US20070270421A1 - Novel pyridine Derivative and Pyrimidine Derivative (1) - Google Patents

Novel pyridine Derivative and Pyrimidine Derivative (1) Download PDF

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US20070270421A1
US20070270421A1 US10/577,065 US57706505A US2007270421A1 US 20070270421 A1 US20070270421 A1 US 20070270421A1 US 57706505 A US57706505 A US 57706505A US 2007270421 A1 US2007270421 A1 US 2007270421A1
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Tomohiro Matsushima
Keiko Takahashi
Setsuo Funasaka
Hiroshi Obaishi
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Eisai R&D Management Co Ltd
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Definitions

  • the present invention relates to a novel pyridine derivative and pyrimidine derivative, a salt thereof or a hydrate of the foregoing, having inhibitory activity against hepatocyte growth factor receptor, anti-tumor activity, inhibitory activity against angiogenesis, inhibitory activity against cancer metastasis or the like.
  • HGFR hepatocyte growth factor receptor
  • pancreatic cancer a gastric cancer, a colorectal cancer, a breast cancer, a prostate cancer, a lung cancer, a renal cancer, a brain tumor or an ovarian cancer
  • HGFR expressed in these cancer cells is considered to be involved in cancer malignancy (aberrant growth, invasion or enhanced metastasis), because HGFR cause autophosphorylation of intracellular tyrosine kinase constitutively or upon stimulation by hepatocyte growth factor (hereafter referred to as HGF).
  • HGF hepatocyte growth factor
  • HGFR is expressed in vascular endothelial cells and is involved in tumor angiogenesis since HGF stimulates HGFR to facilitate proliferate and migration of vascular endothelial cells (non-patent document 2).
  • NK4 an antagonistic peptide for HGF, is reported to block HGF-HGFR signal to inhibit invasion of cancer cells and tumor angiogenesis (non-patent documents 3 and 4).
  • a compound having inhibitory activity for HGFR is expected to be useful as an anti-tumor agent, an angiogenesis inhibitor or an inhibitor for cancer metastasis.
  • the patent documents 1, 2 and 3 are listed.
  • the patent document 1 discloses indolinone derivatives
  • the patent document 2 discloses quinoline derivatives and quinazoline derivatives
  • the patent document 3 discloses imidazole derivatives; therefore the compounds disclosed in these documents are obviously different in the structure from pyridine derivatives and pyrimidine derivatives according to the present invention.
  • the patent document 4 discloses pyridine derivatives and pyrimidine derivatives similar in the structure to the compounds according to the present invention.
  • the patent document 4 does not disclose inhibitory activity for HGFR of the compounds disclosed in the patent document 4 as well as the compounds according to the present invention.
  • Patent document 1 WO 02/096361
  • Patent document 2 WO 03/000660
  • An object of the present invention is to provide a compound showing anti-tumor activity, inhibitory activity against angiogenesis or inhibitory activity against cancer metastasis by inhibiting cellular aberrant growth, morphological change and hypermobility via HGFR in vivo.
  • the present invention provides [1] A compound represented by the following formula, a salt thereof or a hydrate of the foregoing:
  • R 1 represents C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-10 aryl, C 1-6 alkoxy, 5- to 10-membered heteroaryl, a 3- to 10-membered non-aromatic heterocyclic group or a group represented by the formula —NR 11a R 11b , and R 1 may be substituted with a substituent selected from Substituent Group A or Substituent Group B, wherein R 11a and R 11b may be the same or different and each represents hydrogen, C 1-6 alkyl, C 3-6 alkenyl, C 3-6 alkynyl, C 3-10 cycloalkyl, C 6-10 aryl, C 1-6 alkoxy, 5- to 10-membered heteroaryl or a 4- to 10-membered non-aromatic heterocyclic group, and R 11a and R 11b may be substituted with a substituent selected from Substituent Group A or Substitu
  • R 2 and R 3 represent hydrogen
  • R 4 , R 5 , R 6 and R 7 may be the same or different and each represents hydrogen, halogen, hydroxyl, cyano, trifluoromethyl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, amino, mono-C 1-6 alkylamino, di-C 1-6 alkylamino or a group represented by the formula —CO—R 12 , wherein R 12 represents hydrogen, hydroxyl, C 1-6 alkyl, C 1-6 alkoxy, amino, mono-C 1-6 alkylamino or di-C 1-6 alkylamino;
  • R 8 represents hydrogen or C 1-6 alkyl
  • R 9 represents C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-10 aryl, C 3-10 cycloalkyl-C 1-6 alkyl, C 6-10 aryl-C 1-6 alkyl, C 1-6 alkoxy, 5- to 10-membered heteroaryl, a 3- to 10-membered non-aromatic heterocyclic group, 5- to 10-membered heteroaryl-C 1-6 alkyl, 3- to 10-membered non-aromatic heterocyclic-C 1-6 alkyl or a group represented by the formula —NR 11a R 11b , and R 9 may be substituted with a substituent selected from Substituent Group A or Substituent Group B, wherein R 11a and R 11b represent the same meaning as recited above;
  • V 1 and V 2 may be the same or different and each represents oxygen or sulfur
  • W represents a group represented by the formula —N(R W3 )—, wherein R W3 represents hydrogen or C 1-6 alkyl;
  • X represents a group represented by the formula —C(R 10 ) ⁇ or nitrogen, wherein R 10 represents hydrogen, halogen, cyano, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl or a group represented by the formula —CO—R 12 , wherein R 12 represents the same meaning as recited above; and
  • Y represents oxygen, sulfur, sulfinyl, sulfonyl, or a group represented by the formula —N(R Y )—, wherein R Y represents hydrogen or C 1-6 alkyl,
  • Substituent Group A consists of halogen, hydroxyl, mercapto, nitro, cyano and oxo;
  • Substituent Group B consists of C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-10 aryl, 5- to 10-membered heteroaryl, a 3- to 10-membered non-aromatic heterocyclic group, C 1-6 alkoxy, C 3-6 alkenyloxy, C 3-6 alkynyloxy, C 3-10 cycloalkoxy, C 6-10 aryloxy, 5- to 10-membered heteroaryloxy, 4- to 10-membered non-aromatic heterocyclicoxy, C 1-6 alkylthio, C 3-6 alkenylthio, C 3-6 alkynylthio, C 3-10 cycloalkylthio, C 6-10 arylthio, 5- to 10-membered heteroarylthio, 4- to 10-membered non-aromatic heterocyclicthio and a group represented by the formula -T 1 -T 2 -T 3 , and each
  • Substituent Group C consists of halogen, hydroxyl, mercapto, nitro, cyano, oxo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-10 aryl, 5- to 10-membered heteroaryl, a 3- to 10-membered non-aromatic heterocyclic group, C 1-6 alkoxy and C 1-6 alkylthio.
  • Substituent Group D consists of amino, mono-C 1-6 alkylamino and di-C 1-6 alkylamino.
  • R 1 represent a group represented by the formula (II): wherein a represents an integer of 1 to 4, or a group represented by the formula (III): wherein b represents an integer of 1 to 3, and Z represents oxygen, sulfur, carbonyl, sulfonyl or a group represented by the formula —NR Z —, wherein R Z represents hydrogen or C 1-6 alkyl, and the groups represented by the formula (II) or (III) may be substituted with a substituent selected from Substituent Group A or Substituent Group B recited in [1].
  • R 1 represents azetidin-1-yl, pyrrolidin-1-yl, piperidin-1-yl, azepan-1-yl, piperazin-1-yl, diazepan-1-yl, morpholin-4-yl, thiomorpholin-4-yl or 1,1-dioxothiomorpholin-4-yl, and each of the foregoing groups may be substituted with a substituent selected from Substituent Group E,
  • Substituent Group E consists of halogen, hydroxyl, mercapto, cyano, formyl, oxo, C 1-6 alkyl, C 3-10 cycloalkyl, C 1-6 alkoxy, amino, mono-C 1-6 alkylamino, di-C 1-6 alkylamino, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, diazepanyl and a group represented by -T 4 -T 5 , wherein T 4 represents carbonyl or sulfonyl, and T 5 represents C 1-6 alkyl, C 3-10 cycloalkyl, azetidinyl, pyrrolidinyl, piperidinyl, hydroxyl, C 1-6 alkoxy, amino, mono-C 1-6 alkylamino or di-C 1-6 alkylamino,
  • Substituent Group E may be substituted with hydroxyl, C 1-6 alkyl, di-C 1-6 alkylamino, azetidinyl or pyrrolidinyl.
  • Substituent Group E′ consists of methyl, ethyl, dimethylamino, azetidinyl, pyrrolidinyl, piperidinyl and piperazinyl,
  • Substituent Group E′ may be substituted with hydroxyl, methyl, dimethylamino, azetidinyl or pyrrolidinyl.
  • R 1 represents a group represented by the formula —NR 11e R 11f , wherein R 11e represents hydrogen or C 1-6 alkyl, and R 11f represents C 1-6 alkyl, pyrrolidin-3-yl, piperidin-3-yl, piperidin-4-yl or tetrahydropyran-4-yl, and R 11f may be substituted with a substituent selected from Substituent Group E recited in [6].
  • R 1 represents a group represented by the formula —NR 11g R 11h , wherein R 11g represents hydrogen or methyl, and R 11h represents n-propyl, n-butyl, pyrrolidin-3-yl, piperidin-3-yl, piperidin-4-yl or tetrahydropyran-4-yl, and R 11h may be substituted with a substituent selected from Substituent Group E′′,
  • Substituent Group E′′ consists of methyl, ethyl, n-propyl, acetyl, dimethylamino, diethylamino, azetidinyl, pyrrolidinyl and piperazinyl.
