WO1997027801A1 - Laser opto-acoustic imaging system - Google Patents

Laser opto-acoustic imaging system Download PDF

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Publication number
WO1997027801A1
WO1997027801A1 PCT/US1997/001815 US9701815W WO9727801A1 WO 1997027801 A1 WO1997027801 A1 WO 1997027801A1 US 9701815 W US9701815 W US 9701815W WO 9727801 A1 WO9727801 A1 WO 9727801A1
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WO
WIPO (PCT)
Prior art keywords
laser
tissue
stress
acoustic
transducer
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Ceased
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PCT/US1997/001815
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English (en)
French (fr)
Inventor
Alexander A. Oraevsky
Steven L. Jacques
Rinat O. Esenaliev
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University of Texas System
University of Texas at Austin
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University of Texas System
University of Texas at Austin
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Priority to DE69734203T priority Critical patent/DE69734203T2/de
Priority to JP9519218A priority patent/JPH11514549A/ja
Priority to AU18570/97A priority patent/AU732799B2/en
Priority to CA2244732A priority patent/CA2244732C/en
Priority to EP97904228A priority patent/EP0920277B1/en
Publication of WO1997027801A1 publication Critical patent/WO1997027801A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/1702—Systems in which incident light is modified in accordance with the properties of the material investigated with opto-acoustic detection, e.g. for gases or analysing solids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
    • A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00115—Electrical control of surgical instruments with audible or visual output
    • A61B2017/00128—Electrical control of surgical instruments with audible or visual output related to intensity or progress of surgical action
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00844—Feedback systems
    • A61F2009/00851—Optical coherence topography [OCT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00897—Scanning mechanisms or algorithms

Definitions

  • the present invention relates generally to the fields of optics, lasers and medical diagnostic devices. More specifically, the present invention relates to a laser opto-acoustic imaging system capable of producing a three-dimensional image
  • Ultrasonic imaging is currently used widely in clinical medical practice to detect abnormalities in soft tissue organs with acoustic boundaries such as one type of tissue embedded within another type. Ultrasonic imaging has, however, several limitations. For example, ultrasonic imaging is incapable of detecting acoustically homogeiieous tissues, i.e., when ultrasonic properties of all of the tissues scanned are similar).
  • Optical imaging technologies are based on time- resolved or phase-resolved detection of diffusely reflected light pulses or photon density waves.
  • Optical tomographic technologies take advantage of differences in tissue optical properties for diagnostic purposes.
  • ubiquitous light scattering in tissues has been a great obstacle to laser imaging.
  • Optoacoustic spectroscopy methods utilize light to excite an object of interest (molecules or atoms).
  • object of interest molecules or atoms
  • optoacoustic spectroscopy methodology can measure stress amplitude for obtaining absorption spectra.
  • the prior art is deficient in the lack of functional laser opto-acoustic imaging system.
  • the present invention fulfills this longstanding need and desire in the art.
  • Photo-acoustic ultrasound technology for medical imaging has been described in the prior art.
  • the prior art has not understood and correctly manipulated three principles of laser optoacoustic imaging important for sensitivity, spatial resolution and correct interpretation of images. These principles are: ( 1 ) short-pulse laser irradiation to generate transient stress waves under conditions of temporal stress confinement.
  • Such irradiations provides the highest possible amplitude of generated stress with profiles resembling that of light distribution in tissues, which yields sharp images with accurate localization; (2) time- resolved detection of a stress profile for obtaining diagnostic information not from the fact of any signal detection, but from the temporal profile of generated stress wave; (3) use of wide-band piezoelectric detectors to correctly reproduce stress profiles (acoustic waves with wide spectrum of ultrasonic frequencies) to obtain high spatial resolution of tomography.
  • the laser opto- acoustic imaging system (LOAIS) of the present invention partially combines elements of ( 1 ) ultrasonic scanning, (2) optical time- resolved tomography and (3) selective pulsed excitation of tissue heterogeneous structures and time-resolved detection of laser- induced stress waves for obtaining detailed medical diagnostic information.
  • the present invention is directed to both a technique and a device and can be used to image a complex tissue structure on the basis of optical contrast.
  • the technique of the present invention uses a pulsed laser to slightly but quickly heat a specific tissue region with an optical obsorption that differs relative to its surroundings. This slight heating converts to a pressure wave, i.e, a sound wave which propagates outward from the source of the heating.
  • a transducer detects the time, magnitude and shape of the arriving pressure waves.
  • the transducer may be a piezoelectric transducer at the tissue surface or an imbedded transducer.
  • the laser pulse must be sufficiently short to allow the pressure to build up before the pressure can dissipate at the speed of sound (approximately 1500 m/s).
  • the imaging techniques of the present invention are based on optical contrast rather than density changes such as in ultrasound, magnetic resonance imaging or x-ray computed tomography. The method of the present invention, therefore, can be used to image contrast objects not well imaged by these other state of the art imaging techniques.
  • a method of diagnosing a diseased tissue within a normal tissue using laser optoacoustic tomography comprising the steps of: irradiating the surface of the normal tissue with at least one laser pulse so as to penetrate to a sufficient depth and selectively heat a small volume or layer of diseased tissue with a higher optical absorption; causing the diseased tissue to produce a stress wave with a profile resembling that of diseased tissue, said stress wave propagates with minimal alterations to the surface of normal tissue; detecting said stress wave with at least one acoustic transducer; recording the amplitude and temporal profile of laser- induced stress wave by digital oscilloscope; analyzing the amplitude and temporal profile of laser-induced stress wave with a computer.
  • a novel device as a tomography system for biomedical diagnostics comprising: a pulsed laser; a light delivery system; at least one acoustic detector; an electronic system for signal recording and processing; and a computer with software for image reconstruction and analysis.
  • Figure 2 shows that an acoustic transducer signal can be detected in vitro from small volume of liver placed inside large volume of chicken breast muscle tissue.
  • Figure 3 shows that an acoustic transducer signal can be detected from a phantom pathologic tissue (2.5 mm colored gel sphere) embedded within large volume of optically turbid gel cylinder simulating woman's breast. Signal recorded from gel cylinder in case when laser pulse misses and therefore does not heat small color sphere is also presented for comparison.
  • phantom pathologic tissue 2.5 mm colored gel sphere
  • Figure 4 shows a schematic of laser optoacoustic tomography in reflection mode.
  • Figure 5 shows an acoustic transducer signal detected in vivo from chicken cockscomb best known model for port-wine stains .
  • Figure 6 shows an acoustic transducer signal detected in vivo from small tumor located underneath the skin of mouse's lower back.
  • laser optoacoustic tomography refers to a laser optoaccoustic tomography system that employs detection of stress waves reflected from the volume of their generation back to the irradiated tissue surface.
  • laser optoaccoustic tomography is a diagnostic procedure to obtain optical images of layered tissue while detecting laser induced stress profiles.
  • the term "tomography in reflection transmission mode” refers to the laser optoaccoustic tomography system of the present invention that employs the detection of stress waves transmitted from the volume of their generation to rear tissue surfaces, i.e., opposite to irradiated.
  • transient stress waves refers to a stress wave that has limited duration and occupies limited volume.
  • temporal stress confinement refers to the confinement of laser-induced stress within heated volume during the course of laser energy deposition.
  • time-resolved detection of stress profile refers to the detection of transient stress waves with temporal resolution sufficient to reconstruct a pressure wave profile with precision.
  • optical time-resolved tomography refers to a tomography based on time-resolved detection of ultrashort laser pulses transmitted through biological tissue of diagnostic interest.
  • piezoelectric detectors refers to detectors of accoustic, e.g., stress waves utilizing the principle of electric charge generation upon a change of volume within crystals subjected to a pressure wave.
  • ultrasonic scanning refers to a diagnostic procedure that employs delivery of ultrasonic stress waves to a tissue surface followed by the detection of the signals reflected from boundries within the tissue under diagnosis.
  • pulsed heating of tissue refers to the heating of a tissue volume irradiated with laser pulses.
  • the present invention utilizes the time-resolved detection of laser-induced stress (ultrasonic) waves to obtain tomography images of human organs or cellular structures for diagnostic purposes.
  • Diagnostic procedures in which the laser opto-acoustic imaging system of the present invention are useful include: ( 1 ) short laser pulses delivered to the front surface of human organ under investigation. Laser wavelength must be selected to achieve desirable light penetration depth and maximum contrast between normal and abnormal tissues. Heterogeneous absorption of photons and heating of tissue causes generation of thermo-elastic stress that is temporarily confined in the irradiated volume.
  • Short laser pulses serve three purposes: ( 1 ) obtain the most effective generation of transient stress, (2) obtain a stress profile which resembles the profile of heterogeneous light distribution, (3) to obtain images with ultimate accuracy of localization of tissue layer or volume of diagnostic interest.
  • Transient stress waves will propagate toward acoustic transducer (detector).
  • a transducer e.g., a piezoelectric transducer, will convert the stress profile into an electrical signal.
  • the temporal profile of the electrical signal recorded by a digital oscilloscope is converted into a spatial profile of a transient stress distribution.
