UY37917A - Nuevos enantiómeros de una serie de compuestos antivirales - Google Patents
Nuevos enantiómeros de una serie de compuestos antiviralesInfo
- Publication number
- UY37917A UY37917A UY0001037917A UY37917A UY37917A UY 37917 A UY37917 A UY 37917A UY 0001037917 A UY0001037917 A UY 0001037917A UY 37917 A UY37917 A UY 37917A UY 37917 A UY37917 A UY 37917A
- Authority
- UY
- Uruguay
- Prior art keywords
- series
- antiviral compounds
- new
- enantiomers
- new enantiomers
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
La presente invención se refiere a nuevos compuestos antivirales con estereoconfiguración específica, especialmente a enantiómeros novedosos específicos, a un procedimiento para su preparación y a su uso como medicamentos, en particular como medicamentos antivirales.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17195047 | 2017-10-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY37917A true UY37917A (es) | 2019-04-30 |
Family
ID=60022026
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001037917A UY37917A (es) | 2017-10-05 | 2018-10-04 | Nuevos enantiómeros de una serie de compuestos antivirales |
Country Status (36)
Country | Link |
---|---|
US (2) | US11278534B2 (es) |
EP (2) | EP3692039B1 (es) |
JP (1) | JP7215689B2 (es) |
KR (1) | KR20200066619A (es) |
CN (1) | CN111433203B (es) |
AR (1) | AR113344A1 (es) |
AU (1) | AU2018344471B2 (es) |
BR (1) | BR112020006710A2 (es) |
CA (1) | CA3077397A1 (es) |
CL (1) | CL2020000869A1 (es) |
CR (1) | CR20200154A (es) |
DK (1) | DK3692039T3 (es) |
EA (1) | EA202090620A1 (es) |
EC (1) | ECSP20021132A (es) |
ES (1) | ES2939652T3 (es) |
FI (1) | FI3692039T3 (es) |
HR (1) | HRP20230158T1 (es) |
HU (1) | HUE061307T2 (es) |
IL (1) | IL273681A (es) |
JO (1) | JOP20200110A1 (es) |
LT (1) | LT3692039T (es) |
MA (1) | MA50609B1 (es) |
MD (1) | MD3692039T2 (es) |
MX (1) | MX2020003369A (es) |
NI (1) | NI202000025A (es) |
PH (1) | PH12020550132A1 (es) |
PL (1) | PL3692039T3 (es) |
PT (1) | PT3692039T (es) |
RS (1) | RS64000B1 (es) |
SG (1) | SG11202002420SA (es) |
SI (1) | SI3692039T1 (es) |
TW (1) | TWI706941B (es) |
UA (1) | UA126163C2 (es) |
UY (1) | UY37917A (es) |
WO (1) | WO2019068817A1 (es) |
ZA (1) | ZA202002150B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3077397A1 (en) * | 2017-10-05 | 2019-04-11 | Innovative Molecules Gmbh | Enantiomers of substituted thiazoles as antiviral compounds |
US11760701B2 (en) | 2018-02-27 | 2023-09-19 | The Research Foundation For The State University Of New Yrok | Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same |
TW202038947A (zh) | 2018-11-28 | 2020-11-01 | 德商創新分子有限責任公司 | 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑 |
AU2021367976A1 (en) | 2020-10-29 | 2023-06-08 | Innovative Molecules Gmbh | Deuterated aminothiazole compounds as antiviral compounds |
WO2023135303A1 (en) | 2022-01-17 | 2023-07-20 | Innovative Molecules Gmbh | Solid crystalline forms of helicase-primase inhibitors and process of preparation thereof |
WO2024047508A1 (en) | 2022-08-29 | 2024-03-07 | Assembly Biosciences, Inc. | Pharmaceutical compositions for herpes virus |
WO2024049760A1 (en) | 2022-08-29 | 2024-03-07 | Assembly Biosciences, Inc. | Cyclic urea thiazolyl compounds for treatment of hsv |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7100497A (es) | 1970-01-16 | 1971-07-20 | ||
