CY1124523T1 - Ν-[5-(αμινοσουλφονυλο)-4-μεθυλ-1,3-θειαζολ-2-υλ]-ν-μεθυλ-2-[4-(2-πυριδινυλ)-φαινυλ]-ημιενυδρη ελευθερη βαση ακεταμιδιου, μεθοδοι κατασκευης και χρησεις αυτης - Google Patents
Ν-[5-(αμινοσουλφονυλο)-4-μεθυλ-1,3-θειαζολ-2-υλ]-ν-μεθυλ-2-[4-(2-πυριδινυλ)-φαινυλ]-ημιενυδρη ελευθερη βαση ακεταμιδιου, μεθοδοι κατασκευης και χρησεις αυτηςInfo
- Publication number
- CY1124523T1 CY1124523T1 CY20211100407T CY211100407T CY1124523T1 CY 1124523 T1 CY1124523 T1 CY 1124523T1 CY 20211100407 T CY20211100407 T CY 20211100407T CY 211100407 T CY211100407 T CY 211100407T CY 1124523 T1 CY1124523 T1 CY 1124523T1
- Authority
- CY
- Cyprus
- Prior art keywords
- methyl
- preparation
- aminosulfonyl
- thiazol
- pyridinyl
- Prior art date
Links
- 239000012458 free base Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 title 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000029433 Herpesviridae infectious disease Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- IVZKZONQVYTCKC-UHFFFAOYSA-N bay 57-1293 Chemical compound N=1C(C)=C(S(N)(=O)=O)SC=1N(C)C(=O)CC(C=C1)=CC=C1C1=CC=CC=N1 IVZKZONQVYTCKC-UHFFFAOYSA-N 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Η παρούσα εφεύρεση αναφέρεται στο πεδίο των αντι-ιικών δραστικών παραγόντων, ιδιαίτερα της ημιένυδρης μορφής ελεύθερης βάσης Ν-[5-(αμινοσουλφονυλ1)-4-μεθυλ-1,3-θειαζολ-2-υλ]-Ν-μεθυλ-2-[4-(2-πυριδινυλ)-φαινυλ]-ακεταμιδίου, καθώς και σε μεθόδους για την παρασκευή τους. Η παρούσα εφεύρεση αναφέρεται, επίσης, στη χρήση της παραπάνω ένωσης για τη θεραπεία λοιμώξεων από τον ιό του έρπητα και στην παρασκευή φαρμακευτικών ουσιών, οι οποίες περιλαμβάνουν την εν λόγω ένωση.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16200967 | 2016-11-28 | ||
PCT/EP2017/080653 WO2018096170A1 (en) | 2016-11-28 | 2017-11-28 | N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide free base hemihydrate, methods of manufacture and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1124523T1 true CY1124523T1 (el) | 2022-07-22 |
Family
ID=57421711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20211100407T CY1124523T1 (el) | 2016-11-28 | 2021-05-13 | Ν-[5-(αμινοσουλφονυλο)-4-μεθυλ-1,3-θειαζολ-2-υλ]-ν-μεθυλ-2-[4-(2-πυριδινυλ)-φαινυλ]-ημιενυδρη ελευθερη βαση ακεταμιδιου, μεθοδοι κατασκευης και χρησεις αυτης |
Country Status (21)
Country | Link |
---|---|
US (2) | US11021474B2 (el) |
EP (3) | EP3544976B1 (el) |
JP (2) | JP6978501B2 (el) |
KR (2) | KR102622289B1 (el) |
CN (2) | CN116804007A (el) |
AR (1) | AR110249A1 (el) |
AU (3) | AU2017365632B2 (el) |
CA (1) | CA3045059A1 (el) |
CY (1) | CY1124523T1 (el) |
DK (2) | DK3544976T3 (el) |
ES (2) | ES2941390T3 (el) |
HR (1) | HRP20210720T1 (el) |
HU (1) | HUE054703T2 (el) |
LT (1) | LT3544976T (el) |
PL (1) | PL3544976T3 (el) |
PT (2) | PT3544976T (el) |
RS (1) | RS61905B1 (el) |
SI (2) | SI3544976T1 (el) |
TW (2) | TWI737861B (el) |
UY (1) | UY37496A (el) |
WO (1) | WO2018096170A1 (el) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2573085A1 (en) | 2011-09-26 | 2013-03-27 | AiCuris GmbH & Co. KG | N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range |
TWI808591B (zh) * | 2016-11-28 | 2023-07-11 | 德商艾庫瑞斯公司 | N-[5-(胺基磺醯基)-4-甲基-1,3-噻唑-2-基]-n-甲基-2-[4-(2-吡啶基)-苯基]-乙醯胺之游離鹼之硫酸鹽、其醫藥調配物及其用途 |
PT3544976T (pt) * | 2016-11-28 | 2021-05-18 | Aicuris Anti Infective Cures Gmbh | Hemi-hidrato da base livre de n-[5-(aminossulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)-fenil]-acetamida, métodos de fabricação e suas utilizações |
MA50609B1 (fr) | 2017-10-05 | 2023-03-31 | Innovative Molecules Gmbh | Énantiomères de thiazoles substitués utilisés comme composés antiviraux |
