US20110097402A1 - Non-adhesive elastic gelatin matrices - Google Patents

Non-adhesive elastic gelatin matrices Download PDF

Info

Publication number
US20110097402A1
US20110097402A1 US11/664,184 US66418405A US2011097402A1 US 20110097402 A1 US20110097402 A1 US 20110097402A1 US 66418405 A US66418405 A US 66418405A US 2011097402 A1 US2011097402 A1 US 2011097402A1
Authority
US
United States
Prior art keywords
matrix
composition
gelatin
weight
mixtures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/664,184
Other languages
English (en)
Inventor
Valerio DiTizio
Frank DiCosmo
Yuehua Xiao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Covalon Technologies Ltd
Original Assignee
Covalon Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Covalon Technologies Ltd filed Critical Covalon Technologies Ltd
Priority to US11/664,184 priority Critical patent/US20110097402A1/en
Assigned to COVALON TECHNOLOGIES INC. reassignment COVALON TECHNOLOGIES INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DICOSMO, FRANK, DITIZIO, VALERIO, XIAO, YUEHUA
Publication of US20110097402A1 publication Critical patent/US20110097402A1/en
Priority to US13/166,433 priority patent/US8354123B2/en
Abandoned legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/225—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A61L15/325—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/425—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/045—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/04—Alginic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
    • C08L89/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers

Definitions

  • the present invention relates to non-adhesive elastic matrices. More specifically, the present invention relates to non-adhesive cross-linked elastic gelatin matrices, and the method of making the same.
  • the matrices can be provided in a variety of configurations not limited to wound dressings, wound barriers, tissue and vascular coverings.
  • the matrices can also be made to incorporate a variety of pharmaceuticals, chemicals and other agents.
  • the non-adhesive elastic matrices of the present invention can be used alone, or in conjunction with other materials.
  • Gelatin sheets, collagen sheets and sponges are a group of biomaterials that have been used extensively in the medical field. They are dry and absorb and retain large amounts of water. This group of biomaterials is both biocompatible and biodegradable causing little or no inflammation. These biomaterials are useful as wound dressings, artificial skin scaffolds and therapeutic drug delivery devices, whereby the biomaterials can retain therapeutics and deliver such therapeutics to appropriate cells and tissues, as exemplified in Applicant's U.S. Pat. No. 6,475,516.
  • Gelatin and collagen sheets as provided by the prior art are typically inelastic and may have toxic properties.
  • U.S. Pat. No. 3,491,760 describes a pliable, but inelastic, adhesive multilayer wound covering composed of collagen or gelatin which is “foamed” using air bubbles, treated with a plasticizer (glycerol), cross-linked with a 4% glutaraldehyde solution, and the resulting gel film covered with an adhered cover layer.
  • a plasticizer glycol
  • collagen and gelatin matrices cross-linked with glutaraldehyde show residual toxicity.
  • Gelatin sponge materials such as GelfoamTM, are also known. These materials are absorbable, sterile and water insoluble and used to control bleeding during surgery and may also be provided in a powder format. The material is non-elastic. Another non-elastic gelatin sponge currently used is SurgifoamTM. GelfimTM is a non-elastic material obtained from a formaldehyde cross-linked gelatin solution.
  • Hydrolyzed collagen also known as gelatin
  • gelatin has been used as a vehicle for the delivery of therapeutics when covalently attached to the surface of tubular medical devices such as catheters and stents as described in Applicant's U.S. Pat. Nos. 6,132,765 and 6,228,393.
  • the material is hydrated and minimally elastic.
  • Sehal and Vijay describe a method for water-soluble carbodiimide-mediated amidation by using 1-ethyl-3-[3-dimethylaminopropyl carbodiimide (EDC)/N-hydroxy succinimide (NHS).
  • EDC 1-ethyl-3-[3-dimethylaminopropyl carbodiimide
  • NHS N-hydroxy succinimide
  • the method is known to cross-link collagen, gelatin and other proteins.
  • the resultant matrices are not elastic.
  • soft elastic gelatin capsules or “Softgels” are made from a gelatin solution that is plasticized with propylene glycol, sorbitol, glycerin or other approved mixtures.
  • the gelatin in the softgel capsules is not cross-linked in order that the capsules remain soluble when ingested.
  • softgel capsules lack elasticity and resistance to the action of degradative processes such as increased temperature and mild enzymatic action.
  • gelatin matrices that are elastic, and have appreciable tensile strength while not being prone to becoming hard and brittle.
  • the present invention provides substantially non-adhesive, proteinaceous, elastic matrices for a variety of clinical uses. More specifically, the present invention provides substantially non-adhesive, elastic gelatin matrices for use in a variety of applications not limited to, wound barriers, wound dressings, surgical dressings, wraps and in therapeutic drug and/or chemical agent delivery. The present invention also provides a novel method for making the non-adhesive, elastic gelatin matrices of the invention.
  • non-adhesive elastic gelatin matrix is both non-adhesive and elastic such that it is flexible.
  • the matrix is lyophilized such that it does not contain substantial amounts of solvent and comprises a mixture of collagen or denatured collagen, biocompatible polymers, cross-linking agent(s) and optional plasticizer.
  • a lyophilized non-adhesive elastic gelatin matrix is a lyophilized non-adhesive elastic gelatin matrix.
  • non-adhesive elastic protein matrix comprising;
  • collagen or denatured collagen i.e. gelatin is used alone as the protein component of the matrix.
  • collagen and gelatin are used in combination as the protein component of the matrix.
  • a non-adhesive elastic gelatin matrix comprising;
  • the collagen can be used alone or denatured collagen, i.e. gelatin used alone or in combination.
  • a method for making a non-adhesive elastic gelatin matrix comprising:
  • the protein of (a) is gelatin and in other aspects is a mixture of gelatin and collagen.
  • a plasticizer may additionally be added to (b) and/or (c).
  • one or more of a pharmaceutical, chemical or other agent may be added before and/or after the cross-linking reaction of step (c).
  • silver ions, metallic silver or a silver salt may be added to the matrix for the treatment of burns or other trauma to minimize and/or inhibit infection.
  • the matrix may be fabricated as a covering such as wound barrier, wound dressing, vascular wrap and combinations thereof.
  • the matrix may also be fabricated as a sponge.
  • the matrix of the invention may be further used to reduce chronic inflammation, absorb exudates and/or promote a moist wound environment.
  • the matrix of the invention may also have incorporated therein a chemical or other agent that is delivered to a desired tissue for at least one of exfoliation and treatment of age related conditions in mammals.
  • the non-adhesive elastic gelatin matrix may be formed around a web or fibril support. Still in other aspects of the invention, the gelatin matrix of the invention may be used in conjunction with polymer sheets, films, threads or membranes and meshes of silicone, polyurethane, polyethylene, DacronTM, nylon, silk, cellulose and mixtures thereof.
  • the non-adhesive elastic gelatin matrix may be provided as an occlusive device comprising an occlusive structure and the substantially non-adhesive gelatin matrix, wherein the matrix has opposing surfaces such that one surface of the matrix is affixed to one surface of the occlusive structure with the other surface of the matrix being adapted to cover and be in contact with tissue.
  • the occlusive device may be a plastic film for example.
  • the present invention is a novel substantially non-adhesive elastic protein containing matrix that is biocompatible.
  • the matrix is an elastic gelatin matrix that retains its elasticity such that it can be configured in a variety of manners as is required in various clinical conditions.
  • the elastic gelatin matrix of the invention is flexible and has a variety of clinical uses for the treatment of a variety of conditions.
  • the matrix of the invention can be configured into a variety of formats and used in conjunction with other devices or structures.
  • the matrix of the invention may also have a variety of pharmaceuticals, chemicals and/or other agents incorporated into the matrix as desired for a variety of clinical applications.
  • the gelatin matrix of the invention is also substantially non-adhesive meaning that the matrix does not substantially adhere to wounds, tissues (such as but not limited to skin, blood vessels and bone) and organs.
  • the matrix of the invention is absorbent, stable in vivo and in vitro and can be fabricated with a tensile strength and elasticity as required for a desired clinical application.
  • the elastic matrix of the invention is made from a solution comprising protein or a mixture of proteins, biocompatible polymer(s), cross-linking agent(s), solvent(s) and optionally plasticizer(s).
  • the protein for use in the invention is selected from collagen, denatured collagen (i.e. gelatin) and mixtures thereof that are further admixed together with one or more biocompatible polymers. Plasticizers may be optionally added.
  • the solution is lyophilized to essentially remove any solvent and provide the non-adhesive elastic gelatin matrix of the invention.
  • biocompatible polymers for use in the invention are selected from the group consisting of polyethylene glycol (PEG), poly-L-lysine, poly-D-lysine, alginate, chitosan, hyaluronic acid, chondroitin sulfate and mixtures thereof.
  • the cross-linking agents for use in the invention are selected from the group consisting of 1-[3-(dimethylamino)propyl]-3-ethyl carbodiimide (EDC), N-hydroxysuccinimide (NHS), formaldehyde, glutaraldehyde, polyaziridines, diglycidyl ethers and mixtures thereof.
  • EDC 1-[3-(dimethylamino)propyl]-3-ethyl carbodiimide
  • NHS N-hydroxysuccinimide
  • formaldehyde glutaraldehyde
  • polyaziridines diglycidyl ethers and mixtures thereof.
  • diglycidyl ethers diglycidyl ethers and mixtures thereof.
  • EDC and NHS are used in combination as the cross-linking agent.
  • the optional plasticizer for use in the present invention is selected from the group consisting of glycerol, propylene glycol, sorbitol and mixtures thereof.
  • the solvent for use in the present invention is selected from the group consisting of water, methanol, ethanol, isopropanol, dimethylsulfide (DMS), and mixtures thereof.
  • the solvent is water or if used in addition with a polar organic solvent, the solvent ratio is typically about 9:1, water to polar organic solvent, in the final mixture.
  • the solution of collagen and/or gelatin together with the biocompatible polymer(s), cross-linking agent(s), optional plasticizer(s) and solvent(s) are mixed and frozen, and then freeze-dried (i.e. lyophilized).
  • the matrices so produced are substantially non-adhesive and elastic.
  • the ranges for the amounts of protein (collagen or gelatin), the amount of biocompatible polymer, the amount of solvent and the amount of optional plasticizer in the composition solution and in the lyophilized final composition may be as follows:
  • Plasticizer optionally 0-5% 0-10% *Note that the ranges provided in the table above for each of the protein, biocompatible polymer, cross-linking agent, solvent and plasticizer includes any sub ranges of the ranges listed.
  • the non-adhesive elastic gelatin matrix of the invention is made by combining solutions of protein, biocompatible polymers and cross-linking agents in a suitable solvent.
  • the solutions of the various constituents of the matrix as described in the examples are aqueous, however, in aspects of the invention the biocompatible polymer(s) and cross-linking agent(s) may be first dissolved in a polar organic solvent such as but not limited to methanol, ethanol, isopropanol and dimethyl sulfoxide (DMSO), and in such a case, the solvent ratio of the final mixture is typically 9:1 in favor of water.
  • a polar organic solvent such as but not limited to methanol, ethanol, isopropanol and dimethyl sulfoxide (DMSO)
  • solutions of the protein and biocompatible polymer are mixed and incubated for a time period at a temperature such that the protein does not set, i.e. form a gel. Temperatures of about 55° C. are suitable for such incubation. Should polyethylene glycol (PEG) be used as a biocompatible polymer, the PEG is typically added to the mixing and incubating protein solutions. A solution of cross-linking agent is then added and the resultant mixture is mixed for a period of time until a consistent gel is formed. The gel is then pored into a suitable mold and kept at room temperature for about 10 minutes and subsequently cooled at about 4° C. for a time period ranging from about 30 minutes up to about 12 hours.
  • PEG polyethylene glycol
  • the mixture is washed to remove soluble components such as residual PEG and cross-linking agent and lyophilized for a period of about 24 hours or more until the final moisture content of the non-adhesive elastic gelatin matrix is less than about 10%. It is understood by one of skill in the art that the final moisture content of the resultant matrix (lyophilized matrix) can be adjusted to any value up to about 10% by weight of the matrix.
  • the non-adhesive elastic gelatin matrix of the invention can be developed to be drug-eluting on tissues and organs, including but not limited to, skin, tissue lacerations, surgical wounds of skin, tissue and organs, blood vessels and bone.
  • the matrix can be fabricated to have pharmaceutical, chemical and/or other agent incorporated therein.
  • the pharmaceutical, chemical and/or other agent can be incorporated in an amount of about 0.1% to about 10% into the initial formulation step or about 1.0% to about 25% after drying.
  • the lyophilized matrix can be soaked in a solution of the desired pharmaceutical, chemical and/or other agent and then the matrix may be re-lyophilized.
  • Desirable agents for use in conjunction with the present invention include but are not limited to silver ions, metallic silver or a silver salt, chlorohexidine, triclosan, povidone-Iodine, other antimicrobial metals such as copper, platinum, gold, bismuth-based compounds, anesthetics such as lidocaine, antibiotics, immunosuppressants, antiproliferative agents, anti-inflammatory agents, antivirals and combinations thereof.
  • an anti-ageing agent may be provided to the matrix before and/or after lyophilization.
  • Such an anti-aging agent may be selected to treat for example fine lines, wrinkles and skin discolorations.
  • a suitable anti-aging agent may be selected from exfoliants, Vitamin A, Vitamin C, etc. If used to treat brown spots or discoloration an agent such as hydroquinone may be suitable for incorporation into the matrix.
  • the non-adhesive elastic gelatin matrix of the invention can be fabricated in a variety of forms such as a film, sheet, tube or sponge.
  • the matrix of the invention may be used for example but not limited to a wound barrier, wound dressing, vascular wrap and combinations thereof.
  • the matrix of the invention may also be used to reduce chronic inflammation, absorb exudates and/or promote a moist wound environment.
  • the matrix of the invention can also be fabricated as a device in conjunction with other materials such as but not limited to polymer sheets, films, threads, membranes or meshes of silicone, polyurethane, polyethylene, DacronTM, nylon, silk, cellulose and combinations thereof.
  • This may be carried out by chemically modifying the surface of the other material by methods of gamma irradiation, plasma or corona discharge and/or by UV light so that reactive groups are introduced onto the surface of the material.
  • the reactive groups can then be covalently linked to complementary reactive groups present on the non-adhesive elastic matrix of the present invention by methods as described in the Applicant's International Application No. PCT CA02/00246 (the disclosure of which is incorporated herein by reference in its entirety).
  • Gelatin was purchased from Vyse Gelatin Company (5010 North Rose St., Schiller Park, Ill. 60176). Gelatin (300 Bloom) was obtained by the partial hydrolysis of a collagen derived from porcine sources: skin, white connective tissues and bones of animals and processed to yield a pharmaceutical grade gelatin. Sodium alginate (sodium salt) from Macrocystis pyrifera (high viscosity, 2% solution at 25° C. approx 14,000 cps) was purchased from Sigma Co. (St. Louis, Mo.).
  • Gelatin (100 mL) and alginate (71.2 mL) solutions were mixed and Incubated at 55° C. for 30 min. Then 30 mL of PEG 3400 solution was added and mixed. Afterward, 5 mL of fresh EDC/NHS solution was added to the mixture during mixing for 30 seconds. The about 200 ml of gel was poured into a mold and kept at room temperature for 10 min and subsequently cooled at 4° C. for 30 min. The matrix was washed in water overnight to remove soluble components such as PEG and cross-linking agent. Finally, the matrix was lyophilized. Typically, 0.32 ml of gel mixture yields 1 cm 2 of matrix surface area.
  • Gelatin (100 mL) and alginate (71.2 mL) solutions were mixed and incubated at 55° C. for 30 min. Then 30 mL of PEG 3400 solution was added and mixed. Afterward, 5 mL of fresh EDC/NHS solution was added to the mixture during mixing for 30 seconds.
  • the about 200 ml of gel was poured into a mold and kept at room temperature for 10 min and subsequently cooled at 4° C. for 30 min. The matrix was washed in water overnight to remove soluble components such as PEG and cross-linking agent. Usually, 0.32 ml of gel mixture yields 1 cm 2 of matrix surface area. The matrix was soaked in 2.85 L of 10% glycerol (4.4 ml of glycerol per 1 cm 2 of gel). Finally the matrix was lyophilized.
  • Gelatin and alginate solutions were mixed as in previous examples. Then 10 ml of 2% poly-L-lysine was added with mixing. 30 ml of PEG 3400 was added to the mixture and mixed. The remaining procedures to yield the final matrix were identical to previous examples.
  • Gelatin and alginate solutions were mixed as in previous examples. Then 10 ml of 2% poly-L-lysine was added with mixing. 30 ml of PEG 3400 was added to the mixture and mixed. The remaining procedures to yield the hydrated and washed matrix were identical to previous examples. Finally, the matrix was soaked in 2.85 L of 10% glycerol (4.4 ml of glycerol per 1 cm 2 of gel) and then lyophilized.
  • Matrix Synthesis (e.g. 200 ml of Gel)
  • the various matrices as in Examples 1-5 can be poured (prior to the initial cooling/freezing step) directly over other materials (without modification as outlined above), such as but not limited to polymer sheets, films, threads, membranes or meshes of silicone, polyurethane, polyethylene, DacronTM, nylon, silk, cellulose and combinations thereof. that may or may not contain added agents, such as therapeutics, silver-containing materials or other medicaments so as to embed the mesh, net or fibers within the matrices of examples 1-5.
  • materials such as but not limited to polymer sheets, films, threads, membranes or meshes of silicone, polyurethane, polyethylene, DacronTM, nylon, silk, cellulose and combinations thereof. that may or may not contain added agents, such as therapeutics, silver-containing materials or other medicaments so as to embed the mesh, net or fibers within the matrices of examples 1-5.
  • the degradation of cross-linked gelatin-based materials was studied using bacterial collagenase.
  • the collagenase used in this study was from Clostridium (EC 3.4.24.3) and had an activity of 362 U/mg solid.
  • the water uptake ability of the dressing was expressed as the weight ratio of absorbed water to dry dressing (Table 2). Matrices particularly without plasticiser are all very absorbent and can soak up to approximately 30-35 times their weight in water in about 24 hours.
  • Examples 1-5 are directed to the manufacture of a range materials that may be used as carriers for various medicaments such as the antiproliferative and anti-inflammatory drug Sirolimus (Rapamycin) for delivery to the surface of tissues and organs. While the drug Sirolimus is used in this example, it is noted that other drugs may be used either alone or in combination to be delivered to the surface of tissues and organs.
  • Sirolimus the antiproliferative and anti-inflammatory drug Sirolimus
  • Solution 1 2 g of gelatin was added to 180 ml of water; after gelatin was completely hydrated in water, the mixture was incubated at 50° C. to dissolve the gelatin.
  • Solution 2 0.2 g of alginate was added into 20 ml of 0.05 N NaOH, and incubated at 50° C. to dissolve the alginate.
  • Solution 4 2 g of glycerol was added into 200 ml of water
  • Matrix Synthesis (e.g. 200 ml of Gel)
  • the above matrix (or any of the matrices of examples 1-5) was cut into 1 ⁇ 4 cm square. Afterwards, 80 ul of drug solution (1 mg/80 ul ethanol) was added on the surface of the material, or the material was immersed in a solution of drug. After drug loading into the film, the film was allowed to dry and the drug-loaded film was exposed to gamma-irradiation for 8 hr (25 KGy).
  • Injection volume 10 ⁇ l Sirolimus Standards 0 ug/ml, 1 ug/ml, 2.5 ug/ml, 5 ug/ml 10 ug/ml Analysis: Each sample was injected two times for analysis. Each data point is the average of 6 replicate tests.
US11/664,184 2004-09-30 2005-06-15 Non-adhesive elastic gelatin matrices Abandoned US20110097402A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US11/664,184 US20110097402A1 (en) 2004-09-30 2005-06-15 Non-adhesive elastic gelatin matrices
US13/166,433 US8354123B2 (en) 2004-09-30 2011-06-22 Non-adhesive elastic gelatin matrices

