CN115397825A - 三氟甲基和氯双取代的磺酰胺类选择性bcl-2抑制剂的晶体 - Google Patents
三氟甲基和氯双取代的磺酰胺类选择性bcl-2抑制剂的晶体 Download PDFInfo
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- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
一种三氟甲基和氯双取代的磺酰胺类选择性BCL‑2抑制剂的晶体，具体涉及式I化合物的晶体、制备方法及其在预防和治疗与抗凋亡蛋白BCL‑2相关的疾病例如癌症中的用途。
Description
PCT国内申请，说明书已公开。
Claims (17)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020103558424 | 2020-04-29 | ||
| CN202010355842 | 2020-04-29 | ||
| PCT/CN2021/090885 WO2021219065A1 (zh) | 2020-04-29 | 2021-04-29 | 三氟甲基和氯双取代的磺酰胺类选择性bcl-2抑制剂的晶体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115397825A true CN115397825A (zh) | 2022-11-25 |
Family
ID=78374073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180028439.3A Pending CN115397825A (zh) | 2020-04-29 | 2021-04-29 | 三氟甲基和氯双取代的磺酰胺类选择性bcl-2抑制剂的晶体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20230174528A1 (zh) |
| EP (1) | EP4129998A4 (zh) |
| CN (1) | CN115397825A (zh) |
| TW (1) | TW202144350A (zh) |
| WO (1) | WO2021219065A1 (zh) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA108193C2 (uk) * | 2008-12-04 | 2015-04-10 | Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань | |
| EP2376480B1 (en) | 2008-12-05 | 2016-06-01 | AbbVie Inc. | Sulfonamide derivatives as bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| KR101920202B1 (ko) * | 2009-05-26 | 2018-11-21 | 애브비 아일랜드 언리미티드 컴퍼니 | 암，면역 질환 및 자가면역 질환의 치료를 위한 아폽토시스-유도제 |
| PT2642999T (pt) | 2010-11-23 | 2017-01-05 | Abbvie Ireland Unlimited Co | Métodos de tratamento que utilizam inibidores seletivos de bcl-2 |
| CN112888687B (zh) * | 2018-10-29 | 2023-01-24 | 正大天晴药业集团股份有限公司 | 三氟甲基取代的磺酰胺类选择性bcl-2抑制剂 |
-
2021
- 2021-04-29 TW TW110115644A patent/TW202144350A/zh unknown
- 2021-04-29 CN CN202180028439.3A patent/CN115397825A/zh active Pending
- 2021-04-29 US US17/922,223 patent/US20230174528A1/en active Pending
- 2021-04-29 WO PCT/CN2021/090885 patent/WO2021219065A1/zh unknown
- 2021-04-29 EP EP21796153.1A patent/EP4129998A4/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021219065A1 (zh) | 2021-11-04 |
| EP4129998A4 (en) | 2024-05-01 |
| TW202144350A (zh) | 2021-12-01 |
| US20230174528A1 (en) | 2023-06-08 |
| EP4129998A1 (en) | 2023-02-08 |
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