US20120129853A1 - Methods of treatment using selective bcl-2 inhibitors - Google Patents

Methods of treatment using selective bcl-2 inhibitors Download PDF

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Publication number
US20120129853A1
US20120129853A1 US13/301,898 US201113301898A US2012129853A1 US 20120129853 A1 US20120129853 A1 US 20120129853A1 US 201113301898 A US201113301898 A US 201113301898A US 2012129853 A1 US2012129853 A1 US 2012129853A1
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United States
Prior art keywords
methyl
piperazin
chlorophenyl
sulfonyl
benzamide
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Abandoned
Application number
US13/301,898
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English (en)
Inventor
Steven Elmore
Andrew Souers
Li Chun Wang
Tariq Ghayur
Stuart J. Perper
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AbbVie Inc
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Abbott Laboratories
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45218888&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20120129853(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Priority to US13/301,898 priority Critical patent/US20120129853A1/en
Assigned to ABBOTT LABORATORIES reassignment ABBOTT LABORATORIES ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SOUERS, ANDREW, GHAYUR, TARIQ, PERPER, STUART J., WANG, LI CHUN, ELMORE, STEVEN
Publication of US20120129853A1 publication Critical patent/US20120129853A1/en
Assigned to ABBVIE INC. reassignment ABBVIE INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ABBOTT LABORATORIES
Priority to US14/535,070 priority patent/US9345702B2/en
Priority to US15/136,582 priority patent/US9872861B2/en
Priority to US15/838,605 priority patent/US20180369250A1/en
Priority to US16/415,515 priority patent/US20200222413A1/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
US13/301,898 2010-11-23 2011-11-22 Methods of treatment using selective bcl-2 inhibitors Abandoned US20120129853A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US13/301,898 US20120129853A1 (en) 2010-11-23 2011-11-22 Methods of treatment using selective bcl-2 inhibitors
US14/535,070 US9345702B2 (en) 2010-11-23 2014-11-06 Methods of treatment using selective Bcl-2 inhibitors
US15/136,582 US9872861B2 (en) 2010-11-23 2016-04-22 Methods of treatment using selective Bcl-2 inhibitors
US15/838,605 US20180369250A1 (en) 2010-11-23 2017-12-12 Methods of treatment using selective bcl-2 inhibitors
US16/415,515 US20200222413A1 (en) 2010-11-23 2019-05-17 Methods of treatment using selective bcl-2 inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41668910P 2010-11-23 2010-11-23
US13/301,898 US20120129853A1 (en) 2010-11-23 2011-11-22 Methods of treatment using selective bcl-2 inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/535,070 Continuation US9345702B2 (en) 2010-11-23 2014-11-06 Methods of treatment using selective Bcl-2 inhibitors

Publications (1)

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US20120129853A1 true US20120129853A1 (en) 2012-05-24

Family

ID=45218888

Family Applications (5)

Application Number Title Priority Date Filing Date
US13/301,898 Abandoned US20120129853A1 (en) 2010-11-23 2011-11-22 Methods of treatment using selective bcl-2 inhibitors
US14/535,070 Active US9345702B2 (en) 2010-11-23 2014-11-06 Methods of treatment using selective Bcl-2 inhibitors
US15/136,582 Active US9872861B2 (en) 2010-11-23 2016-04-22 Methods of treatment using selective Bcl-2 inhibitors
US15/838,605 Abandoned US20180369250A1 (en) 2010-11-23 2017-12-12 Methods of treatment using selective bcl-2 inhibitors
US16/415,515 Abandoned US20200222413A1 (en) 2010-11-23 2019-05-17 Methods of treatment using selective bcl-2 inhibitors

Family Applications After (4)

Application Number Title Priority Date Filing Date
US14/535,070 Active US9345702B2 (en) 2010-11-23 2014-11-06 Methods of treatment using selective Bcl-2 inhibitors
US15/136,582 Active US9872861B2 (en) 2010-11-23 2016-04-22 Methods of treatment using selective Bcl-2 inhibitors
US15/838,605 Abandoned US20180369250A1 (en) 2010-11-23 2017-12-12 Methods of treatment using selective bcl-2 inhibitors
US16/415,515 Abandoned US20200222413A1 (en) 2010-11-23 2019-05-17 Methods of treatment using selective bcl-2 inhibitors

Country Status (36)

