US20110005918A1 - Compositions, devices, systems, and methods for using a nanopore - Google Patents
Compositions, devices, systems, and methods for using a nanopore Download PDFInfo
- Publication number
- US20110005918A1 US20110005918A1 US12/080,684 US8068408A US2011005918A1 US 20110005918 A1 US20110005918 A1 US 20110005918A1 US 8068408 A US8068408 A US 8068408A US 2011005918 A1 US2011005918 A1 US 2011005918A1
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- United States
- Prior art keywords
- dna
- enzyme
- polynucleotide
- pore
- nanopore
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/25—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving enzymes not classifiable in groups C12Q1/26 - C12Q1/66
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
- C25B3/00—Electrolytic production of organic compounds
- C25B3/20—Processes
- C25B3/29—Coupling reactions
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
- G01N27/3278—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction involving nanosized elements, e.g. nanogaps or nanoparticles
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/4166—Systems measuring a particular property of an electrolyte
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Nanotechnology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Emergency Medicine (AREA)
- Cell Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Enzymes And Modification Thereof (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/080,684 US20110005918A1 (en) | 2007-04-04 | 2008-04-04 | Compositions, devices, systems, and methods for using a nanopore |
US13/615,183 US10059988B2 (en) | 2007-04-04 | 2012-09-13 | Methods for using a nanopore |
US14/056,636 US10081835B2 (en) | 2007-04-04 | 2013-10-17 | Nucleotide sequencing using an array of independently addressable nanopores |
US14/300,453 US20140346059A1 (en) | 2007-04-04 | 2014-06-10 | Compositions, Devices, Systems, and Methods for Using a Nanopore |
US14/919,315 US10196688B2 (en) | 2007-04-04 | 2015-10-21 | Compositions, devices, systems, and methods for using a nanopore |
US15/087,734 US10344327B2 (en) | 2007-04-04 | 2016-03-31 | Compositions, devices, systems, and methods for using a nanopore |
US15/162,225 US9797013B2 (en) | 2007-04-04 | 2016-05-23 | Compositions, devices, systems, and methods for using a nanopore |
US15/713,542 US10208342B2 (en) | 2007-04-04 | 2017-09-22 | Compositions, devices, systems, and methods for using a nanopore |
US15/713,535 US10202645B2 (en) | 2007-04-04 | 2017-09-22 | Compositions, devices, systems, and methods for using a nanopore |
US16/897,052 US20200325535A1 (en) | 2007-04-04 | 2020-06-09 | Compositions, Devices, Systems, and Methods for Using a Nanopore |
US17/098,101 US11970738B2 (en) | 2007-04-04 | 2020-11-13 | Compositions, devices, systems, and methods for using a nanopore |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92178707P | 2007-04-04 | 2007-04-04 | |
US93111507P | 2007-05-21 | 2007-05-21 | |
US96253007P | 2007-07-30 | 2007-07-30 | |
US96753907P | 2007-09-04 | 2007-09-04 | |
US6239108P | 2008-01-25 | 2008-01-25 | |
US12/080,684 US20110005918A1 (en) | 2007-04-04 | 2008-04-04 | Compositions, devices, systems, and methods for using a nanopore |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/615,183 Continuation US10059988B2 (en) | 2007-04-04 | 2012-09-13 | Methods for using a nanopore |
Publications (1)
Publication Number | Publication Date |
---|---|
US20110005918A1 true US20110005918A1 (en) | 2011-01-13 |
Family
ID=39831269
Family Applications (14)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/080,684 Abandoned US20110005918A1 (en) | 2007-04-04 | 2008-04-04 | Compositions, devices, systems, and methods for using a nanopore |
US12/450,633 Active 2029-07-25 US8500982B2 (en) | 2007-04-04 | 2008-04-04 | Compositions, devices, systems, and methods for using a nanopore |
US12/459,059 Active 2029-04-03 US8679747B2 (en) | 2007-04-04 | 2009-06-26 | Compositions, devices, systems, for using a nanopore |
