OLIGONUCLEOTIDES (ODN) FOR SMAD7 AND THEIR USE IN THE MEDICAL FIELD
US20050009059A1 (en) * 2003-05-07 2005-01-13 Affymetrix, Inc. Analysis of methylation status using oligonucleotide arrays
US7403568B2 (en) 2003-08-13 2008-07-22 Apple Inc. Pre-processing method and system for data reduction of video sequences and bit rate reduction of compressed video sequences using temporal filtering
US7430335B2 (en) 2003-08-13 2008-09-30 Apple Inc Pre-processing method and system for data reduction of video sequences and bit rate reduction of compressed video sequences using spatial filtering
WO2005042713A2 (en) 2003-10-28 2005-05-12 The Johns Hopkins University Quantitative multiplex methylation-specific pcr
US9181587B2 (en) 2003-12-01 2015-11-10 Epigenomics Ag Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
EP1561821B1 (en) 2003-12-11 2011-02-16 Epigenomics AG Prognostic markers for prediction of treatment response and/or survival of breast cell proliferative disorder patients
CA2572450A1 (en) 2004-05-28 2005-12-15 Ambion, Inc. Methods and compositions involving microrna
EP1769086A2 (en) * 2004-07-18 2007-04-04 Epigenomics AG Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders
WO2006034879A2 (en) * 2004-09-30 2006-04-06 Epigenomics Ag Epigenetic methods and nucleic acids for the detection of lung cell proliferative disorders
EP2302055B1 (en) 2004-11-12 2014-08-27 Asuragen, Inc. Methods and compositions involving miRNA and miRNA inhibitor molecules
US20060134650A1 (en) * 2004-12-21 2006-06-22 Illumina, Inc. Methylation-sensitive restriction enzyme endonuclease method of whole genome methylation analysis
WO2006088978A1 (en) 2005-02-16 2006-08-24 Epigenomics, Inc. Method for determining the methylation pattern of a polynucleic acid
EP1748080A3 (en) * 2005-03-11 2007-04-11 Epiontis GmbH Specific DNAs for epigenetic characterisation of cells and tissues
EP2402461B1 (en) 2005-03-11 2015-08-12 Epiontis GmbH Method and kit for identifying chondrocytes by the detection of demethylation of C15orf27
PL1871912T3 (en) 2005-04-15 2012-07-31 Epigenomics Ag Method for determining DNA methylation in blood or urine samples
WO2006111586A2 (en) * 2005-04-20 2006-10-26 Proyecto De Biomedicina Cima, S.L. Method for the in vitro determination of the degree of methylation of the line-1 promoter
US20060292585A1 (en) * 2005-06-24 2006-12-28 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
WO2007003397A2 (en) * 2005-07-01 2007-01-11 Epigenomics Ag Method and nucleic acids for the improved treatment of cancers
WO2007032748A1 (en) * 2005-09-15 2007-03-22 Agency For Science, Technology & Research Method for detecting dna methylation
AU2006339538A1 (en) 2005-11-08 2007-09-13 Euclid Diagnostics Llc Materials and methods for assaying for methylation of CpG islands associated with genes in the evaluation of cancer
US20070161006A1 (en) * 2006-01-10 2007-07-12 Vita Genomics, Inc. Single nucleotide polymorphisms in protein-tyrosine phosphatase receptor-type delta for the diagnosis of susceptibility to infection and asthma
WO2007095032A2 (en) * 2006-02-09 2007-08-23 Novartis Ag Mutations and polymorphisms of ptk2b
US20070238115A1 (en) * 2006-02-27 2007-10-11 Dwinell Michael B Method of Diagnosing and Treating Colon Cancer
US7901882B2 (en) 2006-03-31 2011-03-08 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
US8084734B2 (en) * 2006-05-26 2011-12-27 The George Washington University Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays
CA2652975A1 (en) * 2006-05-31 2007-12-13 Orion Genomics Llc Gene methylation in cancer diagnosis
ES2599816T3 (en) * 2006-07-21 2017-02-03 Epigenomics Ag Methods related to the GLI3 gene for the detection of colorectal cancer
WO2008036765A2 (en) * 2006-09-19 2008-03-27 Asuragen, Inc. Micrornas differentially expressed in pancreatic diseases and uses thereof
WO2008073915A2 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Micrornas differentially expressed in leukemia and uses thereof
GB0625321D0 (en) * 2006-12-19 2007-01-24 Univ Surrey Cancer biomarker
CA2667302C (en) 2007-01-18 2013-06-25 Molecor Tecnologia S.L. System for the manufacturing of integrated sockets in biaxially oriented plastic pipes
