Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
  • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/37—Esters of carboxylic acids
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
  • A61K8/42—Amides
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/007—Preparations for dry skin

Definitions

• the present invention relates to a sebaceous excitosecretory agent exhibiting a long-lasting excitosecretory action on sebaceous glands.
• the skin or hair is kept healthy and beautiful by sebum secreted from sebaceous glands.
• the skin gradually loses its smoothness and moistness from adolescence to senescence due to a failure of the sebaceous secretory function, especially in females.
• drugs, medical supplies and cosmetics for oil supply in various forms such as creams, clear lotions and milky lotions, have hitherto been employed.
• An object of the present invention is to provide a sebaceous excitosecretory agent that has a prolonged action of exciting secretion of sebum and continuously accelerates oil supply to the skin.
• Another object of the present invention is to provide a process for exciting secretion of sebum using the above sebaceous excitosecretory agent.
• the inventors of the present invention have studied various physiologically active substances and found as a result that undecylenic acid excites the function of sebaceous glands and thus completed the present invention.
• the present invention relates to a sebaceous excitosecretory agent comprising at least one of undecylenic acid, its salts, its esters, and its amide derivatives as an active ingredient.
• the present invention also relates to a process for exiting secretion of sebum comprising the step of applying the above sebaceous excitosecretory agent onto a skin surface.
• the sebaceous excitosecretory agent of the present invention also proved effective to improve the skin in the convalescence following senile xeroderma and eszematosis of dry type such as atopic dermatitis.
• Undecylenic acid is a fatty acid present in sweat and is known for long to have antimicrobial activity. There has been reported that undecylenic acid is incorporated into shampoos, etc. as an anti-dandruff agent or used as not yet been reported.
• Undecylenic acid to be used in the present invention may be in the form of a free acid as well as a salt, an ester or an amide derivative.
• the salts of undecylenic acid include potassium, sodium, calcium, magnesium, and zinc salts.
• the undecylenic esters include alkyl esters, e.g., methyl, ethyl, propyl, and isopropyl esters; aromatic esters, e.g., benzyl and allyl esters; esters with a polyhydric alcohols, e.g., glycerin, propylene glycol, and polyethylene glycol; and an epoxypropyl ester.
• amide derivatives of undecylenic acid examples include a monoethanolamide and a diethanolamide.
• the salt, ester or amide derivative of undecylenic acid used in the present invention is not limited to the above examples.
• the undecylenic acid and derivatives thereof may be used either individually or in combination of two or more thereof.
• the sebaceous excitosecretory action of undecylenic acid was investigated according to the following Reference Example.
• Ten week-old hamsters were divided into three groups each consisting of 4 animals.
• a first group was maintained on 0.05 ml/animal/day of a 5 wt % solution of undecylenic acid in ethanol applied to the inner side of the auricle for consecutive 14 days.
• a second group was maintained on 0.05 ml/animal/day of a 1 wt % solution of undecylenic acid in ethanol in the same manner.
• ethanol containing no undecylenic acid was administered in the same manner.
• the area of the sebaceous glands in the inner side of the auricle was measured by means of an image analyzer. The results obtained are shown in Table 1 below.
• Components of the sebaceous excitosecretory agent other than the above-mentioned active ingredients can be selected from known components.
• the sebaceous excitosecretory agent of the present invention may have various dose forms, such as clear lotions, oils, ointments, creams, and milky lotions, according to known techniques.
• Undecylenic acid is a fatty acid contained in sweat as stated above and is of no harm to the human body. Therefore, the concentrations of undecylenic acid, its salts, its ester derivatives, and its amide derivatives in these dose forms is not particularly limited and can appropriately be determined according to the dose form as long as the effectiveness of the agent is not adversely affected.
• the concentration is generally from 0.01 to 10% by weight, and preferably from 0.1 to 5% by weight, based on the total amount of the agent.
• the sebaceous excitosecretory agent of the present invention may further contain other components generally employed in conventional cosmetics as long as the effects of the present invention are not impaired.
• the sebaceous excitosecretory agent of the present invention can be used in a conventional manner so as to excite secretion of sebum to prevent drying of the skin.
• the sebaceous excitosecretory agent of the present invention can be applied to dry parts of the skin surface with hands or fingers one or more times a day for the face, or 2 to 4 times a day for hands, legs and other parts.
• the application amount of the sebaceous excitosecretory agent of the present invention varies depending on the composition and the part to which the agent is applied, and is generally from 0.05 to 1.0 g per 100 cm 2 of skin.
• the clear lotion having the above formulation can be used by applying with hands to a dry skin surface of a face, hands, leg and the like several times a day.
• the oil having the above formulation can be used by applying a few drops of the oil to a dry skin surface of a face, hands, legs and the like 1 to several times a day.
• the cream having the above formulation can be used by applying to a dry skin surface of a face, hands, legs and the like 1 to 3 times a day.
• the milky lotion having the above formulation can be used by applying in the similar manner as for the clear lotion.
• the cosmetics for skin care according to the present invention excite the sebaceous secretory function essentially possessed by the human skin and supply oily matters to the skin in a natural and continuous manner to thereby give the skin or hair smoothness and moistness.
• the sebaceous excitosecretory agent of the present invention is effective to improve skin conditions in the convalescence following eszematosis of dry type such as senile xeroderma and atopic dermatitis.

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Birds (AREA)
• Epidemiology (AREA)
• Dermatology (AREA)
• Emergency Medicine (AREA)
• Engineering & Computer Science (AREA)
• Bioinformatics & Cheminformatics (AREA)
• Chemical & Material Sciences (AREA)
• Chemical Kinetics & Catalysis (AREA)
• General Chemical & Material Sciences (AREA)
• Medicinal Chemistry (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Organic Chemistry (AREA)
• Pharmacology & Pharmacy (AREA)
• Cosmetics (AREA)
• Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Applications Claiming Priority (2)

Publications (1)

Family

ID=17316756

Family Applications (1)

Country Status (4)

Cited By (1)

Families Citing this family (6)

Citations (1)

• 1990
  • 1990-09-26 JP JP2258189A patent/JPH082772B2/ja not_active Expired - Fee Related
• 1991
  • 1991-09-23 US US07/763,707 patent/US5190758A/en not_active Expired - Fee Related
  • 1991-09-25 EP EP91116374A patent/EP0477927A1/en not_active Ceased
  • 1991-09-25 CA CA002052231A patent/CA2052231A1/en not_active Abandoned

Patent Citations (1)

Non-Patent Citations (3)

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