HRP20110510T1 - Heteroaril-supstituirani piperidini - Google Patents
Heteroaril-supstituirani piperidini Download PDFInfo
- Publication number
- HRP20110510T1 HRP20110510T1 HR20110510T HRP20110510T HRP20110510T1 HR P20110510 T1 HRP20110510 T1 HR P20110510T1 HR 20110510 T HR20110510 T HR 20110510T HR P20110510 T HRP20110510 T HR P20110510T HR P20110510 T1 HRP20110510 T1 HR P20110510T1
- Authority
- HR
- Croatia
- Prior art keywords
- phenyl
- compound according
- group
- substituted
- formula
- Prior art date
Links
- 150000003053 piperidines Chemical class 0.000 title 1
- -1 monofluoromethyl Chemical group 0.000 claims abstract 57
- 150000001875 compounds Chemical class 0.000 claims abstract 31
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 28
- 125000001424 substituent group Chemical group 0.000 claims abstract 25
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 16
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract 13
- 229910052736 halogen Inorganic materials 0.000 claims abstract 11
- 150000002367 halogens Chemical class 0.000 claims abstract 11
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims abstract 9
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 8
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims abstract 8
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims abstract 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 8
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims abstract 7
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims abstract 7
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims abstract 6
- 125000003282 alkyl amino group Chemical group 0.000 claims abstract 5
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims abstract 5
- 125000005368 heteroarylthio group Chemical group 0.000 claims abstract 4
- 125000003386 piperidinyl group Chemical group 0.000 claims abstract 4
- 125000005871 1,3-benzodioxolyl group Chemical group 0.000 claims abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 3
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims abstract 3
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims abstract 3
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims abstract 2
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims abstract 2
- 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 claims abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 2
- 239000001257 hydrogen Substances 0.000 claims abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 9
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 claims 8
- 239000012453 solvate Substances 0.000 claims 8
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 4
- 238000011321 prophylaxis Methods 0.000 claims 4
- 238000011282 treatment Methods 0.000 claims 4
- 125000002393 azetidinyl group Chemical group 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 230000023555 blood coagulation Effects 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 125000000842 isoxazolyl group Chemical group 0.000 claims 2
- CFHGBZLNZZVTAY-UHFFFAOYSA-N lawesson's reagent Chemical compound C1=CC(OC)=CC=C1P1(=S)SP(=S)(C=2C=CC(OC)=CC=2)S1 CFHGBZLNZZVTAY-UHFFFAOYSA-N 0.000 claims 2
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Natural products C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- 125000003566 oxetanyl group Chemical group 0.000 claims 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 125000000168 pyrrolyl group Chemical group 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 125000004853 tetrahydropyridinyl group Chemical group N1(CCCC=C1)* 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 230000009424 thromboembolic effect Effects 0.000 claims 2
- 125000001425 triazolyl group Chemical group 0.000 claims 2
- NXLNNXIXOYSCMB-UHFFFAOYSA-N (4-nitrophenyl) carbonochloridate Chemical compound [O-][N+](=O)C1=CC=C(OC(Cl)=O)C=C1 NXLNNXIXOYSCMB-UHFFFAOYSA-N 0.000 claims 1
- 125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 230000010100 anticoagulation Effects 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 229910052801 chlorine Chemical group 0.000 claims 1
