CU24103B1 - Compuestos derivados amido espirocíclicos y sales farmacéuticamente aceptable de los mismos - Google Patents
Compuestos derivados amido espirocíclicos y sales farmacéuticamente aceptable de los mismosInfo
- Publication number
- CU24103B1 CU24103B1 CU2012000021A CU20120021A CU24103B1 CU 24103 B1 CU24103 B1 CU 24103B1 CU 2012000021 A CU2012000021 A CU 2012000021A CU 20120021 A CU20120021 A CU 20120021A CU 24103 B1 CU24103 B1 CU 24103B1
- Authority
- CU
- Cuba
- Prior art keywords
- pharmaceutically acceptable
- spirocycles
- same
- salts pharmaceutically
- amido
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La invención refiere a un compuesto de fórmula: o una sal faramcéuticamente aceptable del mismo y a un compuesto de fórmula: Dichos compuestos de la presente invención y sus sales son útiles en el tratamiento de enfermedades inflamatorias, como por ejemplo la artritis reumatoide, la osteoartritis, el asma, la rinitis alérgica, la enfermedad pulmonar obstructiva crónica (EPOC), la psoriasis y la enfermedad inflamatoria de los intestinos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0913342.2A GB0913342D0 (en) | 2009-07-31 | 2009-07-31 | Compounds - 801 |
PCT/GB2010/051242 WO2011012896A2 (en) | 2009-07-31 | 2010-07-29 | Compounds - 801 |
Publications (2)
Publication Number | Publication Date |
---|---|
CU20120021A7 CU20120021A7 (es) | 2012-06-21 |
CU24103B1 true CU24103B1 (es) | 2015-07-30 |
Family
ID=41129405
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU2012000021A CU24103B1 (es) | 2009-07-31 | 2010-07-29 | Compuestos derivados amido espirocíclicos y sales farmacéuticamente aceptable de los mismos |
Country Status (34)
Country | Link |
---|---|
US (2) | US8455483B2 (es) |
EP (1) | EP2459572B1 (es) |
JP (1) | JP5612092B2 (es) |
KR (1) | KR101664525B1 (es) |
CN (1) | CN102625808B (es) |
AR (1) | AR080601A1 (es) |
AU (1) | AU2010277384B2 (es) |
BR (1) | BR112012008043A2 (es) |
CA (1) | CA2768527C (es) |
CL (1) | CL2012000263A1 (es) |
CO (1) | CO6491034A2 (es) |
CR (1) | CR20120054A (es) |
CU (1) | CU24103B1 (es) |
DO (1) | DOP2012000032A (es) |
EA (1) | EA020566B1 (es) |
ES (1) | ES2702467T3 (es) |
GB (1) | GB0913342D0 (es) |
GT (1) | GT201200028A (es) |
HK (1) | HK1171755A1 (es) |
HN (1) | HN2012000217A (es) |
IL (1) | IL217557A (es) |
MX (1) | MX2012001232A (es) |
MY (1) | MY163117A (es) |
NI (1) | NI201200018A (es) |
NZ (1) | NZ597589A (es) |
PE (1) | PE20121441A1 (es) |
SA (1) | SA110310628B1 (es) |
SG (1) | SG177634A1 (es) |
TR (1) | TR201819140T4 (es) |
TW (1) | TWI443103B (es) |
UA (1) | UA106887C2 (es) |
UY (1) | UY32814A (es) |
WO (1) | WO2011012896A2 (es) |
ZA (1) | ZA201201473B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2242759B1 (en) | 2008-02-06 | 2012-09-12 | AstraZeneca AB | Compounds |
TWI466885B (zh) | 2009-07-31 | 2015-01-01 | Japan Tobacco Inc | 含氮螺環化合物及其醫藥用途 |
GB0913342D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | Compounds - 801 |
GB201021992D0 (en) * | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | Compound |
GB201021979D0 (en) * | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | New compound |
WO2016179349A1 (en) * | 2015-05-05 | 2016-11-10 | Northwestern University | Cxcr4 chemokine receptor modulators |
WO2018059537A1 (zh) * | 2016-09-30 | 2018-04-05 | 四川海思科制药有限公司 | 一种二氮杂螺[5.5]十一碳烷衍生物及其用途 |
MY196804A (en) | 2016-12-14 | 2023-05-03 | Beijing Showby Pharmaceutical Co Ltd | Class of bifunctional compounds with quaternary ammonium salt structure |
MX2019014411A (es) | 2017-06-01 | 2020-02-05 | Bristol Myers Squibb Co | Compuestos que contienen nitrogeno sustituido. |