  • Transient stress distribution resembles a profile of absorbed laser energy distribution, which in turn carries certain diagnostic information.
  • Both a laser beam and a piezoelectric transducer are scanned over the area under diagnosis. Positioning of a detector at various locations permits reconstruction of a three dimensional opto-acoustic image from transient stress profiles and time-delays between moments of laser pulsed irradiation and moments of stress detection (the speed of acoustic waves propagation is known for vast majority of tissues). Stress detection can be performed in both, the transmission mode and the reflection mode, which allows substantial flexibility for i n vivo diagnostics of various human organs and other biological systems .
  • Laser opto-acoustic imaging systems can be used in diagnostic screening of breast cancer (mammography), skin tumors and various other lesions (like port-wine stains etc.) whether accessible externally or via endoscopes, detection of brain hematomas (hemorrhages), atherosclerotic lesions in blood vessels, and for general characterization of tissue composition and structure.
  • laser opto-acoustic imaging can provide feedback information during laser medical treatments.
  • the present invention is directed to a method of diagnosing a diseased tissue within a normal tissue using laser optoacoustic tomography, comprising the steps of: irradiating the surface of the normal tissue with at least one laser pulse so as to penetrate to a sufficient depth and selectively heat a small volume or layer of diseased tissue with a higher optical absorption; causing the diseased tissue to produce a stress wave with a profile resembling that of diseased tissue, said stress wave propagates with minimal alterations to the surface of normal tissue; detecting said stress wave with at least one acoustic transducer; recording the amplitude and temporal profile of laser-induced stress wave by digital oscilloscope; analyzing the amplitude and temporal profile of laser-induced stress wave with a computer.
  • the stress profiles are recorded and analyzed by the computer to reconstruct a three-dimensional image.
  • the laser pulse heats certain tissue structures with different light absorption thereby generating stress profiles resembling profiles of absorbed laser energy distribution in heterogeneous tissues followed by time-resolved detection of ultrasonic stress waves.
  • the shape and dimensions of the diseased tissue volume or layer is generally determined from the temporal profile of laser-induced stress, the time of stress wave arrival to the accoustic transducer, and the direction of the stress detection.
  • the accoustic transducer is a piezoelectric detector and the acoustic transducer uses temporal resolution.
  • the transducer determines the geometry of the diagnosed tissue volume without scanning of acoustic transducer at a fixed location of the laser beam.
  • multiple separate optical fibers or laser beams can be used to irradiate large volume of tissue to reduce time of scanning and incident laser fluence.
  • the amplitude and temporal profile of laser-induced stress wave is recorded by a digital oscilloscope.
  • stress detection can be in transmission mode and stress detection of tissue optical heterogeneities occurs at a tissue depth of up to about 12 cm.
  • stress detection can be in reflection mode.
  • the irradiating is in spectral range of therapeutic window from about 600 nm to about 1400 nm. It is further contemplated that one with ordinary skill in this art could use exogenous molecular probes or dyes to enhance contrast of tomographic image.
  • the methods of the present invention may be used to diagnose a wide variety of diseased tissue.
  • the diseased tissue is breast carcinoma, brain hemorrhages, hematomas, atherosclerotic plaques, polyarhtritis, port-wine stains, skin disorders, melanomas or ocular diseases.
  • the irradiation may be delivered via an endoscope and the acoustic transducer may be positioned on the skin surface.
  • the irradiation may be delivered onto the skin surface and the transducer is incorporated with an endoscope and positioned inside the organs.
  • the optical fiber and transducer may be incorporated in endoscope and positioned inside the organs.
  • the present invention also provides a novel device as a tomography system for biomedical diagnostics comprising: a pulsed laser; a light delivery system; at least one acoustic detector; an electronic system for signal recording and processing; and a computer with software for image reconstruction and analysis.
  • Figure 1 illustrates one embodiment of the present invention, i.e., an example of the utility of laser optoacoustic tomography in diagnosing a small diseased tissue volume (black circle) within a large volume of normal tissue.
  • the laser pulse irradiates the surface of the normal tissue and penetrates to a sufficient depth to selectively heat a small volume of diseased tissue with a higher optical absorption.
  • the heated volume of diseased tissue produces a stress wave with a profile resembling that of diseased tissue.
  • the stress wave propagates with minimal alterations to the surface of normal tissue where it is detected by an acoustic transducer with temporal resolution.
  • the amplitude and temporal profile of laser-induced stress wave is recorded by digital oscilloscope and transferred via an interface to a computer for data analysis.
  • Scanning of laser beam allows the irradiation of the entire volume of the tomographically scanned organ and definite heating of any diseased tissues that exist within normal tissue. Scanning of the acoustic transducer along the surface of the organ permits a determination of the exact location of any diseased tissue volumes.
  • the stress profiles are recorded and analyzed by the computer to reconstruct three dimensional images which can be displayed.
  • Tomography in stress transmission mode utilizes detection of stress transients transmitted from the laser- excited volume toward the depth through thick layers of tissue.
  • the emphasis in transmission mode tomography is made on sensitive detection of tissue optical heterogeneities located at substantial depth of tissue (up to 12 cm).
  • Figure 3 shows an acoustic transducer signal detected from a phantom pathologic tissue (2.5 mm colored gel sphere) embedded within large volume of optically turbid gel cylinder.
  • a control signal was used in case the laser irradiation "missed" the colored sphere and is also shown.
  • the gel phantom simulated a woman' s breast by having optical properties of a colored gel sphere similar to those found in breast carcinoma. Moreover, the optical properties of the surrounding gel were similar to those in a woman's breast tissue.
  • the geometry of the experiment is also shown.
  • a laser pulse was delivered from one side of the gel cylinder and a transient stress wave was detected from the opposite side.
  • the location of colored gel sphere which simulated the tumor was not known to the person who performed the diagnostic procedure. Simultaneous scanning of laser beam and acoustic transducer revealed both the location and dimensions of the "tumor”.
  • FIG. 4 shows a schematic diagram of the laser optoacoustic tomography of the present invention in the reflection mode embodiment of stress detection.
  • a laser pulse irradiates the surface of tissue with a wavelength chosen to penetrate the tissue superficially (about 1 mm) and to heat selectively all microstructures within the tissue with the objective of obtaining high contrast and high spatial resolution.
  • Instantly heated volume of layered tissue produces a stress wave that has profile indicating tissue structure. Stress waves were reflected toward the irradiated surface and were detected with minimal alterations by an acoustic transducer with nanosecond temporal resolution.
  • Laser pulses were delivered to the same tissue surface where a stress wave was detected. The amplitude and temporal profile of a laser- induced stress wave was recorded by a digital oscilloscope and transferred via an interface to a computer for data analysis.
  • Tomography in stress reflection mode utilizes detection of stress transients generated in superficial tissue layer and reflected back toward tissue surface .
  • the emphasis in reflection mode tomography is made on high spatial resolution of measured image (up to 1.5 ⁇ m ) .
  • Figure 5 depicts a z-axial optoacoustic image of absorbed laser fluence distribution in cock's comb.
  • the transient stress profile induced by a 14-ns pulse at 532 nm in a cock's comb of a rooster was measured in vivo by an acoustic transducer.
  • the laser beam was about 1 cm in diameter.
  • Time "0" corresponds to a signal detected from the tissue surface. Distinct layers were observed in the cock's comb tissue. Alteration of the detected stress transient due to diffraction of acoustic waves generated in distributed capillary blood vessels (layer 2) yields negative signal.
  • Signals 1 -6 were induced in blood vessels, located at different depths in the tissue. Numbers 1 -5 correspond to the acoustic transducer signals detected in layers with either enhanced density of small blood vessels (1 and 2) or in separated large blood vessels (3, 4 and 5).
  • the layered structure of the cock's comb is clearly depicted (the layer with dense small dermal blood vessels that lies just below the epidermis, the layer of less vascular loose connective tissue, the comb core layer with arteries and veins that supply the more superficial vascular layers of the cockscomb). The depth of their location is measured correctly if compared with cockscomb histology. The lateral position can be found by scanning a focused laser beam along the tissue surface.
  • Figure 6 shows a display of a typical profile of a stress wave induced by nanosecond laser pulses at 532 nm in tissues of a mouse with a small tumor beneath the skin. Signals detected from the volume with cancer and from the tissue with no cancer are presented for comparison. The difference between two presented signals indicate that breast tumor can be diagnosed with laser optoacoustic tomography system of the present invention in a mice model in vivo. This is another example of laser optoacoustic tomography system of the present invention in the reflection embodiment performed in vivo.
  • the object of study was a mouse with a cancer modeling female' s breast tumor grown inside the muscle of the mouse. The imaging experiment was performed twice with two different mice with similar tumor conditions.