Country Link
US (5) US20120129853A1 (ko)
EP (2) EP3028702B1 (ko)
JP (2) JP5876067B2 (ko)
KR (3) KR101841084B1 (ko)
CN (2) CN103402521B (ko)
AR (1) AR083946A1 (ko)
AU (2) AU2011332000B2 (ko)
BR (1) BR112013012854B1 (ko)
CA (1) CA2820618C (ko)
CL (1) CL2013001458A1 (ko)
CR (1) CR20130268A (ko)
CY (1) CY1118442T1 (ko)
DK (1) DK2642999T3 (ko)
DO (1) DOP2017000056A (ko)
EC (1) ECSP13012710A (ko)
ES (2) ES2603129T3 (ko)
GT (1) GT201300136A (ko)
HR (1) HRP20161762T1 (ko)
HU (1) HUE031267T2 (ko)
IL (2) IL226490A (ko)
LT (1) LT2642999T (ko)
MX (1) MX346201B (ko)
MY (2) MY191300A (ko)
NZ (2) NZ610746A (ko)
PH (1) PH12016500939A1 (ko)
PL (1) PL2642999T3 (ko)
PT (1) PT2642999T (ko)
RS (1) RS55545B1 (ko)
RU (1) RU2593231C2 (ko)
SG (2) SG190399A1 (ko)
SI (1) SI2642999T1 (ko)
TW (2) TWI535701B (ko)
UA (2) UA113157C2 (ko)
UY (1) UY33746A (ko)
WO (1) WO2012071374A1 (ko)
ZA (1) ZA201303589B (ko)

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US8722657B2 (en) 2010-11-23 2014-05-13 Abbvie Inc. Salts and crystalline forms of an apoptosis-inducing agent
WO2014158528A1 (en) * 2013-03-14 2014-10-02 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
WO2014165044A1 (en) 2013-03-13 2014-10-09 Abbvie Inc. Processes for the preparation of an apoptosis-inducing agent
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US9045475B2 (en) 2009-05-26 2015-06-02 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US20150241429A1 (en) * 2012-09-11 2015-08-27 Hospital For Special Surgery Irhom2 inhibition for the treatment of complement mediated disorders
WO2016024230A1 (en) 2014-08-11 2016-02-18 Acerta Pharma B.V. Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor, and/or a bcl-2 inhibitor
US9345702B2 (en) 2010-11-23 2016-05-24 Abbvie Inc. Methods of treatment using selective Bcl-2 inhibitors
WO2017079399A1 (en) 2015-11-03 2017-05-11 Genentech, Inc. Combination of bcl-2 inhibitor and mek inhibitor for the treatment of cancer
US9814721B2 (en) 2010-06-03 2017-11-14 Pharmacyclics Llc Use of inhibitors of bruton'S tyrosine kinase (BTK)
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US9884065B2 (en) 2011-12-13 2018-02-06 Buck Institute For Research On Aging Inhibiting activity of senescent cells using a glucocorticoid
US10195213B2 (en) 2015-03-13 2019-02-05 Unity Biotechnology, Inc. Chemical entities that kill senescent cells for use in treating age-related disease
US10213433B2 (en) 2010-10-29 2019-02-26 Abbvie Inc. Solid dispersions containing an apoptosis-inducing agent
US10328058B2 (en) 2014-01-28 2019-06-25 Mayo Foundation For Medical Education And Research Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques
EP3626241A4 (en) * 2017-06-26 2020-05-27 Shenzhen Targetrx, Inc. N-BENZOLSULFONYLBENZAMIDE COMPOUND FOR INHIBITING BCL-2 PROTEIN AND COMPOSITION AND USE THEREOF
US10954567B2 (en) 2012-07-24 2021-03-23 Pharmacyclics Llc Mutations associated with resistance to inhibitors of Bruton's Tyrosine Kinase (BTK)
US11110087B2 (en) 2012-09-07 2021-09-07 Genentech, Inc. Combination therapy of a type II anti-CD20 antibody with a selective Bcl-2 inhibitor
WO2021217051A1 (en) 2020-04-24 2021-10-28 Genentech, Inc. Methods of using anti-cd79b immunoconjugates
US11319316B2 (en) 2016-04-21 2022-05-03 Bioventures, Llc Compounds that induce degradation of anti-apoptotic Bcl-2 family proteins and the uses thereof
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US11369599B2 (en) 2010-10-29 2022-06-28 Abbvie Inc. Melt-extruded solid dispersions containing an apoptosis-inducing agent
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US11517572B2 (en) 2014-01-28 2022-12-06 Mayo Foundation For Medical Education And Research Killing senescent cells and treating senescence-associated conditions using a SRC inhibitor and a flavonoid
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