US20110002977A1 - Liposomal pharmaceutical preparation and method for manufacturing the same - Google Patents

Liposomal pharmaceutical preparation and method for manufacturing the same Download PDF

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Publication number
US20110002977A1
US20110002977A1 US12/521,357 US52135707A US2011002977A1 US 20110002977 A1 US20110002977 A1 US 20110002977A1 US 52135707 A US52135707 A US 52135707A US 2011002977 A1 US2011002977 A1 US 2011002977A1
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United States
Prior art keywords
liposome
liposomal
drug
liposomal drug
phospholipid
Prior art date
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Abandoned
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US12/521,357
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English (en)
Inventor
Chunlei Li
Jinxu Wang
Caixia Wang
Yanhui Li
Dongmin Shen
Wenmin Guo
Li Zhang
Lan Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shijiazhuang Pharma Group Zhongqi Pharmaceutical Technology Co Ltd
Original Assignee
Shijiazhuang Pharma Group Zhongqi Pharmaceutical Technology Co Ltd
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Publication date
Application filed by Shijiazhuang Pharma Group Zhongqi Pharmaceutical Technology Co Ltd filed Critical Shijiazhuang Pharma Group Zhongqi Pharmaceutical Technology Co Ltd
Assigned to SHIJIAZHUANG PHARMA. GROUP ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD reassignment SHIJIAZHUANG PHARMA. GROUP ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: GUO, WENMIN, LI, CHUNLEI, LI, YANHUI, SHEN, DONGMIN, WANG, CAIXIA, WANG, JINXU, ZHANG, LAN, ZHANG, LI
Publication of US20110002977A1 publication Critical patent/US20110002977A1/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
US12/521,357 2006-12-29 2007-12-29 Liposomal pharmaceutical preparation and method for manufacturing the same Abandoned US20110002977A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN200610102339.8 2006-12-29
CN2006101023398A CN101209243B (zh) 2006-12-29 2006-12-29 一种脂质体药物及其制备方法
PCT/CN2007/071403 WO2008080367A1 (fr) 2006-12-29 2007-12-29 Composition de liposome et son procédé de préparation

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2007/071403 A-371-Of-International WO2008080367A1 (fr) 2006-12-29 2007-12-29 Composition de liposome et son procédé de préparation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US15/138,527 Division US10028913B2 (en) 2006-12-29 2016-04-26 Liposomal pharmaceutical preparation and method for manufacturing the same

Publications (1)

Publication Number Publication Date
US20110002977A1 true US20110002977A1 (en) 2011-01-06

Family

ID=39588170

Family Applications (2)

Application Number Title Priority Date Filing Date
US12/521,357 Abandoned US20110002977A1 (en) 2006-12-29 2007-12-29 Liposomal pharmaceutical preparation and method for manufacturing the same
US15/138,527 Active US10028913B2 (en) 2006-12-29 2016-04-26 Liposomal pharmaceutical preparation and method for manufacturing the same

Family Applications After (1)

Application Number Title Priority Date Filing Date
US15/138,527 Active US10028913B2 (en) 2006-12-29 2016-04-26 Liposomal pharmaceutical preparation and method for manufacturing the same

Country Status (16)

Country Link
US (2) US20110002977A1 (fr)
EP (1) EP2123260B1 (fr)
JP (3) JP2010514708A (fr)
KR (1) KR101126629B1 (fr)
CN (1) CN101209243B (fr)
AU (1) AU2007341803B2 (fr)
BR (1) BRPI0720733A2 (fr)
CA (1) CA2673924C (fr)
CO (1) CO6190601A2 (fr)
CU (1) CU23980B1 (fr)
ES (1) ES2401526T3 (fr)
HK (1) HK1133398A1 (fr)
MX (1) MX2009007089A (fr)
MY (1) MY150670A (fr)
RU (1) RU2494729C2 (fr)
WO (1) WO2008080367A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110223675A1 (en) * 2008-11-20 2011-09-15 Terumo Kabushiki Kaisha Drug release means from liposomes and method for evaluating releasability
US20150283272A1 (en) * 2010-10-27 2015-10-08 Vikas Kundra Dual mode gadolinium nanoparticle contrast agents
US20170042810A1 (en) * 2014-04-30 2017-02-16 Fujifilm Corporation Liposome composition and method for producing same
US20170042811A1 (en) * 2014-04-30 2017-02-16 Fujifilm Corporation Liposome composition and method for producing same
US9993427B2 (en) 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
RU2728976C2 (ru) * 2018-03-22 2020-08-03 Зули Холдингз, Лтд. Липосомный состав и его получение
US11166914B2 (en) 2015-11-02 2021-11-09 Fujifilm Corporation Tumor therapeutic agent and kit containing gemcitabine liposome composition
CN113876711A (zh) * 2020-07-01 2022-01-04 江苏长泰药业有限公司 一种盐酸阿霉素脂质体的制备工艺
US11433143B2 (en) * 2017-05-18 2022-09-06 The Regents Of The University Of California Nano-enabled immunotherapy in cancer
WO2022247921A1 (fr) * 2021-05-28 2022-12-01 石药集团中奇制药技术（石家庄）有限公司 Utilisation de liposome de chlorhydrate de mitoxantrone dans la préparation de médicaments pour le traitement de tumeurs solides avancées

