UY32814A - Derivados de amidas espirociclicas y su uso en terapia - Google Patents

Derivados de amidas espirociclicas y su uso en terapia

Info

Publication number
UY32814A
UY32814A UY0001032814A UY32814A UY32814A UY 32814 A UY32814 A UY 32814A UY 0001032814 A UY0001032814 A UY 0001032814A UY 32814 A UY32814 A UY 32814A UY 32814 A UY32814 A UY 32814A
Authority
UY
Uruguay
Prior art keywords
therapy
derivatives
spirociclic
amidas
preparation
Prior art date
Application number
UY0001032814A
Other languages
English (en)
Inventor
Lilian Alcaraz
Andrew Bailey
Nicholas Kindon
Original Assignee
Astrazeneca Ab
Pulmagen Therapeutics Syngery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41129405&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY32814(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab, Pulmagen Therapeutics Syngery Ltd filed Critical Astrazeneca Ab
Publication of UY32814A publication Critical patent/UY32814A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Abstract

Derivados de amida espirocíclica de fórmula I donde AeCH2CH2NH-representa un grupo de unión b(beta)-adrenoceptor, procesos para su preparación, composiciones farmacéuticas que los contienen, un proceso para preparar dichas composiciones farmacéuticas, su uso en terapia, e intermediarios para uso en su preparación.
UY0001032814A 2009-07-31 2010-07-30 Derivados de amidas espirociclicas y su uso en terapia UY32814A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0913342.2A GB0913342D0 (en) 2009-07-31 2009-07-31 Compounds - 801

Publications (1)

Publication Number Publication Date
UY32814A true UY32814A (es) 2011-02-28

Family

ID=41129405

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001032814A UY32814A (es) 2009-07-31 2010-07-30 Derivados de amidas espirociclicas y su uso en terapia

Country Status (34)

Country Link
US (2) US8455483B2 (es)
EP (1) EP2459572B1 (es)
JP (1) JP5612092B2 (es)
KR (1) KR101664525B1 (es)
CN (1) CN102625808B (es)
AR (1) AR080601A1 (es)
AU (1) AU2010277384B2 (es)
BR (1) BR112012008043A2 (es)
CA (1) CA2768527C (es)
CL (1) CL2012000263A1 (es)
CO (1) CO6491034A2 (es)
CR (1) CR20120054A (es)
CU (1) CU24103B1 (es)
DO (1) DOP2012000032A (es)
EA (1) EA020566B1 (es)
ES (1) ES2702467T3 (es)
GB (1) GB0913342D0 (es)
GT (1) GT201200028A (es)
HK (1) HK1171755A1 (es)
HN (1) HN2012000217A (es)
IL (1) IL217557A (es)
MX (1) MX2012001232A (es)
MY (1) MY163117A (es)
NI (1) NI201200018A (es)
NZ (1) NZ597589A (es)
PE (1) PE20121441A1 (es)
SA (1) SA110310628B1 (es)
SG (1) SG177634A1 (es)
TR (1) TR201819140T4 (es)
TW (1) TWI443103B (es)
UA (1) UA106887C2 (es)
UY (1) UY32814A (es)
WO (1) WO2011012896A2 (es)
ZA (1) ZA201201473B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2242759B1 (en) 2008-02-06 2012-09-12 AstraZeneca AB Compounds
TWI466885B (zh) 2009-07-31 2015-01-01 Japan Tobacco Inc 含氮螺環化合物及其醫藥用途
GB0913342D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab Compounds - 801
GB201021992D0 (en) * 2010-12-23 2011-02-02 Astrazeneca Ab Compound
GB201021979D0 (en) * 2010-12-23 2011-02-02 Astrazeneca Ab New compound
WO2016179349A1 (en) * 2015-05-05 2016-11-10 Northwestern University Cxcr4 chemokine receptor modulators
WO2018059537A1 (zh) * 2016-09-30 2018-04-05 四川海思科制药有限公司 一种二氮杂螺[5.5]十一碳烷衍生物及其用途
MY196804A (en) 2016-12-14 2023-05-03 Beijing Showby Pharmaceutical Co Ltd Class of bifunctional compounds with quaternary ammonium salt structure
MX2019014411A (es) 2017-06-01 2020-02-05 Bristol Myers Squibb Co Compuestos que contienen nitrogeno sustituido.
EP3682906A1 (en) * 2019-01-17 2020-07-22 Julius-Maximilians-Universität Würzburg Compound targeting norepinephrine transporter