EP0871619B1 (en) | 1995-12-29 | 2002-11-06 | Boehringer Ingelheim Pharmaceuticals Inc. | Phenyl thiazole derivatives with anti herpes virus properties |
US6040321A (en) * | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
AU3289299A (en) | 1998-02-19 | 1999-09-06 | Tularik Inc. | Antiviral agents |
DK1064273T3 (da) | 1998-03-19 | 2003-03-31 | Upjohn Co | 1,3,4-Thiadiazoler, som er nyttige til behandling af CMV-infektioner |
JP2002539119A (ja) | 1999-03-08 | 2002-11-19 | バイエル アクチェンゲゼルシャフト | チアゾリルウレア誘導体および抗ウイルス剤としてのそれらの使用 |
DE19959958A1 (de) | 1999-12-13 | 2001-08-30 | Bayer Ag | Thiazolylharnstoff-Derivate |
DE19927415A1 (de) | 1999-06-16 | 2000-12-21 | Bayer Ag | Indolinylharnstoffderivate |
DOP2000000109A (es) * | 1999-12-23 | 2002-08-30 | Gerald Kleymann | Derivados de tiazolilamida |
DE10039265A1 (de) | 2000-08-11 | 2002-02-21 | Bayer Ag | Thiazolylamid-Derivate |
WO2001096874A1 (en) | 2000-06-15 | 2001-12-20 | Bayer Aktiengesellschaft | Method for identifying compounds with anti-herpes activity |
DE10038022A1 (de) | 2000-08-04 | 2002-02-14 | Bayer Ag | Inverse Thiazolylamid-Derivate |
DE10044328A1 (de) | 2000-09-07 | 2002-03-21 | Bayer Ag | Thiazolylcarbonyl-Derivate |
DE10044353A1 (de) | 2000-09-07 | 2002-04-04 | Bayer Ag | Unkompetitive Inhibitoren der Helikase-Primase |
DE10044358A1 (de) | 2000-09-07 | 2002-03-21 | Bayer Ag | Thiazolylcarbonylheterocyclyl-Derivate |
DE10129715A1 (de) | 2001-06-22 | 2003-01-02 | Bayer Ag | Thiazolylamide |
DE10129717A1 (de) | 2001-06-22 | 2003-01-02 | Bayer Ag | Kombinationspräparate zur Herpes-Behandlung |
DE10129714A1 (de) | 2001-06-22 | 2003-01-02 | Bayer Ag | Topische Anwendung von Thiazolylamiden |
DE10129716A1 (de) | 2001-06-22 | 2003-01-02 | Bayer Ag | Kombinationspräparate zur Herpes-Behandlung |
DE10131128A1 (de) | 2001-06-28 | 2003-01-16 | Bayer Ag | Sekundäre Sulfonamide |
DE10210319A1 (de) | 2002-03-08 | 2003-09-18 | Bayer Ag | Thiazolylcarbonyl-Derivate |
DE10235967B4 (de) | 2002-08-06 | 2005-09-08 | Bayer Healthcare Ag | Methode zum Identifizieren von Substanzen mit antimikrobieller Wirkung |
DE10300109A1 (de) | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Methode zur Inhibition der Replikation von Herpesviren |
AU2005210474B2 (en) | 2004-01-30 | 2011-07-07 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding cassette transporters |
DE102005014248A1 (de) | 2005-03-30 | 2006-10-05 | Aicuris Gmbh & Co. Kg | Pharmazeutische Zubereitung von N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamid |
US8548554B2 (en) | 2006-12-08 | 2013-10-01 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Dry electrode cap for electro-encephalography |
DE102010046720A1 (de) | 2010-09-23 | 2012-03-29 | Bayer Schering Pharma Aktiengesellschaft | Verfahren zur Herstellung von pan-CDK-Inhibitoren der Formel (l), sowie Intermediate der Herstellung |
CN103269593A (zh) * | 2010-11-01 | 2013-08-28 | 罗马克实验室有限公司 | 烷基亚磺酰基取代的噻唑化物化合物 |
TWI555737B (zh) | 2011-05-24 | 2016-11-01 | 拜耳知識產權公司 | 含有硫醯亞胺基團之4-芳基-n-苯基-1,3,5-三氮雜苯-2-胺 |
EP2573086A1 (en) | 2011-09-26 | 2013-03-27 | AiCuris GmbH & Co. KG | N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate |
AR108175A1 (es) * | 2016-04-06 | 2018-07-25 | Innovative Molecules Gmbh | Compuestos antivíricos de tiazol acetamida |
CA3045063A1 (en) | 2016-11-28 | 2018-05-31 | Aicuris Anti-Infective Cures Gmbh | A maleate salt of the free base of n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-[pyrididnyl)-phenyl]-acetamide |
