US5410035A - Food composition having hypotensive effect - Google Patents

Food composition having hypotensive effect Download PDF

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Publication number
US5410035A
US5410035A US08/051,279 US5127993A US5410035A US 5410035 A US5410035 A US 5410035A US 5127993 A US5127993 A US 5127993A US 5410035 A US5410035 A US 5410035A
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US
United States
Prior art keywords
dextrin
pyrodextrin
indigestible dextrin
amylase
indigestible
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US08/051,279
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English (en)
Inventor
Shigeru Wakabayashi
Kazuhiro Ohkuma
Yoshimi Mochizuki
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Matsutani Chemical Industries Co Ltd
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Matsutani Chemical Industries Co Ltd
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Priority to US08/051,279 priority Critical patent/US5410035A/en
Application granted granted Critical
Publication of US5410035A publication Critical patent/US5410035A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/163—Sugars; Polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A23L29/35—Degradation products of starch, e.g. hydrolysates, dextrins; Enzymatically modified starches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/326—Foods, ingredients or supplements having a functional effect on health having effect on cardiovascular health

Definitions

  • the present invention relates to food compositions or feed compositions having a hypotensive effect and therefore very useful for preventing hypertension.
  • Hypertension is thought attributable to a tangle of genetic factors and other factors, such as dietary factors including excessive intake of salt and obesity, and constitutional or renal factors and endocrine nerve factors including hyperlipidemia, while more than 90% of hypertensives are said to be affected with essential hypertension, the etiology of which has yet to be determined definitely.
  • alimentotherapy The fundamental principles of alimentotherapy are said to be salt restriction, intake of sufficient quantities of proteins from dishes seasoned lightly, intake of milk, vegetables, seaweeds, fruits and the like, restriction of oils and fats to be taken to those of vegetable origin, intake of dietary fibers and refraining from eating out.
  • dietary fibers are divided generally into insoluble fibers and those soluble in water.
  • the former include cellulose, lignin, hemicelluloses A and C, chitin, collagen, etc. Examples of the latter are pectin, guar gum, mannans of devil's-tongues, sodium alginate, carageenan, agar, carboxymethlcellulose, indigestible dextrin, polydextrose and the like.
  • these dietary fibers have a relationship with cancer of the colon, diabetes, hypercholesterolemia, biliary calculus, etc., they have not been fully investigated in connection with hypertension except that the alginate is known to be effective for removing sodium.
  • obesity can be obviated or prevented effectively by ingesting foods which contain hemicellulose extracted from grains or beans or polysaccharides such as pectic substances, guar gum and polydextrose.
  • An object of the present invention is to newly develop a food having a hypotensive effect.
  • Another object of the invention is to newly develop a food having a hypotensive effect afforded by using an indigestible dextrin which is a kind of water-soluble dietary fiber.
  • indigestible dextrins which are water-soluble dietary fibers and developed new food compositions based on the finding that these dextrins have effects to ameliorate the intestinal function, to alleviate hypercholesterolemia and to lower insulin requirements.
  • dextrins of the type mentioned have a hypotensive effect and accomplished the present invention.
  • compositions having a hypotensive effect can be prepared by incorporating into a food an indigestible dextrin which is the indigestible component of pyrodextrin obtained by refining pyrodextrin or which is obtained by concentrating the indigestible component, although pyrodextrin was conventionally almost in no way regarded as a food material.
  • dietary fibers which are not nutritive, were in the past removed as residues in food production processes to the greatest possible extent.
  • the dietary fiber has been defined as "including all indigestible components of foods which can not be digested with human digestive enzymes.”
  • the term "dietary fiber” is used herein also in conformity with this definition and includes water-soluble fibers, insoluble fibers, etc., i.e., all of those as defined above. Examples of dietary fibers are as follows.
  • pectin pectin
  • guar gum mannans of devil's-tongues
  • sodium alginate sodium alginate
  • carageenan etc.
  • the indigestible dextrins for use in the present invention are divided into three general categories.
  • a dextrin prepared by treating pyrodextrin with at least one of ⁇ -amylase, ⁇ -amylase and glucoamylase, and refining the resulting dextrin with activated carbon, ion exchange resins or the like.
  • a dextrin prepared by fractionating the dextrin (i) using an ion exchange resin to obtain a concentrated indigestible component.
  • the composition of the present invention exhibits a hypotensive effect insofar as it contains the indigestible dextrin
