WO1987006226A3 - Derives d'azacycloalkane, activateurs d'absorption contenant ces derives en tant qu'ingredients efficaces, et preparations externes contenant lesdits activateurs d'absorption - Google Patents

Derives d'azacycloalkane, activateurs d'absorption contenant ces derives en tant qu'ingredients efficaces, et preparations externes contenant lesdits activateurs d'absorption Download PDF

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Publication number
WO1987006226A3
WO1987006226A3 PCT/JP1987/000086 JP8700086W WO8706226A3 WO 1987006226 A3 WO1987006226 A3 WO 1987006226A3 JP 8700086 W JP8700086 W JP 8700086W WO 8706226 A3 WO8706226 A3 WO 8706226A3
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives
absorption promoters
absorption
azacycloalkane
effective ingredient
Prior art date
Application number
PCT/JP1987/000086
Other languages
English (en)
Other versions
WO1987006226A2 (fr
Inventor
Masayoshi Tsuji
Hisataka Inoue
Terumi Hachiya
Mikio Nakashima
Masaru Saita
Yuji Shimozono
Akira Nakagawa
Michinori Sakai
Original Assignee
Hisamitsu Pharmaceutical Co
Masayoshi Tsuji
Hisataka Inoue
Terumi Hachiya
Mikio Nakashima
Masaru Saita
Yuji Shimozono
Akira Nakagawa
Michinori Sakai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co, Masayoshi Tsuji, Hisataka Inoue, Terumi Hachiya, Mikio Nakashima, Masaru Saita, Yuji Shimozono, Akira Nakagawa, Michinori Sakai filed Critical Hisamitsu Pharmaceutical Co
Priority to KR1019900702502A priority Critical patent/KR910000480B1/ko
Priority to KR1019870701153A priority patent/KR910000164B1/ko
Priority to KR1019900702501A priority patent/KR910000479B1/ko
Publication of WO1987006226A2 publication Critical patent/WO1987006226A2/fr
Priority to KR1019880701212A priority patent/KR960010698B1/ko
Publication of WO1987006226A3 publication Critical patent/WO1987006226A3/fr
Priority to KR9072500A priority patent/KR910000478B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C07D223/10—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/06—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Dérivés d'azacycloalkane utiles pour activer l'absorption d'un médicament, agent activant l'absorption et comprenant au moins un des dérivés d'azacycloalkane en tant qu'ingrédient efficace pour activer l'absorption, et préparation externe contenant ledit agent d'activation d'absorption, le dérivé ci-décrit étant représenté par la formule (I) dans laquelle A est -CH2- ou -S- par exemple, B est soufre ou oxygène, R est -SR'' où R'' est un groupe alkyle ou un groupe alkylthioalkyle par exemple, ou bien -OR'' où R'' est tel que défini ci-dessus, un groupe alkyle ou un groupe amino substitué, R' est un atome d'hydrogène, un groupe alkyle ou un groupe alkyloxy par exemple, m est un entier de 0 à 5 et n est un entier de 1 à 15.
PCT/JP1987/000086 1986-04-08 1987-02-10 Derives d'azacycloalkane, activateurs d'absorption contenant ces derives en tant qu'ingredients efficaces, et preparations externes contenant lesdits activateurs d'absorption WO1987006226A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
KR1019900702502A KR910000480B1 (ko) 1986-04-08 1987-02-10 아자시클로 알칸유도체의 제조방법
KR1019870701153A KR910000164B1 (ko) 1986-04-08 1987-02-10 아자시클로알칸유도체의 제조방법
KR1019900702501A KR910000479B1 (ko) 1986-04-08 1987-02-10 아자시클로알칸유도체의 제조방법
KR1019880701212A KR960010698B1 (ko) 1987-02-02 1988-02-01 휴대용 선량계 및 그의 선량계를 사용한 피폭집중관리장치
KR9072500A KR910000478B1 (en) 1986-04-08 1990-11-22 Process for preparing azacycloalkane derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP61/79174 1986-04-08
JP61079174A JPH0643390B2 (ja) 1986-04-08 1986-04-08 アザシクロアルカン誘導体

Publications (2)

Publication Number Publication Date
WO1987006226A2 WO1987006226A2 (fr) 1987-10-22
WO1987006226A3 true WO1987006226A3 (fr) 1988-04-07

Family

ID=13682615

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1987/000086 WO1987006226A2 (fr) 1986-04-08 1987-02-10 Derives d'azacycloalkane, activateurs d'absorption contenant ces derives en tant qu'ingredients efficaces, et preparations externes contenant lesdits activateurs d'absorption

Country Status (14)

