US20100256568A1 - Microneedle cartridge assembly and method of applying - Google Patents
Microneedle cartridge assembly and method of applying Download PDFInfo
- Publication number
- US20100256568A1 US20100256568A1 US11/917,442 US91744206A US2010256568A1 US 20100256568 A1 US20100256568 A1 US 20100256568A1 US 91744206 A US91744206 A US 91744206A US 2010256568 A1 US2010256568 A1 US 2010256568A1
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- US
- United States
- Prior art keywords
- microneedle array
- web
- canceled
- cartridge
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
Definitions
- the present invention relates to microneedle array cartridges.
- stratum corneum the outermost layer of the skin.
- microneedles arrays of relatively small structures, sometimes referred to as microneedles or micro-pins, have been disclosed for use in connection with the delivery of therapeutic agents and other substances through the skin and other surfaces.
- the devices are typically pressed against the skin in an effort to pierce the stratum corneum.
- the microneedle arrays are generally used once and then discarded.
- Microneedles on these devices pierce the stratum corneum upon contact, making a plurality of microscopic slits that serve as passageways through which molecules of active components (e.g., therapeutic agents, vaccines, and other substances) can be delivered into the body.
- active components e.g., therapeutic agents, vaccines, and other substances
- the microneedle array can be provided with a reservoir for temporarily retaining an active component in liquid form prior to delivering the active component through the stratum corneum.
- the microneedles can be hollow to provide a liquid flow path directly from the reservoir and through the microneedles to enable delivery of the therapeutic substance through the skin.
- active component(s) may be coated and dried on the microneedle array and delivered directly through the skin after the stratum corneum has been punctured.
- Transdermal adhesive patches are also available and are generally constructed as an adhesive article with a pressure sensitive adhesive coated onto the surface of a backing comprised of a polymeric film, cloth or the like. Transdermal adhesive patches are provided with an adhesive that allows the patch to be releasably adhered to the surface of the skin where a predetermined dosage of an active component can be put in contact with a small surface area of the skin.
- An appropriate biocompatible carrier is normally provided to facilitate the absorption of molecules through the stratum corneum over a period of time while the patch remains adhered to the skin.
- Patches, with or without a microneedle array can have fragile and sanitary characteristics. It is generally desired that the patch and array not be contacted before application to a target site. This presents difficulties in storing and transporting patches to desired locations for eventual application.
- providing collars or other protection for microneedle arrays produces bulky structures that require excessive amounts of materials to manufacture and take up large amounts of space during transportation and storage.
- loading a microneedle array on an applicator device can also be time consuming and difficult for operators.
- the present invention provides an alternative microneedle cartridge design.
- a microneedle array package in another aspect of the present invention, includes a plurality of adhesive patches separably attached to each other, and each of the adhesive patches carrying a microneedle array.
- a microneedle array cartridge in another aspect of the present invention, includes a web of material having a top face, an opposite bottom face and defining a perimeter, an adhesive disposed on the bottom face of the web of material, a microneedle array, and a container.
- the microneedle array is disposed relative to the bottom face of the web of material.
- the container is disposed relative to the bottom face of the web of material, and has a perimeter portion and a central portion for covering at least a portion of the microneedle array.
- the perimeter portion of the container generally extends at least to the perimeter of the web of material, and has a pair of opposing cutout regions that do not extend as far as the perimeter of the web of material.
- a microneedle array cartridge in another aspect of the present invention, includes a web of material having a top face, an opposite bottom face and defusing a perimeter, an adhesive disposed on the bottom face of the web of material, a microneedle array, and a container.
- the microneedle array is disposed relative to the bottom face of the web of material.
- the container extends only from the bottom face of the web of material, and has a perimeter portion and a central portion for covering at least part of the microneedle array. At least part of the perimeter portion of the container contacts the adhesive and the central portion does not contact the adhesive.
- a method for microneedle array application includes slidably mounting a microneedle array cartridge on an applicator device, simultaneously exposing the microneedle array of the cartridge by removing a cover portion of the cartridge when the cartridge is at least partially mounted on the applicator device, and moving the microneedle array toward a target site.
- a method of mounting a microneedle array relative to a microneedle array application device includes slidably positioning a microneedle cartridge having a microneedle array and a removable cover at least partially within a retaining portion of the microneedle array application device, rotating the microneedle cartridge relative to the microneedle array application device within the retaining portion of the microneedle array application device in order to break a seal to allow removal of the cover, and exposing the microneedle array of the microneedle cartridge by removing the cover when the microneedle cartridge is at least partially mounted on the microneedle array applicator device.
- FIG. 1 is a perspective view of a first embodiment of a microneedle cartridge.
- FIG. 2 is a cross-sectional view of the microneedle cartridge of FIG. 1 .
- FIG. 3 is a partial cross-sectional view of the microneedle cartridge of FIGS. 1 and 2 mounted on an applicator device.
- FIG. 4 is a perspective view of the patch of FIGS. 1 , 2 and 3 mounted on the applicator device of FIG. 3 .
- FIG. 6 is a front cross-sectional view of the microneedle cartridge of FIG. 5 .
- FIG. 7 is a side cross-sectional view of the microneedle cartridge of FIGS. 6 and 7 , rotated 90° relative to FIG. 6 .
- FIG. 8 is a bottom view of the microneedle cartridge of FIGS. 5 , 6 and 7 .
- FIG. 9 is a perspective view of a third embodiment of a microneedle cartridge.
- FIG. 10 is a cross-sectional view of the microneedle cartridge of FIG. 9 .
- FIG. 11 is a perspective view of a number of microneedle cartridges arranged as a sheet.
- FIG. 12 is a side view of a number of microneedle cartridges arranged as a roll.
- FIG. 13 is a bottom perspective view of a microneedle cartridge in a mounting fixture.
- FIG. 14 is a bottom perspective view of another embodiment of a microneedle cartridge.
- FIG. 15 is a top perspective view of a mounting fixture and microneedle cartridge partially inserted into an applicator.
- microstructures can include needle or needle-like structures as well as other structures capable of piercing the stratum corneum.
- the microneedles are typically less than 500 microns in height, and sometimes less than 300 microns in height.
- the microneedles are typically more than 20 microns in height, often more than 50 microns in height, and sometimes more than 125 microns in height.
- FIG. 1 is a perspective view of a first embodiment of a microneedle cartridge 20 that includes a patch 22 and a container 24 .
- FIG. 2 is a cross-sectional view of the microneedle cartridge 20 .
- the patch 22 shown in FIGS. 1 and 2 includes a web of material 26 that forms a backing, and a microneedle array 28 supported by and attached to the web of material 26 .
- the web of material 26 is generally flat, and has an upper face 30 and a lower face 32 .
- the web of material 26 can be comprised of a polymeric film, cloth, nonwoven or the like.
- An adhesive 34 such as a pressure sensitive adhesive, is disposed on the lower face 32 of the web of material 26 .
- the microneedle array 28 is located relative to the lower face 32 of the web of material 26 at a generally central portion of the web of material 26 , which has a circular shape.
- the microneedle array 28 can be attached to the web of material 26 , for example, by adhesive, welding, heat bonding, and can be formed integrally with the web of material 26 .
- Suitable materials for the microneedle array 28 include those selected from materials such as acrylonitrile-butadiene-styrene (ABS) polymers, polyphenyl sulfides, polycarbonates, polypropylenes, acetals, acrylics, polyetherimides, polybutylene terephthalates, polyethylene terephthalates as well as other known materials and combinations of two or more of the foregoing.