  • the composition contains the dextrin preferably in an amount of up to 20g by weight. This amount is not absolute but is suitably variable in accordance with the intake of the food composition and the condition of the person who is to take the composition.
  • the food for use in the invention includes a wide variety of foods, typical of which are, for example, beverages, cakes, dressings for frozen cakes, pastelike marine products, etc.
  • the dextrin can be incorporated also in feeds for animals.
  • a 1.0 kg quantity of hot water was added to 1.0 kg of the pyrodextrin thus prepared, and the solution was neutralized with 1N sodium hydroxide to a pH of 5.8.
  • To the solution was added 0.1 % of ⁇ -amylase (Termamyl 120L, product of Novo Industry Co., Ltd.) to effect a reaction at 95° C. for 1 hour.
  • the reaction mixture was thereafter heated to 115° C. to complete the reaction.
  • the reaction mixture was then adjusted to a pH of 5.5 and a temperature 55° C., and 0.05% of ⁇ -amylase (product of Amano Seiyaku Co., Ltd.) and 0.1% of transglucosidase (product of Amano Seiyaku Co., Ltd.) were added to and reacted with the mixture for 24 hours to obtain a dextrin having the following sugar composition.
  • ⁇ -amylase product of Amano Seiyaku Co., Ltd.
  • transglucosidase product of Amano Seiyaku Co., Ltd.
  • the dextrin solution was further refined and concentrated in the usual manner using activated carbon and ion exchange resin, and the product was dried by a spray dryer to obtain a powder.
  • a 5,000 kg of commercial potato starch was placed into a ribbon mixer, 150 liters of 1.0% hydrochloric acid was sprayed on the starch with stirring, and the mixture was subsequently passed through a mixer to prepare a uniform mixture, which was then aged in the ribbon mixer for 5 hours.
  • the mixture was pre-dried by a flush dryer to a water content of 3%, thereafter continuously placed into a roaster of the rotary kiln type and roasted at 180° C. for 2 hours.
  • a 10 kg quantity of pyrodextrin (Arabix #7, product of Matsutani Chemical Industries, Co., Ltd.) was dissolved in 20 kg of water, the solution was adjusted to a pH of 5.5, and 0.2 wt. % of ⁇ -amylase (Klaistase, product of Daiwa Kasei Co., Ltd.) was added to the solution to effect a reaction at 85° C. for 1 hour.
  • the reaction mixture was then maintained at a temperature of 120° C. for 15 minutes to deactivate the amylase, cooled to a temperature of 55° C., adjusted to a pH of 4.5 and reacted with 0.1 wt.
  • glucoamylase product of Amano Seiyaku Co., Ltd.
  • the mixture was then purified using activated carbon and ion exchange resins and thereafter concentrated, giving 1.5 kg of 50% solution.
  • the solution had the sugar composition of 51.2% of glucose, 2.2% of disaccharide, 3.9% of trisaccharide, and 42.8% of tetrasaccharide and higher oligosaccharides.
  • the sugar composition of the product was 4.4% of glucose, 1.2% of disaccharide, 1.7% of trisaccharide and 92.1% of tetrasaccharide.
  • the dextrin was 83.9% in dietary fiber content as determined by the Proskey-AOAC method.
  • the product was further treated in the same manner as in Reference Example 1 to obtain a powder.
  • mice Male rats initially weighing about 300g and spontaneously developing hypertension (17-week-old, provided by Hoshino Test Animal Farm) were preliminarily raised in groups, five rats in each group, then fed on a feed containing an indigestible dextrin of the invention or on a basic feed (AIN prescription) for 15 days, and checked for blood pressure and total blood cholesterol with time. The feed for the dextrin containing groups was changed to the basic feed further until 27th day. The compositions of the feeds were listed in Table 1, and the test results in Tables 2 and 3.
  • Table 2 reveals that the rats raised with the dextrin-containing feed of the invention exhibited a significantly lower blood pressure value than the control group on the 15th day, and higher blood pressure after the change of feed to the basic feed on the 27th day.
  • Table 3 shows that the rats raised with the dextrin-containing feed of the invention were lower in total blood cholesterol value than the control group on the 8th day and the 15th day. These rats were comparable to the control group in feed intake and weight changes. This indicates that the dextrin-containing feeds were satisfactorily usable with safety.
  • a carbonated beverage composition which can be taken as a food for alimentotherapy for a prolonged period of time was prepared according to the following formulation.
  • a jelly composition was prepared according to the following formulation.
  • An ice cream composition was prepared according to the following formulation.
  • Example 3 The carbonated beverage composition of Example 3 was given to 20 hypertensives in an amount of 200g daily for each for 6 months, resulting in reduction of average blood pressure from 111.5 ⁇ 9.7 to 104.8 ⁇ 9.6 mmHg.
  • Example 4 The jelly composition of Example 4 were give in an amount of 300g, and ice cream composition of Example 5 were given in an amount of 200g to each 15 hypertensives daily for each for 6 months. This resulted in reduction of average blood pressure from 108.8 ⁇ 8.3 to 103.2 ⁇ 9.2 mmHg.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Fodder In General (AREA)
US08/051,279 1990-08-07 1993-04-23 Food composition having hypotensive effect Expired - Lifetime US5410035A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US08/051,279 US5410035A (en) 1990-08-07 1993-04-23 Food composition having hypotensive effect

