WO1994028957A1 - Pulverinhalator mit dosiereinrichtung - Google Patents

Pulverinhalator mit dosiereinrichtung Download PDF

Info

Publication number
WO1994028957A1
WO1994028957A1 PCT/EP1994/001038 EP9401038W WO9428957A1 WO 1994028957 A1 WO1994028957 A1 WO 1994028957A1 EP 9401038 W EP9401038 W EP 9401038W WO 9428957 A1 WO9428957 A1 WO 9428957A1
Authority
WO
WIPO (PCT)
Prior art keywords
inhaler according
dos
inhaler
mpul
solids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1994/001038
Other languages
German (de)
English (en)
French (fr)
Inventor
Martin Herder
Wolfgang Göttenauer
André Narodylo
Joachim Goede
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asta Medica GmbH
Original Assignee
Asta Medica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica GmbH filed Critical Asta Medica GmbH
Priority to AU65648/94A priority Critical patent/AU6564894A/en
Publication of WO1994028957A1 publication Critical patent/WO1994028957A1/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder

Definitions

  • inhalative asthma therapy powder inhalers are being used more and more frequently as doser and inhaler devices, since the doser aerosols that were customary up to now can no longer be used because of the use of halogenated hydrocarbons as propellants for environmental reasons.
  • Doser aerosols have the disadvantage that the patient must be able to coordinate the triggering of the spray and the inhalation. This is not always the case under the conditions of an acute asthma attack in which the patient is under severe stress.
  • pulse inhalers there is no need to coordinate inhalation and spray actuation since the patient's inhaled air carries the active ingredient.
  • each dose of the active ingredient is contained in a single hard gel capsule.
  • the capsule is inserted into the device, stabbed through several thorns, and the released content is carried along by the patient's air flow and reaches the patient's lungs.
  • an inert auxiliary such as lactose
  • lactose lactose
  • This invention relates to an inhaler for introducing an amount of solids dosed with a compression pulse into an air stream sucked in by a user according to the preamble of patent claim 1.
  • Solid-state inhalers are now available in large numbers and in many designs.
  • inhalers are used to inhale primarily pharmaceutically active substances or mixtures, in particular powdery substances or mixtures, from a user.
  • EP 518 087 describes a powder inhaler with a rotatably mounted metering disc, in which the specific shape of the Dos 1 Erkavl tat is intended to prevent the powder from accidentally falling out.
  • Another inhaler is known for example from EP 0 069 715 B1.
  • the inhaler described in this patent comprises a storage chamber which opens into a chamber with elastic spring-loaded scrapers, where solid particles penetrate into it by rotating a perforated membrane and continues to cycle to the suction position. At this position, the solid particles are conveyed through the suction tube with the help of a suctioned air flow and with additional air sucked in from the side In the mouthpiece, dispersed through a helical channel and thus as 1 nhal 1 capable 1 total air-solid mixture was administered to the test person.
  • the inhaler described has various night spots. After increasing the number of doses, the metering holes in the membrane become blocked. In addition, solid agglomerates accumulate in the mouthpiece, which pose a risk to the test subjects of the increased amount of pharmaceuticals. By rotating the Dos 1 membrane several times without sucking off the powder, part of the powder is conveyed back into the storage chamber, but when using it, there may also be a risk of increased drug consumption for the test subject.
  • the wall formed as a baffle plate which is another element for the disassembly of the powder, soiled by adhering powder. Improper breathing can cause moisture to enter the inhaler and cause the powder to clog.
  • the solid found in the solid sperm is (3) a compaction pulse, which puts the solid in the Dos 1 Erkav 1 into a state of uniform density.
  • the compression springs (4) which are pre-tensioned between the base body (5) and the upper part (1) with an integrated mouthpiece, make it difficult to pull the Dos 1! Boar (10) suddenly relaxes when the curve nose of the Dos 1 schel be (6) is pulled past the vertical edge of the underlying body of the course.
  • the entire base body (5), together with integrated parts (3, 12, 9, 7, 13, 16), is again boiled with the help of the Dos1 (10) located slope on the curve nose of the Dos1 (6) on the vertical edge of the curve base body (15) lifted and positioned in a horizontal direction to the air duct and thus the still relaxed compression spring between the base body (5) and the upper part (1) (4), pressed together again (see F1g. 3 and F1g. 4).
  • the 1m air duct below the Dos 1 is (6) arranged membrane ent11 (13, 14, 16) prevents accidental blowing into the inhaler, the solids discharge from the air inlet opening 1m upper part (1) the inhaler. The entire metered amount of solids is thus available for the test subject to inhale.
  • the air flap (12) which is arranged in the 1m air duct and which is mounted on the suction duct of the base body (5) with a bearing pin (9), must release the suction duct of the base body (5) through the suction pressure applied by the test subject. Only then is a new dosage possible for the next inhalation process. If a dose is triggered by sticking out and sticking in the Dos 1 boar (10) without a subsequent inhalation process, a new Dos 1 process is initiated by the hook-shaped connection of the air flap retractor (12) on both sides and the boar on the Dos1 ( 10) locked above the integrated spring (see F1g. 6). The risk of administration of an increased amount of pharmaceuticals is thus excluded.
  • F1g. 2 Top view of the inhaler 1m section B-B, marked in F1g. 1.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
PCT/EP1994/001038 1993-06-14 1994-04-02 Pulverinhalator mit dosiereinrichtung Ceased WO1994028957A1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU65648/94A AU6564894A (en) 1993-06-14 1994-04-02 Powder inhaler with metering device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4319514.8 1993-06-14
DE4319514A DE4319514C2 (de) 1993-06-14 1993-06-14 Pulverinhalator