- ABS acrylonitrile-butadiene-styrene
- the microneedle array 28 can carry molecules for eventual delivery through the stratum corneum of a patient's skin (i.e., the skin of a human or non-human test subject). Those molecules can be therapeutic agents, vaccines, and other materials.
- a reservoir can be included with the microneedle array 28 for holding molecules for eventual delivery. Deployment of the patch 22 to a target site permits the molecules to be delivered through or to the stratum corneum.
- Typical examples of flexible films employed as conventional tape backings which may be useful as a backing film include those made from polymer films such as polypropylene; polyethylene, particularly low density polyethylene, linear low density polyethylene, metallocene polyethylenes, and high density polyethylene; polyvinyl chloride; polyester (e.g., polyethylene terephthalate); polyvinylidene chloride; ethylene-vinyl acetate (EVA) copolymer; polyurethane; cellulose acetate; and ethyl cellulose.
- Coextruded multilayer polymeric films are also suitable, such as described in U.S. Pat. No. 5,783,269 (Heilmann et al.), the disclosure of which is incorporated herein by reference.
- Layered backings such as polyethylene terephthalate-aluminum-polyethylene composites and polyethylene terephthalate-EVA composites are also suitable.
- Foam tape backings such as closed cell polyolefin films used in 3MTM 1777 Foam Tape and 3MTM 1779 Foam Tape are also suitable.
- Polyethylenes, polyethylene blends, and polypropylenes are preferred polymer films. Polyethylenes and polyethylene blends are most preferred polymer films.
- the backing film is translucent or transparent. Additives may also be added to the backing film, such as tackifiers, plasticizers, colorants, and anti-oxidants.
- the container 24 is removably attached to the patch 22 to cover the microneedle array 28 .
- the container 24 includes a circular central base portion 36 , a sidewall 38 connected at or near the perimeter of the central base portion 36 , and a perimeter lip 40 connected to the sidewall 38 opposite the central base portion 36 .
- a first portion 42 of the perimeter lip 40 is adhesively affixed to the adhesive 34 on the web of material 26 , and a second portion 44 of the perimeter lip 40 is spaced from the adhesive 34 so as not to adhere to it. This creates a gap or slight separation 46 (see FIG. 2 ).
- the gap 46 facilitates separating the container 24 from the patch 22 for application of the patch 22 to a patient.
- a continuous adhesive connection is formed around the microneedle array 28 between the web of material 26 and the perimeter lip 40 of the container 24 . That continuous connection can form a seal.
- the seal may be a hermetic seal, that is, a seal that can prevent entry or escape of air or other vapors, such as moisture vapor. Sealing the microneedle array 28 between the web of material 26 and the container 24 helps protect the microneedle array 28 from contamination and damage prior to deployment.
- the web of material 26 may be considered to be disposed substantially in a first plane and the first portion 42 of the perimeter lip 40 is disposed substantially in a second plane that is generally parallel to the first plane.
- the web 26 and first portion 42 are largely planar, but that minor variations, for example, due to manufacturing imperfections or due to the flexibility in the web and/or the carrier material may cause slight, but insignificant, deviations from planarity.
- the second portion 44 of the perimeter lip 40 is generally not disposed in the second plane.
- the central base portion 36 and the sidewall 38 of the container 24 define a volume in which the microneedle array 28 can rest.
- the container 24 is spaced from the microneedle array 28 , as the microneedle array 28 is generally susceptible to damage from contact during storage, transportation, and at other times prior to deployment.
- the container 24 can have a relatively low profile, such that the sidewall 38 of the container 24 preferably has as small a height, H, as possible without damaging or risking damage to the microneedle array 28 through contact.
- a low profile container 24 reduces space occupied by the cartridge 20 , for storage and transportation purposes, while still providing protection to the microneedle array 28 .
- a low profile container 24 also reduces the amounts of gases (i.e., air) and contaminants that are exposed to the microneedle array 28 and molecules carried thereon. Because many molecules intended for delivery with the microneedle array 28 can have limited lifespans and may be sensitive to contamination and deterioration, a low profile container 24 reduces the volume of air that is exposed to the microneedle array 28 to limit such negative effects.
- a suitable low-profile height will depend upon the nature of the patch 22 and microneedle array 28 , but the height will typically be less than 2.0 cm, often less than 1.5 cm, and sometimes less than 1.0 cm.
- the container 24 can be formed of a polymer material. Generally, a rigid material is selected in order to better protect the microneedle array 28 from damage and to facilitate storage (e.g., for stacking a plurality of microneedle cartridges 20 ). In one embodiment, the container 24 is a transparent or translucent material. In one embodiment, the container 24 is opaque to protect the microneedle array 28 from exposure to light.
- the retainer members 60 define an opening at one end for accepting patches between the retainer members 60 and the bottom portion 58 of the recess 54 .
- the upper surfaces 62 of the retainer members 60 may be non-stick or release surfaces.
- a non-stick or release surface can be achieved, for example, by a non-stick or release coating applied to the upper surfaces 62 .
- the non-stick or release coating can be selected according to the desired use of the applicator device 50 . For instance, a release coating, such as a low surface energy silicone, fluoropolymer, or fluoro-silicone release coating, can be selected based upon the adhesives used with patches applied using the patch application device 50
- FIG. 4 is a perspective view of the patch 22 mounted on the applicator device 50 .
- the patch 22 In a fully mounted position, as shown in FIG. 4 , the patch 22 is generally aligned relative to the opening 56 in the applicator device 50 (the opening 56 is not visible in FIG. 4 ).
- the retainer members 60 have cutaway portions 64 that provide an enlarged, partially circular open region that is generally aligned with the opening 56 on the bottom portion 58 of the recess 54 .
- the open region defined by the cutaway portions 64 facilitates patch application by reducing the amount of deflection of the patch 22 required to move the patch 22 from a mounted position on the applicator device 50 to a target location, during deployment.
- the microneedle cartridge 20 allows for simple and easy mounting of the patch 22 to the applicator device 50 , for eventually applying the microneedle array 28 (the array 28 is not visible in FIG. 4 ) to a target site.
- Mounting the microneedle patch 22 on the applicator device 50 includes the following steps. First, the microneedle cartridge 20 , with the container 24 affixed thereto, is partially slid onto the retainer members 60 . Ends of the retainer members 60 are positioned in the gap 46 formed between the web of material 26 and the perimeter lip 40 of the container 24 of the microneedle cartridge 20 .
- microneedle cartridge 20 is slid further along the retainer members 60 , simultaneously separating the container 24 from the web of material 26 , until the patch 22 is fully mounted on the applicator device 50 (e.g., such that the microneedle array 28 is aligned with the opening 56 defined in the bottom portion 58 of the recess 54 ).
- the container 24 is removed from (i.e., separated from) the patch 22 to uncover and expose the microneedle array 28 prior to microneedle deployment.
- the mounting fixture 100 comprises alignment members 110 and cartridge holder members 120 .
- the cartridge 20 (shown in more detail in FIG. 14 ) includes a patch 22 and a container 24 .
- the patch 22 includes a web of material 26 that forms a backing, and a microneedle array 28 (not shown) supported by and attached to the web of material 26 .
- An adhesive 34 such as a pressure sensitive adhesive, is disposed on the lower face 32 of the web of material 26 .
- the container 24 is removably attached to the patch 22 to cover the microneedle array 28 .
- the container 24 includes an asymmetric central base portion 36 , a sidewall 38 connected at or near the perimeter of the central base portion 36 , and a perimeter lip 40 connected to the sidewall 38 opposite the central base portion 36 .