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2209732A JPH0745521B2 (ja) 1990-08-07 1990-08-07 高血圧降下作用を有する高血圧降下剤
JP2-209732 1990-08-07
US72972991A 1991-07-15 1991-07-15
US91400492A 1992-07-16 1992-07-16
US08/051,279 US5410035A (en) 1990-08-07 1993-04-23 Food composition having hypotensive effect

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US91400492A Continuation 1990-08-07 1992-07-16

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US5410035A true US5410035A (en) 1995-04-25

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US (1) US5410035A (de)
EP (1) EP0470895B1 (de)
JP (1) JPH0745521B2 (de)
KR (1) KR100201350B1 (de)
AT (1) ATE131007T1 (de)
DE (1) DE69115160T2 (de)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025010A (en) * 1997-11-21 2000-02-15 Lipton, Division Of Conopco, Inc. Multifunctional spread
EP1281721A1 (de) * 2001-08-03 2003-02-05 National Starch and Chemical Investment Holding Corporation Thermisch modifizierte Stärke und Verfahren zu deren Herstellung
US20050220845A1 (en) * 2004-04-02 2005-10-06 Matsutani Chemical Industries Co., Ltd. Foods and drinks having health benefits and method for adding health benefits to foods and drinks
US20060217363A1 (en) * 2001-09-21 2006-09-28 Davis Harry R Methods and therapeutic combinations for the treatment of hypercholesterolemia and xanthoma using sterol absorption inhibitors
US20060222930A1 (en) * 2005-04-04 2006-10-05 Takao Aradachi Battery pack and cordless power tool having the same
US20060222754A1 (en) * 2005-04-04 2006-10-05 Singer Norman S Product and method for enhancing the appeal, and dietary value of foodstuff
US20060233916A1 (en) * 2003-09-15 2006-10-19 Trouw International B.V. Fish fodder for freshwater fish and use of such fodder
WO2007025006A1 (en) * 2005-08-25 2007-03-01 Archer-Daniels-Midland Company Use of dextrin in animal feeds
EP1817965A1 (de) * 2004-12-03 2007-08-15 Arkray, Inc. Wasserlösliche trockennahrung
WO2015051308A1 (en) 2013-10-03 2015-04-09 Altria Client Services Inc. Lozenge
WO2015051306A1 (en) 2013-10-03 2015-04-09 Altria Client Services Inc. Dissolvable chewable tablet
US9351936B2 (en) 2013-10-03 2016-05-31 Altria Client Services Llc Nicotine lozenge
WO2018064043A2 (en) 2016-09-27 2018-04-05 Altria Client Services Llc Tobacco beads
US9999243B2 (en) 2013-10-03 2018-06-19 Altria Client Services Llc Exhausted tobacco lozenge
US10105320B2 (en) 2013-10-03 2018-10-23 Altria Client Services Soluble fiber lozenge
US10244786B2 (en) 2013-10-03 2019-04-02 Altria Client Services Llc Tobacco lozenge
CN112040972A (zh) * 2018-02-16 2020-12-04 森永乳业株式会社 用于降低血压和/或用于减少中性脂肪的组合物
US11771127B2 (en) 2013-10-03 2023-10-03 Altria Client Services Llc Chewable dissolvable nicotine tablet
US11779045B2 (en) 2013-10-03 2023-10-10 Altria Client Services Llc Dissolvable-chewable exhausted-tobacco tablet

