WO1983003549A1 - Surgical adhesive dressing - Google Patents

Surgical adhesive dressing Download PDF

Info

Publication number
WO1983003549A1
WO1983003549A1 PCT/GB1983/000104 GB8300104W WO8303549A1 WO 1983003549 A1 WO1983003549 A1 WO 1983003549A1 GB 8300104 W GB8300104 W GB 8300104W WO 8303549 A1 WO8303549 A1 WO 8303549A1
Authority
WO
WIPO (PCT)
Prior art keywords
dressing
water
adhesive
film
mvp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1983/000104
Other languages
English (en)
French (fr)
Inventor
William Duncan Potter
David Alan Rawlings
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith and Nephew PLC
Original Assignee
Smith and Nephew Associated Companies PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10529632&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1983003549(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smith and Nephew Associated Companies PLC filed Critical Smith and Nephew Associated Companies PLC
Publication of WO1983003549A1 publication Critical patent/WO1983003549A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00Bandages or dressings; Absorbent pads
    • A61F13/02Adhesive bandages or dressings
    • A61F13/023Adhesive bandages or dressings wound covering film layers without a fluid retention layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/24Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/58Adhesives

Definitions

  • Moisture vapour permeable thin films coated with adhesive were disclosed in British Patent No. 1,280,631 and- U.S. Patent No. 3,645,835 as being suitable for use as surgical dressings.
  • one such film has come to prominence under the trade mark "Op-Site" and has found use as a surgical dressing, for example for covering burns, donor sites, surgical incisions, intra ⁇ venous catheter sites and the like.
  • the known dressings have proved useful because they keep out bacteria owing to the microscopically continuous nature of the film and adhesive layer but do not cause maceration of the skin to which it is applied because both the film and the adhesive layer have high moisture vapour permeability (MVP) .
  • MVP moisture vapour permeability
  • the dressing of this invention will have a wet-MVP of not less than * 3000g/m 2, most suitably
  • the film used in this invention may comprise any synthetic or modified natural polymer which has a sufficiently higher wet-MVP than dry-MVP to produce the desired MVP parameters in the dressing.
  • the method set ou in the Descriptions may be employed to determine whether the film material exibits the desired MVP when in contact with water.
  • the film comprises a synthetic polymer although modified natural polymers such as regenerated cellulose or cellulose acetate may be employe if sufficiently plasticised to conform to the movements of the body when adhered thereto.
  • the synthetic polymer employed is an elastomer so that it readily conforms to the movement of the skin when the dressing is in use.
  • the film used in this invention will be hydrophilic, that is will absorb water when immersed therein.
  • the film material when hydrated will contain 5% to 50% water (w/w at 20 C), more aptly from 10% to 40% f water and favourably from 20% to 30% of water.
  • Suitable hydrophilic film material will include polyurethanes, polyether polyamide block copolymers, polyether polyester block copolymers, cross-linked polyvin alcohols, acrylic copolymers, polyamides, regenerated cellulose, cellulose acetate and the like, provided said film material are highly conformable ( whether per se or b plasticisation) and that the material used most suitably h the preceeding water contents when hydrated.
  • the film employed will be a continuous film, that is it will be free of holes (whether microporous or macroporous) which allow the passage of bacteria.
  • the " desirable properties of this invention may be 5 best obtained by employing a film of hydrophilic polyurethane in.combination with an adhesive layer adapted to allow access of water to the film when water is presented to the adhesive face of the dressing.
  • the film will be from 15 to 80 10. microns thick, will more usually be from 20 to 60 microns thick and will preferably be from 25 to 50 micron thick, for example 30, 35 or 40 microns thick.
  • the film will be formed from a hydrophilic polyurethane which when hydrated contains from 5% to 5 50% of water, more aptly from 10% to 40% of water and favourably from 20% to 30% water.
  • the film used in this invention In order to enable visual observation of the wound it is desirable for the film used in this invention to be transparent. This in turn requires that the film should 20 be capable of being self supporting, that is sufficiently coherent when wet or dry to be used without recourse to additional support such as a fabric, for example " a gauze, net or the like.
