HUE054703T2 - N-[5-(amino-szulfonil)-4-metil-1,3-tiazol-2-il]-N-metil-2-[4-(2-piridinil)fenil]acetamid szabad bázis hemihidrát, annak elõállítási eljárásai és alkalmazásai - Google Patents

N-[5-(amino-szulfonil)-4-metil-1,3-tiazol-2-il]-N-metil-2-[4-(2-piridinil)fenil]acetamid szabad bázis hemihidrát, annak elõállítási eljárásai és alkalmazásai

Info

Publication number
HUE054703T2
HUE054703T2 HUE17811883A HUE17811883A HUE054703T2 HU E054703 T2 HUE054703 T2 HU E054703T2 HU E17811883 A HUE17811883 A HU E17811883A HU E17811883 A HUE17811883 A HU E17811883A HU E054703 T2 HUE054703 T2 HU E054703T2
Authority
HU
Hungary
Prior art keywords
methyl
aminosulfonyl
thiazol
pyridinyl
phenyl
Prior art date
Application number
HUE17811883A
Other languages
English (en)
Inventor
Yogeshwar Bachhav
Wilfried Schwab
Alexander Birkmann
Kurt Voegtli
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57421711&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE054703(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of HUE054703T2 publication Critical patent/HUE054703T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
HUE17811883A 2016-11-28 2017-11-28 N-[5-(amino-szulfonil)-4-metil-1,3-tiazol-2-il]-N-metil-2-[4-(2-piridinil)fenil]acetamid szabad bázis hemihidrát, annak elõállítási eljárásai és alkalmazásai HUE054703T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16200967 2016-11-28

Publications (1)

Publication Number Publication Date
HUE054703T2 true HUE054703T2 (hu) 2021-09-28

Family

ID=57421711

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE17811883A HUE054703T2 (hu) 2016-11-28 2017-11-28 N-[5-(amino-szulfonil)-4-metil-1,3-tiazol-2-il]-N-metil-2-[4-(2-piridinil)fenil]acetamid szabad bázis hemihidrát, annak elõállítási eljárásai és alkalmazásai

Country Status (21)

Country Link
US (2) US11021474B2 (hu)
EP (3) EP3544976B1 (hu)
JP (2) JP6978501B2 (hu)
KR (2) KR102536156B1 (hu)
CN (2) CN109996798B (hu)
AR (1) AR110249A1 (hu)
AU (3) AU2017365632B2 (hu)
CA (1) CA3045059A1 (hu)
CY (1) CY1124523T1 (hu)
DK (2) DK3544976T3 (hu)
ES (2) ES2941390T3 (hu)
HR (1) HRP20210720T1 (hu)
HU (1) HUE054703T2 (hu)
LT (1) LT3544976T (hu)
PL (1) PL3544976T3 (hu)
PT (2) PT3544976T (hu)
RS (1) RS61905B1 (hu)
SI (2) SI3544976T1 (hu)
TW (2) TWI737861B (hu)
UY (1) UY37496A (hu)
WO (1) WO2018096170A1 (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2573085A1 (en) 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range
CN110062755B (zh) * 2016-11-28 2023-08-29 艾库里斯有限及两合公司 普瑞利韦的游离碱的马来酸盐、其药物制剂、其制造方法及其用于治疗疱疹病毒的用途
ES2941390T3 (es) * 2016-11-28 2023-05-22 Aicuris Gmbh & Co Kg Hemihidrato de la base libre de la N-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-N-metil-2-[4-(2-piridinil)fenil]acetamida, métodos de fabricación y sus usos
SI3692039T1 (sl) 2017-10-05 2023-04-28 Innovative Molecules Gmbh Enantomeri substituiranih tiazolov kot protivirusne spojine
TW202038947A (zh) 2018-11-28 2020-11-01 德商創新分子有限責任公司 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑
US20230124969A1 (en) * 2020-03-26 2023-04-20 Aicuris Gmbh & Co. Kg Ophthalmic formulation comprising n-[5-(aminosulfonyl)-4-methyl-1,3- thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide hemihydrate
EP3925595A1 (en) * 2020-06-17 2021-12-22 AiCuris GmbH & Co. KG Ophthalmic formulation comprising n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl] acetamide hemihydrate
WO2024047507A1 (en) 2022-08-29 2024-03-07 Assembly Biosciences, Inc. A novel crystalline form of pritelivir
WO2024047506A1 (en) 2022-08-29 2024-03-07 Assembly Biosciences, Inc. A novel crystalline form of pritelivir