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JPH04173094A (ja) * 1990-11-08 1992-06-19 Matsutani Kagaku Kogyo Kk 低カロリー・デキストリンの製造法
JPH05178902A (ja) * 1991-10-29 1993-07-20 Matsutani Kagaku Kogyo Kk 難消化デキストリン
JP3169430B2 (ja) * 1992-04-03 2001-05-28 大日本製薬株式会社 低カロリー食品用組成物
JP3146086B2 (ja) * 1993-03-24 2001-03-12 松谷化学工業株式会社 鶏飼料
JPH0759517A (ja) * 1993-08-24 1995-03-07 Matsutani Chem Ind Ltd 肥満予防効果を有するペットフード
US6422958B1 (en) 1994-02-24 2002-07-23 David W. Repetto Frame for a game racquet formed by filament winding
JP4606550B2 (ja) * 2000-06-09 2011-01-05 松谷化学工業株式会社 易分散性大豆蛋白造粒物及びその製造法
US6991812B2 (en) 2000-09-05 2006-01-31 Kao Corporation Agent for preventing, improving or treating hypertension
JP5535456B2 (ja) * 2008-07-09 2014-07-02 松谷化学工業株式会社 食物繊維と希少糖を含む生体機能改善組成物。
JP5892295B2 (ja) * 2013-11-19 2016-03-23 日清オイリオグループ株式会社 粉末油脂組成物およびその製造方法

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JPS62220169A (ja) * 1986-03-18 1987-09-28 Yakult Honsha Co Ltd 流動性食品
JPS63150226A (ja) * 1986-12-12 1988-06-22 Asahi Chem Ind Co Ltd 医療用高残渣経管流動食
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JPH0646919B2 (ja) * 1990-01-24 1994-06-22 参松工業株式会社 難消化性多糖類を含有する水あめの製造法

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US4510166A (en) * 1984-01-19 1985-04-09 National Starch And Chemical Corporation Converted starches for use as a fat- or oil-replacement in foodstuffs
EP0368451A2 (de) * 1988-10-07 1990-05-16 Matsutani Chemical Industries Co. Ltd. Verfahren zur Herstellung von Dextrin enthaltenden faserigen Nahrungsprodukten