EP3682906A1 (en) * | 2019-01-17 | 2020-07-22 | Julius-Maximilians-Universität Würzburg | Compound targeting norepinephrine transporter |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2707186A (en) | 1954-05-06 | 1955-04-26 | Hoffmann La Roche | Imidazolone derivatives |
AU565621B2 (en) | 1983-04-26 | 1987-09-24 | Smithkline Beckman Corporation | Dopaminergic carbostyrils |
FR2665440B1 (fr) | 1990-07-31 | 1994-02-04 | Lipha | Nouveaux cycloalkylsulfonamides substitues, procedes de preparation et medicaments les contenant. |
GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
IL125686A (en) | 1996-02-13 | 2002-11-10 | Zeneca Ltd | Quinazoline derivatives, processes for their preparation, pharmaceutical preparations containing them and their use in the manufacture of a drug with an anti-angiogenic effect and / or an effect of reducing vascular permeability |
GB9604578D0 (en) | 1996-03-04 | 1996-05-01 | Sericol Ltd | Photocurable compositions |
DE69709319T2 (de) | 1996-03-05 | 2002-08-14 | Astrazeneca Ab | 4-anilinochinazolin derivate |
SE9602263D0 (sv) | 1996-06-07 | 1996-06-07 | Astra Ab | New amino acid derivatives |
GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
TWI258462B (en) | 1999-12-17 | 2006-07-21 | Astrazeneca Ab | Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same |
CN1431999A (zh) | 2000-05-31 | 2003-07-23 | 阿斯特拉曾尼卡有限公司 | 具有血管损伤活性的吲哚衍生物 |
MXPA02012903A (es) | 2000-07-07 | 2004-07-30 | Angiogene Pharm Ltd | Derivados de colquinol como inhibidores de angiogenesis. |
CN1255391C (zh) | 2000-07-07 | 2006-05-10 | 安吉奥金尼药品有限公司 | 作为血管破坏剂的colchinol衍生物 |
CN100569760C (zh) * | 2003-11-21 | 2009-12-16 | 施万制药 | 具有β2肾上腺素能受体激动剂和毒蕈碱性受体拮抗剂活性的化合物 |
TW200531692A (en) | 2004-01-12 | 2005-10-01 | Theravance Inc | Aryl aniline derivatives as β2 adrenergic receptor agonists |
EP1751131B1 (en) | 2004-03-10 | 2008-11-19 | Janssen Pharmaceutica N.V. | Mtp inhibiting aryl piperidines or piperazines substituted with 5-membered heterocycles |
WO2005092841A1 (en) | 2004-03-23 | 2005-10-06 | Pfizer Limited | Compounds having beta-agonist activity |
US20050215542A1 (en) | 2004-03-23 | 2005-09-29 | Pfizer Inc | Compounds for the treatment of diseases |
DE102004024453A1 (de) * | 2004-05-14 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue langwirksame Bronchodilatoren zur Behandlung von Atemwegserkrankungen |
EP1833822A2 (en) | 2004-08-16 | 2007-09-19 | Theravance, Inc. | Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
DE102004045648A1 (de) | 2004-09-21 | 2006-03-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Betamimetika zur Behandlung von Atemwegserkrankungen |
WO2006040568A1 (en) | 2004-10-15 | 2006-04-20 | Astrazeneca Ab | Quinoxalines as b raf inhibitors |
WO2006051373A1 (en) | 2004-11-12 | 2006-05-18 | Pfizer Limited | Compounds for the treatment of diseases |
DE102005007654A1 (de) | 2005-02-19 | 2006-08-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue langwirksame Betamimetika zur Behandlung von Atemwegserkrankungen |
WO2006088173A1 (ja) | 2005-02-21 | 2006-08-24 | Shionogi & Co., Ltd. | Hivインテグラーゼ阻害活性を有する2環性カルバモイルピリドン誘導体 |
TW200738658A (en) | 2005-08-09 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
TW200738659A (en) | 2005-08-29 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
ES2407115T3 (es) * | 2005-11-18 | 2013-06-11 | Ono Pharmaceutical Co., Ltd. | Compuesto que contiene un grupo básico y uso del mismo |
TW200734342A (en) | 2005-12-15 | 2007-09-16 | Astrazeneca Ab | New compounds for the treatment of cardiac arrhythmias |