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61441404P 2004-09-30 2004-09-30
PCT/CA2005/000925 WO2006034568A1 (fr) 2004-09-30 2005-06-15 Matrices de gelatine elastiques non-adhesives
US11/664,184 US20110097402A1 (en) 2004-09-30 2005-06-15 Non-adhesive elastic gelatin matrices

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2005/000925 A-371-Of-International WO2006034568A1 (fr) 2004-09-30 2005-06-15 Matrices de gelatine elastiques non-adhesives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/166,433 Continuation US8354123B2 (en) 2004-09-30 2011-06-22 Non-adhesive elastic gelatin matrices

Publications (1)

Publication Number Publication Date
US20110097402A1 true US20110097402A1 (en) 2011-04-28

Family

ID=36118529

Family Applications (4)

Application Number Title Priority Date Filing Date
US11/664,184 Abandoned US20110097402A1 (en) 2004-09-30 2005-06-15 Non-adhesive elastic gelatin matrices
US11/152,367 Active 2027-05-18 US8361501B2 (en) 2004-09-30 2005-06-15 Non-adhesive elastic gelatin matrices
US13/166,433 Active US8354123B2 (en) 2004-09-30 2011-06-22 Non-adhesive elastic gelatin matrices
US13/750,872 Active US8628800B2 (en) 2004-09-30 2013-01-25 Non-adhesive elastic gelatin matrices

Family Applications After (3)

Application Number Title Priority Date Filing Date
US11/152,367 Active 2027-05-18 US8361501B2 (en) 2004-09-30 2005-06-15 Non-adhesive elastic gelatin matrices
US13/166,433 Active US8354123B2 (en) 2004-09-30 2011-06-22 Non-adhesive elastic gelatin matrices
US13/750,872 Active US8628800B2 (en) 2004-09-30 2013-01-25 Non-adhesive elastic gelatin matrices

Country Status (11)

Country Link
US (4) US20110097402A1 (fr)
EP (1) EP1793872B1 (fr)
JP (1) JP5047797B2 (fr)
AU (1) AU2005289311B2 (fr)
CA (1) CA2580357C (fr)
DK (1) DK1793872T3 (fr)
EA (2) EA016776B9 (fr)
ES (1) ES2581558T3 (fr)
NO (1) NO20071668L (fr)
UA (1) UA88321C2 (fr)
WO (1) WO2006034568A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090022801A1 (en) * 2006-01-31 2009-01-22 David Vachon Compositions and Methods for Promoting the Healing of Tissue of Multicellular Organisms
US20100247544A1 (en) * 2006-01-31 2010-09-30 Dr. David John Vachon Compositions and Methods for Promoting the Healing of Tissue of Multicellular Organisms
EP3088010A1 (fr) 2015-04-28 2016-11-02 DiCosmo, Frank Biomatériaux à base de collagène bioactif et leurs procédés de fabrication
US9970303B2 (en) 2014-05-13 2018-05-15 Entrotech, Inc. Erosion protection sleeve
CN110075346A (zh) * 2019-04-30 2019-08-02 苏州卫生职业技术学院 一种高粘附性水凝胶敷料及其制备方法