  • Substituent Group E′′ may be substituted with methyl or dimethylamino.
  • R 9 represents C 1-6 alkyl, C 3-10 cycloalkyl, C 3-10 cycloalkyl-C 1-6 alkyl, C 6-10 aryl-C 1-6 alkyl, 5- to 10-membered heteroaryl-C 1-6 alkyl or 3- to 10-membered non-aromatic heterocyclic-C 1-6 alkyl, and R 9 may be substituted with a substituent selected from Substituent Group A or Substituent Group B recited in [1].
  • R 9 represents C 3-10 cycloalkyl-C 1-6 alkyl or C 6-10 aryl-C 1-6 alkyl, and R 9 may be substituted with a substituent selected from Substituent Group A or Substituent Group B recited in [1].
  • a pharmaceutical composition comprising a compound according to [1], a salt thereof or a hydrate of the foregoing.
  • An inhibitor for hepatocyte growth factor receptor comprising a compound according to [1], a salt thereof or a hydrate of the foregoing.
  • An angiogenesis inhibitor comprising a compound according to [1], a salt thereof or a hydrate of the foregoing.
  • An anti-tumor agent comprising a compound according to [1], a salt thereof or a hydrate of the foregoing.
  • tumor is a pancreatic cancer, a gastric cancer, a colorectal cancer, a breast cancer, a prostate cancer, a lung cancer, a renal cancer, a brain tumor or an ovarian cancer.
  • An inhibitor for cancer metastasis comprising a compound according to [1], a salt thereof or a hydrate of the foregoing.
  • a prophylactic or therapeutic method for a disease for which inhibition of hepatocyte growth factor receptor is effective comprising administering to a patient, a pharmacologically effective dose of a compound according to [1], a salt thereof or a hydrate of the foregoing.
  • a prophylactic or therapeutic method for a disease for which angiogenesis inhibition is effective comprising administering to a patient, a pharmacologically effective dose of a compound according to [1], a salt thereof or a hydrate of the foregoing.
  • a prophylactic or therapeutic method for a tumor comprising administering to a patient, a pharmacologically effective dose of a compound according to [1], a salt thereof or a hydrate of the foregoing.
  • tumor is a pancreatic cancer, a gastric cancer, a colorectal cancer, a breast cancer, a prostate cancer, a lung cancer, a renal cancer, a brain tumor or an ovarian cancer.
  • a prophylactic or therapeutic method for a cancer metastasis comprising administering to a patient, a pharmacologically effective dose of a compound according to [1], a salt thereof or a hydrate of the foregoing.
  • tumor is a pancreatic cancer, a gastric cancer, a colorectal cancer, a breast cancer, a prostate cancer, a lung cancer, a renal cancer, a brain tumor or an ovarian cancer.
  • metabolite a compound which a compound according to the present invention is metabolized in a living body through oxidation, reduction, hydrolysis, conjugation and the others to provide
  • prodrug a compound which is metabolized in a living body through oxidation, reduction, hydrolysis, conjugation and the others to provide a compound according to the present invention
  • the “salt” includes a salt of an inorganic acid, a salt of an organic acid, a salt of an inorganic base, a salt of an organic base and a salt of an acidic or basic amino acid, among them, a pharmacologically acceptable salt is preferable.
  • the preferable salt of an inorganic acid includes, for example, a salt of hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid and phosphoric acid.
  • the preferable salt of an organic acid includes, for example, a salt of acetic acid, succinic acid, fumaric acid, maleic acid, tartaric acid, citric acid, lactic acid, stearic acid, benzoic acid, methanesulfonic acid, ethanesulfonic acid, and p-toluenesulfonic acid.
  • the preferable salt of an inorganic base includes, for example, an alkali metal salt such as sodium salt and potassium salt, an alkali earth metal salt such as calcium salt and magnesium salt, aluminum salt, and ammonium salt.
  • the preferable salt of an organic base includes, for example, a salt of diethylamine, diethanolamine, meglumine, and N,N-dibenzylethylenediamine.
  • the preferable salt of an acidic amino acid includes, for example, a salt of aspartic acid and glutamic acid.
  • the preferable salt of a basic amino acid includes, for example, a salt of arginine, lysine and ornithine.
  • halogen represents fluorine, chlorine, bromine or iodine.
  • C 1-6 alkyl represents an alkyl of straight or branched chain having a carbon number of 1 to 6, and includes, for specific example, methyl, ethyl, 1-propyl (n-propyl), 2-propyl (i-propyl), 2-methyl-1-propyl (i-butyl), 2-methyl-2-propyl (t-butyl), 1-butyl (n-butyl), 2-butyl (s-butyl), 1-pentyl, 2-pentyl, 3-pentyl, 2-methyl-1-butyl, 3-methyl-1-butyl, 2-methyl-2-butyl, 3-methyl-2-butyl, 2,2-dimethyl-1-propyl, 1-hexyl, 2-hexyl, 3-hexyl, 2-methyl-1-pentyl, 3-methyl-1-pentyl, 4-methyl-1-pentyl, 2-methyl-2-pentyl, 3-methyl-2-pentyl, 4-methyl-2-pentyl, 2-methyl-2-pent
  • the “C 2-6 alkenyl” represents an alkenyl of straight or branched chain having one double bond and a carbon number of 2 to 6, and includes, for specific example, ethenyl (vinyl), 1-propenyl, 2-propenyl (allyl), 1-butenyl, 2-butenyl, 3-butenyl, pentenyl, and hexenyl.
  • C 3-6 alkenyl represents an alkenyl of straight or branched chain having one double bond and a carbon number of 3 to 6, and includes, for specific example, 2-propenyl (allyl), 2-butenyl, 3-butenyl, pentenyl, and hexenyl.
  • C 2-6 alkynyl represents an alkynyl of straight or branched chain having one triple bond and a carbon number of 2 to 6, and includes, for specific example, ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl, pentynyl, and hexynyl.
  • C 3-6 alkynyl represents an alkynyl of straight or branched chain having one triple bond and a carbon number of 3 to 6, and includes, for specific example, 2-propynyl, 2-butynyl, 3-butynyl, pentynyl, and hexynyl.
  • C 1-6 alkylene represents a divalent group derived by eliminating further any one hydrogen from the “C 1-6 alkyl” defined above, and includes, for specific example, methylene, 1,2-ethylene, 1,1-ethylene, 1,3-propylene, tetramethylene, pentamethylene, and hexamethylene.
  • C 3-10 cycloalkyl represents a mono- or di-cyclic saturated aliphatic hydrocarbon group having a carbon number of 3 to 10, and includes, for specific example, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl, cyclodecyl, bicyclo[2.1.0]pentyl, bicyclo[3.1.0]hexyl, bicyclo[2.1.1]hexyl, bicyclo[4.1.0]heptyl, bicyclo[2.2.1]heptyl (norbornyl), bicyclo[3.3.0]octyl, bicyclo[3.2.1]octyl, bicyclo[2.2.2]octyl, bicyclo[4.3.0]nonyl, bicyclo[3.3.1]nonyl, bicyclo[4.4.0]decyl (decalyl),
  • C 6-10 aryl represents an aromatic hydrocarbon ring group having a carbon number of 6 to 10, and includes, for specific example, phenyl, 1-naphthyl, 2-naphthyl, indenyl, azulenyl, and heptalenyl.
  • heteroatom represents nitrogen, oxygen, or sulfur.
  • the “5- to 10-membered heteroaryl” represents an aromatic ring group having 5 to 10 atoms forming the ring and containing 1 to 5 heteroatoms, and includes, for specific example, furyl, thienyl, pyrrolyl, imidazolyl, triazolyl, tetrazolyl, thiazolyl, pyrazolyl, oxazolyl, isoxazolyl, isothiazolyl, furazanyl, thiadiazolyl, oxadiazolyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, triazinyl, purinyl, pteridinyl, quinolyl, isoquinolyl, naphthylidinyl, quinoxalinyl, cinnolinyl, quinazolinyl, phthalazinyl, imidazopyridyl, imidazothiazolyl, imid
  • the preferable example of the “5- to 10-membered heteroaryl” includes furyl, thienyl, pyrrolyl, imidazolyl, thiazolyl, pyrazolyl, oxazolyl, isoxazolyl, isothiazolyl, pyridyl, and pyrimidinyl.
  • the “3- to 10-membered non-aromatic heterocyclic group” represents
  • the nitrogen may have a bond not participating in the formation of the ring.
  • the group includes, for specific example, aziridinyl, azetidinyl, pyrrolidinyl, piperidinyl, azepanyl, azocanyl, piperazinyl, diazepanyl, diazocanyl, diazabicyclo[2.2.1]heptyl, morpholinyl, thiomorpholinyl, 1,1-dioxothiomorpholinyl, oxiranyl, oxetanyl, tetrahydrofuryl, tetrahydropyranyl, dioxanyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, and thiazolidinyl.
  • the preferable example of the “3- to 10-membered non-aromatic heterocyclic group” includes aziridinyl, azetidinyl, pyrrolidinyl, piperidinyl, azepanyl, piperazinyl, diazepanyl, morpholinyl, thiomorpholinyl, 1,1-dioxothiomorpholinyl, tetrahydrofuryl, and tetrahydropyranyl.
  • the “4- to 10-membered non-aromatic heterocyclic group” represents
  • the nitrogen may have a bond not participating in the formation of the ring.
  • the group includes, for specific example, azethidinyl, pyrrolidinyl, piperidinyl, azepanyl, azocanyl, piperazinyl, diazepanyl, diazocanyl, diazabicyclo[2.2.1]heptyl, morpholinyl, thiomorpholinyl, 1,1-dioxothiomorpholinyl, oxetanyl, tetrahydrofuryl, tetrahydropyranyl, dioxanyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, and thiazolidinyl.
