UY31484A1 - Piperidinas heteroaril-sustituidas - Google Patents

Piperidinas heteroaril-sustituidas

Info

Publication number
UY31484A1
UY31484A1 UY31484A UY31484A UY31484A1 UY 31484 A1 UY31484 A1 UY 31484A1 UY 31484 A UY31484 A UY 31484A UY 31484 A UY31484 A UY 31484A UY 31484 A1 UY31484 A1 UY 31484A1
Authority
UY
Uruguay
Prior art keywords
substituted
piperidins
heteroaril
diseases
prophylaxis
Prior art date
Application number
UY31484A
Other languages
English (en)
Spanish (es)
Inventor
Dr Kersten Matthias Gericke
Dr Mark Jean Gnoth
Dr Michael Gerisch
Christoph Gerdes
Georges Degenfeld
Dr Katja Zimmermann
Buchmuller Anja
Rester Ulrich
Dr Dirk Schneider
Dr Eckhard Bender
Dr Mark Meininghaus
Dr Yolanda Cancho-Grande
Dr Mario Jeske
Dr Dirk Heimbach
Dr Dmitry Zubov
Dr Susanne Roehrig
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102007057718A external-priority patent/DE102007057718A1/de
Priority claimed from DE102008010221A external-priority patent/DE102008010221A1/de
Application filed filed Critical
Publication of UY31484A1 publication Critical patent/UY31484A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
UY31484A 2007-11-30 2008-11-24 Piperidinas heteroaril-sustituidas UY31484A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007057718A DE102007057718A1 (de) 2007-11-30 2007-11-30 Heteroaryl-substituierte Piperidine
DE102008010221A DE102008010221A1 (de) 2008-02-20 2008-02-20 Heteroaryl-substituierte Piperidine

Publications (1)

Publication Number Publication Date
UY31484A1 true UY31484A1 (es) 2009-07-17

Family

ID=40580130

Family Applications (1)

Application Number Title Priority Date Filing Date
UY31484A UY31484A1 (es) 2007-11-30 2008-11-24 Piperidinas heteroaril-sustituidas

Country Status (20)