Families Citing this family (514)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
EP1573295A2 (fr) * 2002-12-11 2005-09-14 Ferrosan A/S Tampons a prelevements a base de gelatine
US20070084897A1 (en) 2003-05-20 2007-04-19 Shelton Frederick E Iv Articulating surgical stapling instrument incorporating a two-piece e-beam firing mechanism
US9060770B2 (en) 2003-05-20 2015-06-23 Ethicon Endo-Surgery, Inc. Robotically-driven surgical instrument with E-beam driver
CA2554994C (fr) * 2004-01-30 2015-05-19 Ferrosan A/S Pulverisations et compositions hemostatiques
US8021684B2 (en) * 2004-07-09 2011-09-20 Ferrosan Medical Devices A/S Haemostatic composition comprising hyaluronic acid
US11896225B2 (en) 2004-07-28 2024-02-13 Cilag Gmbh International Staple cartridge comprising a pan
US8215531B2 (en) 2004-07-28 2012-07-10 Ethicon Endo-Surgery, Inc. Surgical stapling instrument having a medical substance dispenser
AU2005289311B2 (en) * 2004-09-30 2011-03-03 Covalon Technologies Inc. Non-adhesive elastic gelatin matrices
US20070194082A1 (en) 2005-08-31 2007-08-23 Morgan Jerome R Surgical stapling device with anvil having staple forming pockets of varying depths
US10159482B2 (en) 2005-08-31 2018-12-25 Ethicon Llc Fastener cartridge assembly comprising a fixed anvil and different staple heights
US11484312B2 (en) 2005-08-31 2022-11-01 Cilag Gmbh International Staple cartridge comprising a staple driver arrangement
US7669746B2 (en) 2005-08-31 2010-03-02 Ethicon Endo-Surgery, Inc. Staple cartridges for forming staples having differing formed staple heights
US7934630B2 (en) 2005-08-31 2011-05-03 Ethicon Endo-Surgery, Inc. Staple cartridges for forming staples having differing formed staple heights
US9237891B2 (en) 2005-08-31 2016-01-19 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical stapling devices that produce formed staples having different lengths
US11246590B2 (en) 2005-08-31 2022-02-15 Cilag Gmbh International Staple cartridge including staple drivers having different unfired heights
US20070106317A1 (en) 2005-11-09 2007-05-10 Shelton Frederick E Iv Hydraulically and electrically actuated articulation joints for surgical instruments
US9861359B2 (en) 2006-01-31 2018-01-09 Ethicon Llc Powered surgical instruments with firing system lockout arrangements
US20110024477A1 (en) 2009-02-06 2011-02-03 Hall Steven G Driven Surgical Stapler Improvements
US20110290856A1 (en) 2006-01-31 2011-12-01 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical instrument with force-feedback capabilities
US11224427B2 (en) 2006-01-31 2022-01-18 Cilag Gmbh International Surgical stapling system including a console and retraction assembly
US7845537B2 (en) 2006-01-31 2010-12-07 Ethicon Endo-Surgery, Inc. Surgical instrument having recording capabilities
US7753904B2 (en) 2006-01-31 2010-07-13 Ethicon Endo-Surgery, Inc. Endoscopic surgical instrument with a handle that can articulate with respect to the shaft
US8186555B2 (en) 2006-01-31 2012-05-29 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting and fastening instrument with mechanical closure system
US11278279B2 (en) 2006-01-31 2022-03-22 Cilag Gmbh International Surgical instrument assembly
US11793518B2 (en) 2006-01-31 2023-10-24 Cilag Gmbh International Powered surgical instruments with firing system lockout arrangements
US8708213B2 (en) 2006-01-31 2014-04-29 Ethicon Endo-Surgery, Inc. Surgical instrument having a feedback system
US8820603B2 (en) 2006-01-31 2014-09-02 Ethicon Endo-Surgery, Inc. Accessing data stored in a memory of a surgical instrument
US20120292367A1 (en) 2006-01-31 2012-11-22 Ethicon Endo-Surgery, Inc. Robotically-controlled end effector
US20070225562A1 (en) 2006-03-23 2007-09-27 Ethicon Endo-Surgery, Inc. Articulating endoscopic accessory channel
US8992422B2 (en) 2006-03-23 2015-03-31 Ethicon Endo-Surgery, Inc. Robotically-controlled endoscopic accessory channel
US8322455B2 (en) 2006-06-27 2012-12-04 Ethicon Endo-Surgery, Inc. Manually driven surgical cutting and fastening instrument
DE102006038252A1 (de) * 2006-08-16 2008-02-21 Lohmann & Rauscher Gmbh & Co. Kg Zubereitung mit marinem Kollagen zur Proteinasehemmung
US8220690B2 (en) 2006-09-29 2012-07-17 Ethicon Endo-Surgery, Inc. Connected surgical staples and stapling instruments for deploying the same
US10130359B2 (en) 2006-09-29 2018-11-20 Ethicon Llc Method for forming a staple
US10568652B2 (en) 2006-09-29 2020-02-25 Ethicon Llc Surgical staples having attached drivers of different heights and stapling instruments for deploying the same
KR20090096704A (ko) 2006-12-22 2009-09-14 큐나노 에이비 직립 나노와이어 구조를 갖는 ｌｅｄ 및 이를 제조하는 방법
US11291441B2 (en) 2007-01-10 2022-04-05 Cilag Gmbh International Surgical instrument with wireless communication between control unit and remote sensor
US8652120B2 (en) 2007-01-10 2014-02-18 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between control unit and sensor transponders
US8684253B2 (en) 2007-01-10 2014-04-01 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between a control unit of a robotic system and remote sensor
US20080169332A1 (en) 2007-01-11 2008-07-17 Shelton Frederick E Surgical stapling device with a curved cutting member
US11039836B2 (en) 2007-01-11 2021-06-22 Cilag Gmbh International Staple cartridge for use with a surgical stapling instrument
EP1961411A1 (fr) * 2007-02-21 2008-08-27 FUJIFILM Manufacturing Europe B.V. Composition de libération contrôlée
EP1961414A1 (fr) * 2007-02-21 2008-08-27 FUJIFILM Manufacturing Europe B.V. Composition de libération contrôlée comprenant une gélatine recombinée
US8349588B2 (en) * 2007-02-21 2013-01-08 Fujifilm Manufacturing Europe B.V. Recombinant XRGD-enriched gelatins having high stability
US7673782B2 (en) 2007-03-15 2010-03-09 Ethicon Endo-Surgery, Inc. Surgical stapling instrument having a releasable buttress material
PL3085363T3 (pl) * 2007-03-28 2019-08-30 Innocoll Pharmaceuticals Limited Urządzenie dostarczające lek dla zapewnienia miejscowej analgezji, miejscowego znieczulenia lub blokady nerwowej
USRE47826E1 (en) 2007-03-28 2020-01-28 Innocoll Pharmaceuticals Limited Drug delivery device for providing local analgesia, local anesthesia or nerve blockage
US8893946B2 (en) 2007-03-28 2014-11-25 Ethicon Endo-Surgery, Inc. Laparoscopic tissue thickness and clamp load measuring devices
WO2008151040A2 (fr) * 2007-05-31 2008-12-11 Cook Biotech Incorporated Produit médical enrobé d'analgésique
US11857181B2 (en) 2007-06-04 2024-01-02 Cilag Gmbh International Robotically-controlled shaft based rotary drive systems for surgical instruments
US8931682B2 (en) 2007-06-04 2015-01-13 Ethicon Endo-Surgery, Inc. Robotically-controlled shaft based rotary drive systems for surgical instruments
US8308040B2 (en) 2007-06-22 2012-11-13 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with an articulatable end effector
US7753245B2 (en) 2007-06-22 2010-07-13 Ethicon Endo-Surgery, Inc. Surgical stapling instruments
US20090004253A1 (en) 2007-06-29 2009-01-01 Brown Laura J Composite device for the repair or regeneration of tissue
US11849941B2 (en) 2007-06-29 2023-12-26 Cilag Gmbh International Staple cartridge having staple cavities extending at a transverse angle relative to a longitudinal cartridge axis
DE102007044648B4 (de) * 2007-09-18 2020-11-26 Carl Freudenberg Kg Bioresorbierbarer Gelatinevliesstoff
US20100298329A1 (en) * 2007-09-19 2010-11-25 Massachusette Institute Of Technology Tolperisone and tolperisone-like drugs for the treatment of k-ras associated cancers
US8679176B2 (en) 2007-12-18 2014-03-25 Cormatrix Cardiovascular, Inc Prosthetic tissue valve
US8257434B2 (en) 2007-12-18 2012-09-04 Cormatrix Cardiovascular, Inc. Prosthetic tissue valve
US8561870B2 (en) 2008-02-13 2013-10-22 Ethicon Endo-Surgery, Inc. Surgical stapling instrument
US8573465B2 (en) 2008-02-14 2013-11-05 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical end effector system with rotary actuated closure systems
US9179912B2 (en) 2008-02-14 2015-11-10 Ethicon Endo-Surgery, Inc. Robotically-controlled motorized surgical cutting and fastening instrument
US8758391B2 (en) 2008-02-14 2014-06-24 Ethicon Endo-Surgery, Inc. Interchangeable tools for surgical instruments
US7819298B2 (en) 2008-02-14 2010-10-26 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with control features operable with one hand
US7866527B2 (en) 2008-02-14 2011-01-11 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with interlockable firing system
JP5410110B2 (ja) 2008-02-14 2014-02-05 エシコン・エンド−サージェリィ・インコーポレイテッド Ｒｆ電極を有する外科用切断・固定器具
US8657174B2 (en) 2008-02-14 2014-02-25 Ethicon Endo-Surgery, Inc. Motorized surgical cutting and fastening instrument having handle based power source
US8636736B2 (en) 2008-02-14 2014-01-28 Ethicon Endo-Surgery, Inc. Motorized surgical cutting and fastening instrument
US11272927B2 (en) 2008-02-15 2022-03-15 Cilag Gmbh International Layer arrangements for surgical staple cartridges
US9770245B2 (en) 2008-02-15 2017-09-26 Ethicon Llc Layer arrangements for surgical staple cartridges
CA2716872C (fr) 2008-02-29 2015-02-10 Ferrosan Medical Devices A/S Dispositif pour la promotion de l'homeostasie et/ou la cicatrisation des plaies
US7857186B2 (en) 2008-09-19 2010-12-28 Ethicon Endo-Surgery, Inc. Surgical stapler having an intermediate closing position
PL3476312T3 (pl) 2008-09-19 2024-03-11 Ethicon Llc Stapler chirurgiczny z urządzeniem do dopasowania wysokości zszywek
US9386983B2 (en) 2008-09-23 2016-07-12 Ethicon Endo-Surgery, Llc Robotically-controlled motorized surgical instrument
US8210411B2 (en) 2008-09-23 2012-07-03 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting instrument
US9005230B2 (en) 2008-09-23 2015-04-14 Ethicon Endo-Surgery, Inc. Motorized surgical instrument
US11648005B2 (en) 2008-09-23 2023-05-16 Cilag Gmbh International Robotically-controlled motorized surgical instrument with an end effector
US8608045B2 (en) 2008-10-10 2013-12-17 Ethicon Endo-Sugery, Inc. Powered surgical cutting and stapling apparatus with manually retractable firing system
WO2010080936A2 (fr) 2009-01-07 2010-07-15 Entrotech, Inc. Stratifiés antimicrobiens contenant de la chlorhexidine
US8517239B2 (en) 2009-02-05 2013-08-27 Ethicon Endo-Surgery, Inc. Surgical stapling instrument comprising a magnetic element driver
US8453907B2 (en) 2009-02-06 2013-06-04 Ethicon Endo-Surgery, Inc. Motor driven surgical fastener device with cutting member reversing mechanism
JP2012517287A (ja) 2009-02-06 2012-08-02 エシコン・エンド−サージェリィ・インコーポレイテッド 被駆動式手術用ステープラの改良
US8444036B2 (en) 2009-02-06 2013-05-21 Ethicon Endo-Surgery, Inc. Motor driven surgical fastener device with mechanisms for adjusting a tissue gap within the end effector
MX2011008735A (es) 2009-02-18 2012-01-12 Cormatrix Cardiovascular Inc Composiciones y metodos para prevenir la arritmia cardiaca.
JP2010213984A (ja) * 2009-03-18 2010-09-30 Naisemu:Kk 柔軟剤及び／又は保湿剤含有生体埋込用医療材料、該医療材料中の柔軟剤及び／又は保湿剤の含有量を調整する方法及び、該生体内埋込用医療材料の製造方法
US8968785B2 (en) * 2009-10-02 2015-03-03 Covidien Lp Surgical compositions
US9925140B2 (en) * 2009-12-22 2018-03-27 National Cheng Kung University Cell tissue gel containing collagen and hyaluronan
US8220688B2 (en) 2009-12-24 2012-07-17 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting instrument with electric actuator directional control assembly
US8851354B2 (en) 2009-12-24 2014-10-07 Ethicon Endo-Surgery, Inc. Surgical cutting instrument that analyzes tissue thickness
CN101791425B (zh) * 2010-03-30 2013-04-10 赵雪林 用于制备医用创伤敷料的抗菌促愈凝胶材料及其制备方法
US9999702B2 (en) 2010-04-09 2018-06-19 Kci Licensing Inc. Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds
US8783543B2 (en) 2010-07-30 2014-07-22 Ethicon Endo-Surgery, Inc. Tissue acquisition arrangements and methods for surgical stapling devices
US11298125B2 (en) 2010-09-30 2022-04-12 Cilag Gmbh International Tissue stapler having a thickness compensator
US9211120B2 (en) 2011-04-29 2015-12-15 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising a plurality of medicaments
US11812965B2 (en) 2010-09-30 2023-11-14 Cilag Gmbh International Layer of material for a surgical end effector
US9629814B2 (en) 2010-09-30 2017-04-25 Ethicon Endo-Surgery, Llc Tissue thickness compensator configured to redistribute compressive forces
US9232941B2 (en) 2010-09-30 2016-01-12 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising a reservoir
US10123798B2 (en) 2010-09-30 2018-11-13 Ethicon Llc Tissue thickness compensator comprising controlled release and expansion
US9364233B2 (en) 2010-09-30 2016-06-14 Ethicon Endo-Surgery, Llc Tissue thickness compensators for circular surgical staplers
US9332974B2 (en) 2010-09-30 2016-05-10 Ethicon Endo-Surgery, Llc Layered tissue thickness compensator
US9220501B2 (en) 2010-09-30 2015-12-29 Ethicon Endo-Surgery, Inc. Tissue thickness compensators
US9320523B2 (en) 2012-03-28 2016-04-26 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising tissue ingrowth features
US9204880B2 (en) 2012-03-28 2015-12-08 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising capsules defining a low pressure environment
EP2621356B1 (fr) 2010-09-30 2018-03-07 Ethicon LLC Système de fermeture comprenant une matrice de retenue et une matrice d'alignement
US9307989B2 (en) 2012-03-28 2016-04-12 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorportating a hydrophobic agent
US9314246B2 (en) 2010-09-30 2016-04-19 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorporating an anti-inflammatory agent
US11925354B2 (en) 2010-09-30 2024-03-12 Cilag Gmbh International Staple cartridge comprising staples positioned within a compressible portion thereof
US10945731B2 (en) 2010-09-30 2021-03-16 Ethicon Llc Tissue thickness compensator comprising controlled release and expansion
US9113865B2 (en) 2010-09-30 2015-08-25 Ethicon Endo-Surgery, Inc. Staple cartridge comprising a layer
US9216019B2 (en) 2011-09-23 2015-12-22 Ethicon Endo-Surgery, Inc. Surgical stapler with stationary staple drivers
US9301752B2 (en) * 2010-09-30 2016-04-05 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising a plurality of capsules
US9566061B2 (en) 2010-09-30 2017-02-14 Ethicon Endo-Surgery, Llc Fastener cartridge comprising a releasably attached tissue thickness compensator
US8695866B2 (en) 2010-10-01 2014-04-15 Ethicon Endo-Surgery, Inc. Surgical instrument having a power control circuit
US8597264B2 (en) 2011-03-24 2013-12-03 Kci Licensing, Inc. Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds
AU2012250197B2 (en) 2011-04-29 2017-08-10 Ethicon Endo-Surgery, Inc. Staple cartridge comprising staples positioned within a compressible portion thereof
BR112013029300A2 (pt) * 2011-05-13 2017-12-19 Univ Alberta polímeros e plásticos derivados de proteínas animais
US9567502B2 (en) * 2011-05-13 2017-02-14 The Governors Of The University Of Alberta Polymers and plastics derived from animal proteins
US9072535B2 (en) 2011-05-27 2015-07-07 Ethicon Endo-Surgery, Inc. Surgical stapling instruments with rotatable staple deployment arrangements
JP2014519906A (ja) 2011-05-27 2014-08-21 コーマトリックス カーディオバスキュラー， インコーポレイテッド 滅菌された無細胞の細胞外マトリックス組成物及びその作製方法
US11207064B2 (en) 2011-05-27 2021-12-28 Cilag Gmbh International Automated end effector component reloading system for use with a robotic system
US20120328557A1 (en) * 2011-06-23 2012-12-27 Excel Med, Llc Adhesive cell tissue gels
DE102011107854A1 (de) * 2011-07-01 2013-01-03 Stefanie Alber Futtermittel
CN102886062A (zh) * 2011-07-21 2013-01-23 武汉市三鼎医用生物制品有限公司 碘化壳聚糖生物抗菌凝胶
US9050084B2 (en) 2011-09-23 2015-06-09 Ethicon Endo-Surgery, Inc. Staple cartridge including collapsible deck arrangement
US9044230B2 (en) 2012-02-13 2015-06-02 Ethicon Endo-Surgery, Inc. Surgical cutting and fastening instrument with apparatus for determining cartridge and firing motion status
WO2013121429A1 (fr) 2012-02-16 2013-08-22 Ramot At Tel-Aviv University Ltd. Formulations et coffrets pour la formation de matrices bioadhésives
IN2014DN08122A (fr) 2012-03-06 2015-05-01 Ferrosan Medical Devices As
ITTO20120258A1 (it) * 2012-03-21 2013-09-22 Fond Istituto Italiano Di Tecnologia Materiali compositi polimerici con proprieta' antimicrobiche e biodegradabili e loro usi.
CN104321024B (zh) 2012-03-28 2017-05-24 伊西康内外科公司 包括多个层的组织厚度补偿件
MX353040B (es) 2012-03-28 2017-12-18 Ethicon Endo Surgery Inc Unidad retenedora que incluye un compensador de grosor de tejido.
RU2639857C2 (ru) 2012-03-28 2017-12-22 Этикон Эндо-Серджери, Инк. Компенсатор толщины ткани, содержащий капсулу для среды с низким давлением
BR112014024153B1 (pt) * 2012-03-28 2021-09-14 Ethicon Endo-Surgery, Inc Compensador fixável a uma bigorna de um instrumento prendedor
JP5935181B2 (ja) * 2012-04-24 2016-06-15 カオシュン メディカル ユニヴァーシティ 創傷治癒用の生体材料およびその調製
GB201207617D0 (en) * 2012-05-02 2012-06-13 Systagenix Wound Man Ip Co Bv Wound dressings
RU2636240C2 (ru) 2012-06-12 2017-11-21 Ферросан Медикал Дивайсиз А/С Сухая гемостатическая композиция
US9101358B2 (en) 2012-06-15 2015-08-11 Ethicon Endo-Surgery, Inc. Articulatable surgical instrument comprising a firing drive
US9204879B2 (en) 2012-06-28 2015-12-08 Ethicon Endo-Surgery, Inc. Flexible drive member
US11197671B2 (en) 2012-06-28 2021-12-14 Cilag Gmbh International Stapling assembly comprising a lockout
US9364230B2 (en) 2012-06-28 2016-06-14 Ethicon Endo-Surgery, Llc Surgical stapling instruments with rotary joint assemblies
US20140001231A1 (en) 2012-06-28 2014-01-02 Ethicon Endo-Surgery, Inc. Firing system lockout arrangements for surgical instruments
CN104487005B (zh) 2012-06-28 2017-09-08 伊西康内外科公司 空夹仓闭锁件
US9282974B2 (en) 2012-06-28 2016-03-15 Ethicon Endo-Surgery, Llc Empty clip cartridge lockout
BR112014032776B1 (pt) 2012-06-28 2021-09-08 Ethicon Endo-Surgery, Inc Sistema de instrumento cirúrgico e kit cirúrgico para uso com um sistema de instrumento cirúrgico
US9289256B2 (en) 2012-06-28 2016-03-22 Ethicon Endo-Surgery, Llc Surgical end effectors having angled tissue-contacting surfaces
US9700310B2 (en) 2013-08-23 2017-07-11 Ethicon Llc Firing member retraction devices for powered surgical instruments
WO2014107234A1 (fr) 2013-01-02 2014-07-10 Kci Licensing, Inc. Couverture de champ de plaie à film flexible, adhérent, et non polyuréthane
US9386984B2 (en) 2013-02-08 2016-07-12 Ethicon Endo-Surgery, Llc Staple cartridge comprising a releasable cover
US20140249618A1 (en) * 2013-02-18 2014-09-04 Elutin, Inc. Site specific drug delivery wraps, systems and methods of use thereof
US9554794B2 (en) 2013-03-01 2017-01-31 Ethicon Endo-Surgery, Llc Multiple processor motor control for modular surgical instruments
RU2669463C2 (ru) 2013-03-01 2018-10-11 Этикон Эндо-Серджери, Инк. Хирургический инструмент с мягким упором
JP6382235B2 (ja) 2013-03-01 2018-08-29 エシコン・エンド−サージェリィ・インコーポレイテッドＥｔｈｉｃｏｎ Ｅｎｄｏ−Ｓｕｒｇｅｒｙ，Ｉｎｃ． 信号通信用の導電路を備えた関節運動可能な外科用器具
US20140263552A1 (en) 2013-03-13 2014-09-18 Ethicon Endo-Surgery, Inc. Staple cartridge tissue thickness sensor system
US9629629B2 (en) 2013-03-14 2017-04-25 Ethicon Endo-Surgey, LLC Control systems for surgical instruments
US9351726B2 (en) 2013-03-14 2016-05-31 Ethicon Endo-Surgery, Llc Articulation control system for articulatable surgical instruments
WO2014151107A1 (fr) * 2013-03-15 2014-09-25 Kcl Licensing, Inc. Compositions cicatrisantes
US9572577B2 (en) 2013-03-27 2017-02-21 Ethicon Endo-Surgery, Llc Fastener cartridge comprising a tissue thickness compensator including openings therein
US9332984B2 (en) 2013-03-27 2016-05-10 Ethicon Endo-Surgery, Llc Fastener cartridge assemblies
US9795384B2 (en) 2013-03-27 2017-10-24 Ethicon Llc Fastener cartridge comprising a tissue thickness compensator and a gap setting element
US10405857B2 (en) 2013-04-16 2019-09-10 Ethicon Llc Powered linear surgical stapler
BR112015026109B1 (pt) 2013-04-16 2022-02-22 Ethicon Endo-Surgery, Inc Instrumento cirúrgico
US9574644B2 (en) 2013-05-30 2017-02-21 Ethicon Endo-Surgery, Llc Power module for use with a surgical instrument
CA2912357C (fr) 2013-06-21 2019-12-31 Ferrosan Medical Devices A/S Composition seche dilatee sous vide, et seringue pour la retenir
CN103333270B (zh) * 2013-07-02 2016-05-11 武汉理工大学 胶原蛋白肽接枝海藻酸钠硫酸酯、制备方法及其用途
JP6416260B2 (ja) 2013-08-23 2018-10-31 エシコン エルエルシー 動力付き外科用器具のための発射部材後退装置
US10111980B2 (en) 2013-12-11 2018-10-30 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
US9968354B2 (en) 2013-12-23 2018-05-15 Ethicon Llc Surgical staples and methods for making the same
US9724092B2 (en) 2013-12-23 2017-08-08 Ethicon Llc Modular surgical instruments
US20150173756A1 (en) 2013-12-23 2015-06-25 Ethicon Endo-Surgery, Inc. Surgical cutting and stapling methods
US9839428B2 (en) 2013-12-23 2017-12-12 Ethicon Llc Surgical cutting and stapling instruments with independent jaw control features
CN103739734A (zh) * 2014-01-14 2014-04-23 武汉理工大学 羧甲基卡拉胶-胶原蛋白肽、制备方法及其用途
US9962161B2 (en) 2014-02-12 2018-05-08 Ethicon Llc Deliverable surgical instrument
BR112016019387B1 (pt) 2014-02-24 2022-11-29 Ethicon Endo-Surgery, Llc Sistema de instrumento cirúrgico e cartucho de prendedores para uso com um instrumento cirúrgico de fixação