- the mounting fixture 100 with mounted cartridge 20 is shown partially mated with an applicator device 50 in FIGS. 15 and 16 .
- the alignment guides 110 contact an outer recess 55 , thus providing for alignment of the cartridge 20 with the retainer members 60 of the applicator 50 .
- the mounting fixture may be used to fully insert the cartridge 20 into the applicator 50 , at which time the mounting fixture 100 and container 24 may be removed, thereby leaving the patch 22 mounted in the applicator 50 .
- the mounting fixture may be easily grasped by a user or otherwise fixed in space, so that the user may bring the applicator 50 towards the stationary mounting fixture to load the patch 22 into the applicator 50 .
- the mounting fixture 100 may be part of a base station that holds multiple cartridges 20 and advances them to the cartridge holder members 120 one at a time.
- the mounting fixture 100 may be integrated with packaging material used to hold one or more cartridges 20 .
- a box of cartridges may have a mounting fixture affixed to an outside surface so that a user could remove a cartridge from the box, place the cartridge in the mounting fixture, and load the cartridge into the applicator as described above.
- a tray holding multiple cartridges could be provided, wherein each cartridge is held in a mounting fixture integrally molded into the tray. Thus each cartridge could be directly loaded from the tray into an applicator.
- FIGS. 3 and 4 The mounting configuration shown in FIGS. 3 and 4 is provided by way of example, and not limitation. In further embodiments, other means of mounting a patch on the applicator device can be used. For instance, in further embodiments, one or more patches can be stored inside the applicator device 50 prior to application, and then dispensed for application to a target site.
- the microneedle cartridge 70 includes a patch 22 and a container 24 .
- the patch 22 includes a web of material 26 , a microneedle array 28 and an adhesive 34 on a bottom face 32 of the web of material 26 , and is generally similar to that shown and described with respect to FIGS. 1-4 above.
- the container 24 is removably attached to the patch 22 to cover the microneedle array 28 .
- the container 24 includes a circular central base portion 36 , a sidewall 38 connected at or near the perimeter of the central base portion 36 , and a perimeter lip 40 connected to the sidewall 38 opposite the central base portion 36 .
- a pair of opposed cutouts 72 are provided in the perimeter lip 40 . The cutouts 72 in the perimeter lip 40 make the container 24 smaller than a width or diameter of the patch 22 in particular regions, and expose portions of the adhesive 34 on the bottom face 32 of the web of material 26 .
- the stiffeners 74 are optional and that in certain embodiments the patch 22 may have sufficient resistance to bending or flexing without the need for additional stiffeners 74 .
- the microneedle array 28 may extend near or up to the inner surface of the sidewalls 38 and thereby provide sufficient rigidity in the suspended portion of the patch 22 .
- FIG. 9 is a perspective view of a third embodiment of a microneedle cartridge 80 .
- FIG. 10 is a cross-sectional view of the microneedle cartridge 80 .
- the microneedle cartridge 80 includes a patch 22 and a container 24 .
- the patch 22 includes a web of material 26 , a microneedle array 28 and an adhesive 34 on a bottom face 32 of the web of material 26 , and is generally similar to those shown and described with respect to FIGS. 1-8 above.
- the container is removably attached to the patch 22 to cover the microneedle array 28 .
- the container 24 includes a circular central base portion 36 , a sidewall 38 connected at or near the perimeter of the central base portion 36 , and a perimeter lip 40 connected to the sidewall 38 opposite the central base portion 36 .
- a gasket 82 is disposed to adhere to the lip 40 of the container 24 and patch (i.e., to the web of material 26 or the adhesive 34 ).
- the gasket 82 is disposed in a substantially continuous band around the microneedle array 28 in order to form a seal between the patch 22 and the container 24 .
- the gasket 82 is an adhesive.
- a different adhesive may be used for the gasket than that used for the adhesive 34 adhered to the bottom face 32 of the web of material 26 .
- Inserting the cartridge 80 into an applicator device can be generally similar to that described above with respect to FIGS. 1-8 . Additionally, the seal formed by the gasket 82 can be broken during an inserting procedure. For example, an operator can rotate the cartridge 80 relative to an applicator device to slice or otherwise break the seal using a blade or other means disposed on the applicator device.
- Applicators used to apply a microneedle array or patch will typically accelerate the microneedle device to reach a desired velocity that is effective to pierce the microneedles into the skin.
- the desired velocity is preferably controlled to limit or prevent stimulation of the underlying nerve tissue.
- the maximum velocity achieved by the microneedle array upon impact with the skin is often 20 meters per second (m/s) or less, potentially 15 m/s or less, and possibly 10 m/s or less. In some instances, the maximum velocity be 8 m/s or less. In other instances, the minimum velocity achieved by the microneedle array upon impact with the skin is often 2 m/s or more, potentially 4 m/s or more, and possibly 6 m/s or more.
- microneedle arrays useful in the various embodiments of the invention may comprise any of a variety of configurations, such as those described in the following patents and patent applications, the disclosures of which are herein incorporated by reference.
- One embodiment for the microneedle arrays comprises the structures disclosed in U.S. Patent Application Publication No. 2003/0045837.
- the disclosed microstructures in the aforementioned patent application are in the form of microneedles having tapered structures that include at least one channel formed in the outside surface of each microneedle.
- the microneedles may have bases that are elongated in one direction.
- the channels in microneedles with elongated bases may extend from one of the ends of the elongated bases towards the tips of the microneedles.
- the channels formed along the sides of the microneedles may optionally be terminated short of the tips of the microneedles.
- the microneedle arrays may also include conduit structures formed on the surface of the substrate on which the microneedle array is located. The channels in the microneedles may be in fluid communication with the conduit structures.
- Another embodiment for the microneedle arrays comprises the structures disclosed in U.S. Patent Application Publication No. 2005/0261631, which describes microneedles having a truncated tapered shape and a controlled aspect ratio.
- Still another embodiment for the microneedle arrays comprises the structures disclosed in U.S. Pat. No. 6,091,975 (Daddona, et al.) which describes blade-like microprotrusions for piercing the skin.
- Still another embodiment for the microneedle devices comprises the structures disclosed in U.S. Pat. No. 6,313,612 (Sherman, et al.) which describes tapered structures having a hollow central channel. Still another embodiment for the micro arrays comprises the structures disclosed in U.S. Pat. No. 6,379,324 (Gartstein, et al.) which describes hollow microneedles having at least one longitudinal blade at the top surface of tip of the microneedle.
- drugs that are of a large molecular weight may be delivered transdermally. Increasing molecular weight of a drug typically causes a decrease in unassisted transdermal delivery.
- Microneedle arrays of the present invention have utility for the delivery of large molecules that are ordinarily difficult to deliver by passive transdermal delivery. Examples of such large molecules include proteins, peptides, nucleotide sequences, monoclonal antibodies, DNA vaccines, polysaccharides, such as heparin, and antibiotics, such as ceftriaxone.
- microneedle patches of the present invention may have utility for enhancing or allowing transdermal delivery of small molecules that are otherwise difficult or impossible to deliver by passive transdermal delivery.
- molecules include salt forms; ionic molecules, such as bisphosphonates, preferably sodium alendronate or pamedronate; and molecules with physicochemical properties that are not conducive to passive transdermal delivery.
- Microneedle patches may be used for immediate delivery, that is where they are applied and immediately removed from the application site, or they may be left in place for an extended time, which may range from a few minutes to as long as 1 week.