WO2018095576A1 (en) | 2016-11-28 | 2018-05-31 | Aicuris Anti-Infective Cures Gmbh | Topical pharmaceutical formulation comprising n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide |
HUE054703T2 (hu) | 2016-11-28 | 2021-09-28 | Aicuris Gmbh & Co Kg | N-[5-(amino-szulfonil)-4-metil-1,3-tiazol-2-il]-N-metil-2-[4-(2-piridinil)fenil]acetamid szabad bázis hemihidrát, annak elõállítási eljárásai és alkalmazásai |
WO2018127207A1 (zh) | 2017-01-09 | 2018-07-12 | 南京明德新药研发股份有限公司 | 噻唑衍生物及其应用 |
CA3077397A1 (en) * | 2017-10-05 | 2019-04-11 | Innovative Molecules Gmbh | Enantiomers of substituted thiazoles as antiviral compounds |
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2018
- 2018-10-04 CA CA3077397A patent/CA3077397A1/en active Pending
- 2018-10-04 PL PL18779696.6T patent/PL3692039T3/pl unknown
- 2018-10-04 BR BR112020006710A patent/BR112020006710A2/pt unknown
- 2018-10-04 CN CN201880065255.2A patent/CN111433203B/zh active Active
- 2018-10-04 ES ES18779696T patent/ES2939652T3/es active Active
- 2018-10-04 MX MX2020003369A patent/MX2020003369A/es unknown
- 2018-10-04 DK DK18779696.6T patent/DK3692039T3/da active
- 2018-10-04 EA EA202090620A patent/EA202090620A1/ru unknown
- 2018-10-04 MA MA50609A patent/MA50609B1/fr unknown
- 2018-10-04 SI SI201830861T patent/SI3692039T1/sl unknown
- 2018-10-04 EP EP18779696.6A patent/EP3692039B1/en active Active
- 2018-10-04 AR ARP180102864A patent/AR113344A1/es unknown
- 2018-10-04 MD MDE20200816T patent/MD3692039T2/ro unknown
- 2018-10-04 PT PT187796966T patent/PT3692039T/pt unknown
- 2018-10-04 KR KR1020207009294A patent/KR20200066619A/ko not_active Application Discontinuation
- 2018-10-04 CR CR20200154A patent/CR20200154A/es unknown
- 2018-10-04 SG SG11202002420SA patent/SG11202002420SA/en unknown
- 2018-10-04 LT LTEPPCT/EP2018/077022T patent/LT3692039T/lt unknown
- 2018-10-04 UA UAA202002635A patent/UA126163C2/uk unknown
- 2018-10-04 AU AU2018344471A patent/AU2018344471B2/en active Active
- 2018-10-04 JO JOP/2020/0110A patent/JOP20200110A1/ar unknown
- 2018-10-04 WO PCT/EP2018/077022 patent/WO2019068817A1/en active Application Filing
- 2018-10-04 EP EP22213253.2A patent/EP4209491A1/en active Pending
- 2018-10-04 JP JP2020519403A patent/JP7215689B2/ja active Active
- 2018-10-04 HR HRP20230158TT patent/HRP20230158T1/hr unknown
- 2018-10-04 TW TW107135101A patent/TWI706941B/zh active
- 2018-10-04 RS RS20230156A patent/RS64000B1/sr unknown
- 2018-10-04 FI FIEP18779696.6T patent/FI3692039T3/fi active
- 2018-10-04 UY UY0001037917A patent/UY37917A/es unknown
- 2018-10-04 US US16/753,814 patent/US11278534B2/en active Active
- 2018-10-04 HU HUE18779696A patent/HUE061307T2/hu unknown
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2020
- 2020-03-25 PH PH12020550132A patent/PH12020550132A1/en unknown
- 2020-03-29 IL IL273681A patent/IL273681A/en unknown
- 2020-04-01 NI NI202000025A patent/NI202000025A/es unknown
- 2020-04-01 CL CL2020000869A patent/CL2020000869A1/es unknown
- 2020-04-03 EC ECSENADI202021132A patent/ECSP20021132A/es unknown
- 2020-05-04 ZA ZA2020/02150A patent/ZA202002150B/en unknown
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2022
- 2022-01-21 US US17/581,166 patent/US20220152008A1/en active Pending
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