US9884456B2 (en) 2014-02-24 2018-02-06 Ethicon Llc Implantable layers and methods for altering one or more properties of implantable layers for use with fastening instruments
US9913642B2 (en) 2014-03-26 2018-03-13 Ethicon Llc Surgical instrument comprising a sensor system
US9743929B2 (en) 2014-03-26 2017-08-29 Ethicon Llc Modular powered surgical instrument with detachable shaft assemblies
US9733663B2 (en) 2014-03-26 2017-08-15 Ethicon Llc Power management through segmented circuit and variable voltage protection
US20150272557A1 (en) 2014-03-26 2015-10-01 Ethicon Endo-Surgery, Inc. Modular surgical instrument system
BR112016021943B1 (pt) 2014-03-26 2022-06-14 Ethicon Endo-Surgery, Llc Instrumento cirúrgico para uso por um operador em um procedimento cirúrgico
US10299792B2 (en) 2014-04-16 2019-05-28 Ethicon Llc Fastener cartridge comprising non-uniform fasteners
BR112016023807B1 (pt) 2014-04-16 2022-07-12 Ethicon Endo-Surgery, Llc Conjunto de cartucho de prendedores para uso com um instrumento cirúrgico
US10206677B2 (en) 2014-09-26 2019-02-19 Ethicon Llc Surgical staple and driver arrangements for staple cartridges
US20150297223A1 (en) 2014-04-16 2015-10-22 Ethicon Endo-Surgery, Inc. Fastener cartridges including extensions having different configurations
BR112016023698B1 (pt) 2014-04-16 2022-07-26 Ethicon Endo-Surgery, Llc Cartucho de prendedores para uso com um instrumento cirúrgico
JP6612256B2 (ja) 2014-04-16 2019-11-27 エシコン エルエルシー 不均一な締結具を備える締結具カートリッジ
WO2015161302A1 (fr) 2014-04-18 2015-10-22 Entrotech Life Sciences, Inc. Procédés de traitement de compositions polymérisables contenant de la chlorhexidine et articles antimicrobiens ainsi formés
US10045781B2 (en) 2014-06-13 2018-08-14 Ethicon Llc Closure lockout systems for surgical instruments
US9737301B2 (en) 2014-09-05 2017-08-22 Ethicon Llc Monitoring device degradation based on component evaluation
BR112017004361B1 (pt) 2014-09-05 2023-04-11 Ethicon Llc Sistema eletrônico para um instrumento cirúrgico
US11311294B2 (en) 2014-09-05 2022-04-26 Cilag Gmbh International Powered medical device including measurement of closure state of jaws
US10105142B2 (en) 2014-09-18 2018-10-23 Ethicon Llc Surgical stapler with plurality of cutting elements
CN107427300B (zh) 2014-09-26 2020-12-04 伊西康有限责任公司 外科缝合支撑物和辅助材料
US11523821B2 (en) 2014-09-26 2022-12-13 Cilag Gmbh International Method for creating a flexible staple line
US10076325B2 (en) 2014-10-13 2018-09-18 Ethicon Llc Surgical stapling apparatus comprising a tissue stop
AU2015333206B2 (en) 2014-10-13 2019-07-11 Ferrosan Medical Devices A/S. Dry composition for use in haemostasis and wound healing
US9924944B2 (en) 2014-10-16 2018-03-27 Ethicon Llc Staple cartridge comprising an adjunct material
US11141153B2 (en) 2014-10-29 2021-10-12 Cilag Gmbh International Staple cartridges comprising driver arrangements
US10517594B2 (en) 2014-10-29 2019-12-31 Ethicon Llc Cartridge assemblies for surgical staplers
US9844376B2 (en) 2014-11-06 2017-12-19 Ethicon Llc Staple cartridge comprising a releasable adjunct material
US10736636B2 (en) 2014-12-10 2020-08-11 Ethicon Llc Articulatable surgical instrument system
RU2703684C2 (ru) 2014-12-18 2019-10-21 ЭТИКОН ЭНДО-СЕРДЖЕРИ, ЭлЭлСи Хирургический инструмент с упором, который выполнен с возможностью избирательного перемещения относительно кассеты со скобами вокруг дискретной неподвижной оси
US9844375B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Drive arrangements for articulatable surgical instruments
US10188385B2 (en) 2014-12-18 2019-01-29 Ethicon Llc Surgical instrument system comprising lockable systems
US9968355B2 (en) 2014-12-18 2018-05-15 Ethicon Llc Surgical instruments with articulatable end effectors and improved firing beam support arrangements
US10085748B2 (en) 2014-12-18 2018-10-02 Ethicon Llc Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors
US9987000B2 (en) 2014-12-18 2018-06-05 Ethicon Llc Surgical instrument assembly comprising a flexible articulation system
US9844374B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member
US10117649B2 (en) 2014-12-18 2018-11-06 Ethicon Llc Surgical instrument assembly comprising a lockable articulation system
BR112017013565B1 (pt) 2014-12-24 2021-12-28 Ferrosan Medical Devices A/S Seringa para retenção e mistura de primeira e segunda substâncias
US10180463B2 (en) 2015-02-27 2019-01-15 Ethicon Llc Surgical apparatus configured to assess whether a performance parameter of the surgical apparatus is within an acceptable performance band
US11154301B2 (en) 2015-02-27 2021-10-26 Cilag Gmbh International Modular stapling assembly
US10182816B2 (en) 2015-02-27 2019-01-22 Ethicon Llc Charging system that enables emergency resolutions for charging a battery
US9993258B2 (en) 2015-02-27 2018-06-12 Ethicon Llc Adaptable surgical instrument handle
US9924961B2 (en) 2015-03-06 2018-03-27 Ethicon Endo-Surgery, Llc Interactive feedback system for powered surgical instruments
US10045776B2 (en) 2015-03-06 2018-08-14 Ethicon Llc Control techniques and sub-processor contained within modular shaft with select control processing from handle
US9808246B2 (en) 2015-03-06 2017-11-07 Ethicon Endo-Surgery, Llc Method of operating a powered surgical instrument
US10548504B2 (en) 2015-03-06 2020-02-04 Ethicon Llc Overlaid multi sensor radio frequency (RF) electrode system to measure tissue compression
US10687806B2 (en) 2015-03-06 2020-06-23 Ethicon Llc Adaptive tissue compression techniques to adjust closure rates for multiple tissue types
US10441279B2 (en) 2015-03-06 2019-10-15 Ethicon Llc Multiple level thresholds to modify operation of powered surgical instruments
JP2020121162A (ja) 2015-03-06 2020-08-13 エシコン エルエルシーＥｔｈｉｃｏｎ ＬＬＣ 測定の安定性要素、クリープ要素、及び粘弾性要素を決定するためのセンサデータの時間依存性評価
US9895148B2 (en) 2015-03-06 2018-02-20 Ethicon Endo-Surgery, Llc Monitoring speed control and precision incrementing of motor for powered surgical instruments
US10245033B2 (en) 2015-03-06 2019-04-02 Ethicon Llc Surgical instrument comprising a lockable battery housing
US10617412B2 (en) 2015-03-06 2020-04-14 Ethicon Llc System for detecting the mis-insertion of a staple cartridge into a surgical stapler
US9993248B2 (en) 2015-03-06 2018-06-12 Ethicon Endo-Surgery, Llc Smart sensors with local signal processing
US9901342B2 (en) 2015-03-06 2018-02-27 Ethicon Endo-Surgery, Llc Signal and power communication system positioned on a rotatable shaft
US10213201B2 (en) 2015-03-31 2019-02-26 Ethicon Llc Stapling end effector configured to compensate for an uneven gap between a first jaw and a second jaw
RU2604223C1 (ru) * 2015-06-04 2016-12-10 Федеральное государственное бюджетное образовательное учреждение высшего образования "Национальный исследовательский Мордовский государственный университет им. Н.П. Огарёва" Способ получения белково-полисахаридной биоразлагаемой пленки
US10335149B2 (en) 2015-06-18 2019-07-02 Ethicon Llc Articulatable surgical instruments with composite firing beam structures with center firing support member for articulation support
BR112017027695A2 (pt) 2015-07-03 2018-09-04 Ferrosan Medical Devices As seringa para retenção e mistura de primeira e segunda substâncias
US11058425B2 (en) 2015-08-17 2021-07-13 Ethicon Llc Implantable layers for a surgical instrument
MX2018002388A (es) 2015-08-26 2018-08-01 Ethicon Llc Tiras de grapas quirurgicas para permitir propiedades variables de la grapa y facilitar la carga del cartucho.
MX2022009705A (es) 2015-08-26 2022-11-07 Ethicon Llc Metodo para formar una grapa contra un yunque de un instrumento de engrapado quirurgico.
US10517599B2 (en) 2015-08-26 2019-12-31 Ethicon Llc Staple cartridge assembly comprising staple cavities for providing better staple guidance
MX2022006189A (es) 2015-09-02 2022-06-16 Ethicon Llc Configuraciones de grapas quirurgicas con superficies de leva situadas entre porciones que soportan grapas quirurgicas.
US10238390B2 (en) 2015-09-02 2019-03-26 Ethicon Llc Surgical staple cartridges with driver arrangements for establishing herringbone staple patterns
US10105139B2 (en) 2015-09-23 2018-10-23 Ethicon Llc Surgical stapler having downstream current-based motor control
US10327769B2 (en) 2015-09-23 2019-06-25 Ethicon Llc Surgical stapler having motor control based on a drive system component
US10076326B2 (en) 2015-09-23 2018-09-18 Ethicon Llc Surgical stapler having current mirror-based motor control
US10085751B2 (en) 2015-09-23 2018-10-02 Ethicon Llc Surgical stapler having temperature-based motor control
US10238386B2 (en) 2015-09-23 2019-03-26 Ethicon Llc Surgical stapler having motor control based on an electrical parameter related to a motor current
US10363036B2 (en) 2015-09-23 2019-07-30 Ethicon Llc Surgical stapler having force-based motor control
US10299878B2 (en) 2015-09-25 2019-05-28 Ethicon Llc Implantable adjunct systems for determining adjunct skew
US10478188B2 (en) 2015-09-30 2019-11-19 Ethicon Llc Implantable layer comprising a constricted configuration
US10736633B2 (en) 2015-09-30 2020-08-11 Ethicon Llc Compressible adjunct with looping members
US11890015B2 (en) 2015-09-30 2024-02-06 Cilag Gmbh International Compressible adjunct with crossing spacer fibers
US10980539B2 (en) 2015-09-30 2021-04-20 Ethicon Llc Implantable adjunct comprising bonded layers
US10292704B2 (en) 2015-12-30 2019-05-21 Ethicon Llc Mechanisms for compensating for battery pack failure in powered surgical instruments
US10368865B2 (en) 2015-12-30 2019-08-06 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US10265068B2 (en) 2015-12-30 2019-04-23 Ethicon Llc Surgical instruments with separable motors and motor control circuits
BR112018016098B1 (pt) 2016-02-09 2023-02-23 Ethicon Llc Instrumento cirúrgico
US11213293B2 (en) 2016-02-09 2022-01-04 Cilag Gmbh International Articulatable surgical instruments with single articulation link arrangements
US10588625B2 (en) 2016-02-09 2020-03-17 Ethicon Llc Articulatable surgical instruments with off-axis firing beam arrangements
US10258331B2 (en) 2016-02-12 2019-04-16 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US10448948B2 (en) 2016-02-12 2019-10-22 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11224426B2 (en) 2016-02-12 2022-01-18 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US10617413B2 (en) 2016-04-01 2020-04-14 Ethicon Llc Closure system arrangements for surgical cutting and stapling devices with separate and distinct firing shafts
US10413297B2 (en) 2016-04-01 2019-09-17 Ethicon Llc Surgical stapling system configured to apply annular rows of staples having different heights
US11607239B2 (en) 2016-04-15 2023-03-21 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US10828028B2 (en) 2016-04-15 2020-11-10 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US11179150B2 (en) 2016-04-15 2021-11-23 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US10405859B2 (en) 2016-04-15 2019-09-10 Ethicon Llc Surgical instrument with adjustable stop/start control during a firing motion
US10426467B2 (en) 2016-04-15 2019-10-01 Ethicon Llc Surgical instrument with detection sensors
US10335145B2 (en) 2016-04-15 2019-07-02 Ethicon Llc Modular surgical instrument with configurable operating mode
US10492783B2 (en) 2016-04-15 2019-12-03 Ethicon, Llc Surgical instrument with improved stop/start control during a firing motion
US10456137B2 (en) 2016-04-15 2019-10-29 Ethicon Llc Staple formation detection mechanisms
US10357247B2 (en) 2016-04-15 2019-07-23 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US10363037B2 (en) 2016-04-18 2019-07-30 Ethicon Llc Surgical instrument system comprising a magnetic lockout
US11317917B2 (en) 2016-04-18 2022-05-03 Cilag Gmbh International Surgical stapling system comprising a lockable firing assembly
US20170296173A1 (en) 2016-04-18 2017-10-19 Ethicon Endo-Surgery, Llc Method for operating a surgical instrument
CN105920650B (zh) * 2016-06-20 2019-11-26 烟台正海生物科技股份有限公司 一种聚维酮碘妇科医用海绵及其制备方法
JP6957532B2 (ja) 2016-06-24 2021-11-02 エシコン エルエルシーＥｔｈｉｃｏｎ ＬＬＣ ワイヤステープル及び打ち抜き加工ステープルを含むステープルカートリッジ
USD826405S1 (en) 2016-06-24 2018-08-21 Ethicon Llc Surgical fastener
USD850617S1 (en) 2016-06-24 2019-06-04 Ethicon Llc Surgical fastener cartridge
USD847989S1 (en) 2016-06-24 2019-05-07 Ethicon Llc Surgical fastener cartridge
US11000278B2 (en) 2016-06-24 2021-05-11 Ethicon Llc Staple cartridge comprising wire staples and stamped staples
US10945727B2 (en) 2016-12-21 2021-03-16 Ethicon Llc Staple cartridge with deformable driver retention features
US10893864B2 (en) 2016-12-21 2021-01-19 Ethicon Staple cartridges and arrangements of staples and staple cavities therein
CN110087565A (zh) 2016-12-21 2019-08-02 爱惜康有限责任公司 外科缝合系统
US11134942B2 (en) 2016-12-21 2021-10-05 Cilag Gmbh International Surgical stapling instruments and staple-forming anvils
US10426471B2 (en) 2016-12-21 2019-10-01 Ethicon Llc Surgical instrument with multiple failure response modes
US11160551B2 (en) 2016-12-21 2021-11-02 Cilag Gmbh International Articulatable surgical stapling instruments
JP7010956B2 (ja) 2016-12-21 2022-01-26 エシコン エルエルシー 組織をステープル留めする方法
US10582928B2 (en) 2016-12-21 2020-03-10 Ethicon Llc Articulation lock arrangements for locking an end effector in an articulated position in response to actuation of a jaw closure system
US10881401B2 (en) 2016-12-21 2021-01-05 Ethicon Llc Staple firing member comprising a missing cartridge and/or spent cartridge lockout
US10856868B2 (en) 2016-12-21 2020-12-08 Ethicon Llc Firing member pin configurations
US10537325B2 (en) 2016-12-21 2020-01-21 Ethicon Llc Staple forming pocket arrangement to accommodate different types of staples
US20180168625A1 (en) 2016-12-21 2018-06-21 Ethicon Endo-Surgery, Llc Surgical stapling instruments with smart staple cartridges
US10687810B2 (en) 2016-12-21 2020-06-23 Ethicon Llc Stepped staple cartridge with tissue retention and gap setting features
US20180168648A1 (en) 2016-12-21 2018-06-21 Ethicon Endo-Surgery, Llc Durability features for end effectors and firing assemblies of surgical stapling instruments
US10667809B2 (en) 2016-12-21 2020-06-02 Ethicon Llc Staple cartridge and staple cartridge channel comprising windows defined therein
US10568624B2 (en) 2016-12-21 2020-02-25 Ethicon Llc Surgical instruments with jaws that are pivotable about a fixed axis and include separate and distinct closure and firing systems
US10898186B2 (en) 2016-12-21 2021-01-26 Ethicon Llc Staple forming pocket arrangements comprising primary sidewalls and pocket sidewalls
US11684367B2 (en) 2016-12-21 2023-06-27 Cilag Gmbh International Stepped assembly having and end-of-life indicator
US10993715B2 (en) 2016-12-21 2021-05-04 Ethicon Llc Staple cartridge comprising staples with different clamping breadths
US10675025B2 (en) 2016-12-21 2020-06-09 Ethicon Llc Shaft assembly comprising separately actuatable and retractable systems
US20180168615A1 (en) 2016-12-21 2018-06-21 Ethicon Endo-Surgery, Llc Method of deforming staples from two different types of staple cartridges with the same surgical stapling instrument
US11419606B2 (en) 2016-12-21 2022-08-23 Cilag Gmbh International Shaft assembly comprising a clutch configured to adapt the output of a rotary firing member to two different systems
CN110099619B (zh) 2016-12-21 2022-07-15 爱惜康有限责任公司 用于外科端部执行器和可替换工具组件的闭锁装置
US10813638B2 (en) 2016-12-21 2020-10-27 Ethicon Llc Surgical end effectors with expandable tissue stop arrangements
US11653914B2 (en) 2017-06-20 2023-05-23 Cilag Gmbh International Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument according to articulation angle of end effector
US11090046B2 (en) 2017-06-20 2021-08-17 Cilag Gmbh International Systems and methods for controlling displacement member motion of a surgical stapling and cutting instrument
US10779820B2 (en) 2017-06-20 2020-09-22 Ethicon Llc Systems and methods for controlling motor speed according to user input for a surgical instrument
US10624633B2 (en) 2017-06-20 2020-04-21 Ethicon Llc Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument
US11382638B2 (en) 2017-06-20 2022-07-12 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified displacement distance
US10390841B2 (en) 2017-06-20 2019-08-27 Ethicon Llc Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation
US10980537B2 (en) 2017-06-20 2021-04-20 Ethicon Llc Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified number of shaft rotations
US10881399B2 (en) 2017-06-20 2021-01-05 Ethicon Llc Techniques for adaptive control of motor velocity of a surgical stapling and cutting instrument
US10307170B2 (en) 2017-06-20 2019-06-04 Ethicon Llc Method for closed loop control of motor velocity of a surgical stapling and cutting instrument
US10888321B2 (en) 2017-06-20 2021-01-12 Ethicon Llc Systems and methods for controlling velocity of a displacement member of a surgical stapling and cutting instrument
US10327767B2 (en) 2017-06-20 2019-06-25 Ethicon Llc Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation
US11071554B2 (en) 2017-06-20 2021-07-27 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on magnitude of velocity error measurements
US10646220B2 (en) 2017-06-20 2020-05-12 Ethicon Llc Systems and methods for controlling displacement member velocity for a surgical instrument
US10881396B2 (en) 2017-06-20 2021-01-05 Ethicon Llc Surgical instrument with variable duration trigger arrangement
USD890784S1 (en) 2017-06-20 2020-07-21 Ethicon Llc Display panel with changeable graphical user interface
US10813639B2 (en) 2017-06-20 2020-10-27 Ethicon Llc Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on system conditions
US10368864B2 (en) 2017-06-20 2019-08-06 Ethicon Llc Systems and methods for controlling displaying motor velocity for a surgical instrument
USD879809S1 (en) 2017-06-20 2020-03-31 Ethicon Llc Display panel with changeable graphical user interface
USD879808S1 (en) 2017-06-20 2020-03-31 Ethicon Llc Display panel with graphical user interface
US11517325B2 (en) 2017-06-20 2022-12-06 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured displacement distance traveled over a specified time interval
US10856869B2 (en) 2017-06-27 2020-12-08 Ethicon Llc Surgical anvil arrangements
US11324503B2 (en) 2017-06-27 2022-05-10 Cilag Gmbh International Surgical firing member arrangements
US10772629B2 (en) 2017-06-27 2020-09-15 Ethicon Llc Surgical anvil arrangements
US11266405B2 (en) 2017-06-27 2022-03-08 Cilag Gmbh International Surgical anvil manufacturing methods
US10993716B2 (en) 2017-06-27 2021-05-04 Ethicon Llc Surgical anvil arrangements
US20180368844A1 (en) 2017-06-27 2018-12-27 Ethicon Llc Staple forming pocket arrangements
USD854151S1 (en) 2017-06-28 2019-07-16 Ethicon Llc Surgical instrument shaft
US10765427B2 (en) 2017-06-28 2020-09-08 Ethicon Llc Method for articulating a surgical instrument
EP3420947B1 (fr) 2017-06-28 2022-05-25 Cilag GmbH International Instrument chirurgical comprenant des coupleurs rotatifs actionnables de façon sélective
US11564686B2 (en) 2017-06-28 2023-01-31 Cilag Gmbh International Surgical shaft assemblies with flexible interfaces
US11259805B2 (en) 2017-06-28 2022-03-01 Cilag Gmbh International Surgical instrument comprising firing member supports
US11058424B2 (en) 2017-06-28 2021-07-13 Cilag Gmbh International Surgical instrument comprising an offset articulation joint
USD869655S1 (en) 2017-06-28 2019-12-10 Ethicon Llc Surgical fastener cartridge
USD906355S1 (en) 2017-06-28 2020-12-29 Ethicon Llc Display screen or portion thereof with a graphical user interface for a surgical instrument
US11020114B2 (en) 2017-06-28 2021-06-01 Cilag Gmbh International Surgical instruments with articulatable end effector with axially shortened articulation joint configurations
US11246592B2 (en) 2017-06-28 2022-02-15 Cilag Gmbh International Surgical instrument comprising an articulation system lockable to a frame
US10211586B2 (en) 2017-06-28 2019-02-19 Ethicon Llc Surgical shaft assemblies with watertight housings
US10903685B2 (en) 2017-06-28 2021-01-26 Ethicon Llc Surgical shaft assemblies with slip ring assemblies forming capacitive channels
US10716614B2 (en) 2017-06-28 2020-07-21 Ethicon Llc Surgical shaft assemblies with slip ring assemblies with increased contact pressure
USD851762S1 (en) 2017-06-28 2019-06-18 Ethicon Llc Anvil
US10932772B2 (en) 2017-06-29 2021-03-02 Ethicon Llc Methods for closed loop velocity control for robotic surgical instrument
US10258418B2 (en) 2017-06-29 2019-04-16 Ethicon Llc System for controlling articulation forces
US10398434B2 (en) 2017-06-29 2019-09-03 Ethicon Llc Closed loop velocity control of closure member for robotic surgical instrument
US10898183B2 (en) 2017-06-29 2021-01-26 Ethicon Llc Robotic surgical instrument with closed loop feedback techniques for advancement of closure member during firing
US11007022B2 (en) 2017-06-29 2021-05-18 Ethicon Llc Closed loop velocity control techniques based on sensed tissue parameters for robotic surgical instrument
KR102038560B1 (ko) * 2017-07-19 2019-11-01 순천향대학교 산학협력단 목재 기반 산화 셀룰로오스와 실크 피브로인을 이용한 다공성 지혈제의 제조방법
