WO1994028957A1 - Pulverinhalator mit dosiereinrichtung - Google Patents
Pulverinhalator mit dosiereinrichtung Download PDFInfo
- Publication number
- WO1994028957A1 WO1994028957A1 PCT/EP1994/001038 EP9401038W WO9428957A1 WO 1994028957 A1 WO1994028957 A1 WO 1994028957A1 EP 9401038 W EP9401038 W EP 9401038W WO 9428957 A1 WO9428957 A1 WO 9428957A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- inhaler according
- dos
- inhaler
- mpul
- solids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Definitions
- inhalative asthma therapy powder inhalers are being used more and more frequently as doser and inhaler devices, since the doser aerosols that were customary up to now can no longer be used because of the use of halogenated hydrocarbons as propellants for environmental reasons.
- Doser aerosols have the disadvantage that the patient must be able to coordinate the triggering of the spray and the inhalation. This is not always the case under the conditions of an acute asthma attack in which the patient is under severe stress.
- pulse inhalers there is no need to coordinate inhalation and spray actuation since the patient's inhaled air carries the active ingredient.
- each dose of the active ingredient is contained in a single hard gel capsule.
- the capsule is inserted into the device, stabbed through several thorns, and the released content is carried along by the patient's air flow and reaches the patient's lungs.
- an inert auxiliary such as lactose
- lactose lactose
- This invention relates to an inhaler for introducing an amount of solids dosed with a compression pulse into an air stream sucked in by a user according to the preamble of patent claim 1.
- Solid-state inhalers are now available in large numbers and in many designs.
- inhalers are used to inhale primarily pharmaceutically active substances or mixtures, in particular powdery substances or mixtures, from a user.
- EP 518 087 describes a powder inhaler with a rotatably mounted metering disc, in which the specific shape of the Dos 1 Erkavl tat is intended to prevent the powder from accidentally falling out.
- Another inhaler is known for example from EP 0 069 715 B1.
- the inhaler described in this patent comprises a storage chamber which opens into a chamber with elastic spring-loaded scrapers, where solid particles penetrate into it by rotating a perforated membrane and continues to cycle to the suction position. At this position, the solid particles are conveyed through the suction tube with the help of a suctioned air flow and with additional air sucked in from the side In the mouthpiece, dispersed through a helical channel and thus as 1 nhal 1 capable 1 total air-solid mixture was administered to the test person.
- the inhaler described has various night spots. After increasing the number of doses, the metering holes in the membrane become blocked. In addition, solid agglomerates accumulate in the mouthpiece, which pose a risk to the test subjects of the increased amount of pharmaceuticals. By rotating the Dos 1 membrane several times without sucking off the powder, part of the powder is conveyed back into the storage chamber, but when using it, there may also be a risk of increased drug consumption for the test subject.
- the wall formed as a baffle plate which is another element for the disassembly of the powder, soiled by adhering powder. Improper breathing can cause moisture to enter the inhaler and cause the powder to clog.
- the solid found in the solid sperm is (3) a compaction pulse, which puts the solid in the Dos 1 Erkav 1 into a state of uniform density.
- the compression springs (4) which are pre-tensioned between the base body (5) and the upper part (1) with an integrated mouthpiece, make it difficult to pull the Dos 1! Boar (10) suddenly relaxes when the curve nose of the Dos 1 schel be (6) is pulled past the vertical edge of the underlying body of the course.
- the entire base body (5), together with integrated parts (3, 12, 9, 7, 13, 16), is again boiled with the help of the Dos1 (10) located slope on the curve nose of the Dos1 (6) on the vertical edge of the curve base body (15) lifted and positioned in a horizontal direction to the air duct and thus the still relaxed compression spring between the base body (5) and the upper part (1) (4), pressed together again (see F1g. 3 and F1g. 4).
- the 1m air duct below the Dos 1 is (6) arranged membrane ent11 (13, 14, 16) prevents accidental blowing into the inhaler, the solids discharge from the air inlet opening 1m upper part (1) the inhaler. The entire metered amount of solids is thus available for the test subject to inhale.
- the air flap (12) which is arranged in the 1m air duct and which is mounted on the suction duct of the base body (5) with a bearing pin (9), must release the suction duct of the base body (5) through the suction pressure applied by the test subject. Only then is a new dosage possible for the next inhalation process. If a dose is triggered by sticking out and sticking in the Dos 1 boar (10) without a subsequent inhalation process, a new Dos 1 process is initiated by the hook-shaped connection of the air flap retractor (12) on both sides and the boar on the Dos1 ( 10) locked above the integrated spring (see F1g. 6). The risk of administration of an increased amount of pharmaceuticals is thus excluded.