  • polyether polyurethanes are particularly suitable for use in the formation of such films. Favoured polyether polyurethanes are essentially free of reactive substituents such as hydroxyl or carboxyl groups. It has been found that certain apt polyurethanes for use in this invention are random polymers containing units derived from diolic compounds and di-isocyanates.
  • Suitable polyurethanes are disclosed in British Patent Specification No. 2093190A at page 3 lines 16 to 47 which are incorporated herein by cross reference.
  • the adhesive layer present on the body contacting surface of the film is favourably an interrupted layer so that areas of the film are free of adhesive, aptly 20 to 75% of the film is free of adhesive, more aptly 30 to 70% of the film face.is free of adhesive and preferably 40 to 60% of the film face is free of adhesive.
  • the use of an interrupted layer in such a manner has been found to be highly beneficial in allowing the desirable variability of MVP to be achieved.
  • the adhesive is generally employed at a mass per unit area of 10 to 80g/m 2 , more aptly 20 to 45g/m 2 and favourably from 25 to 35g/m 2 .
  • the adhesive may be applied around the periphery of the dressings, in lines over the face of the dressing (parallel, at right angles, forming diamond pattern or the like) or in combinations of such systems.
  • the adhesive is preferably one which itself transmi water vapour, for example one which if present as a film 25 microns thick would have a MVP of at least 300g/m 2,
  • Suitable adhesives include polyvinyl ethyl ether adhesive and acrylate surgical adhesives. Preferred adhesives include those described in European Patent Application- o. 81300847 (Publication No. 0035399).
  • the dressings of the invention may be made by any convenient process, for example a film of, for example hydrophilic polyurethane may be roller printed or hand printed with a pattern of adhesive. Alternatively any other convenient method of providing a non-continuous ' adhesive may be employed.
  • the coated films may then be cut, packaged and sterilised in conventional manner, for example by irradiation, heat or ethylene oxide.
  • this invention provides a dressing as hereinbefore described in sterile form. Most aptly the sterile dressing is packaged in a bacteria-proof package such as a paper or aluminium foil pouch.
  • Suitable polyurethane may be produced by the methods of British Patent Specification No. 2093190A and incorporated herein by cross reference are page 6 line 35 to page 8 line 41 thereof.
  • the dressings are provided for use with a silicone release paper to protect the adhesive which protector is removed prior to use of the dressing.
  • Discs of the material under test are clamped over Payne Permeability Cups (flanged metal cups) using sealing rings and screw clamps.
  • the exposed surface area of the test sample is 10cm 2.
  • Each cup contains approximately 10ml. of distilled water.
  • the cups are removed after 24 hours, allowed to cool for 20 minutes and re-weighed.
  • the MVP of the test material is calculated from the weight loss and expressed in units of grams of weight per square metre per 24 hours.
  • Pattern Spreading of Film with Adhesive A solution, of acrylic adhesive in acetone (solids content 35%) was coated directly onto the film of hydrophilic polyurethane using an engraved roller so as to * produce a .reticulated ' (cross hatched) coating of adhesive. After coating the adhesive was allowed to dy ' in air before silicone treated paper protector was applied. The average weight of the adhesive coating was 30 +- 3g/m2.
  • the area of. film covered by.the adhesive was approximately
  • 125 ⁇ g/m 2 and the wet-MVP was 3600g/m2 (compare correspondin values of about llOOg/m 2 and about 1250g/m2 for an analogou material which employed Estate 5714 - a non-hydrophilic polyurethane in place of the hydrophilic polyurethane) .
  • Example 1 The product of Example 1 was cut into 10 x 10cm squares and sealed into pouches. The product was sterilised using ethylene oxide. The resulting sterile dressing may be employed to cover wounds.
  • Examples 1 and 2 may be carried out replacing the hydrophilic polyurethane by those. of British Patent Specification No. 2093190A at page 6 line 35 to page 7 line 25.
  • the resulting dressings are suitable for covering wounds.
  • Example 1 The procedures of Examples 1 and 2 may be repeated using a vinyl ethyl ether adhesive in place of the acrylic adhesive.
  • The: resulting dressings may be employed to cover wounds.
  • a 25 micron film of polyether polyamide block copolymer (Pebax 4011 supplied by ATO Chemical Products, Newbury, UK) had applied thereto by roller a cross hatched pattern of polyvinyl ethyl ether adhesive.
  • the adhesive covered about 75% of area of the film surface and the diamond shaped interstices accounted for about 25% of the area of the film.
  • the average weight of the adhesive layer was approximately 60gsm.
  • the resulting material was cut into 15cm x 15cm squares, placed on silicone release paper (adhesive side to release layer), placed in pouches and sterilised using ethylene oxide.
  • the dressing had a dry-MVP of about 1800g/m and

