EP0936907A2 - Preparation pharmaceutique contenant un derive d'amidine et de la procaine - Google Patents

Preparation pharmaceutique contenant un derive d'amidine et de la procaine

Info

Publication number
EP0936907A2
EP0936907A2 EP97912195A EP97912195A EP0936907A2 EP 0936907 A2 EP0936907 A2 EP 0936907A2 EP 97912195 A EP97912195 A EP 97912195A EP 97912195 A EP97912195 A EP 97912195A EP 0936907 A2 EP0936907 A2 EP 0936907A2
Authority
EP
European Patent Office
Prior art keywords
pharmaceutical preparation
preparation
preparation according
pharmaceutical
trypanosomiasis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97912195A
Other languages
German (de)
English (en)
Inventor
Alain Jacques Bourdichon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Atarost Allgem Tierarzneimittelfabrik Dr Ulrich Bohmer Nachf & Co GmbH
Original Assignee
Atarost Allgem Tierarzneimittelfabrik Dr Ulrich Bohmer Nachf & Co GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atarost Allgem Tierarzneimittelfabrik Dr Ulrich Bohmer Nachf & Co GmbH filed Critical Atarost Allgem Tierarzneimittelfabrik Dr Ulrich Bohmer Nachf & Co GmbH
Publication of EP0936907A2 publication Critical patent/EP0936907A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles

Definitions

  • the invention relates to a pharmaceutical preparation for trypanosomiasis prophylaxis.
  • Arsenic preparations and trypan dyes were used for chemotherapy, but they have harmful side effects.
  • a preparation for trypanosomiasis prophylaxis which contains at least one active substance against protozoa from the group of the amidines, preferably diminazene di-aceturate (4,4'-diamidino-diazoaminobenzenediacetamidoacetate) and / or pentamidine ( 4,4 '- (Pentamethylenedioxy) -dibenzamidin), as well as procaine or a procaine derivative.
  • the preparation also contains phenazone, which has an antipyretic effect in the case of an existing infection.
  • the preparation is preferably used as an injection solution, so that the individual substances first in solution have to be brought.
  • a mixture of cellulose ether, in particular methyl cellulose, glycerol and water, is advantageously mixed with the solids, a clear solution being able to be prepared simply by stirring.
  • Procaine or procaine derivative e.g. hydrochloride
  • Emulsifier-water mixture glycerin
  • Water suitable for pharmaceutical purposes, e.g. physiologically balanced water
  • the preparation according to the invention enables trypanomiasis prophylaxis and advantageously the preparation is also simultaneously suitable for chemotherapy of an existing protozoan infection.
  • the preparation is particularly intended for the veterenary area. However, it is also in human medicine can be used so that, particularly advantageous for vacationers, a kind of vaccination can be carried out.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention vise à mettre au point une préparation pharmaceutique permettant d'assurer la prophylaxie de trypanosomiase. A cet effet, il est prévu une préparation pharmaceutique se caractérisant en ce qu'elle contient au moins un composé du groupe comprenant les amidines et la procaïne ou un dérivé de procaïne, ledit composé étant actif à l'encontre de protozoaires.
EP97912195A 1996-10-18 1997-10-17 Preparation pharmaceutique contenant un derive d'amidine et de la procaine Withdrawn EP0936907A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE29618094U 1996-10-18
DE29618094U DE29618094U1 (de) 1996-10-18 1996-10-18 Pharmazeutisches Präparat
PCT/EP1997/005724 WO1998017266A2 (fr) 1996-10-18 1997-10-17 Preparation pharmaceutique contenant un derive d'amidine et de la procaine

Publications (1)

Publication Number Publication Date
EP0936907A2 true EP0936907A2 (fr) 1999-08-25

Family

ID=8030722

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97912195A Withdrawn EP0936907A2 (fr) 1996-10-18 1997-10-17 Preparation pharmaceutique contenant un derive d'amidine et de la procaine

Country Status (4)

Country Link
EP (1) EP0936907A2 (fr)
AU (1) AU4948297A (fr)
DE (1) DE29618094U1 (fr)
WO (1) WO1998017266A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19853937A1 (de) * 1998-11-24 2000-05-25 Chambord Ltd Pharmazeutisches Präparat

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4309415C2 (de) * 1993-03-19 1996-11-07 Alain Jaques Bourdichon Pharmazeutisches Präparat
EP0643964A3 (fr) * 1993-08-18 1995-08-09 Medipharma Sa Utilisation d'anesthétiques locaux pour la fabrication d'un médicament pour protéger les membranes de cellules plasmatiques.
DE19530708C2 (de) * 1995-08-21 1999-01-07 Atarost Allg Tierarzneimittelf Pharmazeutisches Präparat mit trypanoziden Eigenschaften

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9817266A3 *

Also Published As

Publication number Publication date
WO1998017266A2 (fr) 1998-04-30
AU4948297A (en) 1998-05-15
WO1998017266A3 (fr) 1998-06-25
DE29618094U1 (de) 1998-02-12

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