US11471155B2 (en) 2017-08-03 2022-10-18 Cilag Gmbh International Surgical system bailout
US11304695B2 (en) 2017-08-03 2022-04-19 Cilag Gmbh International Surgical system shaft interconnection
US11944300B2 (en) 2017-08-03 2024-04-02 Cilag Gmbh International Method for operating a surgical system bailout
US10729501B2 (en) 2017-09-29 2020-08-04 Ethicon Llc Systems and methods for language selection of a surgical instrument
US10765429B2 (en) 2017-09-29 2020-09-08 Ethicon Llc Systems and methods for providing alerts according to the operational state of a surgical instrument
USD917500S1 (en) 2017-09-29 2021-04-27 Ethicon Llc Display screen or portion thereof with graphical user interface
US10796471B2 (en) 2017-09-29 2020-10-06 Ethicon Llc Systems and methods of displaying a knife position for a surgical instrument
USD907647S1 (en) 2017-09-29 2021-01-12 Ethicon Llc Display screen or portion thereof with animated graphical user interface
USD907648S1 (en) 2017-09-29 2021-01-12 Ethicon Llc Display screen or portion thereof with animated graphical user interface
US11399829B2 (en) 2017-09-29 2022-08-02 Cilag Gmbh International Systems and methods of initiating a power shutdown mode for a surgical instrument
US10743872B2 (en) 2017-09-29 2020-08-18 Ethicon Llc System and methods for controlling a display of a surgical instrument
US11134944B2 (en) 2017-10-30 2021-10-05 Cilag Gmbh International Surgical stapler knife motion controls
US11090075B2 (en) 2017-10-30 2021-08-17 Cilag Gmbh International Articulation features for surgical end effector
US10779903B2 (en) 2017-10-31 2020-09-22 Ethicon Llc Positive shaft rotation lock activated by jaw closure
US10842490B2 (en) 2017-10-31 2020-11-24 Ethicon Llc Cartridge body design with force reduction based on firing completion
US10779825B2 (en) 2017-12-15 2020-09-22 Ethicon Llc Adapters with end effector position sensing and control arrangements for use in connection with electromechanical surgical instruments
US10869666B2 (en) 2017-12-15 2020-12-22 Ethicon Llc Adapters with control systems for controlling multiple motors of an electromechanical surgical instrument
US10743875B2 (en) 2017-12-15 2020-08-18 Ethicon Llc Surgical end effectors with jaw stiffener arrangements configured to permit monitoring of firing member
US10966718B2 (en) 2017-12-15 2021-04-06 Ethicon Llc Dynamic clamping assemblies with improved wear characteristics for use in connection with electromechanical surgical instruments
US11197670B2 (en) 2017-12-15 2021-12-14 Cilag Gmbh International Surgical end effectors with pivotal jaws configured to touch at their respective distal ends when fully closed
US10828033B2 (en) 2017-12-15 2020-11-10 Ethicon Llc Handheld electromechanical surgical instruments with improved motor control arrangements for positioning components of an adapter coupled thereto
US10687813B2 (en) 2017-12-15 2020-06-23 Ethicon Llc Adapters with firing stroke sensing arrangements for use in connection with electromechanical surgical instruments
US10743874B2 (en) 2017-12-15 2020-08-18 Ethicon Llc Sealed adapters for use with electromechanical surgical instruments
US11006955B2 (en) 2017-12-15 2021-05-18 Ethicon Llc End effectors with positive jaw opening features for use with adapters for electromechanical surgical instruments
US11033267B2 (en) 2017-12-15 2021-06-15 Ethicon Llc Systems and methods of controlling a clamping member firing rate of a surgical instrument
US11071543B2 (en) 2017-12-15 2021-07-27 Cilag Gmbh International Surgical end effectors with clamping assemblies configured to increase jaw aperture ranges
US10779826B2 (en) 2017-12-15 2020-09-22 Ethicon Llc Methods of operating surgical end effectors
US11020112B2 (en) 2017-12-19 2021-06-01 Ethicon Llc Surgical tools configured for interchangeable use with different controller interfaces
US10835330B2 (en) 2017-12-19 2020-11-17 Ethicon Llc Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly
USD910847S1 (en) 2017-12-19 2021-02-16 Ethicon Llc Surgical instrument assembly
US10716565B2 (en) 2017-12-19 2020-07-21 Ethicon Llc Surgical instruments with dual articulation drivers
US10729509B2 (en) 2017-12-19 2020-08-04 Ethicon Llc Surgical instrument comprising closure and firing locking mechanism
US11045270B2 (en) 2017-12-19 2021-06-29 Cilag Gmbh International Robotic attachment comprising exterior drive actuator
US11076853B2 (en) 2017-12-21 2021-08-03 Cilag Gmbh International Systems and methods of displaying a knife position during transection for a surgical instrument
US11883019B2 (en) 2017-12-21 2024-01-30 Cilag Gmbh International Stapling instrument comprising a staple feeding system
US11311290B2 (en) 2017-12-21 2022-04-26 Cilag Gmbh International Surgical instrument comprising an end effector dampener
US11129680B2 (en) 2017-12-21 2021-09-28 Cilag Gmbh International Surgical instrument comprising a projector
CN108144100A (zh) * 2017-12-28 2018-06-12 广州润虹医药科技股份有限公司 一种促进伤口愈合的创面敷料及其制备方法
CN108478849B (zh) * 2018-02-07 2021-04-16 广州迈普再生医学科技股份有限公司 一种可吸收可黏附止血海绵及其制备方法
WO2019215274A1 (fr) 2018-05-09 2019-11-14 Ferrosan Medical Devices A/S Procédé de préparation d'une composition hémostatique
US11045192B2 (en) 2018-08-20 2021-06-29 Cilag Gmbh International Fabricating techniques for surgical stapler anvils
US11207065B2 (en) 2018-08-20 2021-12-28 Cilag Gmbh International Method for fabricating surgical stapler anvils
US11083458B2 (en) 2018-08-20 2021-08-10 Cilag Gmbh International Powered surgical instruments with clutching arrangements to convert linear drive motions to rotary drive motions
US11253256B2 (en) 2018-08-20 2022-02-22 Cilag Gmbh International Articulatable motor powered surgical instruments with dedicated articulation motor arrangements
US11039834B2 (en) 2018-08-20 2021-06-22 Cilag Gmbh International Surgical stapler anvils with staple directing protrusions and tissue stability features
US11291440B2 (en) 2018-08-20 2022-04-05 Cilag Gmbh International Method for operating a powered articulatable surgical instrument
US10842492B2 (en) 2018-08-20 2020-11-24 Ethicon Llc Powered articulatable surgical instruments with clutching and locking arrangements for linking an articulation drive system to a firing drive system
US10856870B2 (en) 2018-08-20 2020-12-08 Ethicon Llc Switching arrangements for motor powered articulatable surgical instruments
US10912559B2 (en) 2018-08-20 2021-02-09 Ethicon Llc Reinforced deformable anvil tip for surgical stapler anvil
US11324501B2 (en) 2018-08-20 2022-05-10 Cilag Gmbh International Surgical stapling devices with improved closure members
USD914878S1 (en) 2018-08-20 2021-03-30 Ethicon Llc Surgical instrument anvil
US10779821B2 (en) 2018-08-20 2020-09-22 Ethicon Llc Surgical stapler anvils with tissue stop features configured to avoid tissue pinch
JP2022506896A (ja) * 2018-11-02 2022-01-17 コバロン テクノロジーズ インコーポレイテッド 発泡体組成物、発泡体マトリックスおよび方法
CN109939260A (zh) * 2019-03-01 2019-06-28 昆明理工大学 一种医用壳聚糖/透明质酸钠偶联水凝胶的制备方法
US11147551B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11172929B2 (en) 2019-03-25 2021-11-16 Cilag Gmbh International Articulation drive arrangements for surgical systems
US11696761B2 (en) 2019-03-25 2023-07-11 Cilag Gmbh International Firing drive arrangements for surgical systems
US11147553B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11452528B2 (en) 2019-04-30 2022-09-27 Cilag Gmbh International Articulation actuators for a surgical instrument
US11432816B2 (en) 2019-04-30 2022-09-06 Cilag Gmbh International Articulation pin for a surgical instrument
US11903581B2 (en) 2019-04-30 2024-02-20 Cilag Gmbh International Methods for stapling tissue using a surgical instrument
US11471157B2 (en) 2019-04-30 2022-10-18 Cilag Gmbh International Articulation control mapping for a surgical instrument
US11253254B2 (en) 2019-04-30 2022-02-22 Cilag Gmbh International Shaft rotation actuator on a surgical instrument
US11648009B2 (en) 2019-04-30 2023-05-16 Cilag Gmbh International Rotatable jaw tip for a surgical instrument
US11426251B2 (en) 2019-04-30 2022-08-30 Cilag Gmbh International Articulation directional lights on a surgical instrument
US11464601B2 (en) 2019-06-28 2022-10-11 Cilag Gmbh International Surgical instrument comprising an RFID system for tracking a movable component
US11478241B2 (en) 2019-06-28 2022-10-25 Cilag Gmbh International Staple cartridge including projections
US11224497B2 (en) 2019-06-28 2022-01-18 Cilag Gmbh International Surgical systems with multiple RFID tags
US11246678B2 (en) 2019-06-28 2022-02-15 Cilag Gmbh International Surgical stapling system having a frangible RFID tag
US11638587B2 (en) 2019-06-28 2023-05-02 Cilag Gmbh International RFID identification systems for surgical instruments
US11051807B2 (en) 2019-06-28 2021-07-06 Cilag Gmbh International Packaging assembly including a particulate trap
US11298132B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Inlernational Staple cartridge including a honeycomb extension
US11219455B2 (en) 2019-06-28 2022-01-11 Cilag Gmbh International Surgical instrument including a lockout key
US11350938B2 (en) 2019-06-28 2022-06-07 Cilag Gmbh International Surgical instrument comprising an aligned rfid sensor
US11771419B2 (en) 2019-06-28 2023-10-03 Cilag Gmbh International Packaging for a replaceable component of a surgical stapling system
US11523822B2 (en) 2019-06-28 2022-12-13 Cilag Gmbh International Battery pack including a circuit interrupter
US11627959B2 (en) 2019-06-28 2023-04-18 Cilag Gmbh International Surgical instruments including manual and powered system lockouts
US11259803B2 (en) 2019-06-28 2022-03-01 Cilag Gmbh International Surgical stapling system having an information encryption protocol
US11684434B2 (en) 2019-06-28 2023-06-27 Cilag Gmbh International Surgical RFID assemblies for instrument operational setting control
US11399837B2 (en) 2019-06-28 2022-08-02 Cilag Gmbh International Mechanisms for motor control adjustments of a motorized surgical instrument
US11376098B2 (en) 2019-06-28 2022-07-05 Cilag Gmbh International Surgical instrument system comprising an RFID system
US11426167B2 (en) 2019-06-28 2022-08-30 Cilag Gmbh International Mechanisms for proper anvil attachment surgical stapling head assembly
US11660163B2 (en) 2019-06-28 2023-05-30 Cilag Gmbh International Surgical system with RFID tags for updating motor assembly parameters
US11291451B2 (en) 2019-06-28 2022-04-05 Cilag Gmbh International Surgical instrument with battery compatibility verification functionality
US11553971B2 (en) 2019-06-28 2023-01-17 Cilag Gmbh International Surgical RFID assemblies for display and communication
US11298127B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Interational Surgical stapling system having a lockout mechanism for an incompatible cartridge
US11497492B2 (en) 2019-06-28 2022-11-15 Cilag Gmbh International Surgical instrument including an articulation lock
CN115066292A (zh) 2019-12-17 2022-09-16 科发龙技术公司 涂覆器件的反应器以及相关系统和方法
US11559304B2 (en) 2019-12-19 2023-01-24 Cilag Gmbh International Surgical instrument comprising a rapid closure mechanism
US11701111B2 (en) 2019-12-19 2023-07-18 Cilag Gmbh International Method for operating a surgical stapling instrument
US11844520B2 (en) 2019-12-19 2023-12-19 Cilag Gmbh International Staple cartridge comprising driver retention members
US11291447B2 (en) 2019-12-19 2022-04-05 Cilag Gmbh International Stapling instrument comprising independent jaw closing and staple firing systems
US11529137B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Staple cartridge comprising driver retention members
US11446029B2 (en) 2019-12-19 2022-09-20 Cilag Gmbh International Staple cartridge comprising projections extending from a curved deck surface
US11529139B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Motor driven surgical instrument
US11576672B2 (en) 2019-12-19 2023-02-14 Cilag Gmbh International Surgical instrument comprising a closure system including a closure member and an opening member driven by a drive screw
US11607219B2 (en) 2019-12-19 2023-03-21 Cilag Gmbh International Staple cartridge comprising a detachable tissue cutting knife
US11931033B2 (en) 2019-12-19 2024-03-19 Cilag Gmbh International Staple cartridge comprising a latch lockout
US11504122B2 (en) 2019-12-19 2022-11-22 Cilag Gmbh International Surgical instrument comprising a nested firing member
US11911032B2 (en) 2019-12-19 2024-02-27 Cilag Gmbh International Staple cartridge comprising a seating cam
US11464512B2 (en) 2019-12-19 2022-10-11 Cilag Gmbh International Staple cartridge comprising a curved deck surface
US11234698B2 (en) 2019-12-19 2022-02-01 Cilag Gmbh International Stapling system comprising a clamp lockout and a firing lockout
US11304696B2 (en) 2019-12-19 2022-04-19 Cilag Gmbh International Surgical instrument comprising a powered articulation system
USD967421S1 (en) 2020-06-02 2022-10-18 Cilag Gmbh International Staple cartridge
USD974560S1 (en) 2020-06-02 2023-01-03 Cilag Gmbh International Staple cartridge
USD975278S1 (en) 2020-06-02 2023-01-10 Cilag Gmbh International Staple cartridge
USD976401S1 (en) 2020-06-02 2023-01-24 Cilag Gmbh International Staple cartridge
USD966512S1 (en) 2020-06-02 2022-10-11 Cilag Gmbh International Staple cartridge
USD975850S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
USD975851S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
US11883024B2 (en) 2020-07-28 2024-01-30 Cilag Gmbh International Method of operating a surgical instrument
RU2747662C1 (ru) * 2020-09-03 2021-05-11 Эльдар Рифович Бакиров Способ укрепления межкишечных анастомозов
US11896217B2 (en) 2020-10-29 2024-02-13 Cilag Gmbh International Surgical instrument comprising an articulation lock
US11617577B2 (en) 2020-10-29 2023-04-04 Cilag Gmbh International Surgical instrument comprising a sensor configured to sense whether an articulation drive of the surgical instrument is actuatable
US11517390B2 (en) 2020-10-29 2022-12-06 Cilag Gmbh International Surgical instrument comprising a limited travel switch
US11844518B2 (en) 2020-10-29 2023-12-19 Cilag Gmbh International Method for operating a surgical instrument
US11452526B2 (en) 2020-10-29 2022-09-27 Cilag Gmbh International Surgical instrument comprising a staged voltage regulation start-up system
US11779330B2 (en) 2020-10-29 2023-10-10 Cilag Gmbh International Surgical instrument comprising a jaw alignment system
USD980425S1 (en) 2020-10-29 2023-03-07 Cilag Gmbh International Surgical instrument assembly
US11931025B2 (en) 2020-10-29 2024-03-19 Cilag Gmbh International Surgical instrument comprising a releasable closure drive lock
USD1013170S1 (en) 2020-10-29 2024-01-30 Cilag Gmbh International Surgical instrument assembly
US11717289B2 (en) 2020-10-29 2023-08-08 Cilag Gmbh International Surgical instrument comprising an indicator which indicates that an articulation drive is actuatable
US11534259B2 (en) 2020-10-29 2022-12-27 Cilag Gmbh International Surgical instrument comprising an articulation indicator
US11744581B2 (en) 2020-12-02 2023-09-05 Cilag Gmbh International Powered surgical instruments with multi-phase tissue treatment
US11944296B2 (en) 2020-12-02 2024-04-02 Cilag Gmbh International Powered surgical instruments with external connectors
US11678882B2 (en) 2020-12-02 2023-06-20 Cilag Gmbh International Surgical instruments with interactive features to remedy incidental sled movements
US11627960B2 (en) 2020-12-02 2023-04-18 Cilag Gmbh International Powered surgical instruments with smart reload with separately attachable exteriorly mounted wiring connections
US11737751B2 (en) 2020-12-02 2023-08-29 Cilag Gmbh International Devices and methods of managing energy dissipated within sterile barriers of surgical instrument housings
US11653915B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Surgical instruments with sled location detection and adjustment features
US11890010B2 (en) 2020-12-02 2024-02-06 Cllag GmbH International Dual-sided reinforced reload for surgical instruments
US11849943B2 (en) 2020-12-02 2023-12-26 Cilag Gmbh International Surgical instrument with cartridge release mechanisms
US11653920B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Powered surgical instruments with communication interfaces through sterile barrier
US11696757B2 (en) 2021-02-26 2023-07-11 Cilag Gmbh International Monitoring of internal systems to detect and track cartridge motion status
US11925349B2 (en) 2021-02-26 2024-03-12 Cilag Gmbh International Adjustment to transfer parameters to improve available power
US11812964B2 (en) 2021-02-26 2023-11-14 Cilag Gmbh International Staple cartridge comprising a power management circuit
US11744583B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Distal communication array to tune frequency of RF systems
US11730473B2 (en) 2021-02-26 2023-08-22 Cilag Gmbh International Monitoring of manufacturing life-cycle
US11950779B2 (en) 2021-02-26 2024-04-09 Cilag Gmbh International Method of powering and communicating with a staple cartridge
US11723657B2 (en) 2021-02-26 2023-08-15 Cilag Gmbh International Adjustable communication based on available bandwidth and power capacity
US11950777B2 (en) 2021-02-26 2024-04-09 Cilag Gmbh International Staple cartridge comprising an information access control system
US11701113B2 (en) 2021-02-26 2023-07-18 Cilag Gmbh International Stapling instrument comprising a separate power antenna and a data transfer antenna
US11793514B2 (en) 2021-02-26 2023-10-24 Cilag Gmbh International Staple cartridge comprising sensor array which may be embedded in cartridge body
US11749877B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Stapling instrument comprising a signal antenna
US11751869B2 (en) 2021-02-26 2023-09-12 Cilag Gmbh International Monitoring of multiple sensors over time to detect moving characteristics of tissue
US11723658B2 (en) 2021-03-22 2023-08-15 Cilag Gmbh International Staple cartridge comprising a firing lockout
US11826012B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Stapling instrument comprising a pulsed motor-driven firing rack
US11826042B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Surgical instrument comprising a firing drive including a selectable leverage mechanism
US11806011B2 (en) 2021-03-22 2023-11-07 Cilag Gmbh International Stapling instrument comprising tissue compression systems
US11717291B2 (en) 2021-03-22 2023-08-08 Cilag Gmbh International Staple cartridge comprising staples configured to apply different tissue compression
US11737749B2 (en) 2021-03-22 2023-08-29 Cilag Gmbh International Surgical stapling instrument comprising a retraction system
US11759202B2 (en) 2021-03-22 2023-09-19 Cilag Gmbh International Staple cartridge comprising an implantable layer
US11786239B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Surgical instrument articulation joint arrangements comprising multiple moving linkage features
US11896219B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Mating features between drivers and underside of a cartridge deck
US11832816B2 (en) 2021-03-24 2023-12-05 Cilag Gmbh International Surgical stapling assembly comprising nonplanar staples and planar staples
US11744603B2 (en) 2021-03-24 2023-09-05 Cilag Gmbh International Multi-axis pivot joints for surgical instruments and methods for manufacturing same
US11793516B2 (en) 2021-03-24 2023-10-24 Cilag Gmbh International Surgical staple cartridge comprising longitudinal support beam
US11849944B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Drivers for fastener cartridge assemblies having rotary drive screws
US11903582B2 (en) 2021-03-24 2024-02-20 Cilag Gmbh International Leveraging surfaces for cartridge installation
US11944336B2 (en) 2021-03-24 2024-04-02 Cilag Gmbh International Joint arrangements for multi-planar alignment and support of operational drive shafts in articulatable surgical instruments
US11849945B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Rotary-driven surgical stapling assembly comprising eccentrically driven firing member
US11896218B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Method of using a powered stapling device
US11786243B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Firing members having flexible portions for adapting to a load during a surgical firing stroke
US11857183B2 (en) 2021-03-24 2024-01-02 Cilag Gmbh International Stapling assembly components having metal substrates and plastic bodies
US11723662B2 (en) 2021-05-28 2023-08-15 Cilag Gmbh International Stapling instrument comprising an articulation control display
CN113577373A (zh) * 2021-07-30 2021-11-02 南京嘉合玉颜生物科技有限公司 一种吸收性明胶海绵的制备方法
US11877745B2 (en) 2021-10-18 2024-01-23 Cilag Gmbh International Surgical stapling assembly having longitudinally-repeating staple leg clusters
US11957337B2 (en) 2021-10-18 2024-04-16 Cilag Gmbh International Surgical stapling assembly with offset ramped drive surfaces
US11937816B2 (en) 2021-10-28 2024-03-26 Cilag Gmbh International Electrical lead arrangements for surgical instruments
CN114533948A (zh) * 2022-02-25 2022-05-27 韩友平 一种生物医用凝胶及其制备方法