Country Link
US (2) US8119663B2 (da)
EP (1) EP2227466B1 (da)
JP (1) JP5450435B2 (da)
KR (1) KR20100114018A (da)
CN (1) CN101932577B (da)
AR (1) AR069417A1 (da)
AT (1) ATE506359T1 (da)
CA (1) CA2706991A1 (da)
CL (1) CL2008003473A1 (da)
DE (1) DE502008003324D1 (da)
DK (1) DK2227466T3 (da)
HK (1) HK1152311A1 (da)
HR (1) HRP20110510T1 (da)
PA (1) PA8805201A1 (da)
PE (1) PE20091026A1 (da)
PL (1) PL2227466T3 (da)
PT (1) PT2227466E (da)
TW (1) TW200936135A (da)
UY (1) UY31484A1 (da)
WO (1) WO2009068214A2 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009014484A1 (de) 2009-03-23 2010-09-30 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022896A1 (de) * 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022894A1 (de) 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022895A1 (de) * 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022897A1 (de) * 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
WO2012001694A1 (en) * 2010-06-28 2012-01-05 Hetero Research Foundation Process for olmesartan medoxomil
WO2012012642A1 (en) 2010-07-22 2012-01-26 Zafgen Corporation Tricyclic compounds and methds of making and using same
WO2012051318A1 (en) 2010-10-12 2012-04-19 Zafgen Corporation Sulphonamide compounds and methods of making and using same
TW201300380A (zh) * 2010-10-19 2013-01-01 Comentis Inc 抑制β－分泌酶活性之噁二唑化合物及其使用方法
KR20140006888A (ko) 2011-01-26 2014-01-16 자프겐 인크. 테트라졸화합물, 그리고, 이를 제조하는 방법 및 이를 이용하는 방법
SG194812A1 (en) 2011-05-06 2013-12-30 Zafgen Inc Partially saturated tricyclic compounds and methods of making and using same
CA2835195A1 (en) 2011-05-06 2012-11-15 Zafgen, Inc. Tricyclic sulfonamide compounds and methods of making and using same
EP2705035B1 (en) 2011-05-06 2016-12-14 Zafgen, Inc. Tricyclic pyrazole sulfonamide compounds and methods of making and using same
JP6035347B2 (ja) 2012-01-18 2016-11-30 ザフゲン，インコーポレイテッド 三環式スルホンアミド化合物ならびにその作製および使用方法
EP2804856B1 (en) 2012-01-18 2017-03-15 Zafgen, Inc. Tricyclic sulfone compounds and methods of making and using same
SG11201503521QA (en) 2012-11-05 2015-06-29 Zafgen Inc Methods of treating liver diseases
US9868717B2 (en) 2012-11-05 2018-01-16 Zafgen, Inc. Tricyclic sulphonamide compounds and methods of making and using same
KR20150079952A (ko) 2012-11-05 2015-07-08 자프겐 인크. 트리시클릭 화합물 및 그의 제조 및 사용 방법
CN103965095A (zh) * 2013-02-04 2014-08-06 艾琪康医药科技（上海）有限公司 1-r1-3-r2-4-氟哌啶及其衍生物的制备方法
CN104341590A (zh) * 2013-08-01 2015-02-11 韩冰 一种树枝状高分子化合物及其制备和用途
TW202100526A (zh) 2019-03-06 2021-01-01 日商第一三共股份有限公司 吡咯并吡唑衍生物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
US5767144A (en) * 1994-08-19 1998-06-16 Abbott Laboratories Endothelin antagonists
BR9707509A (pt) * 1996-02-13 1999-07-27 Abbott Lab Composto composto farmacêutica e processos para antagonizar endotelina para tratar hipertensão insuficiência cardiaca congestiva congestiva restenose emseguida a lessão arterial isquemia cerebral ou miocárdica ou aterosclerose angina coronariana vasosespasmo cerebral insuficiência renal aguda e crônica ulceração gástrica nefrotoxicidade induzida por ciclosporina toxicidade induzida por endotoxina asma distúrbio da lipoproteina relacionados com lpl doenças proliferatives hipertensão pulmonar aguda ou cronica agregação plaquetaria tombose cardiotoxiadade mediada por il-2 noncicepção colite disturbio da permeabulidade vascilar lesão por reperfusão-isquemia doença deraynaud e enxaqueca e para a preparar um composto.
WO1997036873A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
US6403612B2 (en) 2000-01-31 2002-06-11 Merck & Co., Inc. Thrombin receptor antagonists
NZ528820A (en) * 2001-04-19 2007-01-26 Eisai Co Ltd 2-iminopyrrolidine derivatives
US7390822B2 (en) * 2001-10-15 2008-06-24 Janssen Pharmaceutica, N.V. Substituted 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives for reducing ischaemic damage
US7030141B2 (en) * 2001-11-29 2006-04-18 Christopher Franklin Bigge Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
NZ551603A (en) * 2004-06-24 2010-11-26 Incyte Corp N-substituted piperidines and their use as pharmaceuticals
JP2008504279A (ja) 2004-06-24 2008-02-14 インサイト・コーポレイション アミド化合物およびその医薬としての使用
WO2006002349A1 (en) 2004-06-24 2006-01-05 Incyte Corporation Amido compounds and their use as pharmaceuticals
CA2575561A1 (en) 2004-08-10 2006-02-23 Incyte Corporation Amido compounds and their use as pharmaceuticals
DE102004045796A1 (de) 2004-09-22 2006-03-23 Merck Patent Gmbh Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung
JPWO2006051623A1 (ja) * 2004-11-09 2008-05-29 エーザイ株式会社 トロンビン受容体アンタゴニストを有効成分とするくも膜下出血に伴う血管攣縮の治療剤
WO2007038138A2 (en) 2005-09-21 2007-04-05 Incyte Corporation Amido compounds and their use as pharmaceuticals
EA200870216A1 (ru) 2006-01-31 2009-02-27 Инсайт Корпорейшн Амидо соединения и их применение в качестве лекарственных средств
WO2007101270A1 (en) 2006-03-02 2007-09-07 Incyte Corporation MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME
JP2009535420A (ja) * 2006-05-01 2009-10-01 インサイト・コーポレイション １１−βヒドロキシルステロイドデヒドロゲナーゼタイプ１のモジュレーターとしてのテトラ置換ウレア

Also Published As

Publication number Publication date
US20090306139A1 (en) 2009-12-10
ATE506359T1 (de) 2011-05-15
DE502008003324D1 (de) 2011-06-01
JP5450435B2 (ja) 2014-03-26
CN101932577B (zh) 2013-07-17
CL2008003473A1 (es) 2009-08-14
EP2227466A2 (de) 2010-09-15
PL2227466T3 (pl) 2011-09-30
CA2706991A1 (en) 2009-06-04
WO2009068214A2 (de) 2009-06-04
KR20100114018A (ko) 2010-10-22
DK2227466T3 (da) 2011-08-08
CN101932577A (zh) 2010-12-29
HK1152311A1 (en) 2012-02-24
HRP20110510T1 (hr) 2011-08-31
PT2227466E (pt) 2011-07-01
US20120214788A1 (en) 2012-08-23
PA8805201A1 (es) 2010-02-12
TW200936135A (en) 2009-09-01
JP2011504889A (ja) 2011-02-17
US8119663B2 (en) 2012-02-21
EP2227466B1 (de) 2011-04-20
PE20091026A1 (es) 2009-07-26
WO2009068214A3 (de) 2009-08-20
AR069417A1 (es) 2010-01-20

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Legal Events

Date Code Title Description
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Effective date: 20171019