  • the preferable example of the “4- to 10-membered non-aromatic heterocyclic group” includes azetidinyl, pyrrolidinyl, piperidinyl, azepanyl, piperazinyl, diazepanyl, morpholinyl, thiomorpholinyl, 1,1-dioxothiomorpholinyl, tetrahydrofuryl, and tetrahydropyranyl.
  • the “C 3-10 cycloalkyl-C 1-6 alkyl” represents a group obtained by substituting any one hydrogen of the above defined “C 1-6 alkyl” with the above defined “C 3-10 cycloalkyl”, and includes, for specific example, cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, cycloheptylmethyl, cyclooctylmethyl, cyclononylmethyl, cyclodecylmethyl, bicyclo[2.2.1]heptylmethyl (norbornylmethyl), and bicyclo[4.4.0]decylmethyl (decarylmethyl).
  • the “C 6-10 aryl-C 1-6 alkyl” represents a group obtained by substituting any one hydrogen of the above defined “C 1-6 alkyl” with the above defined “C 6-10 aryl”, and includes, for specific example, benzyl, 1-naphthylmethyl, 2-naphthylmethyl, phenethyl, 1-naphthylethyl, and 2-naphthylethyl.
  • the “5- to 10-membered heteroaryl-C 1-6 alkyl” represents a group obtained by substituting any one hydrogen of the above defined “C 1-6 alkyl” with the above defined “5- to 10-membered heteroaryl”, and includes, for specific example, furylmethyl, thienylmethyl, pyrrolylmethyl, imidazolylmethyl, triazolylmethyl, tetrazolylmethyl, thiazolylmethyl, pyrazolylmethyl, oxazolylmethyl, isoxazolylmethyl, isothiazolylmethyl, furazanylmethyl, thiadiazolylmethyl, oxadiazolylmethyl, pyridylmethyl, pyrazinylmethyl, pyridazinylmethyl, pyrimidinylmethyl, triazinylmethyl, furylethyl, thienylethyl, pyrrolylethyl, imidazolylethyl, triazolylethyl, te
  • the preferable example of the “5- to 10-membered heteroaryl C 1-6 alkyl” includes furylmethyl, thienylmethyl, pyrrolylmethyl, imidazolylmethyl, thiazolylmethyl, pyrazolylmethyl, oxazolylmethyl, isoxazolylmethyl, isothiazolylmethyl, pyridylmethyl, pyrimidinylmethyl, furylethyl, thienylethyl, pyrrolylethyl, imidazolylethyl, thiazolylethyl, pyrazolylethyl, oxazolylethyl, isoxazolylethyl, isothiazolylethyl, pyridylethyl, and pyrimidinylethyl.
  • the “3- to 10-membered non-aromatic heterocyclic-C 1-6 alkyl” represents a group obtained by substituting any one hydrogen of the above defined “C 1-6 alkyl” with the above defined “3- to 10-membered heterocyclic group”, and includes, for specific example, aziridinylmethyl, azetidinylmethyl, pyrrolidinylmethyl, piperidinylmethyl, azepanylmethyl, azocanylmethyl, piperazinylmethyl, diazepanylmethyl, diazocanylmethyl, morpholinylmethyl, thiomorpholinylmethyl, 1,1-dioxothiomorpholinylmethyl, oxiranylmethyl, oxetanylmethyl, tetrahydrofurylmethyl, tetrahydropyranylmethyl, dioxanylmethyl, tetrahydrothienylmethyl, tetrahydrothiopyranylmethyl, oxazolidinylmethyl,
  • the preferable example of the “3- to 10-membered non-aromatic heterocyclic-C 1-6 alkyl” includes azetidinylmethyl, pyrrolidinylmethyl, piperidinylmethyl, azepanylmethyl, piperazinylmethyl, diazepanylmethyl, morpholinylmethyl, thiomorpholinylmethyl, tetrahydrofurylmethyl, azetidinylethyl, pyrrolidinylethyl, piperidinylethyl, azepanylethyl, piperazinylethyl, diazepanylethyl, morpholinylethyl, thiomorpholinylethyl, and tetrahydrofurylethyl.
  • the “C 1-6 alkoxy” represents a group obtained by adding oxygen to the terminal of the above defined “C 1-6 alkyl”, and includes, for specific example, methoxy, ethoxy, 1-propoxy (n-propoxy), 2-propoxy (i-propoxy), 2-methyl-1-propoxy (i-butoxy), 2-methyl-2-propoxy (t-butoxy), 1-butoxy (n-butoxy), 2-butoxy (s-butoxy), 1-pentyloxy, 2-pentyloxy, 3-pentyloxy, 2-methyl-1-butoxy, 3-methyl-1-butoxy, 2-methyl-2-butoxy, 3-methyl-2-butoxy, 2,2-dimethyl-1-propoxy, 1-hexyloxy, 2-hexyloxy, 3-hexyloxy, 2-methyl-1-pentyloxy, 3-methyl-1-pentyloxy, 4-methyl-1-pentyloxy, 2-methyl-2-pentyloxy, 3-methyl-2-pentyloxy, 4-methyl-2-pentyloxy, 2-methyl-2-pent
  • C 1-6 alkylthio represents a group obtained by adding sulfur to the terminal of the above defined “C 1-6 alkyl”, and includes, for specific example, methylthio, ethylthio, 1-propylthio (n-propylthio), 2-propylthio (i-propylthio), 2-methyl-1-propylthio (1-butylthio), 2-methyl-2-propylthio (t-butylthio), 1-butylthio (n-butylthio), 2-butylthio (s-butylthio), 1-pentylthio, 2-pentylthio, 3-pentylthio, 2-methyl-1-butylthio, 3-methyl-1-butylthio, 2-methyl-2-butylthio, 3-methyl-2-butylthio, 2,2-dimethyl-1-propylthio, 1-hexylthio, 2-hexylthio, 3-hexylthio, 2-methyl-1-p
  • the “C 3-6 alkenyloxy” represents a group obtained by adding oxygen to the terminal of the above defined “C 3-6 alkenyl”, and includes, for specific example, 2-propenyloxy (allyloxy), 2-butenyloxy, 3-butenyloxy, pentenyloxy, and hexenyloxy.
  • C 3-6 alkenylthio represents a group obtained by adding sulfur to the terminal of the above defined “C 3-6 alkenyl”, and includes, for specific example, 2-propenylthio(allylthio), 2-butenylthio, 3-butenylthio, pentenylthio, and hexenylthio.
  • C 3-6 alkynyloxy represents a group obtained by adding oxygen to the terminal of the above defined “C 3-6 alkynyl”, and includes, for specific example, 2-propynyloxy, 2-butynyloxy, 3-butynyloxy, pentynyloxy, and hexynyloxy.
  • C 3-6 alkynylthio represents a group obtained by adding sulfur to the terminal of the above defined “C 3-6 alkynyl”, and includes, for specific example, 2-propynylthio, 2-butynylthio, 3-butynylthio, pentynylthio, and hexynylthio.
  • the “C 3-10 cycloalkoxy” represents a group obtained by adding oxygen to the terminal of the above defined “C 3-10 cycloalkyl”, and includes, for specific example, cyclopropoxy, cyclobutoxy, cyclopentyloxy, cyclohexyloxy, cycloheptyloxy, and cyclooctyloxy.
  • C 3-10 cycloalkylthio represents a group obtained by adding sulfur to the terminal of the above defined “C 3-10 cycloalkyl”, and includes, for specific example, cyclopropylthio, cyclobutylthio, cyclopentylthio, cyclohexylthio, cycloheptylthio, and cyclooctylthio.
  • the “C 6-10 aryloxy” represents a group obtained by adding oxygen to the terminal of the above defined “C 6-10 aryl”, and includes, for specific example, phenoxy, 1-naphthoxy, 2-naphthoxy, indenyloxy, azulenyloxy, and heptalenyloxy.
  • the “C 6-10 arylthio” represents a group obtained by adding sulfur to the terminal of the above defined “C 6-10 aryl”, and includes, for specific example, phenylthio, 1-naphthylthio, 2-naphthylthio, indenylthio, azulenylthio, and heptalenylthio.
  • the “5- to 10-membered heteroaryloxy” represents a group obtained by adding oxygen to the terminal of the above defined “5- to 10-membered heteroaryl”, and includes, for specific example, furyloxy, thienyloxy, pyrrolyloxy, imidazolyloxy, triazolyloxy, thiazolyloxy, pyrazolyloxy, oxazolyloxy, isoxazolyloxy, isothiazolyloxy, furazanyloxy, thiadiazolyloxy, oxadiazolyloxy, pyridyloxy, pyrazinyloxy, pyridazinyloxy, pyrimidinyloxy, and triazinyloxy.
  • the “5- to 10-membered heteroarylthio” represents a group obtained by adding sulfur to the terminal of the above defined “5- to 10-membered heteroaryl”, and includes, for specific example, furylthio, thienylthio, pyrrolylthio, imidazolylthio, triazolylthio, thiazolylthio, pyrazolylthio, oxazolylthio, isoxazolylthio, isothiazolylthio, furazanylthio, thiadiazolylthio, oxadiazolylthio, pyridylthio, pyrazinylthio, pyridazinylthio, pyrimidinylthio, and triazinylthio.
  • the “4- to 10-membered non-aromatic heterocyclicoxy group” represents a group obtained by adding oxygen to the terminal of the above defined “4- to 10-membered non-aromatic heterocyclic group”, and includes, for specific example, azetidinyloxy, pyrrolidinyloxy, piperidinyloxy, azepanyloxy, azocanyloxy, piperazinyloxy, diazepanyloxy, diazocanyloxy, morpholinyloxy, thiomorpholinyloxy, 1,1-dioxothiomorpholinyloxy, oxetanyloxy, tetrahydrofuryloxy, tetrahydropyranyloxy, tetrahydrothienyloxy, and tetrahydrothiopyranyloxy.
