WO1998017266A2 - Preparation pharmaceutique contenant un derive d'amidine et de la procaine - Google Patents

Preparation pharmaceutique contenant un derive d'amidine et de la procaine Download PDF

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Publication number
WO1998017266A2
WO1998017266A2 PCT/EP1997/005724 EP9705724W WO9817266A2 WO 1998017266 A2 WO1998017266 A2 WO 1998017266A2 EP 9705724 W EP9705724 W EP 9705724W WO 9817266 A2 WO9817266 A2 WO 9817266A2
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical preparation
preparation
preparation according
pharmaceutical
trypanosomiasis
Prior art date
Application number
PCT/EP1997/005724
Other languages
German (de)
English (en)
Other versions
WO1998017266A3 (fr
Inventor
Alain Jacques Bourdichon
Original Assignee
Atarost Allgem. Tierarzneimittelfabrik, Dr. Ulrich Böhmer, Nachf. Gmbh & Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atarost Allgem. Tierarzneimittelfabrik, Dr. Ulrich Böhmer, Nachf. Gmbh & Co. filed Critical Atarost Allgem. Tierarzneimittelfabrik, Dr. Ulrich Böhmer, Nachf. Gmbh & Co.
Priority to AU49482/97A priority Critical patent/AU4948297A/en
Priority to EP97912195A priority patent/EP0936907A2/fr
Publication of WO1998017266A2 publication Critical patent/WO1998017266A2/fr
Publication of WO1998017266A3 publication Critical patent/WO1998017266A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles

Definitions

  • the invention relates to a pharmaceutical preparation for trypanosomiasis prophylaxis.
  • Arsenic preparations and trypan dyes were used for chemotherapy, but they have harmful side effects.
  • a preparation for trypanosomiasis prophylaxis which contains at least one active substance against protozoa from the group of the amidines, preferably diminazene di-aceturate (4,4'-diamidino-diazoaminobenzenediacetamidoacetate) and / or pentamidine ( 4,4 '- (Pentamethylenedioxy) -dibenzamidin), as well as procaine or a procaine derivative.
  • the preparation also contains phenazone, which has an antipyretic effect in the case of an existing infection.
  • the preparation is preferably used as an injection solution, so that the individual substances first in solution have to be brought.
  • a mixture of cellulose ether, in particular methyl cellulose, glycerol and water, is advantageously mixed with the solids, a clear solution being able to be prepared simply by stirring.
  • Procaine or procaine derivative e.g. hydrochloride
  • Emulsifier-water mixture glycerin
  • Water suitable for pharmaceutical purposes, e.g. physiologically balanced water
  • the preparation according to the invention enables trypanomiasis prophylaxis and advantageously the preparation is also simultaneously suitable for chemotherapy of an existing protozoan infection.
  • the preparation is particularly intended for the veterenary area. However, it is also in human medicine can be used so that, particularly advantageous for vacationers, a kind of vaccination can be carried out.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention vise à mettre au point une préparation pharmaceutique permettant d'assurer la prophylaxie de trypanosomiase. A cet effet, il est prévu une préparation pharmaceutique se caractérisant en ce qu'elle contient au moins un composé du groupe comprenant les amidines et la procaïne ou un dérivé de procaïne, ledit composé étant actif à l'encontre de protozoaires.
PCT/EP1997/005724 1996-10-18 1997-10-17 Preparation pharmaceutique contenant un derive d'amidine et de la procaine WO1998017266A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU49482/97A AU4948297A (en) 1996-10-18 1997-10-17 Pharmaceutical preparation
EP97912195A EP0936907A2 (fr) 1996-10-18 1997-10-17 Preparation pharmaceutique contenant un derive d'amidine et de la procaine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE29618094.7 1996-10-18
DE29618094U DE29618094U1 (de) 1996-10-18 1996-10-18 Pharmazeutisches Präparat

Publications (2)

Publication Number Publication Date
WO1998017266A2 true WO1998017266A2 (fr) 1998-04-30
WO1998017266A3 WO1998017266A3 (fr) 1998-06-25

Family

ID=8030722

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/005724 WO1998017266A2 (fr) 1996-10-18 1997-10-17 Preparation pharmaceutique contenant un derive d'amidine et de la procaine

Country Status (4)

Country Link
EP (1) EP0936907A2 (fr)
AU (1) AU4948297A (fr)
DE (1) DE29618094U1 (fr)
WO (1) WO1998017266A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000030611A2 (fr) * 1998-11-24 2000-06-02 Chambord Ltd. Preparation pharmaceutique

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4309415A1 (de) * 1993-03-19 1994-09-22 Alan Jacques Bourdichon Pharmazeutisches Präparat
EP0643964A2 (fr) * 1993-08-18 1995-03-22 Medipharma S.A. Utilisation d'anesthétiques locaux pour la fabrication d'un médicament pour protéger les membranes de cellules plasmatiques
WO1997006769A2 (fr) * 1995-08-21 1997-02-27 Bourdichon Alain Jacques Composition pharmaceutique a proprietes trypanocides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4309415A1 (de) * 1993-03-19 1994-09-22 Alan Jacques Bourdichon Pharmazeutisches Präparat
EP0643964A2 (fr) * 1993-08-18 1995-03-22 Medipharma S.A. Utilisation d'anesthétiques locaux pour la fabrication d'un médicament pour protéger les membranes de cellules plasmatiques
WO1997006769A2 (fr) * 1995-08-21 1997-02-27 Bourdichon Alain Jacques Composition pharmaceutique a proprietes trypanocides

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000030611A2 (fr) * 1998-11-24 2000-06-02 Chambord Ltd. Preparation pharmaceutique
WO2000030611A3 (fr) * 1998-11-24 2000-08-31 Chambord Ltd Preparation pharmaceutique

Also Published As

Publication number Publication date
EP0936907A2 (fr) 1999-08-25
WO1998017266A3 (fr) 1998-06-25
AU4948297A (en) 1998-05-15
DE29618094U1 (de) 1998-02-12

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