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Medicinal Preparation (AREA)
PCT/GB1983/000104 1982-04-08 1983-04-08 Surgical adhesive dressing Ceased WO1983003549A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8210541 1982-04-08
GB8210541 1982-04-08

Publications (1)

Publication Number Publication Date
WO1983003549A1 true WO1983003549A1 (en) 1983-10-27

Family

ID=10529632

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1983/000104 Ceased WO1983003549A1 (en) 1982-04-08 1983-04-08 Surgical adhesive dressing

Country Status (7)

Country Link
US (2) US4595001A (enExample)
EP (1) EP0091800B2 (enExample)
JP (1) JPS59500698A (enExample)
AT (1) ATE17191T1 (enExample)
AU (1) AU560088B2 (enExample)
DE (1) DE3361672D1 (enExample)
WO (1) WO1983003549A1 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657006A (en) * 1982-10-02 1987-04-14 Smith And Nephew Associated Companies P.L.C. Surgical dressing
US4798201A (en) * 1983-04-13 1989-01-17 Smith And Nephew Associated Companies P.L.C. Surgical adhesive dressing
GB2207867A (en) * 1987-08-14 1989-02-15 Smith & Nephew Wound dressings
US5009224A (en) * 1986-09-30 1991-04-23 Minnesota Mining And Manufacturing Company Method for attaching a pressure-sensitive film article having high moisture vapor transmission rate
US5147698A (en) * 1986-09-30 1992-09-15 Minnesota Mining And Manufacturing Company Pressure sensitive adhesive film article having high moisture vapor transmission rate
US10369058B2 (en) 2009-06-16 2019-08-06 3M Innovative Properties Company Conformable medical dressing with self supporting substrate

Families Citing this family (210)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU560088B2 (en) * 1982-04-08 1987-03-26 Smith & Nephew Associated Companies Plc Surgical adhesive dressing
NZ206837A (en) * 1983-01-27 1986-08-08 Johnson & Johnson Prod Inc Thin film adhesive dressing:backing material in three sections
GB8334484D0 (en) * 1983-12-24 1984-02-01 Smith & Nephew Ass Surgical dressing
US4685455A (en) * 1984-10-16 1987-08-11 Akzo Nv Watervapor-permeable, pressure sensitive, antiseptic wound covering material
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US4713068A (en) * 1986-10-31 1987-12-15 Kimberly-Clark Corporation Breathable clothlike barrier having controlled structure defensive composite
US4713069A (en) * 1986-10-31 1987-12-15 Kimberly-Clark Corporation Baffle having zoned water vapor permeability
US4758239A (en) * 1986-10-31 1988-07-19 Kimberly-Clark Corporation Breathable barrier
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US4813942A (en) * 1987-03-17 1989-03-21 Bioderm, Inc. Three step wound treatment method and dressing therefor
GB8710836D0 (en) * 1987-05-07 1987-06-10 Smith & Nephew Ass Wound closure
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US4747401A (en) 1988-05-31
EP0091800B1 (en) 1986-01-02
US4595001A (en) 1986-06-17
AU560088B2 (en) 1987-03-26
AU1379383A (en) 1983-11-04
JPH0261257B2 (enExample) 1990-12-19
DE3361672D1 (en) 1986-02-13
EP0091800B2 (en) 1992-09-16
JPS59500698A (ja) 1984-04-26
EP0091800A1 (en) 1983-10-19
ATE17191T1 (de) 1986-01-15

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