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  • Health & Medical Sciences (AREA)
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  • Acoustics & Sound (AREA)
  • Ophthalmology & Optometry (AREA)
  • Optics & Photonics (AREA)
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  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
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  • Spectroscopy & Molecular Physics (AREA)
  • Vascular Medicine (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
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PCT/US1997/001815 1996-01-31 1997-01-31 Laser opto-acoustic imaging system Ceased WO1997027801A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE69734203T DE69734203T2 (de) 1996-01-31 1997-01-31 Opto akustische laser-abbildungsanordnung
JP9519218A JPH11514549A (ja) 1996-01-31 1997-01-31 レーザー光学音響画像形成装置
AU18570/97A AU732799B2 (en) 1996-01-31 1997-01-31 Laser opto-acoustic imaging system
CA2244732A CA2244732C (en) 1996-01-31 1997-01-31 Laser opto-acoustic imaging system
EP97904228A EP0920277B1 (en) 1996-01-31 1997-01-31 Laser opto-acoustic imaging system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/594,758 US5840023A (en) 1996-01-31 1996-01-31 Optoacoustic imaging for medical diagnosis
US08/594,758 1996-01-31

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WO1997027801A1 true WO1997027801A1 (en) 1997-08-07

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EP (1) EP0920277B1 (enExample)
JP (1) JPH11514549A (enExample)
AU (1) AU732799B2 (enExample)
CA (1) CA2244732C (enExample)
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WO (1) WO1997027801A1 (enExample)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999058957A1 (en) * 1998-05-12 1999-11-18 Optosonics, Inc. Thermoacoustic tissue scanner
US6102857A (en) * 1996-10-04 2000-08-15 Optosonics, Inc. Photoacoustic breast scanner
WO2001017424A1 (en) * 1999-09-03 2001-03-15 Ut-Battelle, Llc. Method and apparatus of spectro-acoustically enhanced ultrasonic detection for diagnostics
US6216025B1 (en) 1999-02-02 2001-04-10 Optosonics, Inc. Thermoacoustic computed tomography scanner
US6309352B1 (en) 1996-01-31 2001-10-30 Board Of Regents, The University Of Texas System Real time optoacoustic monitoring of changes in tissue properties
US6405069B1 (en) 1996-01-31 2002-06-11 Board Of Regents, The University Of Texas System Time-resolved optoacoustic method and system for noninvasive monitoring of glucose
US6839496B1 (en) 1999-06-28 2005-01-04 University College Of London Optical fibre probe for photoacoustic material analysis
WO2009032752A3 (en) * 2007-08-28 2009-04-30 Univ Florida Multimodal nanoparticles for non-invasive bio-imaging
WO2010044660A1 (en) * 2008-10-13 2010-04-22 Academisch Medisch Centrum Van De Universiteit Van Amsterdam Mammography-apparatus and method for screening the occurrence of malignant cells
WO2011070985A1 (en) * 2009-12-11 2011-06-16 Canon Kabushiki Kaisha Photoacoustic apparatus and method for controlling the same
WO2012024687A3 (en) * 2010-08-20 2012-08-09 Purdue Research Foundation Bond-selective vibrational photoacoustic imaging system and method
US8332006B2 (en) 2004-05-06 2012-12-11 Nippon Telegraph And Telephone Corporation Constituent concentration measuring apparatus and constituent concentration measuring apparatus controlling method
US9050009B2 (en) 2010-02-19 2015-06-09 Academisch Medisch Centrum Bij De Universiteit Van Amsterdam Mammography-apparatus
WO2020031181A1 (en) * 2018-08-07 2020-02-13 Elbit Systems Land And C4I Ltd. Two-stage photo-acoustic excitation sensing systems and methods
US11058372B2 (en) 2017-10-31 2021-07-13 Sigmascreening B.V. Mammography apparatus and method of pressurizing a breast
US11793473B2 (en) 2017-06-27 2023-10-24 Teledyne Dalsa B.V. Seat adapted for use with a mammography apparatus

Families Citing this family (304)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
US20080154257A1 (en) * 2006-12-22 2008-06-26 Shiva Sharareh Real-time optoacoustic monitoring with electophysiologic catheters
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
EP0935415B1 (en) 1996-05-01 2006-11-22 Imarx Pharmaceutical Corp. In vitro methods for delivering nucleic acids into a cell
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
DE69737915T2 (de) 1996-09-11 2008-03-13 Bristol-Myers Squibb Medical Imaging, Inc. Verfahren zur diagnostischen Bilderzeugung der Nierenregion unter Verwendung eines Kontrastmittels und eines Vasodilators
US6745067B1 (en) * 1998-09-14 2004-06-01 Lucid, Inc. System for marking the locations of imaged tissue with respect to the surface of the tissue
US6424852B1 (en) * 1996-10-18 2002-07-23 Lucid, Inc. System for confocal imaging within dermal tissue
GB9704737D0 (en) * 1997-03-07 1997-04-23 Optel Instr Limited Biological measurement system
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
GB9712524D0 (en) * 1997-06-16 1997-08-20 Nycomed Imaging As Method
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6091981A (en) * 1997-09-16 2000-07-18 Assurance Medical Inc. Clinical tissue examination
US6063031A (en) * 1997-10-14 2000-05-16 Assurance Medical, Inc. Diagnosis and treatment of tissue with instruments
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US5977538A (en) * 1998-05-11 1999-11-02 Imarx Pharmaceutical Corp. Optoacoustic imaging system
US6478735B1 (en) * 1999-01-28 2002-11-12 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Physiological feedback method and system
WO2001010295A1 (en) * 1999-08-06 2001-02-15 The Board Of Regents Of The University Of Texas System Optoacoustic monitoring of blood oxygenation
US6253621B1 (en) 1999-08-31 2001-07-03 Advanced Micro Devices Micro-void detection
US6277656B1 (en) 1999-09-30 2001-08-21 Rama R. Goruganthu Substrate removal as a function of acoustic analysis
US6430728B1 (en) 1999-09-30 2002-08-06 Advanced Micro Devices, Inc. Acoustic 3D analysis of circuit structures
US6421811B1 (en) 1999-09-30 2002-07-16 Advanced Micro Devices, Inc. Defect detection via acoustic analysis
AU1521201A (en) * 1999-11-12 2001-05-30 Thomas Bende Non-contact photoacoustic spectroscopy for photoablation control
US6751490B2 (en) 2000-03-01 2004-06-15 The Board Of Regents Of The University Of Texas System Continuous optoacoustic monitoring of hemoglobin concentration and hematocrit
GB0015250D0 (en) * 2000-06-22 2000-08-16 Payne Peter A Ophthalmic uses of lasers
IL138073A0 (en) * 2000-08-24 2001-10-31 Glucon Inc Photoacoustic assay and imaging system
US6669926B1 (en) * 2000-10-16 2003-12-30 Mallinckrodt, Inc. Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
ATE454845T1 (de) 2000-10-30 2010-01-15 Gen Hospital Corp Optische systeme zur gewebeanalyse
US9295391B1 (en) 2000-11-10 2016-03-29 The General Hospital Corporation Spectrally encoded miniature endoscopic imaging probe
US7179449B2 (en) * 2001-01-30 2007-02-20 Barnes-Jewish Hospital Enhanced ultrasound detection with temperature-dependent contrast agents
JP2002272738A (ja) * 2001-03-21 2002-09-24 Fuji Photo Film Co Ltd 超音波診断装置
AT503309B1 (de) 2001-05-01 2011-08-15 Gen Hospital Corp Vorrichtung zur bestimmung von atherosklerotischem belag durch messung von optischen gewebeeigenschaften
US6490470B1 (en) 2001-06-19 2002-12-03 Optosonics, Inc. Thermoacoustic tissue scanner
US20050085725A1 (en) * 2001-08-09 2005-04-21 Ron Nagar Photoacoustic assay and imaging system
US6980299B1 (en) 2001-10-16 2005-12-27 General Hospital Corporation Systems and methods for imaging a sample
US7077565B2 (en) * 2001-11-15 2006-07-18 Glucon, Inc. Method for measuring temperature of substances from measurement of absorption coefficients
EP2290318B1 (en) 2002-01-11 2015-08-26 The General Hospital Corporation Apparatus for OCT imaging with axial line focus for improved resolution and depth of field
US7355716B2 (en) 2002-01-24 2008-04-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
US7322972B2 (en) * 2002-04-10 2008-01-29 The Regents Of The University Of California In vivo port wine stain, burn and melanin depth determination using a photoacoustic probe