Publications (1)

Publication Number Publication Date
WO1994028957A1 true WO1994028957A1 (de) 1994-12-22

Family

ID=6490210

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1994/001038 Ceased WO1994028957A1 (de) 1993-06-14 1994-04-02 Pulverinhalator mit dosiereinrichtung

Country Status (6)

Country Link
AU (1) AU6564894A (cs)
DE (1) DE4319514C2 (cs)
IL (1) IL109992A0 (cs)
TW (1) TW238251B (cs)
WO (1) WO1994028957A1 (cs)
ZA (1) ZA944203B (cs)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997000703A1 (en) * 1995-06-21 1997-01-09 Asta Medica Aktiengesellschaft Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments
US7854226B2 (en) 2002-07-31 2010-12-21 Chiesi Farmaceutici S.P.A. Powder inhaler

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19500764C2 (de) * 1995-01-13 2001-09-27 Sofotec Gmbh & Co Kg Vorrichtung zum Verabreichen von Medikamenten in fester, in einem Luftstrom fein verteilter Form
DE19522415C2 (de) * 1995-06-21 2003-12-04 Sofotec Gmbh & Co Kg Arzneimittelpulverpatrone mit integrierter Dosiereinrichtung und Pulverinhalator mit Mitteln zum Betätigen der Dosiereinrichtung der Arzneimittelpulverpatrone
FI20000810A0 (fi) * 2000-04-06 2000-04-06 Orion Yhtymae Oyj Jauheinhalaattori
DE10300032B3 (de) * 2003-01-03 2004-05-27 E. Braun Gmbh Pulverinhalator

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR967494A (fr) * 1947-09-04 1950-11-03 Abbott Lab Dispositif inhalateur
US5113855A (en) * 1990-02-14 1992-05-19 Newhouse Michael T Powder inhaler
EP0505321A2 (de) * 1991-03-21 1992-09-23 Ciba-Geigy Ag Inhalator

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4274403A (en) * 1979-08-29 1981-06-23 Struve Roger L Inhaler
DE3274065D1 (de) * 1981-07-08 1986-12-11 Draco Ab Powder inhalator
SU1121011A1 (ru) * 1983-02-11 1984-10-30 Войсковая часть 51105 Устройство дл введени лекарственных порошков
FI69963C (fi) * 1984-10-04 1986-09-12 Orion Yhtymae Oy Doseringsanordning
SU1503827A1 (ru) * 1987-02-27 1989-08-30 Горьковский Научно-Исследовательский Педиатрический Институт Устройство дл введени лекарственных порошков
IT1230313B (it) * 1989-07-07 1991-10-18 Somova Spa Inalatore per medicamenti in capsule.
DE4027391A1 (de) * 1990-08-30 1992-03-12 Boehringer Ingelheim Kg Treibgasfreies inhalationsgeraet
IT1248059B (it) * 1991-06-14 1995-01-05 Miat Spa Insufflatore multidose per farmaci in polvere

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR967494A (fr) * 1947-09-04 1950-11-03 Abbott Lab Dispositif inhalateur
US5113855A (en) * 1990-02-14 1992-05-19 Newhouse Michael T Powder inhaler
EP0505321A2 (de) * 1991-03-21 1992-09-23 Ciba-Geigy Ag Inhalator

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997000703A1 (en) * 1995-06-21 1997-01-09 Asta Medica Aktiengesellschaft Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments
US5840279A (en) * 1995-06-21 1998-11-24 Asta Medica Aktiengesellschaft Pharmaceutical powder cartridge with integrated metering device and inhaler for powdered medicaments
US6071498A (en) * 1995-06-21 2000-06-06 Asta Medica Aktiengesellschaft Inhaler for powdered medicaments
US7854226B2 (en) 2002-07-31 2010-12-21 Chiesi Farmaceutici S.P.A. Powder inhaler

Also Published As

Publication number Publication date
AU6564894A (en) 1995-01-03
DE4319514A1 (de) 1994-12-15
IL109992A0 (en) 1994-10-07
ZA944203B (en) 1995-02-16
DE4319514C2 (de) 2003-06-18
TW238251B (cs) 1995-01-11

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