UA106887C2 - Похідні спіроциклічних амідів - Google Patents

Похідні спіроциклічних амідів

Info

Publication number
UA106887C2
UA106887C2 UAA201200405A UAA201200405A UA106887C2 UA 106887 C2 UA106887 C2 UA 106887C2 UA A201200405 A UAA201200405 A UA A201200405A UA A201200405 A UAA201200405 A UA A201200405A UA 106887 C2 UA106887 C2 UA 106887C2
Authority
UA
Ukraine
Prior art keywords
derivatives
libreofficeamide
preparation
pharmaceutical compositions
arch2ch2nh
Prior art date
Application number
UAA201200405A
Other languages
English (en)
Russian (ru)
Inventor
Ліліан Алькараз
Ендрю Бейлі
Ніколас Кіндон
Original Assignee
Астразенека Аб
Пульмаґен Терапеутікс (Сінерджі) Лімітед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41129405&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA106887(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Астразенека Аб, Пульмаґен Терапеутікс (Сінерджі) Лімітед filed Critical Астразенека Аб
Publication of UA106887C2 publication Critical patent/UA106887C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Винахід стосується похідних спіроциклічного аміду формули (І) EMBED ISIS/Draw Sketch , (I) де ArCH2CH2NH- є зв'язуючою групою -адренорецептора, способу їх одержання, фармацевтичних композицій, що їх містять, способу одержання таких фармацевтичних композицій, їх застосування в лікуванні та проміжних сполук для використання в їх одержанні.
UAA201200405A 2009-07-31 2010-07-29 Похідні спіроциклічних амідів UA106887C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0913342.2A GB0913342D0 (en) 2009-07-31 2009-07-31 Compounds - 801
PCT/GB2010/051242 WO2011012896A2 (en) 2009-07-31 2010-07-29 Compounds - 801

Publications (1)

Publication Number Publication Date
UA106887C2 true UA106887C2 (uk) 2014-10-27

Family

ID=41129405

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201200405A UA106887C2 (uk) 2009-07-31 2010-07-29 Похідні спіроциклічних амідів

Country Status (34)

Country Link
US (2) US8455483B2 (uk)
EP (1) EP2459572B1 (uk)
JP (1) JP5612092B2 (uk)
KR (1) KR101664525B1 (uk)
CN (1) CN102625808B (uk)
AR (1) AR080601A1 (uk)
AU (1) AU2010277384B2 (uk)
BR (1) BR112012008043A2 (uk)
CA (1) CA2768527C (uk)
CL (1) CL2012000263A1 (uk)
CO (1) CO6491034A2 (uk)
CR (1) CR20120054A (uk)
CU (1) CU24103B1 (uk)
DO (1) DOP2012000032A (uk)
EA (1) EA020566B1 (uk)
ES (1) ES2702467T3 (uk)
GB (1) GB0913342D0 (uk)
GT (1) GT201200028A (uk)
HK (1) HK1171755A1 (uk)
HN (1) HN2012000217A (uk)
IL (1) IL217557A (uk)
MX (1) MX2012001232A (uk)
MY (1) MY163117A (uk)
NI (1) NI201200018A (uk)
NZ (1) NZ597589A (uk)
PE (1) PE20121441A1 (uk)
SA (1) SA110310628B1 (uk)
SG (1) SG177634A1 (uk)
TR (1) TR201819140T4 (uk)
TW (1) TWI443103B (uk)
UA (1) UA106887C2 (uk)
UY (1) UY32814A (uk)
WO (1) WO2011012896A2 (uk)
ZA (1) ZA201201473B (uk)

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US10435375B2 (en) 2015-05-05 2019-10-08 Northwestern University CXCR4 chemokine receptor modulators
WO2018059537A1 (zh) * 2016-09-30 2018-04-05 四川海思科制药有限公司 一种二氮杂螺[5.5]十一碳烷衍生物及其用途
KR102278197B1 (ko) 2016-12-14 2021-07-15 베이징 서우바이 파마슈티컬 컴퍼니 리미티드 4차 암모늄염 구조의 이중기능 화합물
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Also Published As

Publication number Publication date
JP2013500958A (ja) 2013-01-10
PE20121441A1 (es) 2012-11-16
IL217557A (en) 2015-01-29
KR101664525B1 (ko) 2016-10-11
US20130018037A1 (en) 2013-01-17
GT201200028A (es) 2013-09-26
KR20120056838A (ko) 2012-06-04
SG177634A1 (en) 2012-02-28
EP2459572A2 (en) 2012-06-06
US20110053909A1 (en) 2011-03-03
DOP2012000032A (es) 2017-08-15
AU2010277384A1 (en) 2012-03-22
TR201819140T4 (tr) 2019-01-21
CN102625808A (zh) 2012-08-01
HN2012000217A (es) 2015-03-09
CR20120054A (es) 2012-03-26
ZA201201473B (en) 2012-11-28
NZ597589A (en) 2013-12-20
WO2011012896A2 (en) 2011-02-03
ES2702467T3 (es) 2019-03-01
AR080601A1 (es) 2012-04-25
CN102625808B (zh) 2014-08-27
CA2768527A1 (en) 2011-02-03
NI201200018A (es) 2012-09-10
CL2012000263A1 (es) 2012-08-31
IL217557A0 (en) 2012-02-29
TWI443103B (zh) 2014-07-01
CO6491034A2 (es) 2012-07-31
CU20120021A7 (es) 2012-06-21
UY32814A (es) 2011-02-28
JP5612092B2 (ja) 2014-10-22
GB0913342D0 (en) 2009-09-16
SA110310628B1 (ar) 2014-02-27
HK1171755A1 (en) 2013-04-05
EP2459572B1 (en) 2018-09-12
WO2011012896A3 (en) 2011-04-21
MX2012001232A (es) 2012-03-26
AU2010277384B2 (en) 2014-01-30
EA020566B1 (ru) 2014-12-30
CU24103B1 (es) 2015-07-30
TW201107335A (en) 2011-03-01
MY163117A (en) 2017-08-15
US8455483B2 (en) 2013-06-04
US8476265B2 (en) 2013-07-02
EA201290077A1 (ru) 2012-08-30
BR112012008043A2 (pt) 2020-08-25
CA2768527C (en) 2017-07-11

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