  • the “4- to 10-membered non-aromatic heterocyclicthio group” represents a group obtained by adding sulfur to the terminal of the above defined “4- to 10-membered non-aromatic heterocyclic group”, and includes, for specific example, azetidinylthio, pyrrolidinylthio, piperidinylthio, azepanylthio, azocanylthio, piperazinylthio, diazepanylthio, diazocanylthio, oxetanylthio, tetrahydrofurylthio, tetrahydropyranylthio, tetrahydrothienylthio, and tetrahydrothiopyranylthio.
  • the “mono-C 1-6 alkylamino” represents a group obtained by substituting one hydrogen of amino with the above defined “C 1-6 alkyl”, and includes, for specific example, methylamino, ethylamino, 1-propylamino (n-propylamino), 2-propylamino (i-propylamino), 2-methyl-1-propylamino (i-butylamino), 2-methyl-2-propylamino (t-butylamino), 1-butylamino (n-butylamino), 2-butylamino (s-butylamino), 1-pentylamino, 2-pentylamino, 3-pentylamino, 2-methyl-1-butylamino, 3-methyl-1-butylamino, 2-methyl-2-butylamino, 3-methyl-2-butylamino, 2,2-dimethyl-1-propylamino, 1-hexylamino, 2-hexylamino, 3-hexylamin
  • the “mono-C 3-10 cycloalkylamino” represents a group obtained by substituting one hydrogen of amino with the above defined “C 3-10 cycloalkyl”, and includes, for specific example, cyclopropylamino, cyclobutylamino, cyclopentylamino, cyclohexylamino, cycloheptylamino, and cyclooctylamino.
  • the “mono-C 6-10 arylamino” represents a group obtained by substituting one hydrogen of amino with the above defined “C 6-10 aryl”, and includes, for specific example, phenylamino, 1-naphthylamino, 2-naphthylamino, indenylamino, azulenylamino, and heptalenylamino.
  • the “mono-5- to 10-membered heteroarylamino” represents a group obtained by substituting one hydrogen of amino with the above defined “5- to 10-membered heteroaryl”, and includes, for specific example, furylamino, thienylamino, pyrrolylamino, imidazolylamino, triazolylamino, tetrazolylamino, thiazolylamino, pyrazolylamino, oxazolylamino, isoxazolylamino, isothiazolylamino, furazanylamino, thiadiazolylamino, oxadiazolylamino, pyridylamino, pyrazinylamino, pyridazinylamino, pyrimidinylamino, and triazinylamino.
  • the preferable example of the “mono-5- to 10-membered heteroarylamino” includes furylamino, thienylamino, pyrrolylamino, imidazolylamino, thiazolylamino, pyrazolylamino, oxazolylamino, isoxazolylamino, isothiazolylamino, pyridylamino, and pyrimidinylamino.
  • the “mono-4- to 10-membered non-aromatic heterocyclic amino” represents a group obtained by substituting one hydrogen of amino with the above defined “4- to 10-membered non-aromatic heterocyclic group”, and includes, for specific example, azetidinylamino, pyrrolidinylamino, piperidinylamino, azepanylamino, azocanylamino, piperazinylamino, diazepanylamino, diazocanylamino, morpholinylamino, thiomorpholinylamino, 1,1-dioxothiomorpholinylamino, oxetanylamino, tetrahydrofurylamino, tetrahydropyranylamino, tetrahydrothienylamino, and tetrahydrothiopyranylamino.
  • the preferable example of the “mono-4- to 10-membered non-aromatic heterocyclic amino” includes pyrrolidinylamino, piperidinylamino, azepanylamino, piperazinylamino, diazepanylamino, morpholinylamino, thiomorpholinylamino, and tetrahydrofurylamino.
  • the “di-C 1-6 alkylamino” represents a group obtained by substituting two hydrogen of amino with the same or different groups of the above defined “C 1-6 alkyl”, and includes, for specific example, N,N-dimethylamino, N,N-diethylamino, N,N-di-n-propylamino, N,N-di-i-propylamino, N,N-di-n-butylamino, N,N-di-i-butylamino, N,N-di-s-butylamino, N,N-di-t-butylamino, N-ethyl-N-methylamino, N-n-propyl-N-methylamino, N-i-propyl-N-methylamino, N-n-butyl-N-methylamino, N-i-butyl-N-methylamino, N-s-butyl-N-methylamino, and N
  • R 1 represents C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-10 aryl, C 1-6 alkoxy, 5- to 10-membered heteroaryl, a 3- to 10-membered non-aromatic heterocyclic group or a group represented by the formula —NR 11a R 11b , wherein R 11a and R 11b may be the same or different and each represents hydrogen, C 1-6 alkyl, C 3-6 alkenyl, C 3-6 alkynyl, C 3-10 cycloalkyl, C 6-10 aryl, C 1-6 alkoxy, 5- to 10-membered heteroaryl or a 4- to 10-membered non-aromatic heterocyclic group, and R 11a and R 11b may be substituted with a substituent selected from Substituent Group A or Substituent Group B.
  • R 1 may be substituted with a substituent selected from Substituent Group A or Substituent Group B.
  • R 1 includes C 1-6 alkyl optionally substituted with a substituent selected from Substituent Group A or Substituent Group B; a 3- to 10-membered non-aromatic heterocyclic group optionally substituted with a substituent selected from Substituent Group A or Substituent Group B; and a group represented by the formula —NR 11a R 11b , wherein R 11a and R 11b represent the same meaning as described above, and R 11a and R 11b may be substituted with a substituent selected from Substituent Group A or Substituent Group B.
  • R 1 includes C 1-6 alkyl optionally substituted with a substituent selected from Substituent Group D; a group represented by the formula (II): wherein a represents an integer of 1 to 4; a group represented by the formula (III): wherein b represents an integer of 1 to 3, and Z represents oxygen, sulfur, carbonyl, sulfonyl, or a group represented by the formula —NR Z —, wherein R Z represents hydrogen or C 1-6 alkyl, and the groups represented by the formula (II) or (III) may be substituted with a substituent selected from Substituent Group A or Substituent Group B; or a group represented by the formula —NR 11c R 11d , wherein R 11c represents hydrogen or C 1-6 alkyl, and R 11d represents C 1-6 alkyl or a group represented by the formula (IV): wherein c represents an integer of 1 to 3, and Z 1 represents oxygen, sulfur, carbonyl, sulfony
  • R 1 includes C 1-6 alkyl, azetidin-1-yl, pyrrolidin-1-yl, piperidin-1-yl, azepan-1-yl, piperazin-1-yl, diazepan-1-yl, morpholin-4-yl, thiomorpholin-4-yl, 1,1-dioxothiomorpholin-4-yl, or a group represented by the formula —NR 11e R 11f , wherein R 11e represents hydrogen or C 1-6 alkyl, R 11f represents C 1-6 alkyl, pyrrolidin-3-yl, piperidin-3-yl, piperidin-4-yl or tetrahydropyran-4-yl, and R 11f may be substituted with a substituent selected from Substituent Group E, and each of the above substituents may be substituted with a substituent selected from Substituent Group E.
  • R 1 includes azetidin-1-yl, pyrrolidin-1-yl, piperidin-1-yl, piperazin-1-yl, diazepan-1-yl, morpholin-4-yl, and each of the above substituents may be substituted with a substituent selected from Substituent Group E′, or a group represented by the formula —NR 11g R 11h , wherein R 11g represents hydrogen or methyl, R 11h represents n-propyl, n-butyl, pyrrolidin-3-yl, piperidin-3-yl, piperidin-4-yl or tetrahydropyran-4-yl, and R 11h may be substituted with a substituent selected from Substituent Group E′′.
  • R 1 includes a group represented by the formulas: (Meaning of Substituent Group A)
  • the Substituent Group A represents a group consisting of halogen, hydroxyl, mercapto, nitro, cyano and oxo.
  • the Substituent Group B represents a group consisting of C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-10 aryl, 5- to 10-membered heteroaryl, a 3- to 10-membered non-aromatic heterocyclic group, C 1-6 alkoxy, C 3-6 alkenyloxy, C 3-6 alkynyloxy, C 3-10 cycloalkoxy, C 6-10 aryloxy, 5- to 10-membered heteroaryloxy, 4- to 10-membered non-aromatic heterocyclicoxy, C 1-6 alkylthio, C 3-6 alkenylthio, C 3-6 alkynylthio, C 3-10 cycloalkylthio, C 6-10 arylthio, 5- to 10-membered heteroarylthio, 4- to 10-membered non-aromatic heterocyclicthio and a group represented by the formula -T 1 -T 2 -T 3
  • Substituent Group B may be substituted with a substituent selected from Substituent Group C.
  • the Substituent Group C represents a group consisting of halogen, hydroxyl, mercapto, nitro, cyano, oxo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-10 aryl, 5- to 10-membered heteroaryl, a 3- to 10-membered non-aromatic heterocyclic group, C 1-6 alkoxy and C 1-6 alkylthio.
  • the Substituent Group D represents a group consisting of amino, mono-C 1-6 alkylamino and di-C 1-6 alkylamino.