- 239000000460 chlorine Chemical group 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001984 thiazolidinyl group Chemical group 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007057718A DE102007057718A1 (de) | 2007-11-30 | 2007-11-30 | Heteroaryl-substituierte Piperidine |
| DE102008010221A DE102008010221A1 (de) | 2008-02-20 | 2008-02-20 | Heteroaryl-substituierte Piperidine |
| PCT/EP2008/009792 WO2009068214A2 (de) | 2007-11-30 | 2008-11-20 | Heteroaryl-substituierte piperidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110510T1 true HRP20110510T1 (hr) | 2011-08-31 |
Family
ID=40580130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110510T HRP20110510T1 (hr) | 2007-11-30 | 2011-07-07 | Heteroaril-supstituirani piperidini |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8119663B2 (da) |
| EP (1) | EP2227466B1 (da) |
| JP (1) | JP5450435B2 (da) |
| KR (1) | KR20100114018A (da) |
| CN (1) | CN101932577B (da) |
| AR (1) | AR069417A1 (da) |
| AT (1) | ATE506359T1 (da) |
| CA (1) | CA2706991A1 (da) |
| CL (1) | CL2008003473A1 (da) |
| DE (1) | DE502008003324D1 (da) |
| DK (1) | DK2227466T3 (da) |
| HK (1) | HK1152311A1 (da) |
| HR (1) | HRP20110510T1 (da) |
| PA (1) | PA8805201A1 (da) |
| PE (1) | PE20091026A1 (da) |
| PL (1) | PL2227466T3 (da) |
| PT (1) | PT2227466E (da) |
| TW (1) | TW200936135A (da) |
| UY (1) | UY31484A1 (da) |
| WO (1) | WO2009068214A2 (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102009014484A1 (de) | 2009-03-23 | 2010-09-30 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022896A1 (de) * | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022894A1 (de) | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022897A1 (de) * | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102009022895A1 (de) * | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| WO2012001694A1 (en) * | 2010-06-28 | 2012-01-05 | Hetero Research Foundation | Process for olmesartan medoxomil |
| BR112013001613A2 (pt) | 2010-07-22 | 2016-05-24 | Zafgen Inc | compostos tricíclicos e métodos para fazer e usar os mesmos. |
| JP5913333B2 (ja) | 2010-10-12 | 2016-04-27 | ザフゲン，インコーポレイテッド | スルホンアミド化合物、およびそれを製造し使用する方法 |
| WO2012054510A1 (en) * | 2010-10-19 | 2012-04-26 | Comentis, Inc. | Oxadiazole compounds which inhibit beta-secretase activity and methods of use thereof |
| EP2668169B1 (en) | 2011-01-26 | 2017-11-15 | Zafgen, Inc. | Tetrazole compounds and methods of making and using same |
| JP6062423B2 (ja) | 2011-05-06 | 2017-01-18 | ザフゲン，インコーポレイテッド | 部分飽和三環式化合物ならびにその製造および使用方法 |
| WO2012154679A1 (en) | 2011-05-06 | 2012-11-15 | Zafgen Corporation | Tricyclic pyrazole sulfonamide compounds and methods of making and using same |
| CA2835195A1 (en) | 2011-05-06 | 2012-11-15 | Zafgen, Inc. | Tricyclic sulfonamide compounds and methods of making and using same |
| WO2013109739A1 (en) | 2012-01-18 | 2013-07-25 | Zafgen, Inc. | Tricyclic sulfonamide compounds and methods of making and using same |
| EP2804856B1 (en) | 2012-01-18 | 2017-03-15 | Zafgen, Inc. | Tricyclic sulfone compounds and methods of making and using same |
| EP2925737B1 (en) | 2012-11-05 | 2017-06-14 | Zafgen, Inc. | Tricyclic compounds for use in the treatment and/or control of obesity |
| EA028367B1 (ru) | 2012-11-05 | 2017-11-30 | Зафджен, Инк. | Способы лечения заболеваний печени |
| AU2013337282A1 (en) | 2012-11-05 | 2015-05-21 | Zafgen, Inc. | Tricyclic compounds and methods of making and using same |
| CN103965095A (zh) * | 2013-02-04 | 2014-08-06 | 艾琪康医药科技（上海）有限公司 | 1-r1-3-r2-4-氟哌啶及其衍生物的制备方法 |
| CN104341590A (zh) * | 2013-08-01 | 2015-02-11 | 韩冰 | 一种树枝状高分子化合物及其制备和用途 |
| JP7413346B2 (ja) | 2019-03-06 | 2024-01-15 | 第一三共株式会社 | ピロロピラゾール誘導体 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA951618B (en) * | 1994-03-04 | 1996-08-27 | Lilly Co Eli | Antithrombotic agents |
| US5767144A (en) * | 1994-08-19 | 1998-06-16 | Abbott Laboratories | Endothelin antagonists |
| PT885215E (pt) * | 1996-02-13 | 2006-08-31 | Abbott Lab | Novos derivados de pirrolidina substituidos com benzo-1,3-dioxolilo e benzofuranilo como antagonistas de endotelina |
| WO1997036873A1 (en) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone |
| US6403612B2 (en) * | 2000-01-31 | 2002-06-11 | Merck & Co., Inc. | Thrombin receptor antagonists |
| DE60231608D1 (de) * | 2001-04-19 | 2009-04-30 | Eisai R&D Man Co Ltd | Cyclische amidinderivate |
| UA75980C2 (en) * | 2001-10-15 | 2006-06-15 | Janssen Pharmaceutica Nv | Substituted 4-pheny1-4-[1h-imidazol-2-yl] piperidine derivative for reducing ischaemic damages |
| US7030141B2 (en) * | 2001-11-29 | 2006-04-18 | Christopher Franklin Bigge | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade |
| EA200700117A1 (ru) * | 2004-06-24 | 2007-06-29 | Инсайт Корпорейшн | N-замещенные пиперидины и их применение в качестве фармацевтических препаратов |
| JP2008504279A (ja) | 2004-06-24 | 2008-02-14 | インサイト・コーポレイション | アミド化合物およびその医薬としての使用 |
| WO2006002349A1 (en) | 2004-06-24 | 2006-01-05 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| JP2008509910A (ja) | 2004-08-10 | 2008-04-03 | インサイト・コーポレイション | アミド化合物およびその医薬としての使用 |
| DE102004045796A1 (de) * | 2004-09-22 | 2006-03-23 | Merck Patent Gmbh | Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung |
| JPWO2006051623A1 (ja) * | 2004-11-09 | 2008-05-29 | エーザイ株式会社 | トロンビン受容体アンタゴニストを有効成分とするくも膜下出血に伴う血管攣縮の治療剤 |
| WO2007038138A2 (en) | 2005-09-21 | 2007-04-05 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| TW200804341A (en) | 2006-01-31 | 2008-01-16 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| TW200808807A (en) | 2006-03-02 | 2008-02-16 | Incyte Corp | Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
| CA2649677A1 (en) * | 2006-05-01 | 2007-11-15 | Incyte Corporation | Tetrasubstituted ureas as modulators of 11-.beta. hydroxyl steroid dehydrogenase type 1 |
-
2008
- 2008-11-20 PL PL08854224T patent/PL2227466T3/pl unknown
- 2008-11-20 CN CN2008801260263A patent/CN101932577B/zh not_active Expired - Fee Related
- 2008-11-20 DE DE502008003324T patent/DE502008003324D1/de active Active
- 2008-11-20 WO PCT/EP2008/009792 patent/WO2009068214A2/de active Application Filing
- 2008-11-20 CA CA2706991A patent/CA2706991A1/en not_active Abandoned
- 2008-11-20 KR KR1020107014447A patent/KR20100114018A/ko not_active Application Discontinuation
- 2008-11-20 JP JP2010535272A patent/JP5450435B2/ja not_active Expired - Fee Related
- 2008-11-20 EP EP08854224A patent/EP2227466B1/de not_active Not-in-force
- 2008-11-20 DK DK08854224.6T patent/DK2227466T3/da active
- 2008-11-20 AT AT08854224T patent/ATE506359T1/de active
- 2008-11-20 PT PT08854224T patent/PT2227466E/pt unknown
- 2008-11-21 CL CL2008003473A patent/CL2008003473A1/es unknown
- 2008-11-24 UY UY31484A patent/UY31484A1/es not_active Application Discontinuation
- 2008-11-24 AR ARP080105089A patent/AR069417A1/es unknown
- 2008-11-24 PE PE2008001960A patent/PE20091026A1/es not_active Application Discontinuation
- 2008-11-25 PA PA20088805201A patent/PA8805201A1/xx unknown
- 2008-11-25 US US12/323,454 patent/US8119663B2/en not_active Expired - Fee Related
- 2008-11-28 TW TW097146090A patent/TW200936135A/zh unknown
-
2011
- 2011-06-23 HK HK11106516.9A patent/HK1152311A1/xx not_active IP Right Cessation
- 2011-07-07 HR HR20110510T patent/HRP20110510T1/hr unknown
-
2012
- 2012-02-20 US US13/400,491 patent/US20120214788A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US8119663B2 (en) | 2012-02-21 |
| JP2011504889A (ja) | 2011-02-17 |
| WO2009068214A2 (de) | 2009-06-04 |
| DK2227466T3 (da) | 2011-08-08 |
| PA8805201A1 (es) | 2010-02-12 |
| CN101932577A (zh) | 2010-12-29 |
| JP5450435B2 (ja) | 2014-03-26 |
| TW200936135A (en) | 2009-09-01 |
| WO2009068214A3 (de) | 2009-08-20 |
| HK1152311A1 (en) | 2012-02-24 |
| PL2227466T3 (pl) | 2011-09-30 |
| CA2706991A1 (en) | 2009-06-04 |
| US20090306139A1 (en) | 2009-12-10 |
| AR069417A1 (es) | 2010-01-20 |
| CN101932577B (zh) | 2013-07-17 |
| US20120214788A1 (en) | 2012-08-23 |
| EP2227466A2 (de) | 2010-09-15 |
| ATE506359T1 (de) | 2011-05-15 |
| PE20091026A1 (es) | 2009-07-26 |
| CL2008003473A1 (es) | 2009-08-14 |
| PT2227466E (pt) | 2011-07-01 |
| KR20100114018A (ko) | 2010-10-22 |
| DE502008003324D1 (de) | 2011-06-01 |
| EP2227466B1 (de) | 2011-04-20 |
| UY31484A1 (es) | 2009-07-17 |
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