AU2003238655A1 (en) * 2002-06-25 2004-01-06 Glucon Inc. Method and apparatus for determining tissue viability
WO2004006774A2 (en) * 2002-07-12 2004-01-22 Iscience Surgical Corporation Ultrasound interfacing device for tissue imaging
ATE424758T1 (de) 2002-07-26 2009-03-15 Univ Texas Kontinuierliche optoakustische überwachung von hämoglobinkonzentration und hämatokrit
US8054468B2 (en) 2003-01-24 2011-11-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
US7761139B2 (en) 2003-01-24 2010-07-20 The General Hospital Corporation System and method for identifying tissue using low-coherence interferometry
ES2431520T3 (es) * 2003-01-25 2013-11-26 Seno Medical Instruments, Inc. Procedimiento de formación de imágenes optoacústicas de contraste elevado utilizando nanopartículas no esféricas
AU2004225188B2 (en) 2003-03-31 2010-04-15 The General Hospital Corporation Speckle reduction in optical coherence tomography by path length encoded angular compounding
AU2004233870B2 (en) * 2003-04-24 2009-11-05 The Board Of Regents Of The University Of Texas System Noninvasive blood analysis by optical probing of the veins under the tongue
JP2007526620A (ja) 2003-06-06 2007-09-13 ザ・ジェネラル・ホスピタル・コーポレイション 波長同調発信源装置及びその方法
JP4406226B2 (ja) * 2003-07-02 2010-01-27 株式会社東芝 生体情報映像装置
US7733497B2 (en) 2003-10-27 2010-06-08 The General Hospital Corporation Method and apparatus for performing optical imaging using frequency-domain interferometry
WO2005054780A1 (en) 2003-11-28 2005-06-16 The General Hospital Corporation Method and apparatus for three-dimensional spectrally encoded imaging
US20050124897A1 (en) * 2003-12-03 2005-06-09 Scimed Life Systems, Inc. Apparatus and methods for delivering acoustic energy to body tissue
JP4643153B2 (ja) * 2004-02-06 2011-03-02 株式会社東芝 非侵襲生体情報映像装置
KR101239250B1 (ko) 2004-05-29 2013-03-05 더 제너럴 하스피탈 코포레이션 광간섭 단층촬영 화상 진단에서 반사층을 이용한 색 분산보상을 위한 프로세스, 시스템 및 소프트웨어 배열
EP1771755B1 (en) 2004-07-02 2016-09-21 The General Hospital Corporation Endoscopic imaging probe comprising dual clad fibre
AT414212B (de) * 2004-07-20 2006-10-15 Upper Austrian Res Gmbh Thermoakustisches tomographieverfahren und thermoakustischer tomograph
EP1782020B1 (en) 2004-08-06 2012-10-03 The General Hospital Corporation Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography
US8208995B2 (en) 2004-08-24 2012-06-26 The General Hospital Corporation Method and apparatus for imaging of vessel segments
ATE538714T1 (de) 2004-08-24 2012-01-15 Gen Hospital Corp Verfahren, system und software-anordnung zur bestimmung des elastizitätsmoduls
KR101269455B1 (ko) 2004-09-10 2013-05-30 더 제너럴 하스피탈 코포레이션 광 간섭 영상화를 위한 시스템 및 방법
JP4997112B2 (ja) 2004-09-29 2012-08-08 ザ ジェネラル ホスピタル コーポレイション 少なくとも１つの電磁放射を伝送させるための装置およびその製造方法
EP1807722B1 (en) 2004-11-02 2022-08-10 The General Hospital Corporation Fiber-optic rotational device, optical system for imaging a sample
EP2278267A3 (en) 2004-11-24 2011-06-29 The General Hospital Corporation Common-Path Interferometer for Endoscopic OCT
WO2006058346A1 (en) 2004-11-29 2006-06-01 The General Hospital Corporation Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample
JP2008523881A (ja) * 2004-12-20 2008-07-10 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 体の構造を調査する装置及び方法
IL166408A0 (en) * 2005-01-20 2006-01-15 Ultraview Ltd Combined 2d pulse-echo ultrasound and optoacousticsignal for glaucoma treatment
US20060184042A1 (en) * 2005-01-22 2006-08-17 The Texas A&M University System Method, system and apparatus for dark-field reflection-mode photoacoustic tomography
DE602006010993D1 (de) 2005-04-28 2010-01-21 Gen Hospital Corp Bewertung von bildmerkmalen einer anatomischen struktur in optischen kohärenztomographiebildern
EP1887926B1 (en) 2005-05-31 2014-07-30 The General Hospital Corporation System and method which use spectral encoding heterodyne interferometry techniques for imaging
US9060689B2 (en) 2005-06-01 2015-06-23 The General Hospital Corporation Apparatus, method and system for performing phase-resolved optical frequency domain imaging
US20070015992A1 (en) * 2005-06-30 2007-01-18 General Electric Company System and method for optoacoustic imaging
EP2207008A1 (en) 2005-08-09 2010-07-14 The General Hospital Corporation Apparatus and method for performing polarization-based quadrature demodulation in optical coherence tomography
US7843572B2 (en) 2005-09-29 2010-11-30 The General Hospital Corporation Method and apparatus for optical imaging via spectral encoding
WO2007047690A1 (en) 2005-10-14 2007-04-26 The General Hospital Corporation Spectral- and frequency- encoded fluorescence imaging
JP5680826B2 (ja) 2006-01-10 2015-03-04 ザ ジェネラル ホスピタル コーポレイション １以上のスペクトルを符号化する内視鏡技術によるデータ生成システム
WO2007084903A2 (en) 2006-01-19 2007-07-26 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and method for producing one or more optical arrangements
US20090227997A1 (en) * 2006-01-19 2009-09-10 The Regents Of The University Of Michigan System and method for photoacoustic imaging and monitoring of laser therapy
WO2007100937A2 (en) * 2006-01-19 2007-09-07 The Regents Of The University Of Michigan System and method for spectroscopic photoacoustic tomography
WO2007084995A2 (en) 2006-01-19 2007-07-26 The General Hospital Corporation Methods and systems for optical imaging of epithelial luminal organs by beam scanning thereof
US8135450B2 (en) * 2006-01-20 2012-03-13 Esenaliev Rinat O Noninvasive glucose sensing methods and systems
US7740585B2 (en) * 2006-01-20 2010-06-22 Seno Medical Instruments, Inc. Quantitative optoacoustic tomography with enhanced contrast
JP5524487B2 (ja) 2006-02-01 2014-06-18 ザ ジェネラル ホスピタル コーポレイション コンフォーマルレーザ治療手順を用いてサンプルの少なくとも一部分に電磁放射を放射する方法及びシステム。
WO2007149601A2 (en) 2006-02-01 2007-12-27 The General Hospital Corporation Apparatus for controlling at least one of at least two sections of at least one fiber
US7538859B2 (en) 2006-02-01 2009-05-26 The General Hospital Corporation Methods and systems for monitoring and obtaining information of at least one portion of a sample using conformal laser therapy procedures, and providing electromagnetic radiation thereto
US9777053B2 (en) 2006-02-08 2017-10-03 The General Hospital Corporation Methods, arrangements and systems for obtaining information associated with an anatomical sample using optical microscopy
US7982879B2 (en) 2006-02-24 2011-07-19 The General Hospital Corporation Methods and systems for performing angle-resolved fourier-domain optical coherence tomography
US7750536B2 (en) 2006-03-02 2010-07-06 Visualsonics Inc. High frequency ultrasonic transducer and matching layer comprising cyanoacrylate
US7742173B2 (en) 2006-04-05 2010-06-22 The General Hospital Corporation Methods, arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample
WO2007133961A2 (en) 2006-05-10 2007-11-22 The General Hospital Corporation Processes, arrangements and systems for providing frequency domain imaging of a sample
WO2007133964A2 (en) * 2006-05-12 2007-11-22 The General Hospital Corporation Processes, arrangements and systems for providing a fiber layer thickness map based on optical coherence tomography images
CN100456016C (zh) * 2006-05-30 2009-01-28 华南师范大学 多通道电子并行扫描光声实时层析成像的方法及其装置
US20070291275A1 (en) * 2006-06-16 2007-12-20 Prescient Medical, Inc. Side-viewing optical acoustic sensors and their use in intravascular diagnostic probes
EP2047250B1 (en) * 2006-07-11 2018-11-07 The Curators Of The University Of Missouri Photo-acoustic detection device and method
US8501099B2 (en) * 2006-07-11 2013-08-06 The Curators Of The University Of Missouri Photo-acoustic detection device and method
WO2008024948A2 (en) 2006-08-25 2008-02-28 The General Hospital Corporation Apparatus and methods for enhancing optical coherence tomography imaging using volumetric filtering techniques
US8219170B2 (en) 2006-09-20 2012-07-10 Nellcor Puritan Bennett Llc System and method for practicing spectrophotometry using light emitting nanostructure devices
US8175671B2 (en) 2006-09-22 2012-05-08 Nellcor Puritan Bennett Llc Medical sensor for reducing signal artifacts and technique for using the same
US8195264B2 (en) 2006-09-22 2012-06-05 Nellcor Puritan Bennett Llc Medical sensor for reducing signal artifacts and technique for using the same