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5496820A (en) * 1988-10-20 1996-03-05 Peraelampi; Markku Ophthalmic use of S-timolol hemihydrate
DOP2000000109A (es) * 1999-12-23 2002-08-30 Gerald Kleymann Derivados de tiazolilamida
DE10129714A1 (de) 2001-06-22 2003-01-02 Bayer Ag Topische Anwendung von Thiazolylamiden
DE102005014248A1 (de) 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung von N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamid
EP2573086A1 (en) * 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
EP2573085A1 (en) 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range
CN110062755B (zh) * 2016-11-28 2023-08-29 艾库里斯有限及两合公司 普瑞利韦的游离碱的马来酸盐、其药物制剂、其制造方法及其用于治疗疱疹病毒的用途
ES2941390T3 (es) * 2016-11-28 2023-05-22 Aicuris Gmbh & Co Kg Hemihidrato de la base libre de la N-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-N-metil-2-[4-(2-piridinil)fenil]acetamida, métodos de fabricación y sus usos
US20230124969A1 (en) * 2020-03-26 2023-04-20 Aicuris Gmbh & Co. Kg Ophthalmic formulation comprising n-[5-(aminosulfonyl)-4-methyl-1,3- thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide hemihydrate

Also Published As

Publication number Publication date
AU2017365632B2 (en) 2021-07-15
EP3848369A1 (en) 2021-07-14
AR110249A1 (es) 2019-03-13
AU2021221901B2 (en) 2022-08-11
EP3544976B1 (en) 2021-02-17
PT3544976T (pt) 2021-05-18
TW201825483A (zh) 2018-07-16
AU2017365632A1 (en) 2019-06-13
PT3848369T (pt) 2023-04-10
UY37496A (es) 2018-06-29
US11021474B2 (en) 2021-06-01
DK3544976T3 (da) 2021-05-10
DK3848369T3 (da) 2023-03-27
ES2941390T3 (es) 2023-05-22
CN116804007A (zh) 2023-09-26
US20210269429A1 (en) 2021-09-02
SI3848369T1 (sl) 2023-07-31
KR20230075524A (ko) 2023-05-31
US20200123145A1 (en) 2020-04-23
KR102622289B1 (ko) 2024-01-05
KR20190085115A (ko) 2019-07-17
TWI737861B (zh) 2021-09-01
EP4201934A1 (en) 2023-06-28
WO2018096170A9 (en) 2019-12-19
SI3544976T1 (sl) 2021-08-31
CN109996798A (zh) 2019-07-09
JP7289891B2 (ja) 2023-06-12
HRP20210720T1 (hr) 2021-09-03
AU2021221901A1 (en) 2021-09-23
EP3544976A1 (en) 2019-10-02
JP6978501B2 (ja) 2021-12-08
ES2870614T3 (es) 2021-10-27
CN109996798B (zh) 2023-05-05
AU2022263540A1 (en) 2022-12-08
KR102536156B1 (ko) 2023-05-25
CY1124523T1 (el) 2022-07-22
PL3544976T3 (pl) 2021-11-02
TW202207924A (zh) 2022-03-01
CA3045059A1 (en) 2018-05-31
JP2022024043A (ja) 2022-02-08
RS61905B1 (sr) 2021-06-30
WO2018096170A1 (en) 2018-05-31
LT3544976T (lt) 2021-08-10
EP3848369B1 (en) 2023-01-11
TWI811800B (zh) 2023-08-11
JP2020509991A (ja) 2020-04-02

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