US20090170082A1 (en) * 2007-02-02 2009-07-02 Orion Genomics Llc Gene methylation in renal cancer diagnosis
WO2008096146A1 (en) 2007-02-07 2008-08-14 Solexa Limited Preparation of templates for methylation analysis
US20090131354A1 (en) * 2007-05-22 2009-05-21 Bader Andreas G miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
US8361714B2 (en) 2007-09-14 2013-01-29 Asuragen, Inc. Micrornas differentially expressed in cervical cancer and uses thereof
US20090186015A1 (en) * 2007-10-18 2009-07-23 Latham Gary J Micrornas differentially expressed in lung diseases and uses thereof
WO2009070805A2 (en) 2007-12-01 2009-06-04 Asuragen, Inc. Mir-124 regulated genes and pathways as targets for therapeutic intervention
WO2009108917A2 (en) * 2008-02-29 2009-09-03 Oncomethylome Sciences, S.A. Markers for improved detection of breast cancer
US20090233297A1 (en) * 2008-03-06 2009-09-17 Elizabeth Mambo Microrna markers for recurrence of colorectal cancer
EP2990487A1 (en) 2008-05-08 2016-03-02 Asuragen, INC. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
US8541207B2 (en) 2008-10-22 2013-09-24 Illumina, Inc. Preservation of information related to genomic DNA methylation
US8110796B2 (en) 2009-01-17 2012-02-07 The George Washington University Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays
WO2010091296A2 (en) * 2009-02-06 2010-08-12 The Regents Of The University Of California Emx2 in cancer diagnosis and prognosis
US9490113B2 (en) * 2009-04-07 2016-11-08 The George Washington University Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry
US20110086925A1 (en) * 2009-06-09 2011-04-14 Diego Mastroeni Method and System to Detect, Diagnose, and Monitor the Progression of Alzheimer's Disease
EP2494067A1 (en) * 2009-10-28 2012-09-05 Signature Diagnostics AG Method for the prognosis of ovarian carcinoma
US9394570B2 (en) * 2010-04-21 2016-07-19 The Chinese University Of Hong Kong Marker for colon cancer and method for detecting colon cancer
US20130264820A1 (en) 2010-09-06 2013-10-10 Molecor Tecnologia, S. L. Device and method for producing the mouths of biaxially oriented plastic tubes with integrated sealing gaskets
JP6049623B2 (en) * 2010-10-22 2016-12-21 カッパーアールエヌエー，インコーポレイテッド Treatment of IDUA-related diseases by inhibition of natural antisense transcripts to α-L-iduronidase (IDUA)
WO2012162139A1 (en) 2011-05-20 2012-11-29 The Regents Of The University Of California Method to estimate age of individual based on epigenetic markers in biological sample
US10526642B2 (en) 2011-08-25 2020-01-07 Commonwealth Scientific And Industrial Research Organisation DNA methylation in colorectal and breast cancer diagnostic methods
US9644241B2 (en) 2011-09-13 2017-05-09 Interpace Diagnostics, Llc Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease
WO2013131083A1 (en) * 2012-03-02 2013-09-06 Winthrop-University Hospital METHOD FOR USING PROBE BASED PCR DETECTION TO MEASURE THE LEVELS OF CIRCULATING DEMETHYLATED β CELL DERIVED DNA AS A MEASURE OF β CELL LOSS IN DIABETES
WO2014071281A1 (en) 2012-11-02 2014-05-08 The Johns Hopkins University Dna methylation biomarkers of post-partum depression risk
ES2859645T3 (en) 2013-03-14 2021-10-04 Mayo Found Medical Education & Res Neoplasia detection
ES2527724B1 (en) * 2013-05-29 2015-11-10 Fundación Para La Investigación Biomédica Del Hospital Universitario La Paz METHOD FOR PREACHING THE RESPONSE TO THE TREATMENT WITH RADIOTHERAPY COMBINED WITH CISPLATINO-BASED CHEMOTHERAPY
CN106460046A (en) 2014-03-31 2017-02-22 梅奥医学教育和研究基金会 Detecting colorectal neoplasm
US9840742B2 (en) * 2014-06-16 2017-12-12 JBS Science Inc. Detection of hepatitis B virus (HBV) DNA and methylated HBV DNA in urine of patients with HBV-associated hepatocellular carcinoma
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
US10030272B2 (en) 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
WO2017015497A2 (en) * 2015-07-21 2017-01-26 Indiana University Research & Technology Corporation Cell-free methylated and unmethylated dna in diseases resulting from abnormalities in blood glucose levels