Country Link
US (1) US4882359A (fr)
EP (1) EP0241050B1 (fr)
JP (1) JPH0643390B2 (fr)
KR (1) KR910000164B1 (fr)
CN (2) CN1018452B (fr)
AR (1) AR245107A1 (fr)
AT (1) ATE81505T1 (fr)
AU (1) AU601402B2 (fr)
CA (1) CA1336597C (fr)
DE (1) DE3782182T2 (fr)
ES (1) ES2046196T3 (fr)
GR (1) GR3006768T3 (fr)
SU (3) SU1748644A3 (fr)
WO (1) WO1987006226A2 (fr)

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EP0257063B1 (fr) * 1986-01-31 1992-06-17 WHITBY RESEARCH, Inc. Compositions comprenant des azacycloalkanes monosubstitues et leur utilisation
US5234959A (en) * 1988-04-08 1993-08-10 Whitby Research, Inc. Penetration enhancers for transdermal delivery of systemic agents
US5472946A (en) * 1988-04-08 1995-12-05 Peck; James V. Transdermal penetration enhancers
CA1334646C (fr) * 1988-04-08 1995-03-07 James Vanolden Peck Produits stimulant la penetration transdermique
US5041435A (en) * 1988-08-13 1991-08-20 Santen Pharmaceutical Co., Ltd. Cyclic sulfur-containing compounds
JP2835985B2 (ja) * 1989-08-03 1998-12-14 久光製薬株式会社 皮膚外用クリーム製剤
IL91928A (en) * 1989-10-08 1994-07-31 Amrad Res & Dev Pharmaceutical compositions containing prolactin
US5070084A (en) * 1990-02-26 1991-12-03 Campbell James N Treatment of sympathetically maintained pain
US6559186B1 (en) 1990-02-26 2003-05-06 Arc 1, Inc. Compositions and methods of treatment of sympathetically maintained pain
FR2663932B1 (fr) * 1990-06-29 1994-04-29 Cird Galderma N-alkyl oxo-1 et dioxo-1,1 thiamorpholinones-3 et leurs utilisations comme agents de penetration de composes actifs dans des compositions therapeutiques et cosmetiques.
JPH078806B2 (ja) * 1990-08-16 1995-02-01 旭化成工業株式会社 カルシトニン類含有経鼻投与用乳剤
FR2666962B1 (fr) * 1990-09-26 1996-06-14 Oreal Composition antifongique sous forme de spray sec.
US5158763A (en) * 1990-10-09 1992-10-27 Colgate-Palmolive Company Non-staining anti-bacterial oral composition
JPH07595B2 (ja) 1990-10-31 1995-01-11 久光製薬株式会社 アザシクロアルカン誘導体の製造方法
US5206386A (en) * 1991-03-20 1993-04-27 Isp Investments Inc. Controlled release N-substituted pyrrolidone esters and process for the use thereof
JP3090353B2 (ja) * 1991-09-17 2000-09-18 旭化成工業株式会社 パラチロイドホルモン類含有経鼻投与用乳剤
ES2221921T3 (es) * 1992-07-13 2005-01-16 Shiseido Company, Ltd. Composicion para preparacion dermatologica.
WO1995011042A1 (fr) * 1993-10-21 1995-04-27 Hisamitsu Pharmaceutical Co., Inc. Composition administree par voie nasale et preparation contenant celle-ci
DE4337945A1 (de) * 1993-11-06 1995-05-11 Labtec Gmbh Pflaster zur Behandlung von Nagelmykosen
GB9325854D0 (en) * 1993-12-17 1994-02-23 Smithkline Beecham Corp Porcess
US6262117B1 (en) 1999-02-18 2001-07-17 Allergan Sales, Inc. Method and composition for treating acne
JP2000247911A (ja) 1999-02-26 2000-09-12 Hisamitsu Pharmaceut Co Inc 大腸用吸収促進剤
JP4653282B2 (ja) * 2000-05-23 2011-03-16 昭和薬品化工株式会社 ミノサイクリン含有組成物
JP2006515015A (ja) * 2003-01-10 2006-05-18 エフ．ホフマン−ラ　ロシュ　アーゲー プロスタグランジンアゴニストとしての２−ピペリドン誘導体
JP4504210B2 (ja) * 2005-01-25 2010-07-14 花王株式会社 染毛剤組成物
US8026266B2 (en) 2005-11-08 2011-09-27 Arcion Therapeutics, Inc. Treatment of length dependent neuropathy