- F1g. 2 Top view of the inhaler 1m section B-B, marked in F1g. 1.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Anesthesiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU65648/94A AU6564894A (en) | 1993-06-14 | 1994-04-02 | Powder inhaler with metering device |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP4319514.8 | 1993-06-14 | ||
| DE4319514A DE4319514C2 (de) | 1993-06-14 | 1993-06-14 | Pulverinhalator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1994028957A1 true WO1994028957A1 (de) | 1994-12-22 |
Family
ID=6490210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP1994/001038 Ceased WO1994028957A1 (de) | 1993-06-14 | 1994-04-02 | Pulverinhalator mit dosiereinrichtung |
Country Status (6)
| Country | Link |
|---|---|
| AU (1) | AU6564894A (cs) |
| DE (1) | DE4319514C2 (cs) |
| IL (1) | IL109992A0 (cs) |
| TW (1) | TW238251B (cs) |
| WO (1) | WO1994028957A1 (cs) |
| ZA (1) | ZA944203B (cs) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997000703A1 (en) * | 1995-06-21 | 1997-01-09 | Asta Medica Aktiengesellschaft | Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments |
| US7854226B2 (en) | 2002-07-31 | 2010-12-21 | Chiesi Farmaceutici S.P.A. | Powder inhaler |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19500764C2 (de) * | 1995-01-13 | 2001-09-27 | Sofotec Gmbh & Co Kg | Vorrichtung zum Verabreichen von Medikamenten in fester, in einem Luftstrom fein verteilter Form |
| DE19522415C2 (de) * | 1995-06-21 | 2003-12-04 | Sofotec Gmbh & Co Kg | Arzneimittelpulverpatrone mit integrierter Dosiereinrichtung und Pulverinhalator mit Mitteln zum Betätigen der Dosiereinrichtung der Arzneimittelpulverpatrone |
| FI20000810A0 (fi) * | 2000-04-06 | 2000-04-06 | Orion Yhtymae Oyj | Jauheinhalaattori |
| DE10300032B3 (de) * | 2003-01-03 | 2004-05-27 | E. Braun Gmbh | Pulverinhalator |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR967494A (fr) * | 1947-09-04 | 1950-11-03 | Abbott Lab | Dispositif inhalateur |
| US5113855A (en) * | 1990-02-14 | 1992-05-19 | Newhouse Michael T | Powder inhaler |
| EP0505321A2 (de) * | 1991-03-21 | 1992-09-23 | Ciba-Geigy Ag | Inhalator |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4274403A (en) * | 1979-08-29 | 1981-06-23 | Struve Roger L | Inhaler |
| DE3274065D1 (de) * | 1981-07-08 | 1986-12-11 | Draco Ab | Powder inhalator |
| SU1121011A1 (ru) * | 1983-02-11 | 1984-10-30 | Войсковая часть 51105 | Устройство дл введени лекарственных порошков |
| FI69963C (fi) * | 1984-10-04 | 1986-09-12 | Orion Yhtymae Oy | Doseringsanordning |
| SU1503827A1 (ru) * | 1987-02-27 | 1989-08-30 | Горьковский Научно-Исследовательский Педиатрический Институт | Устройство дл введени лекарственных порошков |
| IT1230313B (it) * | 1989-07-07 | 1991-10-18 | Somova Spa | Inalatore per medicamenti in capsule. |
| DE4027391A1 (de) * | 1990-08-30 | 1992-03-12 | Boehringer Ingelheim Kg | Treibgasfreies inhalationsgeraet |
| IT1248059B (it) * | 1991-06-14 | 1995-01-05 | Miat Spa | Insufflatore multidose per farmaci in polvere |
-
1993
- 1993-06-14 DE DE4319514A patent/DE4319514C2/de not_active Expired - Lifetime
-
1994
- 1994-04-02 AU AU65648/94A patent/AU6564894A/en not_active Abandoned
- 1994-04-02 WO PCT/EP1994/001038 patent/WO1994028957A1/de not_active Ceased
- 1994-04-23 TW TW083103630A patent/TW238251B/zh active
- 1994-06-13 IL IL10999294A patent/IL109992A0/xx unknown
- 1994-06-14 ZA ZA944203A patent/ZA944203B/xx unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR967494A (fr) * | 1947-09-04 | 1950-11-03 | Abbott Lab | Dispositif inhalateur |
| US5113855A (en) * | 1990-02-14 | 1992-05-19 | Newhouse Michael T | Powder inhaler |
| EP0505321A2 (de) * | 1991-03-21 | 1992-09-23 | Ciba-Geigy Ag | Inhalator |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997000703A1 (en) * | 1995-06-21 | 1997-01-09 | Asta Medica Aktiengesellschaft | Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments |
| US5840279A (en) * | 1995-06-21 | 1998-11-24 | Asta Medica Aktiengesellschaft | Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments |
| US6071498A (en) * | 1995-06-21 | 2000-06-06 | Asta Medica Aktiengesellschaft | Inhaler for powdered medicaments |
| US7854226B2 (en) | 2002-07-31 | 2010-12-21 | Chiesi Farmaceutici S.P.A. | Powder inhaler |
Also Published As
| Publication number | Publication date |
|---|---|
| AU6564894A (en) | 1995-01-03 |
| DE4319514A1 (de) | 1994-12-15 |
| IL109992A0 (en) | 1994-10-07 |
| ZA944203B (en) | 1995-02-16 |
| DE4319514C2 (de) | 2003-06-18 |
| TW238251B (cs) | 1995-01-11 |
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