US8396527B2 (en) 2006-09-22 2013-03-12 Covidien Lp Medical sensor for reducing signal artifacts and technique for using the same
US8838213B2 (en) 2006-10-19 2014-09-16 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample, and effecting such portion(s)
WO2008067438A2 (en) * 2006-11-29 2008-06-05 The Regents Of University Of Michigan System and method for photoacoustic guided diffuse optical imaging
EP1935346A1 (en) 2006-12-21 2008-06-25 Stichting voor de Technische Wetenschappen Imaging apparatus and method
US20080173093A1 (en) * 2007-01-18 2008-07-24 The Regents Of The University Of Michigan System and method for photoacoustic tomography of joints
EP2102583A2 (en) 2007-01-19 2009-09-23 The General Hospital Corporation Apparatus and method for controlling ranging depth in optical frequency domain imaging
EP2104968A1 (en) 2007-01-19 2009-09-30 The General Hospital Corporation Rotating disk reflection for fast wavelength scanning of dispersed broadband light
WO2008100386A2 (en) * 2007-02-09 2008-08-21 Board Of Regents, The University Of Texas System Intravascular photoacoustic and ultrasound echo imaging
US20080221647A1 (en) * 2007-02-23 2008-09-11 The Regents Of The University Of Michigan System and method for monitoring photodynamic therapy
US20080228073A1 (en) * 2007-03-12 2008-09-18 Silverman Ronald H System and method for optoacoustic imaging of peripheral tissues
WO2008115965A1 (en) * 2007-03-19 2008-09-25 The General Hospital Corporation Apparatus and method for providing a noninvasive diagnosis of internal bleeding
JP5558839B2 (ja) 2007-03-23 2014-07-23 ザ ジェネラル ホスピタル コーポレイション 角度走査及び分散手順を用いて波長掃引レーザを利用するための方法、構成及び装置
US10534129B2 (en) 2007-03-30 2020-01-14 The General Hospital Corporation System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque
US10226206B2 (en) 2007-04-11 2019-03-12 The Board Of Regents Of The University Of Texas System Systems and methods for measuring neonatal cerebral oxygenation
US10307088B2 (en) 2007-04-11 2019-06-04 The Board Of Regents Of The University Of Texas Systems and methods for measuring oxygenation
WO2009008933A2 (en) * 2007-04-11 2009-01-15 The Board Of Regents Of The University Of Texas System Optoacoustic monitoring of multiple parameters
US8045177B2 (en) 2007-04-17 2011-10-25 The General Hospital Corporation Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy
WO2008137637A2 (en) 2007-05-04 2008-11-13 The General Hospital Corporation Methods, arrangements and systems for obtaining information associated with a sample using brillouin microscopy
JP5595534B2 (ja) * 2007-05-15 2014-09-24 キヤノン株式会社 生体情報イメージング装置、生体情報の解析方法、及び生体情報のイメージング方法
JP4739363B2 (ja) * 2007-05-15 2011-08-03 キヤノン株式会社 生体情報イメージング装置、生体情報の解析方法、及び生体情報のイメージング方法
JP2010529465A (ja) 2007-06-08 2010-08-26 プレサイエント メディカル， インコーポレイテッド ラマン分光法を光ファイバ系低コヒーレンスリフレクトメトリと結合した光カテーテル構成
JP5349839B2 (ja) * 2007-06-22 2013-11-20 キヤノン株式会社 生体情報イメージング装置
US20090024040A1 (en) * 2007-07-20 2009-01-22 Prescient Medical, Inc. Wall-Contacting Intravascular Ultrasound Probe Catheters
WO2009018456A2 (en) 2007-07-31 2009-02-05 The General Hospital Corporation Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging
WO2009029843A1 (en) 2007-08-31 2009-03-05 The General Hospital Corporation System and method for self-interference fluoresence microscopy, and computer-accessible medium associated therewith
JP5132228B2 (ja) * 2007-09-12 2013-01-30 キヤノン株式会社 測定方法及び測定装置
JP5201920B2 (ja) * 2007-09-12 2013-06-05 キヤノン株式会社 測定装置
US20090076395A1 (en) * 2007-09-19 2009-03-19 Prescient Medical, Inc. Optimized intravascular ultrasound probe catherers
US20090105588A1 (en) * 2007-10-02 2009-04-23 Board Of Regents, The University Of Texas System Real-Time Ultrasound Monitoring of Heat-Induced Tissue Interactions
WO2009050632A1 (en) 2007-10-16 2009-04-23 Koninklijke Philips Electronics N.V. Apparatus, systems and methods for production and integration of compact illumination schemes
WO2010048258A1 (en) * 2008-10-23 2010-04-29 Washington University In St. Louis Reflection-mode photoacoustic tomography using a flexibly-supported cantilever beam
CN101918811B (zh) 2007-10-25 2013-07-31 圣路易斯华盛顿大学 具有光学横向分辨率的共焦光声显微镜
US7933021B2 (en) 2007-10-30 2011-04-26 The General Hospital Corporation System and method for cladding mode detection
EP2231018A4 (en) * 2007-12-12 2012-11-21 Jeffrey J L Carson THREE-DIMENSIONAL PHOTOACUSTIC IMAGING APPARATUS AND METHOD FOR CALIBRATING AN IMAGING APPARATUS
JP5698538B2 (ja) * 2007-12-28 2015-04-08 コーニンクレッカ フィリップス エヌ ヴェ 組織切除装置、組織切除システム、及び組織切除術の実行を監視するためのプログラム
DE102008017097A1 (de) 2008-01-17 2009-07-30 RUHR-UNIVERSITäT BOCHUM Verfahren zur photoakustischen Generierung einer Bildgebung
US9332942B2 (en) 2008-01-28 2016-05-10 The General Hospital Corporation Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging
US11123047B2 (en) 2008-01-28 2021-09-21 The General Hospital Corporation Hybrid systems and methods for multi-modal acquisition of intravascular imaging data and counteracting the effects of signal absorption in blood
JP5284129B2 (ja) * 2008-02-06 2013-09-11 キヤノン株式会社 イメージング装置、及び解析方法
EP2110076A1 (en) * 2008-02-19 2009-10-21 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Method and device for near-field dual-wave modality imaging
WO2009116029A2 (en) * 2008-03-17 2009-09-24 Or-Nim Medical Ltd. Apparatus for non invasive optical monitoring
US8593619B2 (en) 2008-05-07 2013-11-26 The General Hospital Corporation System, method and computer-accessible medium for tracking vessel motion during three-dimensional coronary artery microscopy
EP2288948A4 (en) 2008-06-20 2011-12-28 Gen Hospital Corp Fused fiber optic coupler arrangement and method for use thereof
JP4829934B2 (ja) * 2008-07-11 2011-12-07 キヤノン株式会社 検査装置
WO2010009136A2 (en) 2008-07-14 2010-01-21 The General Hospital Corporation Apparatus and methods for color endoscopy
CN102137618B (zh) * 2008-07-25 2015-06-17 健康与环境慕尼黑德国研究中心赫姆霍茨中心(有限公司) 组织生物标志物的定量多光谱光声断层摄影(msot)
JP5419404B2 (ja) * 2008-09-04 2014-02-19 キヤノン株式会社 光音響装置
JP5451014B2 (ja) * 2008-09-10 2014-03-26 キヤノン株式会社 光音響装置
US8433382B2 (en) 2008-09-30 2013-04-30 Covidien Lp Transmission mode photon density wave system and method
US8532751B2 (en) 2008-09-30 2013-09-10 Covidien Lp Laser self-mixing sensors for biological sensing
US8386000B2 (en) 2008-09-30 2013-02-26 Covidien Lp System and method for photon density wave pulse oximetry and pulse hemometry
US8142368B2 (en) * 2008-10-02 2012-03-27 Artann Laboratories Inc. Method of characterization and differentiation of tissue
JP5235586B2 (ja) * 2008-10-03 2013-07-10 キヤノン株式会社 生体情報処理装置及び生体情報処理方法
JP5305818B2 (ja) * 2008-10-03 2013-10-02 キヤノン株式会社 生体情報取得装置
JP5183406B2 (ja) * 2008-10-03 2013-04-17 キヤノン株式会社 生体情報処理装置及び生体情報処理方法
JP5279435B2 (ja) * 2008-10-03 2013-09-04 キヤノン株式会社 被検体情報取得装置、被検体情報取得装置の制御方法
JP2010088627A (ja) * 2008-10-07 2010-04-22 Canon Inc 生体情報処理装置および生体情報処理方法
US8937724B2 (en) 2008-12-10 2015-01-20 The General Hospital Corporation Systems and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling
JP5241465B2 (ja) * 2008-12-11 2013-07-17 キヤノン株式会社 光音響イメージング装置および光音響イメージング方法
WO2010080991A2 (en) 2009-01-09 2010-07-15 Washington University In St. Louis Miniaturized photoacoustic imaging apparatus including a rotatable reflector
JP2012515930A (ja) 2009-01-26 2012-07-12 ザ ジェネラル ホスピタル コーポレーション 広視野の超解像顕微鏡を提供するためのシステム、方法及びコンピューターがアクセス可能な媒体
US9178330B2 (en) 2009-02-04 2015-11-03 The General Hospital Corporation Apparatus and method for utilization of a high-speed optical wavelength tuning source
US9351642B2 (en) 2009-03-12 2016-05-31 The General Hospital Corporation Non-contact optical system, computer-accessible medium and method for measurement at least one mechanical property of tissue using coherent speckle technique(s)
EP2408376A1 (en) * 2009-03-17 2012-01-25 UWM Research Foundation, Inc. Systems and methods for photoacoustic opthalmoscopy
AU2010239360A1 (en) * 2009-04-20 2011-11-24 The Curators Of The University Of Missouri Photoacoustic detection of analytes in solid tissue and detection system