  • the Substituent Group E represents a group consisting of halogen, hydroxyl, mercapto, cyano, formyl, oxo, C 1-6 alkyl, C 3-10 cycloalkyl, C 1-6 alkoxy, amino, mono-C 1-6 alkylamino, di-C 1-6 alkylamino, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, diazepanyl and a group represented by -T 4 -T 5 , wherein T 4 represents carbonyl or sulfonyl, and T 5 represents C 1-6 alkyl, C 3-10 cycloalkyl, azetidinyl, pyrrolidinyl, piperidinyl, hydroxyl, C 1-6 alkoxy, amino, mono-C 1-6 alkylamino or di-C 1-6 alkylamino.
  • Substituent Group E may be substituted with hydroxyl, C 1-6 alkyl, di-C 1-6 alkylamino, azetidinyl or pyrrolidinyl.
  • the Substituent Group E′ represents a group consisting of methyl, ethyl, dimethylamino, azetidinyl, pyrrolidinyl, piperidinyl and piperazinyl.
  • Each group included in Substituent Group E′ may be substituted with hydroxyl, methyl, dimethylamino, azetidinyl or pyrrolidinyl.
  • the Substituent Group E′′ represents a group consisting of methyl, ethyl, n-propyl, acetyl, dimethylamino, diethylamino, azetidinyl, pyrrolidinyl and piperazinyl.
  • Substituent Group E′′ may be substituted with methyl or dimethylamino.
  • R 2 and R 3 represent hydrogen.
  • R 4 , R 5 , R 6 and R 7 may be the same or different and each represents hydrogen, halogen, hydroxyl, cyano, trifluoromethyl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, amino, mono-C 1-6 alkylamino, di-C 1-6 alkylamino or a group represented by the formula —CO—R 12 , wherein R 12 represents hydrogen, hydroxyl, C 1-6 alkyl, C 1-6 alkoxy, amino, mono-C 1-6 alkylamino or di-C 1-6 alkylamino.
  • R 4 , R 5 , R 6 and R 7 includes hydrogen, halogen, C 1-6 alkyl, C 1-6 alkoxy and trifluoromethyl.
  • R 4 , R 5 , R 6 and R 7 includes hydrogen, halogen and C 1-6 alkyl.
  • R 4 , R 5 , R 6 and R 7 includes hydrogen, fluorine, chlorine and methyl.
  • R 4 , R 5 , R 6 and R 7 may be in any one of the following cases: (1) all of them represent hydrogen, (2) all of them represent substituents other than hydrogen, and (3) some of them represent hydrogen and the others represent substituents other than hydrogen. Preferably, 2 to 4 of R 4 , R 5 , R 6 and R 7 represent hydrogen.
  • R 8 represents hydrogen or C 1-6 alkyl.
  • the preferable example of R 8 includes hydrogen.
  • R 9 represents C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-10 aryl, C 3-10 cycloalkyl-C 1-6 alkyl, C 6-10 aryl-C 1-6 alkyl, C 1-6 alkoxy, 5- to 10-membered heteroaryl, a 3- to 10-membered non-aromatic heterocyclic group, 5- to 10-membered heteroaryl-C 1-6 alkyl, 3- to 10-membered non-aromatic heterocyclic-C 1-6 alkyl or a group represented by the formula —NR 11a R 11b , wherein R 11a and R 11b represent the same meaning as described above.
  • R 9 may be substituted with a substituent selected from Substituent Group A or Substituent Group B.
  • V 1 represents oxygen or sulfur.
  • V 1 includes oxygen.
  • V 2 represents oxygen or sulfur.
  • W represents a group represented by the formula —N(R W3 )—, wherein R W3 represents hydrogen or C 1-6 alkyl.
  • the preferable example of W includes a group represented by —NH—.
  • the preferable combination of W and V 2 includes:
  • the more preferable combination includes:
  • R 9 includes C 1-6 alkyl, C 3-10 cycloalkyl, C 3-10 cycloalkyl-C 1-6 alkyl, C 6-10 aryl-C 1-6 alkyl, 5- to 10-membered heteroaryl-C 1-6 alkyl, and 3- to 10-membered non-aromatic heterocyclic-C 1-6 alkyl, and R 9 may be substituted with a substituent selected from Substituent Group A or Substituent Group B.
  • R 9 includes C 3-10 cycloalkyl-C 1-6 alkyl, and C 6-10 aryl-C 1-6 alkyl, and R 9 may be substituted with a substituent selected from Substituent Group A or Substituent Group B.
  • R 9 includes C 3-10 cycloalkyl-C 1-6 alkyl, and C 6-10 aryl-C 1-6 alkyl, and R 9 may be substituted with a substituent selected from Substituent Group F, wherein Substituent Group F consists of halogen, trifluoromethyl, cyano, C 1-6 alkyl and C 1-6 alkoxy.
  • R 9 includes cyclopentylmethyl, cyclohexylmethyl, cycloheptylmethyl, norbornan-2-ylmethyl and benzyl, and R 9 may be substituted with a substituent selected from Substituent Group F.
  • X represents a group represented by the formula —C(R 10 ) ⁇ or nitrogen, wherein R 10 represents hydrogen, halogen, cyano, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl or a group represented by the formula —CO—R 12 , wherein R 12 represents the same meaning as described above.
  • the preferable example of X includes a group represented by the formula —C(R 10a ) ⁇ or nitrogen, wherein R 10a represents hydrogen, halogen or cyano.
  • the more preferable example of X includes a group represented by the formula —CH ⁇ or nitrogen.
  • Y represents oxygen, sulfur, sulfinyl, sulfonyl or a group represented by the formula —N(R Y )—, wherein R Y represents hydrogen or C 1-6 alkyl.
  • the preferable example of Y includes oxygen or a group represented by the formula —NH—.
  • the more preferable example of Y includes oxygen.
  • the preferable compound according to the present invention represented by the formula (I) includes a compound represented by the following formula (I-1):
  • R 1 and X represent the same meanings as those in the above formula (I).
  • W 10 represents a group represented by the formulas: wherein the left bonding hands bond with —NH—, and the right bonding hands bond with R 90 . (Meaning of R 40 , R 50 and R 60 )
  • R 40 , R 50 and R 60 may be the same or different and each represents hydrogen, halogen or C 1-6 alkyl.
  • R 40 , R 50 and R 60 may be the same or different and each represents hydrogen, fluorine, chlorine or methyl.
  • R 40 and R 50 each represents hydrogen, fluorine, chlorine or methyl
  • R 60 represents hydrogen
  • R 90 represents C 1-6 alkyl, C 3-10 cycloalkyl, C 6-10 aryl, 5- to 10-membered heteroaryl, C 3-10 cycloalkyl-C 1-6 alkyl, C 6-10 aryl-C 1-6 alkyl, or 5- to 10-membered heteroaryl-C 1-6 alkyl.
  • R 90 may be substituted with a substituent selected from Substituent Group F, wherein Substituent Group F consists of halogen, trifluoromethyl, cyano, C 1-6 alkyl and C 1-6 alkoxy.
  • R 90 includes C 3-10 cycloalkyl-C 1-6 alkyl and C 6-10 aryl-C 1-6 alkyl, and R 90 may be substituted with a substituent selected from Substituent Group F.
  • R 90 includes cyclopentylmethyl, cyclohexylmethyl, cycloheptylmethyl, norbornan-2-ylmethyl and benzyl, and R 90 may be substituted with a substituent selected from Substituent Group F.
  • the preferable compound of the formula (I) includes a compound obtained by selecting respective aspects of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , V 1 , V 2 , W, X and Y in the compound and combining them arbitrarily.
  • the preferable compound of the formula (I-1) includes a compound obtained by selecting respective aspects of R 1 , R 40 , R 50 , R 60 , R 90 , W 10 and X in the compound and combining them arbitrarily.
  • the preferable compound of the formula (I) or the formula (I-1) includes, for specific example, Ex. 3, Ex. 13, Ex. 22, Ex. 28, Ex. 38, Ex. 39, Ex. 52, Ex. 100, Ex. 170, Ex. 172, Ex. 174, Ex. 178, Ex. 179, Ex. 180, Ex. 181, Ex. 182, Ex. 183, Ex. 184, Ex. 185, Ex. 188, Ex. 189, Ex. 190, Ex. 191, Ex. 192, Ex. 193, Ex. 194, Ex. 195, Ex. 196, Ex. 201, Ex. 208, Ex. 209, Ex. 219, Ex. 221, Ex. 223, Ex. 224, Ex. 225, Ex. 245, Ex.
  • the compound according to the present invention has an inhibitory activity of HGFR tyrosine kinase (Pharmacological Test Examples 1 and 3), and thus inhibits proliferation of human cancer cells caused by HGFR activation (Pharmacological Test Example 2), whereby to exhibit inhibitory activity of tumor proliferation (Pharmacological Test Example 5).
  • the compound according to the present invention also inhibits migration of human cancer cells (Pharmacological Test Example 4).
  • the compound according to the present invention inhibits proliferation and tube formation of vascular endothelial cells via HGF-HGFR signal (Pharmacological Test Examples 6 and 7).
  • HGFR Overexpression of HGFR is reported to involve in malignancy of cancer (overgrowth, invasion and enhanced metastasis) in a pancreatic cancer, a gastric cancer, a colorectal cancer, a breast cancer, a prostate cancer, a lung cancer, a renal cancer, a brain tumor, an ovarian cancer and a blood cancer
  • Cancer Research, 54, 5775-5778 (1994) Biochemical and Biophysical Research Communication, 189, 227-232 (1992); Oncogene, 7, 181-185 (1992); Cancer, 82, 1513-1520 (1998); J.
  • HGFR activation in vascular endothelial cells is reported to facilitate tumor angiogenesis (Advances in Cancer Research, 67, 257-279 (1995)).