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3491760A (en) * 1965-07-09 1970-01-27 Braun Intern Gmbh B Wound coverings
US4703108A (en) * 1984-03-27 1987-10-27 University Of Medicine & Dentistry Of New Jersey Biodegradable matrix and methods for producing same
US5399361A (en) * 1992-05-01 1995-03-21 Amgen Inc. Collagen-containing sponges as drug delivery compositions for proteins
US5550187A (en) * 1988-11-21 1996-08-27 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
US5744545A (en) * 1988-11-21 1998-04-28 Collagen Corporation Biocompatible adhesive compositions
US6132765A (en) * 1996-04-12 2000-10-17 Uroteq Inc. Drug delivery via therapeutic hydrogels
US20020131933A1 (en) * 1996-01-16 2002-09-19 Yves Delmotte Biopolymer membrane and methods for its preparation
US20030039695A1 (en) * 2001-08-10 2003-02-27 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Collagen carrier of therapeutic genetic material, and method
US20060068013A1 (en) * 2004-09-30 2006-03-30 Ditizio Valerio Non-adhesive elastic gelatin matrices

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA409076A (fr) * 1942-12-01 Lionel Daniels Joseph Machine a scier par chaine
US3491780A (en) * 1967-12-11 1970-01-27 Maytag Co Self-cleaning filter for dishwasher
US4925924A (en) 1984-03-27 1990-05-15 University Of Medicine And Dentistry Of New Jersey Biocompatible synthetic and collagen compositions having a dual-type porosity for treatment of wounds and pressure ulcers and therapeutic methods thereof
US5475052A (en) * 1988-11-21 1995-12-12 Collagen Corporation Collagen-synthetic polymer matrices prepared using a multiple step reaction
RU2033149C1 (ru) * 1990-02-09 1995-04-20 Ленинградский научно-исследовательский институт гематологии и переливания крови Способ получения гемостатического препарата
JPH03286772A (ja) * 1990-03-31 1991-12-17 Sanwa Kagaku Kenkyusho Co Ltd 創傷治療被覆材
NL9200683A (nl) 1992-04-13 1993-11-01 Thyssen De Reus Bv Mechanisme voor het vergrendelen van een draaias, zoals een scharnieras voor een liftdeur.
RU2034572C1 (ru) * 1992-11-03 1995-05-10 Малое многопрофильное предприятие "ПОЛИКОМ" Гемостатическая губка
US5492976A (en) * 1994-01-03 1996-02-20 The Sherwin-Williams Company Anhydride-functional polymers comprising ene reaction products of unsaturated anhydrides and polyolefins
CA2140053C (fr) 1994-02-09 2000-04-04 Joel S. Rosenblatt Systeme a base de collagene pour l'administration de drogue injectable, et utilisation
US6228383B1 (en) * 1994-03-03 2001-05-08 Gs Development Ab Use of fatty acid esters as bioadhesive substances
RU2118176C1 (ru) * 1996-09-27 1998-08-27 Истранов Леонид Прокофьевич Способ получения коллагеновых пластинок
AU4819897A (en) * 1996-10-16 1998-05-11 Fusion Medical Technologies, Inc. Films having improved characteristics and methods for their preparation and use
US5800832A (en) * 1996-10-18 1998-09-01 Virotex Corporation Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces
US20020025921A1 (en) 1999-07-26 2002-02-28 Petito George D. Composition and method for growing, protecting, and healing tissues and cells
AUPP437698A0 (en) * 1998-06-30 1998-07-23 Baumgart, Karl Methods for treatment of coronary, carotid and other vascular disease
US6132785A (en) * 1998-10-29 2000-10-17 J. R. Simplot Company Process for preparing batter coated french fried potato strips
AU7989100A (en) * 1999-10-01 2001-05-10 Acrymed Silver-containing compositions, devices and methods for making