TW202038947A (zh) | 2018-11-28 | 2020-11-01 | 德商創新分子有限責任公司 | 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑 |
AU2021241823A1 (en) * | 2020-03-26 | 2022-09-15 | Aic316 Gmbh | Ophthalmic formulation comprising N-(5-(aminosulfonyl)-4-methyl-1,3- thiazol-2-yl)-N-methyl-2-(4-(2-pyridinyl)phenyl)acetamide hemihydrate |
EP3925595A1 (en) * | 2020-06-17 | 2021-12-22 | AiCuris GmbH & Co. KG | Ophthalmic formulation comprising n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl] acetamide hemihydrate |
WO2024047507A1 (en) | 2022-08-29 | 2024-03-07 | Assembly Biosciences, Inc. | A novel crystalline form of pritelivir |
WO2024047506A1 (en) | 2022-08-29 | 2024-03-07 | Assembly Biosciences, Inc. | A novel crystalline form of pritelivir |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5496820A (en) * | 1988-10-20 | 1996-03-05 | Peraelampi; Markku | Ophthalmic use of S-timolol hemihydrate |
DOP2000000109A (es) * | 1999-12-23 | 2002-08-30 | Gerald Kleymann | Derivados de tiazolilamida |
DE10129714A1 (de) | 2001-06-22 | 2003-01-02 | Bayer Ag | Topische Anwendung von Thiazolylamiden |
DE102005014248A1 (de) * | 2005-03-30 | 2006-10-05 | Aicuris Gmbh & Co. Kg | Pharmazeutische Zubereitung von N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamid |
EP2573086A1 (en) * | 2011-09-26 | 2013-03-27 | AiCuris GmbH & Co. KG | N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate |
EP2573085A1 (en) * | 2011-09-26 | 2013-03-27 | AiCuris GmbH & Co. KG | N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range |
TWI808591B (zh) * | 2016-11-28 | 2023-07-11 | 德商艾庫瑞斯公司 | N-[5-(胺基磺醯基)-4-甲基-1,3-噻唑-2-基]-n-甲基-2-[4-(2-吡啶基)-苯基]-乙醯胺之游離鹼之硫酸鹽、其醫藥調配物及其用途 |
PT3544976T (pt) | 2016-11-28 | 2021-05-18 | Aicuris Anti Infective Cures Gmbh | Hemi-hidrato da base livre de n-[5-(aminossulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)-fenil]-acetamida, métodos de fabricação e suas utilizações |
AU2021241823A1 (en) * | 2020-03-26 | 2022-09-15 | Aic316 Gmbh | Ophthalmic formulation comprising N-(5-(aminosulfonyl)-4-methyl-1,3- thiazol-2-yl)-N-methyl-2-(4-(2-pyridinyl)phenyl)acetamide hemihydrate |
-
2017
- 2017-11-28 PT PT178118832T patent/PT3544976T/pt unknown
- 2017-11-28 CN CN202310418723.2A patent/CN116804007A/zh active Pending
- 2017-11-28 KR KR1020237017062A patent/KR102622289B1/ko active IP Right Grant
- 2017-11-28 KR KR1020197018286A patent/KR102536156B1/ko active IP Right Grant
- 2017-11-28 AR ARP170103302A patent/AR110249A1/es unknown
- 2017-11-28 WO PCT/EP2017/080653 patent/WO2018096170A1/en unknown
- 2017-11-28 TW TW106141448A patent/TWI737861B/zh active
- 2017-11-28 PT PT211574207T patent/PT3848369T/pt unknown
- 2017-11-28 TW TW110135747A patent/TWI811800B/zh active
- 2017-11-28 RS RS20210576A patent/RS61905B1/sr unknown
- 2017-11-28 SI SI201730749T patent/SI3544976T1/sl unknown
- 2017-11-28 JP JP2019528091A patent/JP6978501B2/ja active Active
- 2017-11-28 CA CA3045059A patent/CA3045059A1/en active Pending
- 2017-11-28 AU AU2017365632A patent/AU2017365632B2/en active Active
- 2017-11-28 DK DK17811883.2T patent/DK3544976T3/da active
- 2017-11-28 ES ES21157420T patent/ES2941390T3/es active Active
- 2017-11-28 EP EP17811883.2A patent/EP3544976B1/en active Active
- 2017-11-28 ES ES17811883T patent/ES2870614T3/es active Active
- 2017-11-28 EP EP21157420.7A patent/EP3848369B1/en active Active
- 2017-11-28 DK DK21157420.7T patent/DK3848369T3/da active
- 2017-11-28 LT LTEP17811883.2T patent/LT3544976T/lt unknown
- 2017-11-28 HU HUE17811883A patent/HUE054703T2/hu unknown
- 2017-11-28 UY UY0001037496A patent/UY37496A/es unknown
- 2017-11-28 SI SI201731326T patent/SI3848369T1/sl unknown
- 2017-11-28 PL PL17811883T patent/PL3544976T3/pl unknown
- 2017-11-28 EP EP22211343.3A patent/EP4201934A1/en not_active Withdrawn
- 2017-11-28 US US16/464,448 patent/US11021474B2/en active Active
- 2017-11-28 CN CN201780073223.2A patent/CN109996798B/zh active Active
-
2021
- 2021-04-02 US US17/221,000 patent/US20210269429A1/en active Pending
- 2021-05-07 HR HRP20210720TT patent/HRP20210720T1/hr unknown
- 2021-05-13 CY CY20211100407T patent/CY1124523T1/el unknown
- 2021-08-27 AU AU2021221901A patent/AU2021221901B2/en active Active
- 2021-11-11 JP JP2021184218A patent/JP7289891B2/ja active Active
-
2022
- 2022-11-03 AU AU2022263540A patent/AU2022263540A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1124523T1 (el) | Ν-[5-(αμινοσουλφονυλο)-4-μεθυλ-1,3-θειαζολ-2-υλ]-ν-μεθυλ-2-[4-(2-πυριδινυλ)-φαινυλ]-ημιενυδρη ελευθερη βαση ακεταμιδιου, μεθοδοι κατασκευης και χρησεις αυτης | |
CY1124726T1 (el) | Παραγωγα κιναζολινης που χρησιμοποιουνται για την αντιμετωπιση του hiv | |
CY1124548T1 (el) | Παραγωγα μονο- ή δισυποκατεστημενης ινδολης ως αναστολεις αναδιπλασιασμου του δαγκειου ιου | |
CY1124855T1 (el) | 2-(μορφολιν-4-υλ)-1,7-ναφθυριδινες | |
CL2018003291A1 (es) | Amidas heterocíclicas útiles como moduladores de proteínas (divisional de solicitud cl 2850-2018). | |
CY1122792T1 (el) | Παραγωγα μονο- ή δισυποκατεστημενης ινδολης ως αναστολεις αναδιπλασιασμου δαγκειου ιου | |
CY1119066T1 (el) | Αναστολεις κρυσταλλικης βρωμο-περιοχης | |
CY1125083T1 (el) | Υποκατεστημενα βενζαμιδια 1,3-θειαζολ-2-υλιου | |
UY37710A (es) | Inhibidores de la replicación del virus de la inmunodeficiencia humana | |
EA201690556A1 (ru) | Способы и фармацевтические композиции для лечения вызванных вирусом гепатита в инфекций | |
NI201700101A (es) | Composiciones farmacéuticas que comprenden n - (3, 5 - dimetoxifenil) - n'- (1-metiletil) - n - [3-(1-metil-1h-pirazol-4-il) quinoxalina-6-il]etano-1,2-diamina | |
CY1123604T1 (el) | Υδροχλωρικα αλατα ν-(κυανομεθυλ)-4-(2-(4-μορφολινοφαινυλαμινο)πυριμιδιν-4-υλ)βενζαμιδιου | |
CL2016000866A1 (es) | Forma salina de hidrocloruro para la inhibición de ezh2 | |
UY37741A (es) | Derivados de indolina sustituidos como inhibidores de la replicación del virus del dengue | |
EA201690687A1 (ru) | Ингибиторы репликации вируса иммунодефицита | |
CL2014001599A1 (es) | Compuestos derivados de nucleosidos sustituidos en 4’-azido, 3’-fluoro o sus sales, como inhibidores de la replicacion del rna del vhc; composicion farmaceutica que los comprende; y su uso para el tratamiento o la profilaxis de la infeccion por el virus de la hepatitis c (vhc). | |
CL2016001918A1 (es) | Heteroaril amidas como inhibidores de agregación de proteína | |
CL2014000149A1 (es) | Metodo para sintetizar n-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil) fenil)]acetamida y mesilato monohidrato cristalino del mismo; composicion farmaceutica que lo contiene; combinacion farmaceutica; uso en el tratamiento y/o profilaxis de una infeccion por virus herpes simplex. | |
EA201691554A1 (ru) | 4'-дифторметилзамещенные производные нуклеозидов в качестве ингибиторов репликации рнк вируса гриппа | |
AR111469A1 (es) | Sal de un compuesto del derivado de aminopiridina, una forma cristalina de la misma, y un proceso para preparar la misma | |
EA201892246A1 (ru) | Производные аминотиазола, полученные в качестве противовирусных средств | |
CL2017000014A1 (es) | Derivados de isondolina para su uso en el tratamiento de una infección viral | |
MA53973A (fr) | Inhibiteurs de la réplication du virus de l'immunodéficience humaine | |
CL2022000531A1 (es) | Composiciones y métodos para el tratamiento de infecciones virales. | |
CY1122892T1 (el) | Παραγωγα 3-(καρβοξυμεθυλ)-8-αμινο-2-οξο-1,3-διαζα-σπειρο-[4.5]-δεκανιου |