  • the compound according to the present invention which has excellent inhibitory activity against HGFR is useful as an anti-tumor agent, an inhibitor against angiogenesis or a cancer metastasis inhibitor against various kinds of cancers such as a pancreatic cancer, a gastric cancer, a colorectal cancer, a breast cancer, a prostate cancer, a lung cancer, a renal cancer, a brain tumor and an ovarian cancer.
  • the compound of the present invention can be produced by methods described below. But the method for producing the compound of the present invention is not limited to these methods.
  • Y 1 represents oxygen, sulfur or the formula —N(R Y1 )—, wherein R Y1 represents hydrogen or C 1-6 alkyl; L 1 represents a leaving group; R 101 represents C 1-6 alkyl or benzyl; R 102 represents C 1-6 alkyl, benzyl or 2-(trimethylsilyl)ethyl; R 80 represents C 1-6 alkyl; P represents a protecting group for amino; and the other symbols represent the same meaning as defined above.
  • the compound (1a) includes, for example, 4-nitropicolinic acid ester, 4-chloropicolinic acid ester, 6-chloropyrimidine-4-carboxylic acid ester.
  • 4-nitropicolinic acid ester and 4-chloropicolinic acid ester can be obtained by the esterification of 4-nitropicolinic acid and 4-chloropicolinic acid, both of which are commercially available (See Production Example 111).
  • 6-chloropyrimidine-4-carboxylic acid ester methyl 6-chloropyrimidine-4-carboxylate is described in Ukr. Kihm. Zh., 1982, Vol. 48, p 67 (CAS No. 6627-22-1).
  • 6-chloropyrimidine-4-carboxylic acid ester also can be produced according to a method described in J. Heterocycl. Chem., 1, 130 (1964).
  • the compound (1d) includes, for example, commercially available compounds such as 2-amino-4-chloropyridine and 4-amino-6-chloropyrimidine.
  • the compound (1d) also can be produced via ⁇ Process 1A-1>, ⁇ Process 1A-2> and ⁇ Process 1A-3> described below, using the compound (1a) as a starting material.
  • the compound (1f) includes, for example, commercially available compounds such as p-methylaminophenol sulfate and N-methyl-1, 4-phenylenediamine dihydrochloride.
  • the compound (1e) can be obtained by protecting a group represented by the formula R 80 NH— of the compound (1f).
  • the general reaction for protecting amino can be used.
  • the compound (1e) can be obtained by a reaction of the compound (1f) with ethyl chloroformate, methyl chloroformate, benzyl chloroformate, di-t-butyl dicarbonate or trifluoroacetic anhydride.
  • the compound (1g) includes, for example, commercially available compounds such as acetaminophen, N-(hydroxyphenyl)formamide, 4-(N-t-butoxycarbonylamino)phenol, 4-trifluoroacetoamidophenol, 4-acetoamidothiophenol, 4-(methylcarbamyl)aniline and 4-(t-butylcarbamyl)aniline.
  • commercially available compounds such as acetaminophen, N-(hydroxyphenyl)formamide, 4-(N-t-butoxycarbonylamino)phenol, 4-trifluoroacetoamidophenol, 4-acetoamidothiophenol, 4-(methylcarbamyl)aniline and 4-(t-butylcarbamyl)aniline.
  • the compound (1h) includes, for example, commercially available compounds such as 4-nitrophenol, 2-chloro-4-nitrophenol, 2-fluoro-4-nitrophenol, 3-fluoro-4-nitrophenol, 3-methyl-4-nitrophenol, 4-nitrothiophenol, 4-nitroaniline and 2-methoxy-4-nitroaniline.
  • the compound (1i) includes, for example, commercially available compounds such as 4-aminophenol, 4-amino-3-chlorophenol hydrochloride, 4-amino-2,5-dimethylphenol, 4-amino-2,6-dichlorophenol, 5-amino-2-hydroxybenzonitrile, 4-aminothiophenol, p-phenylenediamine and 2,5-diaminoanisol sulfate.
  • commercially available compounds such as 4-aminophenol, 4-amino-3-chlorophenol hydrochloride, 4-amino-2,5-dimethylphenol, 4-amino-2,6-dichlorophenol, 5-amino-2-hydroxybenzonitrile, 4-aminothiophenol, p-phenylenediamine and 2,5-diaminoanisol sulfate.
  • the above compounds can also be produced from commercially available compounds by a known method.
  • the process is a process for producing the compound (1b) from the compound (1a).
  • a base an inorganic base such as sodium hydroxide, potassium hydroxide and lithium hydroxide can be used.
  • As the solvent methanol, ethanol, water or the like can be used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the process is a process for rearrangement of the compound (1b) to the compound (1c).
  • the compound (1c) can be obtained by a reaction of the compound (1b) with an alcohol represented by the formula R 102 —OH in the presence of diphenylphosphoryl azide and triethylamine.
  • R 102 includes t-butyl, benzyl and 2-(trimethylsilyl)ethyl.
  • As the solvent N,N-dimethylformamide, N-methylpyrrolidone, toluene or the like can be used as well as t-butanol or benzylalcohol.
  • the reaction temperature is between room temperature and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the process is a process for producing the compound (1d) from the compound (1c) by decarbamation.
  • general deprotection for amino can be used and specific examples are deprotection using an acid such as hydrochloric acid and trifluoroacetic acid, deprotection using an inorganic base such as sodium hydroxide and potassium hydroxide, and deprotection using tetrabutylammonium fluoride.
  • the solvent methanol, ethanol, water, tetrahydrofuran, N,N-dimethylformamide or the like can be used.
  • the reaction temperature is between room temperature and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • These processes are processes for coupling the compound (1d) with the compounds (1e), (1f), (1g), (1h) or (1i) to produce the compounds (1j), (1n), (1k), (1l) or (1m), respectively.
  • the solvent N-methylpyrrolidone, N,N-dimethylformamide, dimethyl sulfoxide, 2-ethoxyethanol, chlorobenzene or the like can be used.
  • a base or an acid may be added in the reaction system, and specifically an organic base such as triethylamine and diisopropylethylamine, an inorganic base such as potassium carbonate, cesium carbonate and sodium hydride, or an acid such as pyridine hydrochloride and hydrochloric acid can be used.
  • the reaction temperature is between room temperature and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the process is a process for deprotecting the compound (1j) to produce the compound (1n).
  • general deprotection for amino can be applied, for specific example, deprotection using an acid such as hydrochloric acid and trifluoroacetic acid, deprotection using an inorganic base such as sodium hydroxide and potassium hydroxide, and deprotection using tetrabutylammonium fluoride.
  • a protecting group is benzyloxycarbonyl and R 4 , R 5 , R 6 , R 7 and R 10 are not any of chlorine, bromine and iodine
  • deprotection by catalytic hydrogenation using palladium-carbon or palladium hydroxide as a catalyst can also be used.
  • the solvent methanol, ethanol, water, tetrahydrofuran, N,N-dimethylformamide or the like can be used.
  • the reaction temperature is between room temperature and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the process is a process for deprotecting the compound (1k) to produce the compound (1m).
  • the conditions similar to those in ⁇ Process 1A-5> can be used.
  • the process is a process for reducing nitro of the compound (1l) to produce the compound (1m).
  • Generally used conditions for reduction from nitro to amino can be applied, for specific example, reduction using iron-ammonium chloride, or iron-acetic acid.
  • R 4 , R 5 , R 6 , R 7 and R 10 are not any of chlorine, bromine and iodine, catalytic hydrogenation using palladium hydroxide or palladium-carbon as a catalyst also can be used.
  • the solvent methanol, ethanol, water, N,N-dimethylformamide, ethyl acetate, tetrahydrofuran or the like can be used.
  • the reaction temperature is between room temperature and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the process is a process for alkylating the compound (1m) to produce the compound (1n).
  • Reductive amination of aldehyde or ketone can convert hydrogen to C 1-6 alkyl.
  • the reducing agent sodium cyanoborohydride and sodium triacetoxyborohydride can be used.
  • the solvent methanol, tetrahydrofuran, dichloromethane, dichloroethane or the like can be used.
  • a method for reducing a benzotriazole derivative with sodium borohydride can also be used, as described in Tetrahedron, 47(16), 2683(1991).
  • the compound (1n) wherein R 80 is methyl can be obtained by reduction with sodium borohydride, a benzotriazol-1-ylmethylaniline derivative obtained by a reaction of the compound (1m) with 1-(hydroxymethyl)-1H-benzotriazole.
  • an alcohol such as methanol or ethanol, or a mixed solvent of an alcohol with N,N-dimethylformamide, acetic acid or water can be used for the solvent.
  • the reaction temperature is between ⁇ 5° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • an alcohol such as methanol or ethanol, or a mixed solvent of an alcohol with N,N-dimethylformamide or the like can be used as the solvent.
  • the reaction temperature is between ⁇ 5° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the process is an alternative method for producing the compound (1j) by alkylating the compound (1k) to produce the compound (1j).
  • the compound (1j) can be obtained by a reaction with alkyl halide in the presence of a base such as potassium carbonate or sodium hydride.
  • a base such as potassium carbonate or sodium hydride.
  • tetrahydrofuran, N,N-dimethylformamide or the like can be used as the solvent.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the process is a process for protecting amino of the compound (1o) to produce the compound (1s).
  • a general reaction for protecting amino can be used. Specifically for example, a reaction with ethyl chloroformate, methyl chloroformate, benzyl chloroformate, di-t-butyl dicarbonate and trifluoroacetic anhydride can be used.
  • a base may be added in the reaction system, and an organic base such as pyridine, triethylamine and diisopropylethylamine, and an inorganic base such as sodium carbonate, potassium carbonate and sodium hydrogencarbonate can be used.
  • As the solvent tetrahydrofuran, acetone, water, dioxane or the like can be used.
  • the reaction temperature is between room temperature and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the process is a process for alkylating the compound (1p) to produce the compound (1s).
  • the methods similar to those in ⁇ Process 1A-13> can be used.
  • the process is a process for alkylating the compound (1r) to produce the compound (1o).
  • the methods similar to those in ⁇ Process 1A-12> can be used.
  • the process is a process for protecting amino of the compound (1r) to produce the compound (1p).
  • the methods similar to those in ⁇ Process 1B-6> can be used.
  • the process is a process for reducing nitro of the compound (1q) to produce the compound (1r).
  • the methods similar to those in ⁇ Process 1A-11> can be used.
  • the process is a process for producing the compound (1t) from the compound (1ps) (the compound (1ps) represents the compound (1p) or the compound (1s) described in [Production method 1-B]).
  • the methods similar to those in ⁇ Process 1A-1> can be used.
  • the process is a process for producing the compound (1u) from the compound (1t).
  • the methods similar to those in ⁇ Process 1A-2> can be used.
  • the process is a process for deprotecting the two protecting groups “R 102 —O—C( ⁇ O)—” and “P” of the compound (1u) to produce the compound (1n).
  • deprotection using an acid such as hydrochloric acid and trifluoroacetic acid
  • deprotection using an inorganic base such as sodium hydroxide and potassium hydroxide
  • deprotection using tetrabutylammonium fluoride deprotection by catalytic hydrogenation using palladium-carbon or palladium hydroxide as a catalyst can be appropriately combined to produce the compound (1n).
  • These processes are processes for deprotecting only one of the two protecting groups “R 102 —O—C( ⁇ O)—” and “P” of the compound (1u) to produce the compound (1v) or the compound (1w), respectively.
  • the process is applicable only when the two protecting groups “R 102 —O—C( ⁇ O)—” and “P” are different.
  • a group represented by the formula R 102 —O—C( ⁇ O)— is 2-(trimethylsilyl)ethoxycarbonyl and P is benzyloxycarbonyl
  • deprotection using tetrabutylammonium fluoride or deprotection by catalytic hydrogenation can be applied to deprotect selectively only one of the two protecting groups.
  • the process is a process for deprotecting the compound (1v) to produce the compound (1n).
  • the method described in ⁇ Process 1A-5> can be used.
  • the process is a process for deprotecting the compound (1w) to produce the compound (1n).
  • the method described in ⁇ Process 1A-5> can be used.
  • L 2 represents a leaving group.
  • the other symbols represent the same meanings as defined above.
  • the compound (2a) includes, for example, commercially available compounds such as 4,6-dichloropyrimidine, 2-chloro-4-nitropyridine, and 2,4-dichloropyridine.
  • the compound (2a) also can be produced from commercially available compounds by a known method.
  • L 1 is a reactive group higher than L 2 .
  • L 1 is nitro and L 2 is chlorine.
  • the process is a process for reducing nitro of the compound (2b) to produce the compound (2c).
  • Generally used conditions of reduction from nitro to amino can be used. Specifically, for example a reduction using iron-ammonium chloride or iron-acetic acid can be used.
  • As the solvent methanol, ethanol, water, N,N-dimethylformamide, tetrahydrofuran or the like can be used.
  • the reaction temperature is between room temperature and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the process is a process for protecting amino of the compound (2c) to produce the compound (2d).
  • the methods similar to those in ⁇ Process 1B-6> can be used.
  • the process is a process for alkylating the compound (2d) to produce the compound (2e).
  • the methods similar to those in ⁇ Process 1A-13> can be used.
  • the process is a process for protecting amino of the compound (2f) to produce the compound (2e).
  • the methods similar to those in ⁇ Process 1B-6> can be used.
  • the process is a process for alkylating the compound (2c) to produce the compound (2f).
  • the methods similar to those in ⁇ Process 1A-12> can be used.
  • These process are processes for converting the leaving group L 2 of the compound (2b), (2c), (2d), (2e) or (2f) to amino to produce the compound (1l), (1m), (1k), (1j) or (1n), respectively.
  • the process can be carried out using, for example, an ammonia-ethanol solution in a sealed tube.
  • the reaction temperature is a reflux temperature.
  • the reaction time is between 10 minutes and 100 hours.
  • W 1 represents a direct bond, a group represented by the formula —C(R W1 )(R W2 )— or a group represented by the formula —NH—, wherein R W1 and R W2 may be the same or different and each represents hydrogen, halogen, C 1-6 alkyl or C 1-6 alkoxy; and the other symbols represent the same meanings as defined above.
  • R 9a represents C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-10 aryl, C 3-10 cycloalkyl-C 1-6 alkyl, C 6-10 aryl-C 1-6 alkyl, 5- to 10-membered heteroaryl, a 3- to 10-membered non-aromatic heterocyclic group (limited to the group having a bonding hand from a carbon forming the ring), 5- to 10-membered heteroaryl-C 1-6 alkyl, and 3- to 10-membered non-aromatic heterocyclic-C 1-6 alkyl, and R 9a may be substituted with a substituent selected from Substituent Group A or Substituent Group B, and if R 9a has hydroxyl, or primary or secondary amino as a substituent group, the substituent group may be protected by a suitable protecting group, and the other symbols represent the same meanings as defined above.
  • the process is a process for producing an acylthiourea derivative (3a) from the compound (1mn) (the compound (1mn) represents the compound (1m) or the compound (1n) described in [Production method 1-A], the same applies hereinafter).
  • a method for reacting acyl isothiocyanate represented by the formula R 9a —C( ⁇ O)—NCS with the compound (1mn) can be used.
  • an acid such as camphor sulfonic acid can be added.
  • a mixed solvent of toluene-methanol, a mixed solvent of toluene-ethanol, acetonitrile, N,N-dimethylformamide, and tetrahydrofuran can be used.
  • the reaction temperature is between room temperature and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours. If hydroxyl, primary amino or secondary amino of R 9a is protected, deprotection is suitably carried out in any process down to a final product.
  • the acyl isothiocyanate represented by the formula R 9a —C( ⁇ O)—NCS can be obtained by reacting an acyl chloride represented by the formula R 9a —C( ⁇ O)—Cl with potassium thiocyanate.
  • the solvent acetonitrile, ethyl acetate or the like can be used.
  • the reaction temperature is between room temperature and a reflux temperature.
  • the reaction time is between 10 minutes and 100 hours.
  • the process is a process for providing the compound (3b) from the compound (1w).
  • the methods similar to those in ⁇ Process 3A-1> can be used.
  • the process is a process for deprotecting the compound (3b) to produce the compound (3a).
  • the methods similar to those in 5 ⁇ Process 1A-5> can be used.
  • the process is a process for producing the acylurea derivative (3f) from the compound (1mn).
  • a method for reacting acyl isocyanate represented by the formula R 9a C( ⁇ O)—NCO with the compound (1n) can be used.
  • the solvent N,N-dimethylformamide, tetrahydrofuran or the like can be used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours. If hydroxyl, primary amino or secondary amino of R 9a is protected, deprotection is suitably carried out in any process down to a final product.
  • the acyl isocyanate represented by the formula R 9a —C( ⁇ O)—NCO can be obtained by reacting an amide represented by the formula R 9 —C( ⁇ O)—NH 2 with oxalyl chloride.
  • the solvent 1,2-dichloroethane or the like can be used.
  • the reaction temperature is between room temperature and a reflux temperature.
  • the reaction time is between 1 hour and 100 hours.
  • the process is a process for producing the acylurea derivative (3g) from the compound (1w).
  • the methods similar to those in ⁇ Process 3B-1> can be used.
  • the process is a process for deprotecting the compound (3g) to produce the compound (3f).
  • the methods similar to those in ⁇ Process 1A-5> can be used.
  • R 103 represents C 1-6 alkyl or benzyl
  • R 9b represents 3- to 10-membered non-aromatic heterocyclic group (limited to a group having nitrogen as a ring constituent atom, the nitrogen having a bonding hand), or a group represented by the formula —NR 11a R 11b , wherein R 11a and R 11b represent the same meaning as defined above, and R 9b may be substituted with a substituent selected from Substituent Group A or Substituent Group B, and if R 9b has hydroxyl, primary amino, or secondary amino as a substituent group, the group may be protected by a suitable protecting group, and the other symbols represent the same meanings as defined above.
  • the compound (3k) includes, for example, commercially available compounds such as benzyl malonate, and mono-benzyl 2-fluoromalonate.
  • the compound (3l) includes, for example, commercially available compounds such as ethyl malonyl chloride, methyl malonyl chloride, ethyl oxalyl chloride, and methyl oxalyl chloride.
  • the above compounds can also be produced from commercially available compounds by a known method.
  • the process is a process for condensing the compound (3k) with an amine represented by the formula R 9b —H or a salt thereof to produce the compound (3m).
  • a general condensation of a carboxylic acid with an amine can be used.
  • N,N-dimethylformamide and tetrahydrofuran can be used, and for the condensing agent, carbonyldiimidazole, dicyclohexylcarbodiimide, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, and (1H-1,2,3-benzotriazol-1-yloxy)(tri(dimethylamino))phosphonium hexafluorophosphate can be used.
  • An organic base such as triethylamine also can be appropriately used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the process is a process for condensing the compound (3l) with an amine represented by the formula R 9b —H or a salt thereof to produce the compound (3m).
  • an amine represented by the formula R 9b —H or a salt thereof As the solvent, N,N-dimethylformamide, tetrahydrofuran, dichloromethane or the like can be used. An organic base such as triethylamine also can be appropriately used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the process is a process for producing the compound (3n) from the compound (3m).
  • hydrolysis using a base can be used.
  • the base lithium hydroxide or the like can be used.