US13/615,183 Active 2029-08-12 US10059988B2 (en) | 2007-04-04 | 2012-09-13 | Methods for using a nanopore |
US14/056,636 Active US10081835B2 (en) | 2007-04-04 | 2013-10-17 | Nucleotide sequencing using an array of independently addressable nanopores |
US14/192,785 Active 2028-08-19 US9481908B2 (en) | 2007-04-04 | 2014-02-27 | Compositions, devices, systems, and methods for using a nanopore |
US14/300,453 Abandoned US20140346059A1 (en) | 2007-04-04 | 2014-06-10 | Compositions, Devices, Systems, and Methods for Using a Nanopore |
US14/919,315 Active US10196688B2 (en) | 2007-04-04 | 2015-10-21 | Compositions, devices, systems, and methods for using a nanopore |
US15/087,734 Active 2029-08-05 US10344327B2 (en) | 2007-04-04 | 2016-03-31 | Compositions, devices, systems, and methods for using a nanopore |
US15/162,225 Active US9797013B2 (en) | 2007-04-04 | 2016-05-23 | Compositions, devices, systems, and methods for using a nanopore |
US15/713,542 Active US10208342B2 (en) | 2007-04-04 | 2017-09-22 | Compositions, devices, systems, and methods for using a nanopore |
US15/713,535 Active US10202645B2 (en) | 2007-04-04 | 2017-09-22 | Compositions, devices, systems, and methods for using a nanopore |
US16/897,052 Pending US20200325535A1 (en) | 2007-04-04 | 2020-06-09 | Compositions, Devices, Systems, and Methods for Using a Nanopore |
US17/098,101 Active 2028-04-26 US11970738B2 (en) | 2007-04-04 | 2020-11-13 | Compositions, devices, systems, and methods for using a nanopore |
Family Applications After (13)
Application Number | Title | Priority Date | Filing Date |
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US12/450,633 Active 2029-07-25 US8500982B2 (en) | 2007-04-04 | 2008-04-04 | Compositions, devices, systems, and methods for using a nanopore |
US12/459,059 Active 2029-04-03 US8679747B2 (en) | 2007-04-04 | 2009-06-26 | Compositions, devices, systems, for using a nanopore |
US13/615,183 Active 2029-08-12 US10059988B2 (en) | 2007-04-04 | 2012-09-13 | Methods for using a nanopore |
US14/056,636 Active US10081835B2 (en) | 2007-04-04 | 2013-10-17 | Nucleotide sequencing using an array of independently addressable nanopores |
US14/192,785 Active 2028-08-19 US9481908B2 (en) | 2007-04-04 | 2014-02-27 | Compositions, devices, systems, and methods for using a nanopore |
US14/300,453 Abandoned US20140346059A1 (en) | 2007-04-04 | 2014-06-10 | Compositions, Devices, Systems, and Methods for Using a Nanopore |
US14/919,315 Active US10196688B2 (en) | 2007-04-04 | 2015-10-21 | Compositions, devices, systems, and methods for using a nanopore |
US15/087,734 Active 2029-08-05 US10344327B2 (en) | 2007-04-04 | 2016-03-31 | Compositions, devices, systems, and methods for using a nanopore |
US15/162,225 Active US9797013B2 (en) | 2007-04-04 | 2016-05-23 | Compositions, devices, systems, and methods for using a nanopore |
US15/713,542 Active US10208342B2 (en) | 2007-04-04 | 2017-09-22 | Compositions, devices, systems, and methods for using a nanopore |
US15/713,535 Active US10202645B2 (en) | 2007-04-04 | 2017-09-22 | Compositions, devices, systems, and methods for using a nanopore |
US16/897,052 Pending US20200325535A1 (en) | 2007-04-04 | 2020-06-09 | Compositions, Devices, Systems, and Methods for Using a Nanopore |
US17/098,101 Active 2028-04-26 US11970738B2 (en) | 2007-04-04 | 2020-11-13 | Compositions, devices, systems, and methods for using a nanopore |
Country Status (9)
Country | Link |
---|---|
US (14) | US20110005918A1 (zh) |
EP (2) | EP3798317B1 (zh) |
JP (3) | JP5646987B2 (zh) |
KR (1) | KR101521990B1 (zh) |
CN (1) | CN101680873B (zh) |
AU (1) | AU2008236694B2 (zh) |
CA (1) | CA2684801C (zh) |
IL (1) | IL201303A0 (zh) |
WO (1) | WO2008124107A1 (zh) |
Cited By (25)
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US20090298072A1 (en) * | 2006-06-07 | 2009-12-03 | The Trustees Of Columbia University In The City Of | DNA Sequencing by Nanopore Using Modified Nucleotides |
