WO1990006748A3 - Emploi de certains herbicides dans le traitement du cancer et production de protoporphyrine ix - Google Patents

Emploi de certains herbicides dans le traitement du cancer et production de protoporphyrine ix Download PDF

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Publication number
WO1990006748A3
WO1990006748A3 PCT/US1989/005599 US8905599W WO9006748A3 WO 1990006748 A3 WO1990006748 A3 WO 1990006748A3 US 8905599 W US8905599 W US 8905599W WO 9006748 A3 WO9006748 A3 WO 9006748A3
Authority
WO
WIPO (PCT)
Prior art keywords
protoporphyrin
cells
production
cancer treatment
certain herbicides
Prior art date
Application number
PCT/US1989/005599
Other languages
English (en)
Other versions
WO1990006748A2 (fr
Inventor
Blaik Phillip Halling
Debra Ann Witkowski
Original Assignee
Fmc Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to SU894895765A priority Critical patent/RU2074719C1/ru
Priority to MC89@@D priority patent/MC2171A1/fr
Priority to MD94-0294A priority patent/MD861G2/ro
Priority to BR898907817A priority patent/BR8907817A/pt
Priority to KR1019900701747A priority patent/KR930003116B1/ko
Priority to DE3991484A priority patent/DE3991484C2/de
Priority to JP2501659A priority patent/JP2545000B2/ja
Application filed by Fmc Corp filed Critical Fmc Corp
Publication of WO1990006748A2 publication Critical patent/WO1990006748A2/fr
Publication of WO1990006748A3 publication Critical patent/WO1990006748A3/fr
Priority to MW1191A priority patent/MW1191A1/xx
Priority to FI912784A priority patent/FI912784A0/fi
Priority to NO912228A priority patent/NO912228D0/no
Priority to DK110791A priority patent/DK110791A/da
Priority to SE9101807A priority patent/SE505938C2/sv
Priority to LVP-93-1060A priority patent/LV10303B/lv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Sont décrits un procédé et une composition pharmaceutique pour tuer des cellules tumorales mammifères en exposant lesdites cellules à de la lumière en présence d'un tétrapyrrole photoactivable. Le perfectionnement consiste à traiter lesdites cellules avec un composé qui inhibe la conversion enzymatique du protoporphyrinogène en protoporphyrine IX par oxydase du protoporphyrinogène dans lesdites cellules, provoquant ainsi une accumulation de protoporphyrine IX dans lesdites cellules. Est également décrit un procédé pour la production de protoporphyrine IX qui consiste à cultiver des microalgues eucaryotiques en présence d'un inhibiteur d'oxydase de protoporphyrinogène.
PCT/US1989/005599 1988-12-12 1989-12-08 Emploi de certains herbicides dans le traitement du cancer et production de protoporphyrine ix WO1990006748A2 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
SU894895765A RU2074719C1 (ru) 1988-12-12 1989-12-08 Способ разрушения опухолевых клеток млекопитающих и фармацевтическая композиция для разрушения опухолевых клеток млекопитающих
MC89@@D MC2171A1 (fr) 1988-12-12 1989-12-08 Production et utilisation de porphyrines
MD94-0294A MD861G2 (ro) 1988-12-12 1989-12-08 Procedeu şi compoziţie farmaceutică pentru distrugerea celulelor tumorale ale mamiferelor
BR898907817A BR8907817A (pt) 1988-12-12 1989-12-08 Processo para matar celulas de tumor de mamiferos,composicao farmaceutica para uso no processo,inibidor especifico da conversao enzimatica,processo para elevar o teor de protoporfirina ix e processo para detectar ou localizar celulas e tumores em mamiferos e para a producao de protoporfirina ix
KR1019900701747A KR930003116B1 (ko) 1988-12-12 1989-12-08 종양의 광역학적 치료용 조성물
DE3991484A DE3991484C2 (de) 1988-12-12 1989-12-08 Arzneimittel mit einem Gehalt an einem spezifischen Inhibitor der enzymatischen Umwandlung von Protoporphyrinogen zu Protoporphyrin IX durch Protoporphyrinogen-Oxidase
JP2501659A JP2545000B2 (ja) 1988-12-12 1989-12-08 ポルフィリンの製造とその使用法
MW1191A MW1191A1 (en) 1988-12-12 1991-05-17 Production and use of porphyrins
FI912784A FI912784A0 (fi) 1988-12-12 1991-06-10 Framstaellning och anvaendning av porfyriner.
DK110791A DK110791A (da) 1988-12-12 1991-06-11 Fremgangsmaade og anvendelse af porphyriner
NO912228A NO912228D0 (no) 1988-12-12 1991-06-11 Fremstilling og anvendelse av porfyriner.
SE9101807A SE505938C2 (sv) 1988-12-12 1991-06-12 Protoporfyrinogen inhibitorer och användning därav i kompositioner för att detektera och behandla tumörer
LVP-93-1060A LV10303B (en) 1988-12-12 1993-09-09 Method for elimination of breast cancer cells