- an extended time of delivery may be from 1 to 30 minutes to allow for more complete delivery of a drug than can be obtained upon application and immediate removal.
- an extended time of delivery may be from 4 hours to 1 week to provide for a sustained release of drug.
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- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Packages (AREA)
- Wrappers (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
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Priority Applications (1)
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US11/917,442 US20100256568A1 (en) | 2005-06-27 | 2006-06-23 | Microneedle cartridge assembly and method of applying |
Applications Claiming Priority (3)
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US69444605P | 2005-06-27 | 2005-06-27 | |
PCT/US2006/024672 WO2007002522A1 (en) | 2005-06-27 | 2006-06-23 | Microneedle cartridge assembly and method of applying |
US11/917,442 US20100256568A1 (en) | 2005-06-27 | 2006-06-23 | Microneedle cartridge assembly and method of applying |
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PCT/US2006/024672 A-371-Of-International WO2007002522A1 (en) | 2005-06-27 | 2006-06-23 | Microneedle cartridge assembly and method of applying |
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US16/390,160 Abandoned US20190240470A1 (en) | 2005-06-27 | 2019-04-22 | Microneedle cartridge assembly and method of applying |
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US16/390,160 Abandoned US20190240470A1 (en) | 2005-06-27 | 2019-04-22 | Microneedle cartridge assembly and method of applying |
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---|---|---|---|---|
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US9522263B2 (en) | 2010-04-28 | 2016-12-20 | Kimberly-Clark Worldwide, Inc. | Device for delivery of rheumatoid arthritis medication |
US9522262B2 (en) | 2010-04-28 | 2016-12-20 | Kimberly-Clark Worldwide, Inc. | Medical devices for delivery of siRNA |
US9526883B2 (en) | 2010-04-28 | 2016-12-27 | Kimberly-Clark Worldwide, Inc. | Composite microneedle array including nanostructures thereon |
US9550053B2 (en) | 2011-10-27 | 2017-01-24 | Kimberly-Clark Worldwide, Inc. | Transdermal delivery of high viscosity bioactive agents |
US9586044B2 (en) | 2010-04-28 | 2017-03-07 | Kimberly-Clark Worldwide, Inc. | Method for increasing the permeability of an epithelial barrier |
US20170106179A1 (en) * | 2014-03-26 | 2017-04-20 | Nissha Printing Co., Ltd. | A method of manufacturing a conical-projections-sheet packaging body |
US20170128708A1 (en) * | 2014-07-30 | 2017-05-11 | Toppan Printing Co., Ltd. | Microneedle unit |
US20170217656A1 (en) * | 2014-09-30 | 2017-08-03 | Nissha Printing Co., Ltd. | Microneedle-sheet packaging body and method of manufacturing the same |
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US20190283933A1 (en) * | 2015-12-04 | 2019-09-19 | Cosmed Pharmaceutical Co.,Ltd. | Microneedle patch storage tool, lower pallet and upper pallet |
US10500387B2 (en) * | 2014-06-18 | 2019-12-10 | Toppan Printing Co., Ltd. | Microneedle unit |
US10596040B2 (en) * | 2015-01-27 | 2020-03-24 | Toppan Printing Co., Ltd. | Transdermal administration device |
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US10751072B2 (en) | 2004-01-30 | 2020-08-25 | Vaxxas Pty Limited | Delivery device |
US10773065B2 (en) | 2011-10-27 | 2020-09-15 | Sorrento Therapeutics, Inc. | Increased bioavailability of transdermally delivered agents |
US10821275B2 (en) | 2012-06-27 | 2020-11-03 | Cosmed Pharmaceutical Co., Ltd. | Protective release sheet for microneedle patch |
US10828478B2 (en) | 2014-04-24 | 2020-11-10 | Georgia Tech Research Corporation | Microneedles and methods of manufacture thereof |
US10939912B2 (en) | 2016-03-01 | 2021-03-09 | Kitotech Medical, Inc. | Microstructure-based systems, apparatus, and methods for wound closure |
US11103259B2 (en) | 2015-09-18 | 2021-08-31 | Vaxxas Pty Limited | Microprojection arrays with microprojections having large surface area profiles |
US11116953B2 (en) | 2015-02-13 | 2021-09-14 | Medrx Co., Ltd. | Microneedle applicator and microneedle patch application device |
US11147955B2 (en) | 2015-02-18 | 2021-10-19 | Alma Therapeutics Ltd. | Regulator device for drug patch |
US11175128B2 (en) | 2017-06-13 | 2021-11-16 | Vaxxas Pty Limited | Quality control of substrate coatings |
US11179553B2 (en) | 2011-10-12 | 2021-11-23 | Vaxxas Pty Limited | Delivery device |
US11185511B2 (en) | 2013-09-25 | 2021-11-30 | Blueberry Therapeutics Limited | Antifungal topical composition and methods of treatment |
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US11957346B2 (en) | 2022-02-18 | 2024-04-16 | Kitotech Medical, Inc. | Force modulating deep skin staples and instruments |
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Publication number | Priority date | Publication date | Assignee | Title |
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US20130158482A1 (en) | 2010-07-26 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Rapid delivery and/or receiving of fluids |
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US20130158468A1 (en) | 2011-12-19 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Delivering and/or receiving material with respect to a subject surface |
EP2701598A1 (en) | 2011-04-29 | 2014-03-05 | Seventh Sense Biosystems, Inc. | Systems and methods for collecting fluid from a subject |
EP3087919B2 (en) | 2011-04-29 | 2022-04-13 | Seventh Sense Biosystems, Inc. | Receiving fluids |
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WO2014105458A1 (en) | 2012-12-27 | 2014-07-03 | 3M Innovative Properties Company | Article with hollow microneedles and method of making |
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CN105324147B (zh) * | 2013-06-18 | 2018-03-02 | 久光制药株式会社 | 施放器 |
US10039911B2 (en) | 2013-06-19 | 2018-08-07 | Hisamitsu Pharmaceutical Co., Inc. | Applicator |
WO2015111672A1 (ja) * | 2014-01-24 | 2015-07-30 | 凸版印刷株式会社 | マイクロニードルユニット |
WO2015129894A1 (ja) * | 2014-02-27 | 2015-09-03 | 凸版印刷株式会社 | マイクロニードルユニット、および、マイクロニードル用容器 |
WO2015148688A1 (en) * | 2014-03-26 | 2015-10-01 | Nanomed Skincare, Inc. | Plunger-like mass transportation device for dermal and transdermal delivery of a liquid or solid composition |
CN104069585B (zh) * | 2014-07-03 | 2017-12-12 | 台州薇凯生物科技有限公司 | 可分离式微针系统及其制造方法 |
WO2016036866A1 (en) | 2014-09-04 | 2016-03-10 | Corium International, Inc. | Microstructure array, methods of making, and methods of use |
JP6364304B2 (ja) * | 2014-10-01 | 2018-07-25 | 久光製薬株式会社 | 貼付剤及び包装用容器 |