US20100035260A1 (en) * | 2007-04-04 | 2010-02-11 | Felix Olasagasti | Compositions, devices, systems, for using a Nanopore |
WO2012102797A3 (en) * | 2011-01-24 | 2013-01-03 | Genia Technologies, Inc. | System for communicating information from an array of sensors |
US8845880B2 (en) | 2010-12-22 | 2014-09-30 | Genia Technologies, Inc. | Nanopore-based single DNA molecule characterization, identification and isolation using speed bumps |
US8986629B2 (en) | 2012-02-27 | 2015-03-24 | Genia Technologies, Inc. | Sensor circuit for controlling, detecting, and measuring a molecular complex |
US20150119259A1 (en) * | 2012-06-20 | 2015-04-30 | Jingyue Ju | Nucleic acid sequencing by nanopore detection of tag molecules |
US9041420B2 (en) | 2010-02-08 | 2015-05-26 | Genia Technologies, Inc. | Systems and methods for characterizing a molecule |
US9110478B2 (en) | 2011-01-27 | 2015-08-18 | Genia Technologies, Inc. | Temperature regulation of measurement arrays |
US9322062B2 (en) | 2013-10-23 | 2016-04-26 | Genia Technologies, Inc. | Process for biosensor well formation |
US9494554B2 (en) | 2012-06-15 | 2016-11-15 | Genia Technologies, Inc. | Chip set-up and high-accuracy nucleic acid sequencing |
US9551697B2 (en) | 2013-10-17 | 2017-01-24 | Genia Technologies, Inc. | Non-faradaic, capacitively coupled measurement in a nanopore cell array |
US9605307B2 (en) | 2010-02-08 | 2017-03-28 | Genia Technologies, Inc. | Systems and methods for forming a nanopore in a lipid bilayer |
US9605309B2 (en) | 2012-11-09 | 2017-03-28 | Genia Technologies, Inc. | Nucleic acid sequencing using tags |
US9678055B2 (en) | 2010-02-08 | 2017-06-13 | Genia Technologies, Inc. | Methods for forming a nanopore in a lipid bilayer |
US9759711B2 (en) | 2013-02-05 | 2017-09-12 | Genia Technologies, Inc. | Nanopore arrays |
US20180036331A1 (en) * | 2016-03-24 | 2018-02-08 | The Board Of Regents Of The University Of Texas System | Treatment of drug resistant proliferative diseases with telomerase mediated telomere altering compounds |
US10246479B2 (en) | 2012-04-09 | 2019-04-02 | The Trustees Of Columbia University In The City Of New York | Method of preparation of nanopore and uses thereof |
US10421995B2 (en) | 2013-10-23 | 2019-09-24 | Genia Technologies, Inc. | High speed molecular sensing with nanopores |
US10443096B2 (en) | 2010-12-17 | 2019-10-15 | The Trustees Of Columbia University In The City Of New York | DNA sequencing by synthesis using modified nucleotides and nanopore detection |
US10732183B2 (en) | 2013-03-15 | 2020-08-04 | The Trustees Of Columbia University In The City Of New York | Method for detecting multiple predetermined compounds in a sample |
US20200308641A1 (en) * | 2012-01-20 | 2020-10-01 | Roche Sequencing Solutions, Inc. | Nanopore based molecular detection and sequencing |
US10934581B2 (en) | 2014-04-30 | 2021-03-02 | International Business Machines Corporation | Bow tie DNA compositions and methods |
US11298086B2 (en) | 2018-10-05 | 2022-04-12 | Samsung Electronics Co., Ltd. | Apparatus and method for estimating blood pressure |
US11339365B2 (en) | 2012-02-16 | 2022-05-24 | The Regents Of The University Of California | Nanopore sensor for enzyme-mediated protein translocation |
US11603562B2 (en) | 2018-05-22 | 2023-03-14 | Axbio Inc. | Methods, systems, and compositions for nucleic acid sequencing |
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US7238485B2 (en) * | 2004-03-23 | 2007-07-03 | President And Fellows Of Harvard College | Methods and apparatus for characterizing polynucleotides |
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US8273532B2 (en) | 2007-10-02 | 2012-09-25 | President And Fellows Of Harvard College | Capture, recapture, and trapping of molecules with a nanopore |
GB2453377A (en) | 2007-10-05 | 2009-04-08 | Isis Innovation | Transmembrane protein pores and molecular adapters therefore. |
GB0724736D0 (en) | 2007-12-19 | 2008-01-30 | Oxford Nanolabs Ltd | Formation of layers of amphiphilic molecules |
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