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US28515188A 1988-12-12 1988-12-12
US285,151 1988-12-12
US33500789A 1989-04-07 1989-04-07
US335,007 1989-04-07
US35133189A 1989-05-03 1989-05-03
US351,331 1989-05-03

Publications (2)

Publication Number Publication Date
WO1990006748A2 WO1990006748A2 (fr) 1990-06-28
WO1990006748A3 true WO1990006748A3 (fr) 1990-10-04

Family

ID=27403508

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/005599 WO1990006748A2 (fr) 1988-12-12 1989-12-08 Emploi de certains herbicides dans le traitement du cancer et production de protoporphyrine ix

Country Status (28)

Country Link
EP (1) EP0447491B1 (fr)
JP (1) JP2545000B2 (fr)
KR (1) KR930003116B1 (fr)
AR (1) AR243605A1 (fr)
AT (1) AT400520B (fr)
AU (1) AU633537B2 (fr)
BR (1) BR8907817A (fr)
CA (1) CA2004979A1 (fr)
CH (1) CH681779A5 (fr)
DE (2) DE3991484T (fr)
DK (1) DK110791A (fr)
EG (1) EG18822A (fr)
ES (1) ES2051675T3 (fr)
FI (1) FI912784A0 (fr)
GB (1) GB2247404B (fr)
GR (1) GR1000609B (fr)
HU (1) HUT58202A (fr)
IE (1) IE62621B1 (fr)
IL (1) IL92622A (fr)
LU (1) LU87949A1 (fr)
LV (1) LV10303B (fr)
MC (1) MC2171A1 (fr)
NO (1) NO912228D0 (fr)
NZ (1) NZ231658A (fr)
OA (1) OA09362A (fr)
PT (1) PT92546B (fr)
SE (1) SE505938C2 (fr)
WO (1) WO1990006748A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5298502A (en) * 1988-12-12 1994-03-29 Fmc Corporation Method and composition for photodynamic treatment and detection of tumors
US5132101A (en) * 1990-05-04 1992-07-21 Cytopharm, Inc. Acetylene-cumulene porphycene compounds for photodynamic therapy
US5244671A (en) * 1991-01-29 1993-09-14 Cytopharm, Inc. Derivatives of porphycene for photodynamic therapy of cancer
US5179120A (en) * 1991-06-28 1993-01-12 Cytopharm, Inc. Porphycene compounds for photodynamic therapy
TW492975B (en) * 1993-07-26 2002-07-01 Novartis Ag Tryptase inhibitor
GB9318841D0 (en) * 1993-09-10 1993-10-27 Res Foundation Of The Norwegia Composition
US5767373A (en) 1994-06-16 1998-06-16 Novartis Finance Corporation Manipulation of protoporphyrinogen oxidase enzyme activity in eukaryotic organisms
US5939602A (en) * 1995-06-06 1999-08-17 Novartis Finance Corporation DNA molecules encoding plant protoporphyrinogen oxidase and inhibitor-resistant mutants thereof
US6023012A (en) * 1996-02-28 2000-02-08 Novartis Finance Corporation DNA molecules encoding plant protoporphyrinogen oxidase
US6084155A (en) * 1995-06-06 2000-07-04 Novartis Ag Herbicide-tolerant protoporphyrinogen oxidase ("protox") genes
BR9707783A (pt) * 1996-02-28 1999-07-27 Novartis Ag Promotores provenientes de genes para protoporfirnogênio oxidase em vegetais
JPH10330359A (ja) * 1997-03-31 1998-12-15 Nippon Bayeragrochem Kk フエニルアセチレン誘導体及び除草剤
DE102005017152B4 (de) * 2005-04-13 2007-02-08 Lindauer Dornier Gmbh Verfahren zum Trocknen von vorzugsweise plattenförmigen Produkten und Durchlauftrockner in Mehretagenbauweise
EA023754B1 (ru) 2009-06-19 2016-07-29 Басф Се Гербицидные бензоксазиноны
BR112012009987A2 (pt) * 2009-11-02 2015-09-29 Basf Se ''tetraidroftalimidas de fórmula ia ,processo para preparação de composições herbicidas ativas e método para controlar vegetações indesejadas''
EP2621924B1 (fr) 2010-10-01 2015-03-04 Basf Se Benzoxazinones herbicides
BR112013014782A2 (pt) 2010-12-15 2016-07-19 Basf Se composição, método para o controle de vegetação indesejada, uso de composições, método para proteger a atividade fitotóxica de uma benzoxazinona de fórmula i e método de proteção
CN102875569A (zh) * 2012-09-27 2013-01-16 南开大学 具有除草活性和抗肝癌活性的异噁唑并嘧啶酮(或三嗪酮)类化合物
CA3043986A1 (fr) * 2016-12-16 2018-06-21 Basf Se Phenyltriazolinones herbicides