TW200745084A (en) | 2006-03-08 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
GB0613154D0 (en) * | 2006-06-30 | 2006-08-09 | Novartis Ag | Organic Compounds |
AU2007284548A1 (en) * | 2006-08-15 | 2008-02-21 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
TW200833670A (en) | 2006-12-20 | 2008-08-16 | Astrazeneca Ab | Novel compounds 569 |
US20100056508A1 (en) * | 2006-12-20 | 2010-03-04 | Astrazeneca Ab | Amine derivatives and their use in beta-2-adrenoreceptor mediated diseases |
GB0702413D0 (en) * | 2007-02-07 | 2007-03-21 | Argenta Discovery Ltd | New chemical compounds |
WO2008096129A1 (en) | 2007-02-07 | 2008-08-14 | Argenta Discovery Ltd | Nitrogen containing hetrocyclic compounds useful as bifunctional modulators of m3 receptors and beta- 2 receptors |
GB0702459D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | Salts 669 |
EP2242759B1 (en) * | 2008-02-06 | 2012-09-12 | AstraZeneca AB | Compounds |
GB0913342D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | Compounds - 801 |
-
2009
- 2009-07-31 GB GBGB0913342.2A patent/GB0913342D0/en not_active Ceased
-
2010
- 2010-07-29 PE PE2012000138A patent/PE20121441A1/es active IP Right Grant
- 2010-07-29 BR BR112012008043-1A patent/BR112012008043A2/pt not_active Application Discontinuation
- 2010-07-29 MX MX2012001232A patent/MX2012001232A/es active IP Right Grant
- 2010-07-29 CN CN201080043822.8A patent/CN102625808B/zh not_active Expired - Fee Related
- 2010-07-29 CU CU2012000021A patent/CU24103B1/es active IP Right Grant
- 2010-07-29 MY MYPI2012000429A patent/MY163117A/en unknown
- 2010-07-29 EA EA201290077A patent/EA020566B1/ru not_active IP Right Cessation
- 2010-07-29 AU AU2010277384A patent/AU2010277384B2/en not_active Ceased
- 2010-07-29 NZ NZ597589A patent/NZ597589A/en not_active IP Right Cessation
- 2010-07-29 SG SG2012002358A patent/SG177634A1/en unknown
- 2010-07-29 KR KR1020127005165A patent/KR101664525B1/ko active IP Right Grant
- 2010-07-29 TR TR2018/19140T patent/TR201819140T4/tr unknown
- 2010-07-29 JP JP2012522254A patent/JP5612092B2/ja not_active Expired - Fee Related
- 2010-07-29 CA CA2768527A patent/CA2768527C/en not_active Expired - Fee Related
- 2010-07-29 UA UAA201200405A patent/UA106887C2/uk unknown
- 2010-07-29 WO PCT/GB2010/051242 patent/WO2011012896A2/en active Application Filing
- 2010-07-29 ES ES10752118T patent/ES2702467T3/es active Active
- 2010-07-29 EP EP10752118.9A patent/EP2459572B1/en active Active
- 2010-07-30 US US12/847,000 patent/US8455483B2/en active Active
- 2010-07-30 AR ARP100102795A patent/AR080601A1/es active IP Right Grant
- 2010-07-30 TW TW099125331A patent/TWI443103B/zh not_active IP Right Cessation
- 2010-07-30 UY UY0001032814A patent/UY32814A/es not_active Application Discontinuation
- 2010-07-31 SA SA110310628A patent/SA110310628B1/ar unknown
-
2012
- 2012-01-12 CO CO12004253A patent/CO6491034A2/es active IP Right Grant
- 2012-01-16 IL IL217557A patent/IL217557A/en active IP Right Grant
- 2012-01-31 GT GT201200028A patent/GT201200028A/es unknown
- 2012-01-31 DO DO2012000032A patent/DOP2012000032A/es unknown
- 2012-01-31 CL CL2012000263A patent/CL2012000263A1/es unknown
- 2012-01-31 CR CR20120054A patent/CR20120054A/es unknown
- 2012-01-31 HN HN2012000217A patent/HN2012000217A/es unknown
- 2012-01-31 NI NI201200018A patent/NI201200018A/es unknown
- 2012-02-28 ZA ZA2012/01473A patent/ZA201201473B/en unknown
- 2012-09-14 US US13/617,978 patent/US8476265B2/en active Active
- 2012-12-07 HK HK12112653.9A patent/HK1171755A1/xx not_active IP Right Cessation
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