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3491760A (en) * 1965-07-09 1970-01-27 Braun Intern Gmbh B Wound coverings
US4703108A (en) * 1984-03-27 1987-10-27 University Of Medicine & Dentistry Of New Jersey Biodegradable matrix and methods for producing same
US5550187A (en) * 1988-11-21 1996-08-27 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
US5744545A (en) * 1988-11-21 1998-04-28 Collagen Corporation Biocompatible adhesive compositions
US5399361A (en) * 1992-05-01 1995-03-21 Amgen Inc. Collagen-containing sponges as drug delivery compositions for proteins
US20020131933A1 (en) * 1996-01-16 2002-09-19 Yves Delmotte Biopolymer membrane and methods for its preparation
US6132765A (en) * 1996-04-12 2000-10-17 Uroteq Inc. Drug delivery via therapeutic hydrogels
US6228393B1 (en) * 1996-04-12 2001-05-08 Uroteq, Inc. Drug delivery via therapeutic hydrogels
US6475516B2 (en) * 1996-04-12 2002-11-05 Dicosmo Frank Drug delivery via therapeutic hydrogels
US20030039695A1 (en) * 2001-08-10 2003-02-27 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Collagen carrier of therapeutic genetic material, and method
US20060068013A1 (en) * 2004-09-30 2006-03-30 Ditizio Valerio Non-adhesive elastic gelatin matrices