JP5566456B2 (ja) 2009-06-29 2014-08-06 ヘルムホルツ・ツェントルム・ミュンヒェン・ドイチェス・フォルシュンクスツェントルム・フューア・ゲズントハイト・ウント・ウムベルト（ゲーエムベーハー） 被写体を熱音響撮像するための撮像装置及び撮像方法、コンピュータプログラム並びにコンピュータで読み取り可能な記憶媒体を備える装置
US11490826B2 (en) 2009-07-14 2022-11-08 The General Hospital Corporation Apparatus, systems and methods for measuring flow and pressure within a vessel
WO2011012274A1 (en) 2009-07-27 2011-02-03 Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Imaging device and method for optoacoustic imaging of small animals
JP5525787B2 (ja) * 2009-09-14 2014-06-18 株式会社東芝 生体情報映像装置
US8494604B2 (en) 2009-09-21 2013-07-23 Covidien Lp Wavelength-division multiplexing in a multi-wavelength photon density wave system
US8788001B2 (en) 2009-09-21 2014-07-22 Covidien Lp Time-division multiplexing in a multi-wavelength photon density wave system
US9057695B2 (en) * 2009-09-24 2015-06-16 Canon Kabushiki Kaisha Apparatus and method for irradiating a scattering medium with a reconstructive wave
US8798704B2 (en) 2009-09-24 2014-08-05 Covidien Lp Photoacoustic spectroscopy method and system to discern sepsis from shock
CN102596049B (zh) * 2009-10-29 2015-04-08 佳能株式会社 光声装置
CN104856728B (zh) * 2009-10-29 2019-07-23 佳能株式会社 光声装置
JP5538856B2 (ja) 2009-12-11 2014-07-02 キヤノン株式会社 光音響装置
WO2011074102A1 (ja) 2009-12-17 2011-06-23 キヤノン株式会社 測定システム、画像形成方法及びプログラム
JP5448918B2 (ja) * 2010-02-24 2014-03-19 キヤノン株式会社 生体情報処理装置
KR20130004326A (ko) 2010-03-05 2013-01-09 더 제너럴 하스피탈 코포레이션 특정 해상도에서 적어도 하나의 해부학적 구조의 미세 영상을 제공하는 시스템, 방법 및 컴퓨터 접근 가능 매체
US9086365B2 (en) 2010-04-09 2015-07-21 Lihong Wang Quantification of optical absorption coefficients using acoustic spectra in photoacoustic tomography
JP5641773B2 (ja) * 2010-04-28 2014-12-17 キヤノン株式会社 測定装置
US9069130B2 (en) 2010-05-03 2015-06-30 The General Hospital Corporation Apparatus, method and system for generating optical radiation from biological gain media
US9795301B2 (en) 2010-05-25 2017-10-24 The General Hospital Corporation Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images
US9557154B2 (en) 2010-05-25 2017-01-31 The General Hospital Corporation Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions
US10285568B2 (en) 2010-06-03 2019-05-14 The General Hospital Corporation Apparatus and method for devices for imaging structures in or at one or more luminal organs
JP5761935B2 (ja) 2010-07-22 2015-08-12 キヤノン株式会社 被検体情報取得装置、被検体情報取得方法および被検体情報取得プログラム
US8930145B2 (en) 2010-07-28 2015-01-06 Covidien Lp Light focusing continuous wave photoacoustic spectroscopy and its applications to patient monitoring
US8686335B2 (en) 2011-12-31 2014-04-01 Seno Medical Instruments, Inc. System and method for adjusting the light output of an optoacoustic imaging system
US9289191B2 (en) 2011-10-12 2016-03-22 Seno Medical Instruments, Inc. System and method for acquiring optoacoustic data and producing parametric maps thereof
US20130109950A1 (en) * 2011-11-02 2013-05-02 Seno Medical Instruments, Inc. Handheld optoacoustic probe
US9510758B2 (en) 2010-10-27 2016-12-06 The General Hospital Corporation Apparatus, systems and methods for measuring blood pressure within at least one vessel
US8954130B2 (en) 2010-12-17 2015-02-10 Canon Kabushiki Kaisha Apparatus and method for irradiating a medium
US8817255B2 (en) 2010-12-17 2014-08-26 Canon Kabushiki Kaisha Apparatus and method for irradiating a scattering medium
US8976433B2 (en) 2010-12-17 2015-03-10 Canon Kabushiki Kaisha Apparatus and method for irradiating a scattering medium
US8521247B2 (en) 2010-12-29 2013-08-27 Covidien Lp Certification apparatus and method for a medical device computer
US8997572B2 (en) 2011-02-11 2015-04-07 Washington University Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detection
RU2486501C2 (ru) * 2011-02-28 2013-06-27 Александр Алексеевич Карабутов Способ лазерной оптико-акустической томографии и устройство для его реализации (варианты)
WO2012125649A2 (en) * 2011-03-14 2012-09-20 Lawrence Livermore National Security, Llc Non-contact optical system for detecting ultrasound waves from a surface
JP5917012B2 (ja) 2011-04-11 2016-05-11 キヤノン株式会社 レーザー装置および光音響装置
US10206607B2 (en) * 2011-04-29 2019-02-19 The Board Of Regents Of The University Of Texas System Methods and apparatus for optoacoustic guidance and confirmation of placement of indwelling medical apparatus
JP6240064B2 (ja) 2011-04-29 2017-11-29 ザ ジェネラル ホスピタル コーポレイション 散乱媒質の深さ分解した物理的及び／又は光学的特性を決定する方法
US9304490B2 (en) 2011-05-27 2016-04-05 Canon Kabushiki Kaisha Apparatus and method for irradiating a medium
US9442095B2 (en) 2011-06-15 2016-09-13 Northwestern University Optical coherence photoacoustic microscopy
JP2014523536A (ja) 2011-07-19 2014-09-11 ザ ジェネラル ホスピタル コーポレイション 光コヒーレンストモグラフィーにおいて偏波モード分散補償を提供するためのシステム、方法、装置およびコンピュータアクセス可能な媒体
JP5917037B2 (ja) 2011-07-29 2016-05-11 キヤノン株式会社 被検体情報取得装置および被検体情報取得方法
US10241028B2 (en) 2011-08-25 2019-03-26 The General Hospital Corporation Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures
JP2015502562A (ja) 2011-10-18 2015-01-22 ザ ジェネラル ホスピタル コーポレイション 再循環光学遅延を生成および／または提供するための装置および方法
US9055869B2 (en) 2011-10-28 2015-06-16 Covidien Lp Methods and systems for photoacoustic signal processing
US9445786B2 (en) 2011-11-02 2016-09-20 Seno Medical Instruments, Inc. Interframe energy normalization in an optoacoustic imaging system
US20130338475A1 (en) 2012-06-13 2013-12-19 Seno Medical Instruments, Inc. Optoacoustic imaging system with fiber optic cable
US10433732B2 (en) 2011-11-02 2019-10-08 Seno Medical Instruments, Inc. Optoacoustic imaging system having handheld probe utilizing optically reflective material
US9733119B2 (en) 2011-11-02 2017-08-15 Seno Medical Instruments, Inc. Optoacoustic component utilization tracking
US20140005544A1 (en) 2011-11-02 2014-01-02 Seno Medical Instruments, Inc. System and method for providing selective channel sensitivity in an optoacoustic imaging system
US11287309B2 (en) 2011-11-02 2022-03-29 Seno Medical Instruments, Inc. Optoacoustic component utilization tracking
US9814394B2 (en) 2011-11-02 2017-11-14 Seno Medical Instruments, Inc. Noise suppression in an optoacoustic system
US9743839B2 (en) 2011-11-02 2017-08-29 Seno Medical Instruments, Inc. Playback mode in an optoacoustic imaging system
US9757092B2 (en) 2011-11-02 2017-09-12 Seno Medical Instruments, Inc. Method for dual modality optoacoustic imaging
US9730587B2 (en) * 2011-11-02 2017-08-15 Seno Medical Instruments, Inc. Diagnostic simulator
US20130116538A1 (en) 2011-11-02 2013-05-09 Seno Medical Instruments, Inc. Optoacoustic imaging systems and methods with enhanced safety
US11191435B2 (en) 2013-01-22 2021-12-07 Seno Medical Instruments, Inc. Probe with optoacoustic isolator
US20130289381A1 (en) 2011-11-02 2013-10-31 Seno Medical Instruments, Inc. Dual modality imaging system for coregistered functional and anatomical mapping
JP5936330B2 (ja) 2011-11-04 2016-06-22 キヤノン株式会社 音響波測定装置および音響波測定装置の制御方法
US8886294B2 (en) 2011-11-30 2014-11-11 Covidien Lp Methods and systems for photoacoustic monitoring using indicator dilution
US9131852B2 (en) 2011-12-05 2015-09-15 Covidien Lp Methods and systems for photoacoustic monitoring using indicator dilution
US9186068B2 (en) 2011-12-05 2015-11-17 Covidien Lp Methods and systems for photoacoustic monitoring using hypertonic and isotonic indicator dilutions
KR102144551B1 (ko) * 2012-01-23 2020-08-14 토모웨이브 래버러토리즈, 인코포레이티드 레이저 광음향 초음파 영상 시스템 및 그 사용 방법
AU2013229748B2 (en) 2012-03-09 2017-11-02 Seno Medical Instruments, Inc. Statistical mapping in an optoacoustic imaging system
US9629528B2 (en) 2012-03-30 2017-04-25 The General Hospital Corporation Imaging system, method and distal attachment for multidirectional field of view endoscopy
US9833146B2 (en) 2012-04-17 2017-12-05 Covidien Lp Surgical system and method of use of the same
US8885155B2 (en) 2012-04-30 2014-11-11 Covidien Lp Combined light source photoacoustic system
KR101974580B1 (ko) 2012-05-03 2019-05-02 삼성전자주식회사 레이저 유도 초음파 장치 및 이를 이용한 영상 생성 방법
US11490797B2 (en) 2012-05-21 2022-11-08 The General Hospital Corporation Apparatus, device and method for capsule microscopy
JP5984547B2 (ja) 2012-07-17 2016-09-06 キヤノン株式会社 被検体情報取得装置およびその制御方法
JP6227652B2 (ja) 2012-08-22 2017-11-08 ザ ジェネラル ホスピタル コーポレイション ソフトリソグラフィを用いてミニチュア内視鏡を製作するためのシステム、方法、およびコンピュータ・アクセス可能媒体
US11020006B2 (en) 2012-10-18 2021-06-01 California Institute Of Technology Transcranial photoacoustic/thermoacoustic tomography brain imaging informed by adjunct image data
JP6080485B2 (ja) * 2012-10-18 2017-02-15 キヤノン株式会社 被検体情報取得装置および被検体情報取得装置の制御方法
EP2742854B1 (en) 2012-12-11 2021-03-10 iThera Medical GmbH Handheld device and method for tomographic optoacoustic imaging of an object
DE102012223651A1 (de) * 2012-12-18 2014-06-18 Carl Zeiss Ag Abbildungsverfahren für ein Resektat und Bilderzeugungsvorrichtung zum Durchführen eines solchen Abbildungsverfahrens
JP6112861B2 (ja) 2012-12-28 2017-04-12 キヤノン株式会社 被検体情報取得装置、信号処理装置および表示装置
EP2754388B1 (en) 2013-01-15 2020-09-09 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH System and method for quality-enhanced high-rate optoacoustic imaging of an object
JP6192297B2 (ja) 2013-01-16 2017-09-06 キヤノン株式会社 被検体情報取得装置、表示制御方法、およびプログラム
WO2014120791A1 (en) 2013-01-29 2014-08-07 The General Hospital Corporation Apparatus, systems and methods for providing information regarding the aortic valve
US11179028B2 (en) 2013-02-01 2021-11-23 The General Hospital Corporation Objective lens arrangement for confocal endomicroscopy
US9380981B2 (en) 2013-03-15 2016-07-05 Covidien Lp Photoacoustic monitoring technique with noise reduction
EP2967491B1 (en) 2013-03-15 2022-05-11 The General Hospital Corporation A transesophageal endoscopic system for determining a mixed venous oxygen saturation of a pulmonary artery
JP2016515019A (ja) 2013-03-15 2016-05-26 セノ メディカル インストルメンツ，インク． 診断ベクトル分類サポートのためのシステムおよび方法
JP5575293B2 (ja) * 2013-03-22 2014-08-20 キヤノン株式会社 被検体情報取得装置及び被検体情報取得方法
WO2014176132A1 (en) * 2013-04-22 2014-10-30 The Curators Of The University Of Missouri Photoacoustic probe for burn injury diagnosis
US9784681B2 (en) 2013-05-13 2017-10-10 The General Hospital Corporation System and method for efficient detection of the phase and amplitude of a periodic modulation associated with self-interfering fluorescence
EP3021735A4 (en) 2013-07-19 2017-04-19 The General Hospital Corporation Determining eye motion by imaging retina. with feedback
WO2015009932A1 (en) 2013-07-19 2015-01-22 The General Hospital Corporation Imaging apparatus and method which utilizes multidirectional field of view endoscopy
EP3025173B1 (en) 2013-07-26 2021-07-07 The General Hospital Corporation Apparatus with a laser arrangement utilizing optical dispersion for applications in fourier-domain optical coherence tomography
EP3054853A4 (en) 2013-10-11 2017-05-17 Seno Medical Instruments, Inc. Systems and methods for component separation in medical imaging
WO2015077355A1 (en) * 2013-11-19 2015-05-28 Washington University Systems and methods of grueneisen-relaxation photoacoustic microscopy and photoacoustic wavefront shaping
EP3071094A1 (en) 2013-11-22 2016-09-28 Massachusetts Institute Of Technology System and method for non-contact ultrasound
WO2015105870A1 (en) 2014-01-08 2015-07-16 The General Hospital Corporation Method and apparatus for microscopic imaging
EP3099242B1 (en) 2014-01-31 2021-05-19 Tomowave Laboratories, Inc. Optoacoustic image mapping of tissue temperature
WO2015116986A2 (en) 2014-01-31 2015-08-06 The General Hospital Corporation System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device
WO2015131098A1 (en) 2014-02-27 2015-09-03 Seno Medical Instruments, Inc. Probe adapted to control blood flow through vessels during imaging and method of use of same
EP3116405B1 (en) 2014-03-12 2024-09-11 Fujifilm Sonosite, Inc. High frequency ultrasound transducer having an ultrasonic lens with integral central matching layer
WO2015153982A1 (en) 2014-04-04 2015-10-08 The General Hospital Corporation Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s)
US10238369B2 (en) 2014-06-10 2019-03-26 The Johns Hopkins University Real time ultrasound thermal dose monitoring system for tumor ablation therapy
EP3166494A4 (en) 2014-07-08 2018-03-21 The Board of Regents of The University of Texas System Systems and methods for measuring fetal cerebral oxygenation
JP2017525435A (ja) 2014-07-25 2017-09-07 ザ ジェネラル ホスピタル コーポレイション インビボ・イメージングおよび診断のための機器、デバイスならびに方法
US10539675B2 (en) 2014-10-30 2020-01-21 Seno Medical Instruments, Inc. Opto-acoustic imaging system with detection of relative orientation of light source and acoustic receiver using acoustic waves
WO2016149107A1 (en) 2015-03-14 2016-09-22 Board Of Regents Systems and methods for measuring neonatal cerebral oxygenation
US10028662B2 (en) 2015-05-14 2018-07-24 Endra Life Sciences Inc. Systems and methods for imaging biological tissue structures
US10898166B2 (en) 2015-05-14 2021-01-26 Endra Life Sciences Inc. Systems and methods for imaging biological tissue structures
US10602931B2 (en) 2016-03-14 2020-03-31 Massachusetts Institute Of Technology System and method for non-contact ultrasound with enhanced safety
US12036000B2 (en) 2016-05-27 2024-07-16 The Regents Of The University Of Michigan Method of photoacoustic imaging intraocular tumors including back-projection reconstruction to measure heterogeneity
US11672426B2 (en) 2017-05-10 2023-06-13 California Institute Of Technology Snapshot photoacoustic photography using an ergodic relay
US10806513B2 (en) 2018-01-16 2020-10-20 Bin Rao Methods and apparatus for optimizing selective photothermolysis
WO2019152045A1 (en) * 2018-02-02 2019-08-08 Xinova, LLC Real-time treatment adjustment based on dosimetric data
EP3761851B1 (en) 2018-03-09 2025-08-27 Technische Universität München Sensor for tissue measurements
US10799292B2 (en) * 2018-05-04 2020-10-13 Bin Rao High power tunable optical parametric oscillator for selective photothermolysis laser surgeries
EP3836831A4 (en) 2018-08-14 2022-05-18 California Institute of Technology MULTIFOCAL PHOTOACOUSTIC MICROSCOPY THROUGH AN ERGODIC RELAY
CN109044282B (zh) * 2018-08-28 2024-05-31 南京星顿医疗科技有限公司 融合触觉传感和光断层扫描成像的检测装置与检测方法
US11592652B2 (en) 2018-09-04 2023-02-28 California Institute Of Technology Enhanced-resolution infrared photoacoustic microscopy and spectroscopy
US11369280B2 (en) 2019-03-01 2022-06-28 California Institute Of Technology Velocity-matched ultrasonic tagging in photoacoustic flowgraphy
US11701035B2 (en) 2019-10-28 2023-07-18 Bruce M. Landy Noninvasive blood glucose detector and method using IR
US11986269B2 (en) 2019-11-05 2024-05-21 California Institute Of Technology Spatiotemporal antialiasing in photoacoustic computed tomography
DE112021003889T5 (de) * 2020-07-21 2023-05-04 Gyrus Acmi, Inc. D/B/A Olympus Surgical Technologies America Laserbehandlung mit akustischer rückkopplung
US12504363B2 (en) 2021-08-17 2025-12-23 California Institute Of Technology Three-dimensional contoured scanning photoacoustic imaging and virtual staining
CN114469010A (zh) * 2022-04-19 2022-05-13 常州英诺激光科技有限公司 基于激光能量补偿技术的光声血氧测量装置及方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4710030A (en) * 1985-05-17 1987-12-01 Bw Brown University Research Foundation Optical generator and detector of stress pulses
US4727420A (en) * 1984-10-16 1988-02-23 Fuji Photo Film Co., Ltd. Acoustooptic image formation
US5398685A (en) * 1992-01-10 1995-03-21 Wilk; Peter J. Endoscopic diagnostic system and associated method
US5421337A (en) * 1989-04-14 1995-06-06 Massachusetts Institute Of Technology Spectral diagnosis of diseased tissue
US5582578A (en) * 1995-08-01 1996-12-10 Duke University Method for the comminution of concretions
US5602894A (en) * 1994-08-04 1997-02-11 Bardash; Michael J. Three-dimensional imaging system using laser generated ultrashort x-ray pulses

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4028933A (en) * 1974-02-15 1977-06-14 The Board Of Trustees Of Leland Stanford Junior University Acoustic microscope
FR2405485A1 (fr) * 1977-10-07 1979-05-04 Thomson Csf Systeme de visualisation par ultrasons d'une coupe mince d'un corps
US4430897A (en) * 1981-05-14 1984-02-14 The Board Of Trustees Of The Leland Stanford University Acoustic microscope and method
NO880891L (no) * 1987-03-03 1988-09-05 Elizabeth May Dowling Fremgangsmaate og apparat for maaling eller deteksjon av konsentrasjonen av en substans.