JP6528423B2 (ja) * | 2015-01-30 | 2019-06-12 | 凸版印刷株式会社 | 経皮投与デバイス、および、経皮投与デバイス収容体 |
JP2016150134A (ja) * | 2015-02-18 | 2016-08-22 | 凸版印刷株式会社 | 針状体パッケージ |
US10004887B2 (en) * | 2015-02-18 | 2018-06-26 | Alma Therapeutics Ltd. | Transdermal delivery assembly |
US10857093B2 (en) | 2015-06-29 | 2020-12-08 | Corium, Inc. | Microarray for delivery of therapeutic agent, methods of use, and methods of making |
KR101757866B1 (ko) * | 2015-10-08 | 2017-07-14 | 주식회사 라파스 | 마이크로니들패치 포장케이스 |
CN108367143B (zh) | 2015-12-21 | 2021-02-12 | 美德阿利克斯株式会社 | 微针贴片施用器及其壳体 |
CN105833424A (zh) * | 2016-03-21 | 2016-08-10 | 南通纺织丝绸产业技术研究院 | 一种丝素蛋白微针贴及其制备方法 |
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US20190351207A1 (en) | 2017-01-25 | 2019-11-21 | Cosmed Pharmaceutical Co., Ltd. | Microneedle patch applying device |
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JP2018191783A (ja) * | 2017-05-15 | 2018-12-06 | 富士フイルム株式会社 | マイクロニードルアレイユニット、および容器 |
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WO2019092957A1 (ja) * | 2017-11-07 | 2019-05-16 | ニプロ株式会社 | 穿刺用器具 |
JP6914359B2 (ja) * | 2017-11-30 | 2021-08-04 | 久光製薬株式会社 | アプリケータ、カートリッジ、およびアプリケーション・キット |
WO2019166572A1 (en) | 2018-02-28 | 2019-09-06 | Pharming Intellectual Property B.V. | Pharmaceutical system for transdermal administration of a c1 -esterase inhibitor |
JP1632957S (enrdf_load_stackoverflow) | 2018-10-30 | 2019-06-03 | ||
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US11389376B2 (en) | 2020-12-21 | 2022-07-19 | Mediccene Inc. | Wearable intravenous fluid delivery system |
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US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
US12023156B2 (en) | 2021-10-13 | 2024-07-02 | Satio, Inc. | Dermal patch for collecting a physiological sample |
NL2028261B1 (en) * | 2021-05-20 | 2022-12-06 | Uprax Microsolutions B V | Microneedle patch applicator systems, docking platforms, applicators and microneedle patches, methods of mounting microneedle patches on applicators and of applying microneedle patches. |
KR102613830B1 (ko) * | 2021-06-17 | 2023-12-14 | 주식회사 에스엔비아 | 마이크로구조체 카트리지 및 마이크로구조체 어플리케이터 |
JP2023107763A (ja) * | 2022-01-22 | 2023-08-03 | 計芳 鈴木 | 口腔内薬液供給システム |
Citations (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3072122A (en) * | 1959-01-15 | 1963-01-08 | Rosenthal Sol Roy | Package for transcutaneous injection |
US3678150A (en) * | 1971-07-27 | 1972-07-18 | American Cyanamid Co | Process for improving the stability of ppd, qt and histoplasmin on tine applicators |
US3964482A (en) * | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
US4381963A (en) * | 1980-07-30 | 1983-05-03 | The University Of Rochester | Micro fabrication molding process |
US4382513A (en) * | 1981-02-06 | 1983-05-10 | W. R. Grace & Co., Cryovac Div. | Packages having readily peelable seals |
US4656068A (en) * | 1983-12-23 | 1987-04-07 | Plicon Corporation | Pellable seal package |
US4666441A (en) * | 1985-12-17 | 1987-05-19 | Ciba-Geigy Corporation | Multicompartmentalized transdermal patches |
US5152917A (en) * | 1991-02-06 | 1992-10-06 | Minnesota Mining And Manufacturing Company | Structured abrasive article |
US5160823A (en) * | 1991-01-03 | 1992-11-03 | Hutchinson Technology, Inc. | Moving mask laser imaging |
US5223261A (en) * | 1988-02-26 | 1993-06-29 | Riker Laboratories, Inc. | Transdermal estradiol delivery system |
US5250023A (en) * | 1989-10-27 | 1993-10-05 | Korean Research Institute on Chemical Technology | Transdermal administration method of protein or peptide drug and its administration device thereof |
US5256360A (en) * | 1992-03-25 | 1993-10-26 | Panasonic Technologies, Inc. | Method of manufacturing a precision micro-filter |
US5342737A (en) * | 1992-04-27 | 1994-08-30 | The United States Of America As Represented By The Secretary Of The Navy | High aspect ratio metal microstructures and method for preparing the same |
US5376317A (en) * | 1992-12-08 | 1994-12-27 | Galic Maus Ventures | Precision surface-replicating thermoplastic injection molding method and apparatus, using a heating phase and a cooling phase in each molding cycle |
US5380760A (en) * | 1993-11-19 | 1995-01-10 | Minnesota Mining And Manufacturing Company | Transdermal prostaglandin composition |
US5543108A (en) * | 1992-07-11 | 1996-08-06 | Forschungzentrym Karlsruhe Gmbh | Method of making microstructured bodies of plastic material |
US5591139A (en) * | 1994-06-06 | 1997-01-07 | The Regents Of The University Of California | IC-processed microneedles |
US5611806A (en) * | 1994-05-23 | 1997-03-18 | Samsung Electro-Mechanics Co., Ltd. | Skin perforating device for transdermal medication |
US5645977A (en) * | 1995-09-22 | 1997-07-08 | Industrial Technology Research Institute | Method of making molds for manufacturing multiple-lead microstructures |
US5656286A (en) * | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
US5657516A (en) * | 1995-10-12 | 1997-08-19 | Minnesota Mining And Manufacturing Company | Dual structured fastener elements |
US5658515A (en) * | 1995-09-25 | 1997-08-19 | Lee; Abraham P. | Polymer micromold and fabrication process |
US5783269A (en) * | 1995-04-26 | 1998-07-21 | Fresenius Ag | Non-PVC multilayer film for medical bags |
US5879326A (en) * | 1995-05-22 | 1999-03-09 | Godshall; Ned Allen | Method and apparatus for disruption of the epidermis |
US5983136A (en) * | 1996-09-17 | 1999-11-09 | Deka Products Limited Partnership | System for delivery of drugs by transport |
US6050988A (en) * | 1997-12-11 | 2000-04-18 | Alza Corporation | Device for enhancing transdermal agent flux |
US6076248A (en) * | 1993-09-13 | 2000-06-20 | 3M Innovative Properties Company | Method of making a master tool |
US6091975A (en) * | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
US6132755A (en) * | 1995-07-14 | 2000-10-17 | Boehringer Ingelheim Kg | Transcorneal drug-release system |
US6256533B1 (en) * | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
US6312612B1 (en) * | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
US6322808B1 (en) * | 1997-12-11 | 2001-11-27 | Alza Corporation | Device for enhancing transdermal agent flux |
US6331266B1 (en) * | 1999-09-29 | 2001-12-18 | Becton Dickinson And Company | Process of making a molded device |
US6334856B1 (en) * | 1998-06-10 | 2002-01-01 | Georgia Tech Research Corporation | Microneedle devices and methods of manufacture and use thereof |
US20020045859A1 (en) * | 2000-10-16 | 2002-04-18 | The Procter & Gamble Company | Microstructures for delivering a composition cutaneously to skin |
US6379324B1 (en) * | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
US20020082543A1 (en) * | 2000-12-14 | 2002-06-27 | Jung-Hwan Park | Microneedle devices and production thereof |
US20020091357A1 (en) * | 2000-10-13 | 2002-07-11 | Trautman Joseph C. | Microprotrusion member retainer for impact applicator |
US20020095134A1 (en) * | 1999-10-14 | 2002-07-18 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
US6454755B1 (en) * | 1995-05-22 | 2002-09-24 | Silicon Microdevices | Method and apparatus for transdermal delivery of compounds utilizing disruption of the epidermis |
US20020138049A1 (en) * | 1998-06-10 | 2002-09-26 | Allen Mark G. | Microneedle devices and methods of manufacture and use thereof |
US20020169416A1 (en) * | 2000-11-30 | 2002-11-14 | Gonnelli Robert R. | Fluid delivery and measurement systems and methods |
US20020177858A1 (en) * | 2000-10-16 | 2002-11-28 | Sherman Faiz Feisal | Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation |
US20020198509A1 (en) * | 1999-10-14 | 2002-12-26 | Mikszta John A. | Intradermal delivery of vaccines and gene therapeutic agents via microcannula |
US6511463B1 (en) * | 1999-11-18 | 2003-01-28 | Jds Uniphase Corporation | Methods of fabricating microneedle arrays using sacrificial molds |
US20030045837A1 (en) * | 2001-09-05 | 2003-03-06 | Delmore Michael D. | Microneedle arrays and methods of manufacturing the same |
US6532386B2 (en) * | 1998-08-31 | 2003-03-11 | Johnson & Johnson Consumer Companies, Inc. | Electrotransort device comprising blades |
US6533949B1 (en) * | 2000-08-28 | 2003-03-18 | Nanopass Ltd. | Microneedle structure and production method therefor |
US6551849B1 (en) * | 1999-11-02 | 2003-04-22 | Christopher J. Kenney | Method for fabricating arrays of micro-needles |
US20030078549A1 (en) * | 2001-06-08 | 2003-04-24 | Stupar Philip Anthony | Microfabricated surgical devices and methods of making the same |
US6565532B1 (en) * | 2000-07-12 | 2003-05-20 | The Procter & Gamble Company | Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup |
US20030095582A1 (en) * | 2000-12-21 | 2003-05-22 | Ackley Donald E. | Microneedle array systems |
US6591124B2 (en) * | 2001-05-11 | 2003-07-08 | The Procter & Gamble Company | Portable interstitial fluid monitoring system |
US20030135166A1 (en) * | 2001-09-28 | 2003-07-17 | Gonnelli Robert R. | Switchable microneedle arrays and systems and methods relating to same |
US20030135167A1 (en) * | 2001-09-19 | 2003-07-17 | Gonnelli Robert R. | Microneedles, microneedle arrays, and systems and methods relating to same |
US20030135201A1 (en) * | 2001-09-28 | 2003-07-17 | Gonnelli Robert R. | Microneedle with membrane |
US20030135161A1 (en) * | 2002-01-15 | 2003-07-17 | Fleming Patrick R. | Microneedle devices and methods of manufacture |
US6595947B1 (en) * | 2000-05-22 | 2003-07-22 | Becton, Dickinson And Company | Topical delivery of vaccines |
US6603998B1 (en) * | 1999-01-28 | 2003-08-05 | Cyto Pulse Sciences, Inc. | Delivery of macromolecules into cells |
US20030148401A1 (en) * | 2001-11-09 | 2003-08-07 | Anoop Agrawal | High surface area substrates for microarrays and methods to make same |
US6605332B2 (en) * | 1997-07-29 | 2003-08-12 | 3M Innovative Properties Company | Unitary polymer substrate having napped surface of frayed end microfibers |
US20030199810A1 (en) * | 2001-11-30 | 2003-10-23 | Trautman Joseph Creagan | Methods and apparatuses for forming microprojection arrays |
US6663820B2 (en) * | 2001-03-14 | 2003-12-16 | The Procter & Gamble Company | Method of manufacturing microneedle structures using soft lithography and photolithography |
US6686299B2 (en) * | 2001-06-21 | 2004-02-03 | Carlo D. Montemagno | Nanosyringe array and method |
US20040049150A1 (en) * | 2000-07-21 | 2004-03-11 | Dalton Colin Cave | Vaccines |
US6713291B2 (en) * | 1999-01-28 | 2004-03-30 | Alan D. King | Electrodes coated with treating agent and uses thereof |
US20040060902A1 (en) * | 2002-02-05 | 2004-04-01 | Evans John D. | Microprotrusion array and methods of making a microprotrusion |
US6743211B1 (en) * | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
US6770480B1 (en) * | 1998-07-22 | 2004-08-03 | Psimedica Limited | Transferring materials into cells using porous silicon |
US20040176732A1 (en) * | 2000-06-02 | 2004-09-09 | Frazier A Bruno | Active needle devices with integrated functionality |
US6797276B1 (en) * | 1996-11-14 | 2004-09-28 | The United States Of America As Represented By The Secretary Of The Army | Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response |
US6835184B1 (en) * | 1999-09-24 | 2004-12-28 | Becton, Dickinson And Company | Method and device for abrading skin |
US20050025778A1 (en) * | 2003-07-02 | 2005-02-03 | Cormier Michel J.N. | Microprojection array immunization patch and method |
US20050065463A1 (en) * | 2003-09-18 | 2005-03-24 | Nano Device And System Research Inc. | Applicator for applying functional substances into human skin |
US20050106226A1 (en) * | 2003-10-24 | 2005-05-19 | Cormier Michel J. | Pretreatment method and system for enhancing transdermal drug delivery |
US6899838B2 (en) * | 2002-07-12 | 2005-05-31 | Becton, Dickinson And Company | Method of forming a mold and molding a micro-device |
US20050118388A1 (en) * | 1999-11-15 | 2005-06-02 | Velcro Industries B.V., A Netherlands Corporation | Skin attachment member |
US20050137525A1 (en) * | 2003-06-04 | 2005-06-23 | Georgia Tech Research Corporation | Drilling microneedle device |
US20050228340A1 (en) * | 2004-03-24 | 2005-10-13 | Cleary Gary W | Transdermal delivery device |
US20050261631A1 (en) * | 2002-07-19 | 2005-11-24 | 3M Innovative Properties Company | Microneedle devices and microneedle delivery apparatus |
US20070250018A1 (en) * | 2004-08-12 | 2007-10-25 | Hirotoshi Adachi | Transdermal Drug Administration System with Microneedles |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3630346A (en) * | 1970-06-01 | 1971-12-28 | Lilly Co Eli | Components for making a strip package |
DE3827431A1 (de) † | 1988-02-06 | 1989-08-17 | Minninger Konrad | Pflaster |
JPH05179Y2 (enrdf_load_stackoverflow) * | 1988-12-19 | 1993-01-06 | ||
DE3844247A1 (de) † | 1988-12-29 | 1990-07-12 | Minnesota Mining & Mfg | Vorrichtung, insbesondere pflaster zum transdermalen verabreichen eines medikaments |
JPH0298942U (enrdf_load_stackoverflow) * | 1989-01-24 | 1990-08-07 | ||
JPH0284622A (ja) | 1989-08-11 | 1990-03-26 | Minolta Camera Co Ltd | 測光装置およびそれを備えたカメラ |
EP0662918A1 (en) | 1992-09-30 | 1995-07-19 | R.P. Scherer Corporation | Stepped-edge blister pack and use of steps |
US5620095A (en) * | 1993-06-11 | 1997-04-15 | Minnesota Mining And Manufacturing Company | Orthopedic casting material and hermetic package |