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090022801A1 (en) * 2006-01-31 2009-01-22 David Vachon Compositions and Methods for Promoting the Healing of Tissue of Multicellular Organisms
US20100247544A1 (en) * 2006-01-31 2010-09-30 Dr. David John Vachon Compositions and Methods for Promoting the Healing of Tissue of Multicellular Organisms
US8795730B2 (en) 2006-01-31 2014-08-05 David John Vachon Compositions and methods for promoting the healing of tissue of multicellular organisms
US9970303B2 (en) 2014-05-13 2018-05-15 Entrotech, Inc. Erosion protection sleeve
EP3088010A1 (fr) 2015-04-28 2016-11-02 DiCosmo, Frank Biomatériaux à base de collagène bioactif et leurs procédés de fabrication
US11058749B2 (en) 2015-04-28 2021-07-13 Frank DiCosmo Bioactive collagen biomaterials and methods for making
CN110075346A (zh) * 2019-04-30 2019-08-02 苏州卫生职业技术学院 一种高粘附性水凝胶敷料及其制备方法

Also Published As

Publication number Publication date
EA016776B9 (ru) 2012-11-30
EA200700589A1 (ru) 2007-10-26
EA200900997A1 (ru) 2009-12-30
EP1793872A4 (fr) 2011-08-03
UA88321C2 (ru) 2009-10-12
AU2005289311B2 (en) 2011-03-03
US20130137780A1 (en) 2013-05-30
US8354123B2 (en) 2013-01-15
NO20071668L (no) 2007-06-28
DK1793872T3 (en) 2016-07-25
US20110311629A1 (en) 2011-12-22
JP2008514316A (ja) 2008-05-08
CA2580357A1 (fr) 2006-04-06
EA016776B1 (ru) 2012-07-30
US20060068013A1 (en) 2006-03-30
EP1793872B1 (fr) 2016-05-11
US8361501B2 (en) 2013-01-29
EP1793872A1 (fr) 2007-06-13
JP5047797B2 (ja) 2012-10-10
US8628800B2 (en) 2014-01-14
EA012609B1 (ru) 2009-10-30
WO2006034568A1 (fr) 2006-04-06
ES2581558T3 (es) 2016-09-06
AU2005289311A1 (en) 2006-04-06
CA2580357C (fr) 2014-01-28

Similar Documents

Publication Publication Date Title
US8628800B2 (en) Non-adhesive elastic gelatin matrices
Hwang et al. Gentamicin-loaded wound dressing with polyvinyl alcohol/dextran hydrogel: gel characterization and in vivo healing evaluation
Puertas-Bartolomé et al. Bioadhesive functional hydrogels: Controlled release of catechol species with antioxidant and antiinflammatory behavior
Choi et al. Study on gelatin-containing artificial skin: I. Preparation and characteristics of novel gelatin-alginate sponge
KR101103423B1 (ko) 생체 주입형 조직 접착성 하이드로젤 및 이의 생의학적 용도
US8029774B2 (en) Wound healing polymeric networks
Kim et al. Development of clindamycin-loaded wound dressing with polyvinyl alcohol and sodium alginate
ES2416458T3 (es) Materiales para vendajes
Luo et al. Thermogelling chitosan-based polymers for the treatment of oral mucosa ulcers
WO2022143217A1 (fr) Dispositif médical, hydrogel médical, procédé de préparation et application associés
KR101820306B1 (ko) 갈산-키토산 결합체 및 이를 이용한 창상치료용 조성물
WO2020134757A1 (fr) Colle d'étanchéité médicale capable de favoriser la cicatrisation des plaies et son procédé de préparation
Huang et al. Preparation of novel stable microbicidal hydrogel films as potential wound dressing
Fan et al. Flexible dual-functionalized hyaluronic acid hydrogel adhesives formed in situ for rapid hemostasis
Valipour et al. Preparation and characterization of wound healing hydrogel based on fish skin collagen and chitosan cross-linked by dialdehyde starch
Özkahraman et al. Synthesis of chitosan-based hydrogels as a novel drug release device for wound healing
CN114425105B (zh) 一种抗菌、止血、促修复、防粘连的组合使用型多功能材料的制备方法及应用
Baranes‐Zeevi et al. Novel drug‐eluting soy‐protein structures for wound healing applications
RU2582220C1 (ru) Повязка для лечения ран на основе хитозана
Olami et al. Novel soy protein blend scaffolds loaded with antibiotics: Drug release profile—bacterial inhibition effects
Islam et al. Polymer Matrixes Used in Wound Healing Applications
Evranos The Synthesis of Ph-responsıve Polymeric Film wıth an Enhanced Mechanical Properties for Wound Dress Applications
Bibire et al. Biopolymers for Surgical Applications. Coatings 2022, 12, 211
Parker Design and Preliminary Investigation of Crosslinked Chitosan Sponges for Tailorable Drug Delivery and Infection Control
TW201519916A (zh) 複合水膠材料及其製備方法

Legal Events

Date Code Title Description
AS Assignment

Owner name: COVALON TECHNOLOGIES INC., CANADA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:DITIZIO, VALERIO;DICOSMO, FRANK;XIAO, YUEHUA;REEL/FRAME:021363/0512

Effective date: 20050729

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION