UY36311A - Indazoles sustituidos con bencilo - Google Patents

Indazoles sustituidos con bencilo

Info

Publication number
UY36311A
UY36311A UY0001036311A UY36311A UY36311A UY 36311 A UY36311 A UY 36311A UY 0001036311 A UY0001036311 A UY 0001036311A UY 36311 A UY36311 A UY 36311A UY 36311 A UY36311 A UY 36311A
Authority
UY
Uruguay
Prior art keywords
indazols
bencilo
replaced
compounds
formula
Prior art date
Application number
UY0001036311A
Other languages
English (en)
Spanish (es)
Inventor
Hans-Georg Lerchen
Earwed Cleve
Wilhelm Bone
Ursula Mönning
Manfred Möwes
Lars Bärfacker
Hans Briem
Gerhard Siemeister
Joachim Kuhnke
Marion Hitchcock
Anne Mengel
Amaury Ernesto Fernandez-Montalvan
Simon Holton
Thomas Müller
Jens SCHRÖDER
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of UY36311A publication Critical patent/UY36311A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
UY0001036311A 2014-09-19 2015-09-18 Indazoles sustituidos con bencilo UY36311A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14185604 2014-09-19
EP15176903 2015-07-15

Publications (1)

Publication Number Publication Date
UY36311A true UY36311A (es) 2016-04-29

Family

ID=54140475

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001036311A UY36311A (es) 2014-09-19 2015-09-18 Indazoles sustituidos con bencilo

Country Status (27)

Country Link
US (1) US10350206B2 (en:Method)
EP (1) EP3194379A1 (en:Method)
JP (1) JP6664385B2 (en:Method)
KR (1) KR20170049604A (en:Method)
CN (1) CN107001331A (en:Method)
AP (1) AP2017009803A0 (en:Method)
AU (1) AU2015316796A1 (en:Method)
BR (1) BR112017005444A2 (en:Method)
CA (1) CA2961589A1 (en:Method)
CL (1) CL2017000654A1 (en:Method)
CO (1) CO2017002532A2 (en:Method)
CR (1) CR20170100A (en:Method)
CU (1) CU20170029A7 (en:Method)
DO (1) DOP2017000078A (en:Method)
EA (1) EA032401B1 (en:Method)
EC (1) ECSP17016797A (en:Method)
IL (1) IL251071A0 (en:Method)
MA (1) MA39484A (en:Method)
MX (1) MX2017003664A (en:Method)
NI (1) NI201700034A (en:Method)
PE (1) PE20170697A1 (en:Method)
PH (1) PH12017500509A1 (en:Method)
SG (1) SG11201702082VA (en:Method)
TN (1) TN2017000092A1 (en:Method)
TW (1) TW201615636A (en:Method)
UY (1) UY36311A (en:Method)
WO (1) WO2016042084A1 (en:Method)

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JP2016525076A (ja) 2013-06-21 2016-08-22 バイエル ファーマ アクチエンゲゼルシャフト 置換されたベンジルピラゾール類
CN105452237A (zh) 2013-06-21 2016-03-30 拜耳制药股份公司 杂芳基取代的吡唑
CN105764893A (zh) 2013-10-30 2016-07-13 拜耳制药股份公司 杂芳基取代的吡唑
SMT202400446T1 (it) 2014-02-06 2024-11-15 Nxera Pharma Uk Ltd Composti aza biciclici come agonisti del recettore muscarinico
JP6545199B2 (ja) 2014-06-17 2019-07-17 バイエル ファーマ アクチエンゲゼルシャフト 3−アミノ−1,5,6,7−テトラヒドロ−4h−インドール−4−オン類
US10350206B2 (en) 2014-09-19 2019-07-16 Bayer Pharma Aktiengesellschaft Benzyl substituted indazoles as BUB1 inhibitors
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
CA2976790C (en) 2015-02-20 2024-02-27 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
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WO2018158175A1 (en) 2017-02-28 2018-09-07 Bayer Pharma Aktiengesellschaft Combination of bub1 inhibitors
JP7090639B2 (ja) 2017-04-11 2022-06-24 サンシャイン・レイク・ファーマ・カンパニー・リミテッド フッ素置換されたインダゾール化合物及びその使用
WO2018206547A1 (en) 2017-05-12 2018-11-15 Bayer Pharma Aktiengesellschaft Combination of bub1 and atr inhibitors
WO2018215282A1 (en) 2017-05-26 2018-11-29 Bayer Pharma Aktiengesellschaft Combination of bub1 and pi3k inhibitors
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
KR20210018265A (ko) 2018-05-04 2021-02-17 인사이트 코포레이션 Fgfr 억제제의 고체 형태 및 이의 제조 방법
MX2020011639A (es) 2018-05-04 2021-02-15 Incyte Corp Sales de un inhibidor de receptores de factor de crecimiento de fibroblastos (fgfr).
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021067374A1 (en) 2019-10-01 2021-04-08 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
JP7675711B2 (ja) 2019-10-14 2025-05-13 インサイト・コーポレイション Fgfr阻害剤としての二環式複素環
WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
WO2021113479A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
CR20220285A (es) 2019-12-04 2022-10-27 Incyte Corp Derivados de un inhibidor de fgfr
WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
JP2024513575A (ja) 2021-04-12 2024-03-26 インサイト・コーポレイション Fgfr阻害剤及びネクチン-4標的化剤を含む併用療法
AR126102A1 (es) 2021-06-09 2023-09-13 Incyte Corp Heterociclos tricíclicos como inhibidores de fgfr
EP4352060A1 (en) 2021-06-09 2024-04-17 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors

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WO2018158175A1 (en) 2017-02-28 2018-09-07 Bayer Pharma Aktiengesellschaft Combination of bub1 inhibitors
WO2018206547A1 (en) 2017-05-12 2018-11-15 Bayer Pharma Aktiengesellschaft Combination of bub1 and atr inhibitors
WO2018215282A1 (en) 2017-05-26 2018-11-29 Bayer Pharma Aktiengesellschaft Combination of bub1 and pi3k inhibitors

Also Published As

Publication number Publication date
US10350206B2 (en) 2019-07-16
EA032401B1 (ru) 2019-05-31
EP3194379A1 (en) 2017-07-26
CN107001331A (zh) 2017-08-01
CR20170100A (es) 2017-04-24
JP6664385B2 (ja) 2020-03-13
DOP2017000078A (es) 2017-06-30
TN2017000092A1 (en) 2018-07-04
SG11201702082VA (en) 2017-04-27
KR20170049604A (ko) 2017-05-10
MX2017003664A (es) 2017-07-13
MA39484A (fr) 2016-03-24
WO2016042084A1 (en) 2016-03-24
AU2015316796A1 (en) 2017-03-30
EA201790649A1 (ru) 2017-09-29
CL2017000654A1 (es) 2017-12-11
TW201615636A (zh) 2016-05-01
IL251071A0 (en) 2017-04-30
PH12017500509A1 (en) 2017-08-30
AP2017009803A0 (en) 2017-03-31
US20170273980A1 (en) 2017-09-28
CU20170029A7 (es) 2017-08-08
CA2961589A1 (en) 2016-03-24
BR112017005444A2 (pt) 2018-04-24
CO2017002532A2 (es) 2017-07-11
ECSP17016797A (es) 2017-05-31
JP2017530962A (ja) 2017-10-19
PE20170697A1 (es) 2017-06-24
NI201700034A (es) 2017-06-16

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Effective date: 20220712