CA2201315A1 (en) | 1994-09-30 | 1996-04-11 | Peter Ping Ling | Direct introduction of foreign materials into cells |
JPH0977131A (ja) * | 1995-09-13 | 1997-03-25 | Dainippon Printing Co Ltd | 包装体およびその製造方法 |
DE69720057T2 (de) * | 1996-12-20 | 2003-09-25 | Alza Corp., Palo Alto | Vorrichtung und verfahren zur erhöhung des transdermalen wirkstoffeflusses |
AR022471A1 (es) | 1999-02-02 | 2002-09-04 | Ortho Mcneil Pharm Inc | Metodo para la fabricacion de matrices transdermicas |
DE19916523A1 (de) † | 1999-04-13 | 2000-06-15 | Hartmann Paul Ag | Pflaster auf Folienbasis |
US6499595B1 (en) * | 1999-07-29 | 2002-12-31 | The Gillette Company | Container for shaving cartridge or other stored item |
US6623457B1 (en) * | 1999-09-22 | 2003-09-23 | Becton, Dickinson And Company | Method and apparatus for the transdermal administration of a substance |
US6589202B1 (en) * | 2000-06-29 | 2003-07-08 | Becton Dickinson And Company | Method and apparatus for transdermally sampling or administering a substance to a patient |
AU2001293460A1 (en) * | 2000-10-05 | 2002-04-15 | Thomas Marsoner | Medical injection device |
AU2003209645A1 (en) * | 2002-03-04 | 2003-09-16 | Nano Pass Technologies Ltd. | Devices and methods for transporting fluid across a biological barrier |
GB0216831D0 (en) * | 2002-07-19 | 2002-08-28 | Glaxo Group Ltd | Medicament dispenser |
JP2004065775A (ja) * | 2002-08-08 | 2004-03-04 | Sanwa Kagaku Kenkyusho Co Ltd | 針状構造体を備えたデバイス |
JP2004114552A (ja) | 2002-09-27 | 2004-04-15 | Mitsuboshi Belting Ltd | 針状体の製造方法および針状体 |
CN1905842A (zh) | 2003-11-21 | 2007-01-31 | 阿尔扎公司 | 超声促进疫苗透皮释放的方法和系统 |
CA2613111C (en) | 2005-06-27 | 2015-05-26 | 3M Innovative Properties Company | Microneedle array applicator device and method of array application |
-
2006
- 2006-06-23 EP EP06785522.1A patent/EP1896115B2/en not_active Not-in-force
- 2006-06-23 AT AT06785522T patent/ATE477833T1/de not_active IP Right Cessation
- 2006-06-23 AU AU2006261899A patent/AU2006261899B2/en not_active Ceased
- 2006-06-23 DE DE602006016279T patent/DE602006016279D1/de active Active
- 2006-06-23 WO PCT/US2006/024672 patent/WO2007002522A1/en active Application Filing
- 2006-06-23 JP JP2008519436A patent/JP2008543528A/ja not_active Withdrawn
- 2006-06-23 CA CA2613114A patent/CA2613114C/en not_active Expired - Fee Related
- 2006-06-23 US US11/917,442 patent/US20100256568A1/en not_active Abandoned
- 2006-06-23 CN CN2006800230083A patent/CN101208129B/zh not_active Expired - Fee Related
-
2012
- 2012-11-19 JP JP2012253421A patent/JP5676548B2/ja active Active
-
2017
- 2017-05-26 US US15/606,753 patent/US10307578B2/en active Active
-
2019
- 2019-04-22 US US16/390,160 patent/US20190240470A1/en not_active Abandoned
Patent Citations (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3072122A (en) * | 1959-01-15 | 1963-01-08 | Rosenthal Sol Roy | Package for transcutaneous injection |
US3964482A (en) * | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
US3678150A (en) * | 1971-07-27 | 1972-07-18 | American Cyanamid Co | Process for improving the stability of ppd, qt and histoplasmin on tine applicators |
US4381963A (en) * | 1980-07-30 | 1983-05-03 | The University Of Rochester | Micro fabrication molding process |
US4382513A (en) * | 1981-02-06 | 1983-05-10 | W. R. Grace & Co., Cryovac Div. | Packages having readily peelable seals |
US4656068A (en) * | 1983-12-23 | 1987-04-07 | Plicon Corporation | Pellable seal package |
US4666441A (en) * | 1985-12-17 | 1987-05-19 | Ciba-Geigy Corporation | Multicompartmentalized transdermal patches |
US5223261A (en) * | 1988-02-26 | 1993-06-29 | Riker Laboratories, Inc. | Transdermal estradiol delivery system |
US5656286A (en) * | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
US5250023A (en) * | 1989-10-27 | 1993-10-05 | Korean Research Institute on Chemical Technology | Transdermal administration method of protein or peptide drug and its administration device thereof |
US5160823A (en) * | 1991-01-03 | 1992-11-03 | Hutchinson Technology, Inc. | Moving mask laser imaging |
US5152917B1 (en) * | 1991-02-06 | 1998-01-13 | Minnesota Mining & Mfg | Structured abrasive article |
US5152917A (en) * | 1991-02-06 | 1992-10-06 | Minnesota Mining And Manufacturing Company | Structured abrasive article |
US5256360A (en) * | 1992-03-25 | 1993-10-26 | Panasonic Technologies, Inc. | Method of manufacturing a precision micro-filter |
US5342737A (en) * | 1992-04-27 | 1994-08-30 | The United States Of America As Represented By The Secretary Of The Navy | High aspect ratio metal microstructures and method for preparing the same |
US5543108A (en) * | 1992-07-11 | 1996-08-06 | Forschungzentrym Karlsruhe Gmbh | Method of making microstructured bodies of plastic material |
US5376317A (en) * | 1992-12-08 | 1994-12-27 | Galic Maus Ventures | Precision surface-replicating thermoplastic injection molding method and apparatus, using a heating phase and a cooling phase in each molding cycle |
US6129540A (en) * | 1993-09-13 | 2000-10-10 | Minnesota Mining & Manufacturing Company | Production tool for an abrasive article and a method of making same |
US6076248A (en) * | 1993-09-13 | 2000-06-20 | 3M Innovative Properties Company | Method of making a master tool |
US5380760A (en) * | 1993-11-19 | 1995-01-10 | Minnesota Mining And Manufacturing Company | Transdermal prostaglandin composition |
US5611806A (en) * | 1994-05-23 | 1997-03-18 | Samsung Electro-Mechanics Co., Ltd. | Skin perforating device for transdermal medication |
US5591139A (en) * | 1994-06-06 | 1997-01-07 | The Regents Of The University Of California | IC-processed microneedles |
US5783269A (en) * | 1995-04-26 | 1998-07-21 | Fresenius Ag | Non-PVC multilayer film for medical bags |
US5879326A (en) * | 1995-05-22 | 1999-03-09 | Godshall; Ned Allen | Method and apparatus for disruption of the epidermis |
US6454755B1 (en) * | 1995-05-22 | 2002-09-24 | Silicon Microdevices | Method and apparatus for transdermal delivery of compounds utilizing disruption of the epidermis |
US6132755A (en) * | 1995-07-14 | 2000-10-17 | Boehringer Ingelheim Kg | Transcorneal drug-release system |
US5645977A (en) * | 1995-09-22 | 1997-07-08 | Industrial Technology Research Institute | Method of making molds for manufacturing multiple-lead microstructures |
US5658515A (en) * | 1995-09-25 | 1997-08-19 | Lee; Abraham P. | Polymer micromold and fabrication process |
US5657516A (en) * | 1995-10-12 | 1997-08-19 | Minnesota Mining And Manufacturing Company | Dual structured fastener elements |
US5983136A (en) * | 1996-09-17 | 1999-11-09 | Deka Products Limited Partnership | System for delivery of drugs by transport |