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* Cited by examiner, † Cited by third party
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US6025010A (en) * 1997-11-21 2000-02-15 Lipton, Division Of Conopco, Inc. Multifunctional spread
US6203842B1 (en) * 1997-11-21 2001-03-20 Lipton, Division Of Conopco, Inc. Multifunctional spread
EP1281721A1 (de) * 2001-08-03 2003-02-05 National Starch and Chemical Investment Holding Corporation Thermisch modifizierte Stärke und Verfahren zu deren Herstellung
US20030031775A1 (en) * 2001-08-03 2003-02-13 Altieri Paul A. Thermally converted starches and the method of preparation thereof
US6746705B2 (en) 2001-08-03 2004-06-08 National Starch And Chemical Investment Holding Corporation Thermally converted starches and the method of preparation thereof
US20060217363A1 (en) * 2001-09-21 2006-09-28 Davis Harry R Methods and therapeutic combinations for the treatment of hypercholesterolemia and xanthoma using sterol absorption inhibitors
US8632830B2 (en) 2003-09-15 2014-01-21 Trouw International B.V. Fish fodder for freshwater fish and use of such fodder
US20060233916A1 (en) * 2003-09-15 2006-10-19 Trouw International B.V. Fish fodder for freshwater fish and use of such fodder
US20050220845A1 (en) * 2004-04-02 2005-10-06 Matsutani Chemical Industries Co., Ltd. Foods and drinks having health benefits and method for adding health benefits to foods and drinks
US8618078B2 (en) 2004-04-02 2013-12-31 Matsutani Chemical Industry Co., Ltd. Foods and drinks having health benefits and method for adding health benefits to foods and drinks
US20090239823A1 (en) * 2004-04-02 2009-09-24 Matsutani Chemical Industries Co., Ltd. Foods and drinks having health benefits and method for adding health benefits to foods and drinks
EP1817965A1 (de) * 2004-12-03 2007-08-15 Arkray, Inc. Wasserlösliche trockennahrung
US20080131580A1 (en) * 2004-12-03 2008-06-05 Arkray, Inc. Water-Soluble Dry Food
EP1817965A4 (de) * 2004-12-03 2009-07-08 Arkray Inc Wasserlösliche trockennahrung
US20060222754A1 (en) * 2005-04-04 2006-10-05 Singer Norman S Product and method for enhancing the appeal, and dietary value of foodstuff
US20060222930A1 (en) * 2005-04-04 2006-10-05 Takao Aradachi Battery pack and cordless power tool having the same
US20070048432A1 (en) * 2005-08-25 2007-03-01 Archer-Daniels-Midland Company Use of dextrin in animal feeds
WO2007025006A1 (en) * 2005-08-25 2007-03-01 Archer-Daniels-Midland Company Use of dextrin in animal feeds
US9351936B2 (en) 2013-10-03 2016-05-31 Altria Client Services Llc Nicotine lozenge
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US11849753B2 (en) 2013-10-03 2023-12-26 Altria Client Services Llc Tobacco lozenge
US9943511B2 (en) 2013-10-03 2018-04-17 Altria Client Services Llc Nicotine lozenge
US9999243B2 (en) 2013-10-03 2018-06-19 Altria Client Services Llc Exhausted tobacco lozenge
US10105320B2 (en) 2013-10-03 2018-10-23 Altria Client Services Soluble fiber lozenge
US10244786B2 (en) 2013-10-03 2019-04-02 Altria Client Services Llc Tobacco lozenge
US10702516B2 (en) 2013-10-03 2020-07-07 Altria Client Services Llc Nicotine lozenge
US11779045B2 (en) 2013-10-03 2023-10-10 Altria Client Services Llc Dissolvable-chewable exhausted-tobacco tablet
US11771127B2 (en) 2013-10-03 2023-10-03 Altria Client Services Llc Chewable dissolvable nicotine tablet
WO2015051306A1 (en) 2013-10-03 2015-04-09 Altria Client Services Inc. Dissolvable chewable tablet
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EP3753569A4 (de) * 2018-02-16 2021-12-15 Morinaga Milk Industry Co., Ltd. Zusammensetzung zur senkung des blutdrucks und / oder zur senkung von neutralfetten
CN112040972A (zh) * 2018-02-16 2020-12-04 森永乳业株式会社 用于降低血压和/或用于减少中性脂肪的组合物

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JPH0491765A (ja) 1992-03-25
EP0470895B1 (de) 1995-12-06
ATE131007T1 (de) 1995-12-15
DE69115160D1 (de) 1996-01-18
KR100201350B1 (ko) 1999-06-15
JPH0745521B2 (ja) 1995-05-17
DE69115160T2 (de) 1996-05-09
KR920003987A (ko) 1992-03-27
EP0470895A1 (de) 1992-02-12

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