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4393071A (en) * 1975-03-17 1983-07-12 Naoharu Fujii Method of treating gastric, mammary, lung and uterus tumors

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
US4404019A (en) * 1980-12-24 1983-09-13 Sumitomo Chemical Company, Limited 3-Chloro-1-phenyl-1,2,4-triazolin-5-ones and their use as herbicides
CH651029A5 (de) * 1980-12-25 1985-08-30 Nihon Nohyaku Co Ltd Triazolin-derivate, verfahren zu ihrer herstellung und sie enthaltende herbizide mittel.
JPS60190711A (ja) * 1984-03-09 1985-09-28 Tokyo Tanabe Co Ltd プロトポルフイリン類注射用製剤
US4755217A (en) * 1987-01-15 1988-07-05 Fmc Corporation Triazinedione herbicides
US4761174A (en) * 1987-04-14 1988-08-02 Fmc Corporation Triazolin-5-one herbicides

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
US4393071A (en) * 1975-03-17 1983-07-12 Naoharu Fujii Method of treating gastric, mammary, lung and uterus tumors

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
Biochemical and Biophysical Research Communications, Vol. 106, No. 3, 15 June 1982, Academic Press, Inc. (New York, US) J.M. CAMADRO et al.: " A New Assay for Protoporphyrinogen Oxidase - Evidence for a Total Deficiency in that Activity in a Heme-Less Mutant of Saccharomyces Cerevisiae", pages 724-730 *
Br. J. Cancer, Vol. 56, No. 5, 1987 (London, GB) Z. MALIK et al.: "Destruction of Erythroleukaemic Cells by Photoactivation of Endogenous Porphyrins", pages 589-595 *
FEBS Letters, Vol. 245, No. 1, 2, 1989 Elsevier (Amsterdam, NL) M. MATRINGE et al.: "Protoporphyrinogen Oxidase Inhibition by three Peroxidizing Herbicides: Oxadiazon, LS, 82-556 and M&B 39279", pages 35-38 *
Human Genetics, Vol. 58, 1981, Springer Verlag (Berlin, DE), J. DEYBACH et al.: "The Inherited Enzymatic Defect in Porphyria Variegata", pages 425-428 *
J. PESTICIDE Sci, Vol. 11, 1986 (Tokyo, JP) K. WAKABAYASHI et al.: "Effect of Cyclic Imide Herbicides on Chlorophyll Formation in Higher Plants", pages 635-640 *
Mol. Gen. Genet., Vol. 188, No. 1, 1982 Springer Verlag (Berlin, DE) M.S. CRAWFORD et al.: "Identification of the Primary Lesion in a Protoporphyrin Accumulating Mutant of Chlamydomonas Reinhardtii", pages 1-6 *