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2707186A (en) 1954-05-06 1955-04-26 Hoffmann La Roche Imidazolone derivatives
AU565621B2 (en) 1983-04-26 1987-09-24 Smithkline Beckman Corporation Dopaminergic carbostyrils
FR2665440B1 (fr) 1990-07-31 1994-02-04 Lipha Nouveaux cycloalkylsulfonamides substitues, procedes de preparation et medicaments les contenant.
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
IL125686A (en) 1996-02-13 2002-11-10 Zeneca Ltd Quinazoline derivatives, processes for their preparation, pharmaceutical preparations containing them and their use in the manufacture of a drug with an anti-angiogenic effect and / or an effect of reducing vascular permeability
GB9604578D0 (en) 1996-03-04 1996-05-01 Sericol Ltd Photocurable compositions
DE69709319T2 (de) 1996-03-05 2002-08-14 Astrazeneca Ab 4-anilinochinazolin derivate
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
TWI258462B (en) 1999-12-17 2006-07-21 Astrazeneca Ab Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same
CN1431999A (zh) 2000-05-31 2003-07-23 阿斯特拉曾尼卡有限公司 具有血管损伤活性的吲哚衍生物
MXPA02012903A (es) 2000-07-07 2004-07-30 Angiogene Pharm Ltd Derivados de colquinol como inhibidores de angiogenesis.
CN1255391C (zh) 2000-07-07 2006-05-10 安吉奥金尼药品有限公司 作为血管破坏剂的colchinol衍生物
CN100569760C (zh) * 2003-11-21 2009-12-16 施万制药 具有β2肾上腺素能受体激动剂和毒蕈碱性受体拮抗剂活性的化合物
TW200531692A (en) 2004-01-12 2005-10-01 Theravance Inc Aryl aniline derivatives as β2 adrenergic receptor agonists
EP1751131B1 (en) 2004-03-10 2008-11-19 Janssen Pharmaceutica N.V. Mtp inhibiting aryl piperidines or piperazines substituted with 5-membered heterocycles
WO2005092841A1 (en) 2004-03-23 2005-10-06 Pfizer Limited Compounds having beta-agonist activity
US20050215542A1 (en) 2004-03-23 2005-09-29 Pfizer Inc Compounds for the treatment of diseases
DE102004024453A1 (de) * 2004-05-14 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue langwirksame Bronchodilatoren zur Behandlung von Atemwegserkrankungen
EP1833822A2 (en) 2004-08-16 2007-09-19 Theravance, Inc. Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
DE102004045648A1 (de) 2004-09-21 2006-03-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Betamimetika zur Behandlung von Atemwegserkrankungen
WO2006040568A1 (en) 2004-10-15 2006-04-20 Astrazeneca Ab Quinoxalines as b raf inhibitors
WO2006051373A1 (en) 2004-11-12 2006-05-18 Pfizer Limited Compounds for the treatment of diseases
DE102005007654A1 (de) 2005-02-19 2006-08-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue langwirksame Betamimetika zur Behandlung von Atemwegserkrankungen
WO2006088173A1 (ja) 2005-02-21 2006-08-24 Shionogi & Co., Ltd. Ｈｉｖインテグラーゼ阻害活性を有する２環性カルバモイルピリドン誘導体
TW200738658A (en) 2005-08-09 2007-10-16 Astrazeneca Ab Novel compounds
TW200738659A (en) 2005-08-29 2007-10-16 Astrazeneca Ab Novel compounds
ES2407115T3 (es) * 2005-11-18 2013-06-11 Ono Pharmaceutical Co., Ltd. Compuesto que contiene un grupo básico y uso del mismo
TW200734342A (en) 2005-12-15 2007-09-16 Astrazeneca Ab New compounds for the treatment of cardiac arrhythmias
TW200745084A (en) 2006-03-08 2007-12-16 Astrazeneca Ab Novel compounds
GB0613154D0 (en) * 2006-06-30 2006-08-09 Novartis Ag Organic Compounds
AU2007284548A1 (en) * 2006-08-15 2008-02-21 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
TW200833670A (en) 2006-12-20 2008-08-16 Astrazeneca Ab Novel compounds 569
US20100056508A1 (en) * 2006-12-20 2010-03-04 Astrazeneca Ab Amine derivatives and their use in beta-2-adrenoreceptor mediated diseases
GB0702413D0 (en) * 2007-02-07 2007-03-21 Argenta Discovery Ltd New chemical compounds
WO2008096129A1 (en) 2007-02-07 2008-08-14 Argenta Discovery Ltd Nitrogen containing hetrocyclic compounds useful as bifunctional modulators of m3 receptors and beta- 2 receptors
GB0702459D0 (en) 2007-02-08 2007-03-21 Astrazeneca Ab Salts 669
EP2242759B1 (en) * 2008-02-06 2012-09-12 AstraZeneca AB Compounds
GB0913342D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab Compounds - 801

Also Published As

Publication number Publication date
GB0913342D0 (en) 2009-09-16
GT201200028A (es) 2013-09-26
CU20120021A7 (es) 2012-06-21
CO6491034A2 (es) 2012-07-31
TR201819140T4 (tr) 2019-01-21
CN102625808B (zh) 2014-08-27
HK1171755A1 (en) 2013-04-05
EA020566B1 (ru) 2014-12-30
CA2768527A1 (en) 2011-02-03
AU2010277384B2 (en) 2014-01-30
JP2013500958A (ja) 2013-01-10
EA201290077A1 (ru) 2012-08-30
EP2459572A2 (en) 2012-06-06
WO2011012896A2 (en) 2011-02-03
CR20120054A (es) 2012-03-26
EP2459572B1 (en) 2018-09-12
PE20121441A1 (es) 2012-11-16
SG177634A1 (en) 2012-02-28
SA110310628B1 (ar) 2014-02-27
NZ597589A (en) 2013-12-20
MX2012001232A (es) 2012-03-26
TWI443103B (zh) 2014-07-01
AR080601A1 (es) 2012-04-25
KR20120056838A (ko) 2012-06-04
WO2011012896A3 (en) 2011-04-21
ES2702467T3 (es) 2019-03-01
US8476265B2 (en) 2013-07-02
US8455483B2 (en) 2013-06-04
BR112012008043A2 (pt) 2020-08-25
US20110053909A1 (en) 2011-03-03
NI201200018A (es) 2012-09-10
CU24103B1 (es) 2015-07-30
CN102625808A (zh) 2012-08-01
ZA201201473B (en) 2012-11-28
JP5612092B2 (ja) 2014-10-22
HN2012000217A (es) 2015-03-09
TW201107335A (en) 2011-03-01
CL2012000263A1 (es) 2012-08-31
IL217557A (en) 2015-01-29
DOP2012000032A (es) 2017-08-15
CA2768527C (en) 2017-07-11
AU2010277384A1 (en) 2012-03-22
KR101664525B1 (ko) 2016-10-11
US20130018037A1 (en) 2013-01-17
IL217557A0 (en) 2012-02-29
MY163117A (en) 2017-08-15
UA106887C2 (uk) 2014-10-27

Similar Documents

Publication Publication Date Title
UY32814A (es) Derivados de amidas espirociclicas y su uso en terapia
CR11623A (es) Compuestos
UY32611A (es) Compuestos de 1-cianoetilheterociclilcarboxamida sustituidos 750
DOP2010000178A (es) Peptidil nitrilos como inhibidores de dipeptidil peptidasa i
CO6640270A2 (es) Morfolinopirimidad y su uso en terapia
UY31611A1 (es) Compuestos que comprenden un grupo ciclobutoxi
UY31918A (es) Compuestos de pirazol inhibidores de fgfr, composiciones farmaceuticas que los comprenden, procesos para su preparacion y su uso como medicamento
DOP2014000203A (es) Compuestos de heterociclilo
DOP2011000361A (es) Nuevos derivados de pirimidina y sus usos en el tratamiento del cancer y otras enfermedades
CO6541643A2 (es) Derivados de imidazopirina como inhibidores de jak
UY32863A (es) COMPUESTOS DE HEXAHIDROOXAZINOPTERINA PARA USO COMO INHIBIDORES DE mTOR
BR112014007134A2 (pt) usos de um composto da fórmula (b), compostos, composição farmacêutica, método de preparação do composto e uso de uma quantidade efetiva de um composto
ECSP14013215A (es) Compuestos novedosos
CL2012000921A1 (es) Compuestos derivados de espiropiperidina-metilbenciloxifenil, activadores del receptor rpg-40; composicion farmaceutica que los comprende; y uso del compuesto para tratar diabetes.
CO6351783A2 (es) Derivados de indazoles sustituidos con fenilo o piridinilo
GT201200321A (es) Derivados de heteroaril imidazolona como inhibidores de jak
ECSP099338A (es) Derivados de quiniclidina de ácido (hetero) arilcicloheptano carboxíclico como antagonistas del receptor muscarínico
CL2009001346A1 (es) Compuestos derivados heterociclicos, inhibidores de la adn girasa; proceso de preparacion de dichos compuestos; composicion farmaceutica que los comprende; y su uso para el tratamiento de una infeccion bacteriana.
UY31905A (es) Derivados de benzoxazinona, procesos de preparación, composiciones farmacéuticas conteniéndolos y aplicaciones.
UY32674A (es) Derivados heterociclicos de la urea y sus metodos de empleo
UY31871A (es) Compuestos que comprenden un grupo ciclobutoxi
CR20160084A (es) Derivados de amida como agonistas del receptor del ácido lisofosfatídico
BR112012009670A2 (pt) compostos de cumarina como moduladores de receptor com utilidade terapêutica
CL2010001432A1 (es) Compuestos derivados de 2-oxo-alquil-1-piperazin-2-ona, afines por los receptores p75ntr; procedimiento para preparar los compuestos; compuesto intermediario; medicamento y composicion farmaceutica que comprende a uno de los compuestos; y su uso en la preparacion de medicamentos utiles para tratar enfermedades neurodegenerativas.
CL2010001508A1 (es) Compuestos derivados de sulfanilmetil, sulfinilmetil y sulfonilmetil indol; composicion farmaceutica que los comprende; procedimiento de preparacion de dichos compuestos y uso para tratar y/o prevenir enfermedades cardiovasculares.

Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20190214