JP6664385B2 - Bub1阻害薬としてのベンジル置換インダゾール類 - Google Patents

Bub1阻害薬としてのベンジル置換インダゾール類 Download PDF

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JP6664385B2
JP6664385B2 JP2017514825A JP2017514825A JP6664385B2 JP 6664385 B2 JP6664385 B2 JP 6664385B2 JP 2017514825 A JP2017514825 A JP 2017514825A JP 2017514825 A JP2017514825 A JP 2017514825A JP 6664385 B2 JP6664385 B2 JP 6664385B2
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methyl
amino
indazol
difluoro
alkyl
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JP2017530962A (ja
JP2017530962A5 (en:Method
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メンゲル,アンヌ
ラーチェン,ハンス−ゲオルク
モーヴェス,マンフレッド
ミュラー,トーマス
バルファッカー,ラルス
ヒッチコック,マリオン
クレーブ,アルウェド
クーンケ,ヨアヒム
ブリーム,ハンス
シーメイスター,ゲルハルト
ボネ,ヴィルヘルム
フェルナンデス−モンタルヴァン,アマウリー・エルネスト
シュレーダー,イェンス
メンニング,ウルスラ
ホルトン,シモン
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バイエル ファーマ アクチエンゲゼルシャフト
バイエル ファーマ アクチエンゲゼルシャフト
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2017514825A 2014-09-19 2015-09-17 Bub1阻害薬としてのベンジル置換インダゾール類 Expired - Fee Related JP6664385B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP14185604.7 2014-09-19
EP14185604 2014-09-19
EP15176903 2015-07-15
EP15176903.1 2015-07-15
PCT/EP2015/071340 WO2016042084A1 (en) 2014-09-19 2015-09-17 Benzyl substituted indazoles as bub1 inhibitors

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JP2017530962A JP2017530962A (ja) 2017-10-19
JP2017530962A5 JP2017530962A5 (en:Method) 2018-10-25
JP6664385B2 true JP6664385B2 (ja) 2020-03-13

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US (1) US10350206B2 (en:Method)
EP (1) EP3194379A1 (en:Method)
JP (1) JP6664385B2 (en:Method)
KR (1) KR20170049604A (en:Method)
CN (1) CN107001331A (en:Method)
AP (1) AP2017009803A0 (en:Method)
AU (1) AU2015316796A1 (en:Method)
BR (1) BR112017005444A2 (en:Method)
CA (1) CA2961589A1 (en:Method)
CL (1) CL2017000654A1 (en:Method)
CO (1) CO2017002532A2 (en:Method)
CR (1) CR20170100A (en:Method)
CU (1) CU20170029A7 (en:Method)
DO (1) DOP2017000078A (en:Method)
EA (1) EA032401B1 (en:Method)
EC (1) ECSP17016797A (en:Method)
IL (1) IL251071A0 (en:Method)
MA (1) MA39484A (en:Method)
MX (1) MX2017003664A (en:Method)
NI (1) NI201700034A (en:Method)
PE (1) PE20170697A1 (en:Method)
PH (1) PH12017500509A1 (en:Method)
SG (1) SG11201702082VA (en:Method)
TN (1) TN2017000092A1 (en:Method)
TW (1) TW201615636A (en:Method)
UY (1) UY36311A (en:Method)
WO (1) WO2016042084A1 (en:Method)

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MX2020011639A (es) 2018-05-04 2021-02-15 Incyte Corp Sales de un inhibidor de receptores de factor de crecimiento de fibroblastos (fgfr).
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US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021067374A1 (en) 2019-10-01 2021-04-08 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
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US10350206B2 (en) 2019-07-16
UY36311A (es) 2016-04-29
EA032401B1 (ru) 2019-05-31
EP3194379A1 (en) 2017-07-26
CN107001331A (zh) 2017-08-01
CR20170100A (es) 2017-04-24
DOP2017000078A (es) 2017-06-30
TN2017000092A1 (en) 2018-07-04
SG11201702082VA (en) 2017-04-27
KR20170049604A (ko) 2017-05-10
MX2017003664A (es) 2017-07-13
MA39484A (fr) 2016-03-24
WO2016042084A1 (en) 2016-03-24
AU2015316796A1 (en) 2017-03-30
EA201790649A1 (ru) 2017-09-29
CL2017000654A1 (es) 2017-12-11
TW201615636A (zh) 2016-05-01
IL251071A0 (en) 2017-04-30
PH12017500509A1 (en) 2017-08-30
AP2017009803A0 (en) 2017-03-31
US20170273980A1 (en) 2017-09-28
CU20170029A7 (es) 2017-08-08
CA2961589A1 (en) 2016-03-24
BR112017005444A2 (pt) 2018-04-24
CO2017002532A2 (es) 2017-07-11
ECSP17016797A (es) 2017-05-31
JP2017530962A (ja) 2017-10-19
PE20170697A1 (es) 2017-06-24
NI201700034A (es) 2017-06-16

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