Pesticide Biochemistry and Physiology, Vol. 31, 1988, Academic Press, Inc. (New York, US) J. LYDON et al.: "Porphyrin Synthesis is Required for Photobleaching Activity of the P-Nitrosubstituted Diphenyl Ether Herbicides", pages 74-83 *
Pesticide Biochemistry and Physiology, Vol. 32, 1988, Academic Press, Inc. (New York, US) M. MATRINGE et al.: "Effects of Acifluorfen-Methyl on Cucumber Cotyledons: Porphyrin Accumulation", pages 164-172 *
Plant Physiol., Vol. 87, 1988 (Bethesda, US) D.A. WITKOWSKI et al.: "Accumulation of Photodynamic Tetrapyrroles Induced by Acifluorfen-Methyl", pages 632-637 *
The New England Journal of Medicine, Vol. 302, No. 14, 3 April 1980 (Boston, US) D.A. BRENNER et al.: "The Enzymatic Defect in Variegate Porphyria", pages 765-768 *
Zeitschrift fur Naturforschung, Vol. 43, No. 9-10, 1988, Verlag der Zeitschrift fur Naturforschung (Tubingen, DE) G. SANDMANN et al.: "Accumulation of Protoporphyrin IX in the Presence of Peroxidizing Herbicedes", pages 699-704 *

Also Published As

Publication number Publication date
GR1000609B (el) 1992-08-31
IE62621B1 (en) 1995-02-22
LU87949A1 (fr) 1991-12-16
DE3991484C2 (de) 1995-02-23
JP2545000B2 (ja) 1996-10-16
SE505938C2 (sv) 1997-10-27
JPH04501420A (ja) 1992-03-12
SE9101807L (sv) 1991-06-12
EP0447491A1 (fr) 1991-09-25
OA09362A (en) 1992-09-15
HUT58202A (en) 1992-02-28
EP0447491B1 (fr) 1993-08-11
CH681779A5 (fr) 1993-05-28
AU633537B2 (en) 1993-02-04
GR890100817A (en) 1991-03-15
WO1990006748A2 (fr) 1990-06-28
KR910700046A (ko) 1991-03-13
FI912784A0 (fi) 1991-06-10
NO912228L (no) 1991-06-11
GB9110472D0 (en) 1991-11-27
DK110791A (da) 1991-08-12
MC2171A1 (fr) 1992-05-22
DE3991484T (fr) 1991-11-21
DK110791D0 (da) 1991-06-11
ES2051675T3 (es) 1994-11-01
IL92622A (en) 1996-05-14
NO912228D0 (no) 1991-06-11
EG18822A (en) 1994-09-29
PT92546B (pt) 1995-09-12
ES2051675T1 (es) 1994-07-01
GB2247404A (en) 1992-03-04
BR8907817A (pt) 1991-10-22
PT92546A (pt) 1990-06-29
CA2004979A1 (fr) 1990-06-12
AU4822290A (en) 1990-07-10
NZ231658A (en) 1992-05-26
IE893925L (en) 1990-06-12
AT400520B (de) 1996-01-25
KR930003116B1 (ko) 1993-04-19
GB2247404B (en) 1993-03-03
LV10303B (en) 1995-08-20
AR243605A1 (es) 1993-08-31
ATA903489A (de) 1995-06-15
IL92622A0 (en) 1990-08-31
LV10303A (lv) 1994-10-20
SE9101807D0 (sv) 1991-06-12

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