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GB947910A (en) * 1960-11-04 1964-01-29 Gen Aniline & Film Corp Surface active ethers of n-(hydroxymethyl)-lactams
DE1177641B (de) * 1962-06-12 1964-09-10 Kalk Chemische Fabrik Gmbh Verfahren zur Herstellung von N-(ª‰-Hydroxy-alkyl)-oxazolidonen-(4) bzw. deren Polyaether
US3232952A (en) * 1963-09-20 1966-02-01 Kalk Chemische Fabrik Gmbh Di-(oxazolidinone-(4)-n-alkyl)-ethers
US3281425A (en) * 1962-11-02 1966-10-25 Kalk Chemische Fabrik Gmbh Ethers of n-methylol-2, 2, 5, 5-tetraalkyloxazolidinone-(4)
DE1695846A1 (de) * 1967-05-05 1971-05-13 Schwarzkopf Gmbh Hans Verfahren zur Darstellung von Thioaethern mit reduktiven Eigenschaften
DE2114295A1 (de) * 1970-03-27 1971-10-14 Gaf Corp Substituierte AEtherderivate des N-Hydroxymethyl-2-pyrrolidinon und Verfahren zu deren Herstellung
DE2114251A1 (de) * 1970-03-30 1971-10-14 Gaf Corp Tertiaere Aminomethylderivate des N-Hydroxymethyl-2-pyrrolidinon und Verfahren zu deren Herstellung
DE2117240A1 (de) * 1970-04-13 1971-10-28 GAF Corp., New York, N.Y. (V.StA.) N-substituierte-thiomethyl-Derivate des N-hydroxymethyl-2-pyrrolidinons und Verfahren zu ihrer Herstellung
GB2118438A (en) * 1982-04-15 1983-11-02 Oreal Cosmetic compositions containing thiamorpholinones
GB2118553A (en) * 1982-04-15 1983-11-02 Oreal Thiamorpholinones

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DE871154C (de) * 1942-08-26 1953-03-19 Basf Ag Verfahren zur Herstellung oberflaechenwirksamer Verbindungen
GB947910A (en) * 1960-11-04 1964-01-29 Gen Aniline & Film Corp Surface active ethers of n-(hydroxymethyl)-lactams
DE1177641B (de) * 1962-06-12 1964-09-10 Kalk Chemische Fabrik Gmbh Verfahren zur Herstellung von N-(ª‰-Hydroxy-alkyl)-oxazolidonen-(4) bzw. deren Polyaether
US3281425A (en) * 1962-11-02 1966-10-25 Kalk Chemische Fabrik Gmbh Ethers of n-methylol-2, 2, 5, 5-tetraalkyloxazolidinone-(4)
US3232952A (en) * 1963-09-20 1966-02-01 Kalk Chemische Fabrik Gmbh Di-(oxazolidinone-(4)-n-alkyl)-ethers
DE1695846A1 (de) * 1967-05-05 1971-05-13 Schwarzkopf Gmbh Hans Verfahren zur Darstellung von Thioaethern mit reduktiven Eigenschaften
DE2114295A1 (de) * 1970-03-27 1971-10-14 Gaf Corp Substituierte AEtherderivate des N-Hydroxymethyl-2-pyrrolidinon und Verfahren zu deren Herstellung
DE2114251A1 (de) * 1970-03-30 1971-10-14 Gaf Corp Tertiaere Aminomethylderivate des N-Hydroxymethyl-2-pyrrolidinon und Verfahren zu deren Herstellung
DE2117240A1 (de) * 1970-04-13 1971-10-28 GAF Corp., New York, N.Y. (V.StA.) N-substituierte-thiomethyl-Derivate des N-hydroxymethyl-2-pyrrolidinons und Verfahren zu ihrer Herstellung
GB2118438A (en) * 1982-04-15 1983-11-02 Oreal Cosmetic compositions containing thiamorpholinones
GB2118553A (en) * 1982-04-15 1983-11-02 Oreal Thiamorpholinones

Also Published As

Publication number Publication date
ATE81505T1 (de) 1992-10-15
CN1020605C (zh) 1993-05-12
SU1750423A3 (ru) 1992-07-23
CN87100666A (zh) 1987-10-21
WO1987006226A2 (fr) 1987-10-22
EP0241050B1 (fr) 1992-10-14
DE3782182T2 (de) 1993-02-25
CA1336597C (fr) 1995-08-08
SU1750422A3 (ru) 1992-07-23
AU7020787A (en) 1987-11-09
EP0241050A3 (en) 1988-12-28
JPS62238261A (ja) 1987-10-19
KR910000164B1 (ko) 1991-01-21
SU1748644A3 (ru) 1992-07-15
CN1018452B (zh) 1992-09-30
DE3782182D1 (de) 1992-11-19
ES2046196T3 (es) 1994-02-01
US4882359A (en) 1989-11-21
AU601402B2 (en) 1990-09-13
JPH0643390B2 (ja) 1994-06-08
GR3006768T3 (fr) 1993-06-30
AR245107A1 (es) 1993-12-30
EP0241050A2 (fr) 1987-10-14
CN1060287A (zh) 1992-04-15
KR880701227A (ko) 1988-07-26

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