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CN101209243B (zh) 2006-12-29 2010-12-08 石药集团中奇制药技术（石家庄）有限公司 一种脂质体药物及其制备方法
US20090136937A1 (en) 2007-05-09 2009-05-28 Coleman Matthew A Methods and systems for monitoring production of a target protein in a nanolipoprotein particle
JP5622719B2 (ja) 2009-03-30 2014-11-12 エーザイ・アール・アンド・ディー・マネジメント株式会社 リポソーム組成物の製造方法
DK2415470T3 (en) * 2009-03-30 2016-09-19 Eisai R&D Man Co Ltd liposome
AU2014200717B2 (en) * 2009-03-30 2016-02-25 Eisai R&D Management Co., Ltd. Liposome composition
CN101897667B (zh) * 2009-05-26 2012-01-25 石药集团中奇制药技术（石家庄）有限公司 一种盐酸多柔比星脂质体注射剂及其制备工艺
IN2012DN00570A (fr) * 2009-07-14 2015-06-12 Polypid Ltd
CN102038640B (zh) * 2009-10-26 2013-11-13 石药集团中奇制药技术（石家庄）有限公司 一种含有胆固醇的peg修饰物的脂质体药物及其制备方法
WO2011143271A2 (fr) * 2010-05-10 2011-11-17 Schmidt Michael A Liposomes thérapeutiques et leurs procédés de production et d'utilisation
CN101912363A (zh) * 2010-07-29 2010-12-15 蔡海德 溶解超滤-喷雾干燥-分子分散包衣-水化制粒-冷冻干燥生产脂质体组合药物
US20140328759A1 (en) * 2011-10-25 2014-11-06 The University Of British Columbia Limit size lipid nanoparticles and related methods
US9644038B2 (en) 2011-12-21 2017-05-09 The Regents Of The University Of California Apolipoprotein nanodiscs with telodendrimer
TR201908531T4 (tr) * 2012-11-20 2019-08-21 Arbutus Biopharma Corp Terapöti̇k kullanim i̇çi̇n li̇pozom kapsüllü vi̇nkri̇sti̇ni̇n preparasyonuna yöneli̇k geli̇şti̇ri̇lmi̇ş yöntem
CA2906732C (fr) 2013-03-15 2023-08-08 The University Of British Columbia Nanoparticules lipidiques pour la transfection et procedes associes
US10220095B2 (en) 2013-03-15 2019-03-05 Taiwan Liposome Company, Ltd Controlled drug release liposome compositions and methods thereof
KR101503492B1 (ko) * 2013-07-03 2015-03-19 전북대학교산학협력단 지질 및 리소좀 효소를 포함하는 리포좀 캡슐 및 그 제조방법
WO2017044899A1 (fr) 2015-09-11 2017-03-16 Lawrence Livermore National Security, Llc Apolipoprotéines synthétique, et compositions, procédés et systèmes associés pour la formation de particules de nanolipoprotéine
IL268099B1 (en) * 2017-01-18 2024-01-01 Temasek Life Sciences Laboratory Ltd Hyperstabilized liposomes that increase targeting of mitotic cells
WO2018204421A2 (fr) 2017-05-02 2018-11-08 Lawrence Livermore National Security, Llc Télonanoparticules momp et compositions, procédés et systèmes s'y rapportant
WO2018204495A1 (fr) * 2017-05-02 2018-11-08 Synthetic Genomics, Inc. Particules de nanolipoprotéine et compositions, procédés et systèmes associés pour le chargement d'arn
CN108721644B (zh) * 2018-06-05 2021-06-08 常州金远药业制造有限公司 一种紫杉烷类药物脂质体制备方法
CN110711178A (zh) 2018-07-11 2020-01-21 石药集团中奇制药技术（石家庄）有限公司 盐酸米托蒽醌脂质体治疗非霍奇金淋巴瘤的用途
US11083705B2 (en) 2019-07-26 2021-08-10 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
CA3167470A1 (fr) * 2020-02-10 2021-08-19 Chunlei Li Utilisation d'un liposome de chlorhydrate de mitoxantrone permettant le traitement du cancer du sein
WO2021180184A1 (fr) * 2020-03-12 2021-09-16 石药集团中奇制药技术（石家庄）有限公司 Utilisation de liposomes de chlorhydrate de mitoxantrone
WO2021208842A1 (fr) * 2020-04-13 2021-10-21 石药集团中奇制药技术（石家庄）有限公司 Utilisation de liposome de chlorhydrate de mitoxantrone
JP2023537049A (ja) 2020-08-07 2023-08-30 石薬集団中奇制薬技術（石家庄）有限公司 ミトキサントロン塩酸塩リポソームとペグアスパラガーゼの使用
US20240024257A1 (en) * 2020-08-27 2024-01-25 Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. Use of mitoxantrone hydrochloride liposome and cyclophosphamide, vincristine and prednisone
AU2021399438A1 (en) * 2020-12-15 2023-07-06 Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd Use of mitoxantrone hydrochloride liposome
US20240122875A1 (en) 2021-04-16 2024-04-18 Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd Use of mitoxantrone hydrochloride liposome
CN115770288A (zh) * 2021-09-07 2023-03-10 石药集团中奇制药技术（石家庄）有限公司 米托蒽醌脂质体、硼替佐米和地塞米松治疗多发性骨髓瘤的用途
CN117940164A (zh) * 2022-04-26 2024-04-26 石药集团中奇制药技术（石家庄）有限公司 米托蒽醌脂质体联合抗血管生成靶向药治疗卵巢癌的用途

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US20110223675A1 (en) * 2008-11-20 2011-09-15 Terumo Kabushiki Kaisha Drug release means from liposomes and method for evaluating releasability
US20150283272A1 (en) * 2010-10-27 2015-10-08 Vikas Kundra Dual mode gadolinium nanoparticle contrast agents
US9993427B2 (en) 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
US11633357B2 (en) 2013-03-14 2023-04-25 Zuli Holdings, Ltd. Liposome formulation and manufacture
US10265269B2 (en) 2013-03-14 2019-04-23 Biorest Ltd. Liposome formulation and manufacture
US10646442B2 (en) * 2014-04-30 2020-05-12 Fujifilm Corporation Liposome composition and method for producing same
JPWO2015166986A1 (ja) * 2014-04-30 2017-04-20 富士フイルム株式会社 リポソーム組成物及びその製造方法
US10391057B2 (en) * 2014-04-30 2019-08-27 Fujifilm Corporation Liposome composition and method for producing same
US20170042811A1 (en) * 2014-04-30 2017-02-16 Fujifilm Corporation Liposome composition and method for producing same
US10898435B2 (en) 2014-04-30 2021-01-26 Fujifilm Corporation Liposome composition and method for producing same
US20170042810A1 (en) * 2014-04-30 2017-02-16 Fujifilm Corporation Liposome composition and method for producing same
US11684575B2 (en) 2014-04-30 2023-06-27 Fujifilm Corporation Liposome composition and method for producing same
US11166914B2 (en) 2015-11-02 2021-11-09 Fujifilm Corporation Tumor therapeutic agent and kit containing gemcitabine liposome composition
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US11433143B2 (en) * 2017-05-18 2022-09-06 The Regents Of The University Of California Nano-enabled immunotherapy in cancer
RU2728976C2 (ru) * 2018-03-22 2020-08-03 Зули Холдингз, Лтд. Липосомный состав и его получение
CN113876711A (zh) * 2020-07-01 2022-01-04 江苏长泰药业有限公司 一种盐酸阿霉素脂质体的制备工艺
WO2022247921A1 (fr) * 2021-05-28 2022-12-01 石药集团中奇制药技术（石家庄）有限公司 Utilisation de liposome de chlorhydrate de mitoxantrone dans la préparation de médicaments pour le traitement de tumeurs solides avancées

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JP6187961B2 (ja) 2017-08-30
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MY150670A (en) 2014-02-28
CA2673924C (fr) 2013-10-01
US20160235671A1 (en) 2016-08-18
KR20090094043A (ko) 2009-09-02
EP2123260A4 (fr) 2010-03-17
EP2123260B1 (fr) 2013-02-20
CU23980B1 (es) 2014-01-29
ES2401526T3 (es) 2013-04-22
RU2494729C2 (ru) 2013-10-10
AU2007341803A1 (en) 2008-07-10
JP2015180652A (ja) 2015-10-15
CU20090114A7 (es) 2011-02-24
JP2010514708A (ja) 2010-05-06
CN101209243A (zh) 2008-07-02
MX2009007089A (es) 2009-10-08
EP2123260A1 (fr) 2009-11-25
CA2673924A1 (fr) 2008-07-10
JP2013177397A (ja) 2013-09-09
HK1133398A1 (en) 2010-03-26
US10028913B2 (en) 2018-07-24
RU2009126983A (ru) 2011-02-10
CN101209243B (zh) 2010-12-08
CO6190601A2 (es) 2010-08-19
KR101126629B1 (ko) 2012-03-26
BRPI0720733A2 (pt) 2014-01-07

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