US6797276B1 (en) * | 1996-11-14 | 2004-09-28 | The United States Of America As Represented By The Secretary Of The Army | Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response |
US6605332B2 (en) * | 1997-07-29 | 2003-08-12 | 3M Innovative Properties Company | Unitary polymer substrate having napped surface of frayed end microfibers |
US6322808B1 (en) * | 1997-12-11 | 2001-11-27 | Alza Corporation | Device for enhancing transdermal agent flux |
US6050988A (en) * | 1997-12-11 | 2000-04-18 | Alza Corporation | Device for enhancing transdermal agent flux |
US6091975A (en) * | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
US20020138049A1 (en) * | 1998-06-10 | 2002-09-26 | Allen Mark G. | Microneedle devices and methods of manufacture and use thereof |
US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
US6334856B1 (en) * | 1998-06-10 | 2002-01-01 | Georgia Tech Research Corporation | Microneedle devices and methods of manufacture and use thereof |
US6770480B1 (en) * | 1998-07-22 | 2004-08-03 | Psimedica Limited | Transferring materials into cells using porous silicon |
US6532386B2 (en) * | 1998-08-31 | 2003-03-11 | Johnson & Johnson Consumer Companies, Inc. | Electrotransort device comprising blades |
US6713291B2 (en) * | 1999-01-28 | 2004-03-30 | Alan D. King | Electrodes coated with treating agent and uses thereof |
US6603998B1 (en) * | 1999-01-28 | 2003-08-05 | Cyto Pulse Sciences, Inc. | Delivery of macromolecules into cells |
US6451240B1 (en) * | 1999-06-09 | 2002-09-17 | The Procter & Gamble Company | Method of manufacturing an intracutaneous microneedle array |
US6652478B1 (en) * | 1999-06-09 | 2003-11-25 | The Procter & Gamble Company | Intracutaneous edged microneedle apparatus |
US6931277B1 (en) * | 1999-06-09 | 2005-08-16 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
US6256533B1 (en) * | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
US6312612B1 (en) * | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
US6379324B1 (en) * | 1999-06-09 | 2002-04-30 | The Procter & Gamble Company | Intracutaneous microneedle array apparatus |
US6835184B1 (en) * | 1999-09-24 | 2004-12-28 | Becton, Dickinson And Company | Method and device for abrading skin |
US6331266B1 (en) * | 1999-09-29 | 2001-12-18 | Becton Dickinson And Company | Process of making a molded device |
US20020053756A1 (en) * | 1999-09-29 | 2002-05-09 | Becton Dickinson And Company | Method and apparatus for manufacturing a device |
US20020198509A1 (en) * | 1999-10-14 | 2002-12-26 | Mikszta John A. | Intradermal delivery of vaccines and gene therapeutic agents via microcannula |
US20020095134A1 (en) * | 1999-10-14 | 2002-07-18 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
US6551849B1 (en) * | 1999-11-02 | 2003-04-22 | Christopher J. Kenney | Method for fabricating arrays of micro-needles |
US20050118388A1 (en) * | 1999-11-15 | 2005-06-02 | Velcro Industries B.V., A Netherlands Corporation | Skin attachment member |
US6511463B1 (en) * | 1999-11-18 | 2003-01-28 | Jds Uniphase Corporation | Methods of fabricating microneedle arrays using sacrificial molds |
US6743211B1 (en) * | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
US6595947B1 (en) * | 2000-05-22 | 2003-07-22 | Becton, Dickinson And Company | Topical delivery of vaccines |
US20040176732A1 (en) * | 2000-06-02 | 2004-09-09 | Frazier A Bruno | Active needle devices with integrated functionality |
US6565532B1 (en) * | 2000-07-12 | 2003-05-20 | The Procter & Gamble Company | Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup |
US20040049150A1 (en) * | 2000-07-21 | 2004-03-11 | Dalton Colin Cave | Vaccines |
US6533949B1 (en) * | 2000-08-28 | 2003-03-18 | Nanopass Ltd. | Microneedle structure and production method therefor |
US20020091357A1 (en) * | 2000-10-13 | 2002-07-11 | Trautman Joseph C. | Microprotrusion member retainer for impact applicator |
US20020177858A1 (en) * | 2000-10-16 | 2002-11-28 | Sherman Faiz Feisal | Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation |
US20020045859A1 (en) * | 2000-10-16 | 2002-04-18 | The Procter & Gamble Company | Microstructures for delivering a composition cutaneously to skin |
US20020169416A1 (en) * | 2000-11-30 | 2002-11-14 | Gonnelli Robert R. | Fluid delivery and measurement systems and methods |
US20020082543A1 (en) * | 2000-12-14 | 2002-06-27 | Jung-Hwan Park | Microneedle devices and production thereof |
US20030095582A1 (en) * | 2000-12-21 | 2003-05-22 | Ackley Donald E. | Microneedle array systems |
US6663820B2 (en) * | 2001-03-14 | 2003-12-16 | The Procter & Gamble Company | Method of manufacturing microneedle structures using soft lithography and photolithography |
US6591124B2 (en) * | 2001-05-11 | 2003-07-08 | The Procter & Gamble Company | Portable interstitial fluid monitoring system |
US20030078549A1 (en) * | 2001-06-08 | 2003-04-24 | Stupar Philip Anthony | Microfabricated surgical devices and methods of making the same |
US6686299B2 (en) * | 2001-06-21 | 2004-02-03 | Carlo D. Montemagno | Nanosyringe array and method |
US20030045837A1 (en) * | 2001-09-05 | 2003-03-06 | Delmore Michael D. | Microneedle arrays and methods of manufacturing the same |
US6881203B2 (en) * | 2001-09-05 | 2005-04-19 | 3M Innovative Properties Company | Microneedle arrays and methods of manufacturing the same |
US20030135167A1 (en) * | 2001-09-19 | 2003-07-17 | Gonnelli Robert R. | Microneedles, microneedle arrays, and systems and methods relating to same |
US20030135201A1 (en) * | 2001-09-28 | 2003-07-17 | Gonnelli Robert R. | Microneedle with membrane |
US20030135166A1 (en) * | 2001-09-28 | 2003-07-17 | Gonnelli Robert R. | Switchable microneedle arrays and systems and methods relating to same |
US20030148401A1 (en) * | 2001-11-09 | 2003-08-07 | Anoop Agrawal | High surface area substrates for microarrays and methods to make same |
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Also Published As
Publication number | Publication date |
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US20190240470A1 (en) | 2019-08-08 |
AU2006261899A1 (en) | 2007-01-04 |
EP1896115B2 (en) | 2020-01-22 |
ATE477833T1 (de) | 2010-09-15 |
EP1896115B1 (en) | 2010-08-18 |
CA2613114A1 (en) | 2007-01-04 |
JP5676548B2 (ja) | 2015-02-25 |
US20170266428A1 (en) | 2017-09-21 |
WO2007002522A1 (en) | 2007-01-04 |
DE602006016279D1 (de) | 2010-09-30 |
CN101208129B (zh) | 2011-03-30 |
AU2006261899B2 (en) | 2012-05-10 |
EP1896115A1 (en) | 2008-03-12 |
CN101208129A (zh) | 2008-06-25 |
US10307578B2 (en) | 2019-06-04 |
CA2613114C (en) | 2015-02-24 |
JP2013066730A (ja) | 2013-04-18 |
JP2008543528A (ja) | 2008-12-04 |
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