US5141331A (en) * 1988-02-19 1992-08-25 Oscar Oehler Ultrasonic temperature measurement and uses in optical spectroscopy and calorimetry
JP2685482B2 (ja) * 1988-04-08 1997-12-03 株式会社日立製作所 粒子状物質の分析方法及び装置
DE3842916C1 (enExample) * 1988-12-21 1990-02-01 Messerschmitt-Boelkow-Blohm Gmbh, 8012 Ottobrunn, De
US4950897A (en) * 1989-01-04 1990-08-21 University Of Toronto Innovations Foundation Thermal wave sub-surface defect imaging and tomography apparatus
US5136172A (en) * 1989-08-16 1992-08-04 Hitachi, Ltd. Method and apparatus for detecting photoacoustic signal
US5254112A (en) * 1990-10-29 1993-10-19 C. R. Bard, Inc. Device for use in laser angioplasty
DE4128744C1 (enExample) * 1991-08-29 1993-04-22 Siemens Ag, 8000 Muenchen, De
US5269309A (en) * 1991-12-11 1993-12-14 Fort J Robert Synthetic aperture ultrasound imaging system
FR2712697B1 (fr) * 1993-11-19 1995-12-15 Commissariat Energie Atomique Procédé d'analyse élémentaire par spectrométrie d'émission optique sur plasma produit par laser en présence d'argon.
DE4400674C2 (de) * 1994-01-12 1995-10-26 Siemens Ag Photoakustischer Sensor
FR2728452B1 (fr) * 1994-12-22 1997-07-25 Dior Christian Parfums Dispositif pour l'analyse photoacoustique de peau in situ
US5615675A (en) * 1996-04-19 1997-04-01 Regents Of The University Of Michigan Method and system for 3-D acoustic microscopy using short pulse excitation and 3-D acoustic microscope for use therein

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727420A (en) * 1984-10-16 1988-02-23 Fuji Photo Film Co., Ltd. Acoustooptic image formation
US4710030A (en) * 1985-05-17 1987-12-01 Bw Brown University Research Foundation Optical generator and detector of stress pulses
US5421337A (en) * 1989-04-14 1995-06-06 Massachusetts Institute Of Technology Spectral diagnosis of diseased tissue
US5398685A (en) * 1992-01-10 1995-03-21 Wilk; Peter J. Endoscopic diagnostic system and associated method
US5602894A (en) * 1994-08-04 1997-02-11 Bardash; Michael J. Three-dimensional imaging system using laser generated ultrashort x-ray pulses
US5582578A (en) * 1995-08-01 1996-12-10 Duke University Method for the comminution of concretions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0920277A4 *

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6309352B1 (en) 1996-01-31 2001-10-30 Board Of Regents, The University Of Texas System Real time optoacoustic monitoring of changes in tissue properties
US6405069B1 (en) 1996-01-31 2002-06-11 Board Of Regents, The University Of Texas System Time-resolved optoacoustic method and system for noninvasive monitoring of glucose
US6102857A (en) * 1996-10-04 2000-08-15 Optosonics, Inc. Photoacoustic breast scanner
US6292682B1 (en) 1996-10-04 2001-09-18 Optosonics, Inc. Photoacoustic breast scanner
US6104942A (en) * 1998-05-12 2000-08-15 Optosonics, Inc. Thermoacoustic tissue scanner
WO1999058957A1 (en) * 1998-05-12 1999-11-18 Optosonics, Inc. Thermoacoustic tissue scanner
US6216025B1 (en) 1999-02-02 2001-04-10 Optosonics, Inc. Thermoacoustic computed tomography scanner
US6839496B1 (en) 1999-06-28 2005-01-04 University College Of London Optical fibre probe for photoacoustic material analysis
WO2001017424A1 (en) * 1999-09-03 2001-03-15 Ut-Battelle, Llc. Method and apparatus of spectro-acoustically enhanced ultrasonic detection for diagnostics
US9060691B2 (en) 2004-05-06 2015-06-23 Nippon Telegraph And Telephone Corporation Constituent concentration measuring apparatus and constituent concentration measuring apparatus controlling method
US8332006B2 (en) 2004-05-06 2012-12-11 Nippon Telegraph And Telephone Corporation Constituent concentration measuring apparatus and constituent concentration measuring apparatus controlling method
US9008742B2 (en) 2004-05-06 2015-04-14 Nippon Telegraph And Telephone Corporation Constituent concentration measuring apparatus and constituent concentration measuring apparatus controlling method
US9198580B2 (en) 2004-05-06 2015-12-01 Nippon Telegraph And Telephone Corporation Constituent concentration measuring apparatus and constituent concentration measuring apparatus controlling method
US20130129633A1 (en) * 2007-08-28 2013-05-23 University Of Florida Research Foundation, Inc. Multimodal nanoparticles for non-invasive bio-imaging
US8361437B2 (en) 2007-08-28 2013-01-29 University Of Florida Research Foundation, Inc. Multimodal nanoparticles for non-invasive bio-imaging
US8617522B2 (en) * 2007-08-28 2013-12-31 University Of Florida Research Foundation, Inc. Multimodal nanoparticles for non-invasive bio-imaging
WO2009032752A3 (en) * 2007-08-28 2009-04-30 Univ Florida Multimodal nanoparticles for non-invasive bio-imaging
WO2010044660A1 (en) * 2008-10-13 2010-04-22 Academisch Medisch Centrum Van De Universiteit Van Amsterdam Mammography-apparatus and method for screening the occurrence of malignant cells
US9084560B2 (en) 2009-12-11 2015-07-21 Canon Kabushiki Kaisha Photoacoustic apparatus and method for controlling the same
WO2011070985A1 (en) * 2009-12-11 2011-06-16 Canon Kabushiki Kaisha Photoacoustic apparatus and method for controlling the same
US9050009B2 (en) 2010-02-19 2015-06-09 Academisch Medisch Centrum Bij De Universiteit Van Amsterdam Mammography-apparatus
WO2012024687A3 (en) * 2010-08-20 2012-08-09 Purdue Research Foundation Bond-selective vibrational photoacoustic imaging system and method
US11793473B2 (en) 2017-06-27 2023-10-24 Teledyne Dalsa B.V. Seat adapted for use with a mammography apparatus
US11058372B2 (en) 2017-10-31 2021-07-13 Sigmascreening B.V. Mammography apparatus and method of pressurizing a breast
WO2020031181A1 (en) * 2018-08-07 2020-02-13 Elbit Systems Land And C4I Ltd. Two-stage photo-acoustic excitation sensing systems and methods
US11187648B2 (en) 2018-08-07 2021-11-30 Elbit Systems Land C4I Ltd. Two-stage photo-acoustic excitation sensing systems and methods

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EP0920277A1 (en) 1999-06-09
AU732799B2 (en) 2001-05-03
JPH11514549A (ja) 1999-12-14
DE69734203T2 (de) 2006-07-13
AU1857097A (en) 1997-08-22
US5840023A (en) 1998-11-24
DE69734203D1 (de) 2005-10-20
CA2244732C (en) 2010-04-20
EP0920277A4 (enExample) 1999-06-09
EP0920277B1 (en) 2005-09-14
CA2244732A1 (en) 1997-08-07

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