CN108138235B (en) 2015-08-31 2022-04-15 梅约医药教育及研究基金会 Detection of gastric tumors
US10370726B2 (en) 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
WO2017180886A1 (en) 2016-04-14 2017-10-19 Mayo Foundation For Medical Education And Research Detecting pancreatic high-grade dysplasia
CN105734152B (en) * 2016-04-20 2019-02-26 苏州吉诺瑞生物科技有限公司 Detect the primer pair and its application of the expression of people SRPK2 gene
EP4293128A3 (en) * 2016-09-02 2024-03-20 Mayo Foundation for Medical Education and Research Detecting hepatocellular carcinoma
US20190284636A1 (en) * 2016-10-26 2019-09-19 Brown University A method to measure myeloid suppressor cells for diagnosis and prognosis of cancer
EP3589732A4 (en) 2017-02-28 2021-05-19 Mayo Foundation for Medical Education and Research Detecting prostate cancer
EP3717644A4 (en) 2017-11-30 2021-12-29 Mayo Foundation for Medical Education and Research Detecting breast cancer
EP3744858A4 (en) * 2017-12-01 2021-04-14 Biochain (Beijing) Science & Technology, Inc. Composition for detecting esophageal cancer and use thereof
CN108977457B (en) * 2018-08-31 2021-04-02 长江大学 Preparation method of finless eel antibacterial peptide
SG11202107670TA (en) 2019-01-18 2021-08-30 Univ California Dna methylation measurement for mammals based on conserved loci
DE102020111423B4 (en) 2020-04-27 2022-03-03 Precision For Medicine Gmbh MYH11/NDE1 region as an epigenetic marker for the identification of endothelial progenitor cells (EPCs)
CA3184128A1 (en) * 2020-06-23 2021-12-30 Kathleen Barnes Methods for diagnosing respiratory pathogens and predicting covid-19 related outcomes
JP2023538557A (en) 2020-08-15 2023-09-08 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Treatment of Obesity in Subjects Having a Variant Nucleic Acid Molecule Encoding a Calcitonin Receptor (CALCR)
WO2023175019A1 (en) 2022-03-15 2023-09-21 Genknowme S.A. Method determining the difference between the biological age and the chronological age of a subject

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5843654A (en) * 1992-12-07 1998-12-01 Third Wave Technologies, Inc. Rapid detection of mutations in the p53 gene
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
JPH09507121A (en) * 1993-10-26 1997-07-22 アフィマックス テクノロジーズ ナームロゼ ベノートスハップ Nucleic acid probe array on biological chip
US5804407A (en) * 1993-11-04 1998-09-08 University Technologies International, Inc. Method of expressing genes in mammalian cells
US5756668A (en) * 1994-11-15 1998-05-26 The Johns Hopkins University School Of Medicine Hypermethylated in cancer polypeptide, HIC-1
US6017704A (en) * 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
WO1998056952A1 (en) * 1997-06-09 1998-12-17 University Of Southern California A cancer diagnostic method based upon dna methylation differences
US6342350B1 (en) * 1997-09-05 2002-01-29 The General Hospital Corporation Alpha-2-macroglobulin diagnostic test
DE19754482A1 (en) * 1997-11-27 1999-07-01 Epigenomics Gmbh Process for making complex DNA methylation fingerprints
CA2312052A1 (en) * 1997-12-05 1999-06-17 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Method for identifying nucleic acids by means of matrix-assisted laser desorption/ionisation mass spectrometry
DE19905082C1 (en) * 1999-01-29 2000-05-18 Epigenomics Gmbh Identification of methylation patterns of cytosine in genome DNA comprises chemical treatment to produce different base pairing behavior between cytosine and 5-methylcytosine
EP1283905A2 (en) * 2000-03-15 2003-02-19 Epigenomics AG Diagnosis of diseases associated with the cell cycle
AU2001275663A1 (en) * 2000-04-06 2001-10-23 Epigenomics Ag Diagnosis of diseases associated with DNA replication by assessing DNA methylation
DE10128508A1 (en) * 2001-06-14 2003-02-06 Epigenomics Ag Methods and nucleic acids for the differentiation of prostate tumors
EP1502222A2 (en) * 2001-07-02 2005-02-02 Epigenomics AG A distributed system for epigenetic based prediction of complex phenotypes

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AU2001283915A1 (en) 2002-01-08
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