  • R 103 is a benzyl and R 9b does not have chlorine, bromine and iodine as a substituent group
  • catalytic hydrogenation using palladium-carbon or palladium hydroxide as a catalyst also can be used.
  • the solvent methanol, ethanol, water, N,N-dimethylformamide, tetrahydrofuran, ethyl acetate or the like can be used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the process is a process for condensing the compound (1mn) with the compound (3n) to produce the compound (3o).
  • the condensing agent 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, (1H-1,2,3-benzotriazol-1-yloxy)(tri(dimethylamino))phosphonium hexafluorophosphate or the like can be used.
  • An organic base such as triethylamine also can be appropriately used.
  • As the solvent tetrahydrofuran, N,N-dimethylformamide or the like can be used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the process is a process for producing the compound (3r) from the compound (3q).
  • the methods similar to those in ⁇ Process 1A-1> can be used.
  • the process is a process for rearrangement of the compound (3r) to the compound (3p).
  • the methods similar to those in ⁇ Process 1A-2> can be used.
  • the process is a process for deprotecting the compound (3p) to produce the compound (3o).
  • the methods similar to those in ⁇ Process 1A-5> can be used.
  • the process is a process for converting the leaving group L 2 of the compound (3s) to amino to produce the compound (3o).
  • the methods similar to those in ⁇ Process 2-11> can be used.
  • the process is a process for producing the compound (3t) from the compound (1mn).
  • a method wherein the compound (1 mn) is reacted with N-(chlorocarbonyl)isocyanate or phenyl isocyanateformate followed by reacting with an amine represented by the formula R 9b —H and the like can be used.
  • a base such as diisopropylamine and triethylamine also may be used.
  • dichloromethane, dichloroethane, tetrahydrofuran or the like can be used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the process is a process for producing the compound (3u) from the compound (1w).
  • the methods similar to those in ⁇ Process 3D-1> can be used.
  • the process is a process for deprotecting the compound (3u) to produce the compound (3t).
  • the methods similar to those in ⁇ Process 1A-5> can be used.
  • R 9b has amino or hydroxyl as a substituent group, or if Y 1 is a group represented by the formula —NH—, they can be appropriately protected in any preceding process and deprotected in any succeeding process of this process.
  • R 101 or R 102 is C 1-6 alkyl or 2-(trimethylsilyl)ethyl and R 103 is benzyl
  • catalytic hydrogenation can be carried out to produce the compound (4d) or (4f).
  • R W3 represents hydrogen or C 1-6 alkyl, and the other symbols represent the same meanings as defined above.
  • the compound (5a) can be produced from an amine represented by the formula R W3 —NH with phenyl chloroformate or phenyl chlorothionoformate according to a method described in WO 02/32872 (Production method 16, Production example 316-1 or Production example 316-2), or a method described in J. Org. Chem., 2000, 65(19), 6237.
  • amine represented by the formula R W3 —NH commercially available compounds can be used.
  • the compound (5b) can be produced by a reaction of a carboxylic acid represented by the formula R 9a —C( ⁇ O)—OH with thionyl chloride or the like.
  • a carboxylic acid represented by the formula R 9a —C( ⁇ O)—OH for the carboxylic acid represented by the formula R 9a —C( ⁇ O)—OH, commercially available compounds can be used.
  • the process is a process for producing the compound (5c) from the compound (5a) by acylation using the compound (5b).
  • the solvent tetrahydrofuran, benzene, toluene, xylene, chlorobenzene or the like can be used.
  • a base such as sodium hydride, pyridine and triethylamine also may be used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • These processes are processes for producing the compound (5f) or (5g) by reacting the compound (1mn) or (1w) with the compound (5c), respectively.
  • the solvent N,N-dimethylformamide, dimethylsulfoxide, N-methylpyrrolidone, tetrahydrofuran or the like can be used.
  • a base such as sodium hydride, pyridine and triethylamine also may be used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • R 9a has amino or hydroxyl as a substituent group, or if Y 1 is a group represented by the formula —NH—, they can be appropriately protected in any preceding process and deprotected in any succeeding process of this process, respectively.
  • the process is a process for deprotecting the compound (5g) to produce the compound (5f).
  • the methods similar to those in ⁇ Process 1A-5> can be used.
  • the compound (6a) can be obtained by an urea formation reaction of an amine represented by the formula R W3 —NH and an amine represented by the formula R 9b —H.
  • the compound can be produced according to a method described in Synthesis, 1189 (1997).
  • As the amine represented by the formula R W3 —NH and the amine represented by the formula R 9b —H commercially available compounds can be used.
  • the process is a process for producing the compound (6b) from the compound (6a).
  • a reagent phenyl chloroformate or phenyl chlorothionoformate is used.
  • solvent tetrahydrofuran, benzene, toluene, xylene, chlorobenzene or the like can be used.
  • a base such as sodium hydride, pyridine and triethylamine also may be used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • These processes are processes for reacting the compound (1mn) or (1w) with the compound (6b) to produce the compound (6c) or (6d), respectively.
  • the solvent N,N-dimethylformamide, dimethylsulfoxide, N-methylpyrrolidone, tetrahydrofuran or the like can be used.
  • a base such as sodium hydride, pyridine and triethylamine also may be used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • R 9b has amino or hydroxyl as a substituent group, or if Y 1 is a group represented by the formula —NH—, they can be appropriately protected in any preceding process and deprotected in any succeeding process of the process, respectively.
  • the process is a process for deprotecting the compound (6d) to produce the compound (6c).
  • the methods similar to those in ⁇ Process 1A-5> can be used.
  • R 1a represents 3- to 10-membered non-aromatic heterocyclic group (limited to a group having nitrogen as a ring constituent atom, and the nitrogen having a bonding hand), or a group represented by the formula —NR 11a R 11b , wherein R 11a and R 11b each represents the same meaning as defined above, and R 1a may be substituted with a substituent selected from Substituent Group A or Substituent Group B, and if R 1a has hydroxyl, primary amino or secondary amino as a substituent group, the group may be protected by a suitable protecting group; and the other symbols represent the same meanings as defined above.
  • These processes are processes for producing the compound (7a), (7b), (7c), (7d) or (7e) from the compound (1l), (1m), (1k), (1j) or (1n), respectively.
  • the compound (1l), (1m), (1k), (1j) or (1n) can be reacted with a carbamate derivative, a thiocarbamate derivative, an isocyanate derivative or an isothiocyanate derivative to convert to a corresponding urea derivative or thiourea derivative.
  • a carbamate derivative e.g., a thiocarbamate derivative, an isocyanate derivative or an isothiocyanate derivative to convert to a corresponding urea derivative or thiourea derivative.
  • an organic base such as pyridine, triethylamine and diisopropylethylamine
  • an inorganic base such as potassium carbonate, cesium carbonate, sodium hydride and sodium hydroxide
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the method includes a method wherein the compound (1l), (1k) or (1j) is reacted with a ketone or aldehyde-containing amine, followed by reductive amination with an amine to introduce an amine side chain on R 1a .
  • the reducing agent sodium cyanoborohydride and sodium triacetoxyborohydride or the like can be used.
  • the solvent methanol, tetrahydrofuran, dichloromethane, dichloroethane or the like can be used. Furthermore, the compound (1l), (1k) or (1j) can be reacted with an ester-containing amine to produce a compound, an ester portion of which is then hydrolyzed with a base such as lithium hydroxide, sodium hydroxide and potassium hydroxide in hydrous ethanol, followed by converting with a condensing agent to an amide derivative. As the solvent, N,N-dimethylformamide, tetrahydrofuran or the like can be used.
  • 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and (1H-1,2,3-benzotriazol-1-yloxy)(tri(dimethylamino))phosphonium hexafluorophosphate can be used as the condensing agent.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the process is a process for reducing the compound (7a) to produce the compound (7b).
  • the methods similar to those in ⁇ Process 1A-11> can be used.
  • the process is a process for protecting amino of the compound (7b) to produce the compound (7c).
  • the methods similar to those in ⁇ Process 1B-6> can be used.
  • the process is a process for alkylating the compound (7c) to produce the compound (7d).
  • the methods similar to those in ⁇ Process 1A-13> can be used.
  • the process is a process for deprotecting the compound (7d) to produce the compound (7e).
  • the methods similar to those in ⁇ Process 1A-5> can be used.
  • the process is a process for alkylating the compound (7b) to produce the compound (7e).
  • the methods similar to those in ⁇ Process 1A-12> can be used.
  • R 1b represents C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 cycloalkyl, C 6-10 aryl, C 3-10 cycloalkyl-C 1-6 alkyl, C 6-10 aryl-C 1-6 alkyl, 5- to 10-membered heteroaryl, a 3- to 10-membered non-aromatic heterocyclic group (limited to the group having a bonding hand from a carbon forming the ring), 5- to 10-membered heteroaryl-C 1-6 alkyl, and 3- to 10-membered non-aromatic heterocyclic-C 1-6 alkyl, and R 1b may be substituted with a substituent selected from Substituent Group A or Substituent Group B, and if R 1b has a hydroxyl, or primary or secondary amino substituent group, the substituent group may be protected by a suitable protecting group; and the other symbols represent the same meanings as defined above.
  • These processes are processes for producing the compound (7f), (7g), (7h), (7i) or (7j) from the compound (1l), (1m), (1k), (1j) or (1n), respectively.
  • a condensing agent such as (1H-1,2,3-benzotriazol-1-yloxy)(tri(dimethylamino
  • an amide derivative can be synthesized, followed by converting with the Lawesson's reagent (Org. Synth., 1990, VII, 372; J. Org. Chem., 1990, 55(14), 4484) to the thioamide.
  • the solvent tetrahydrofuran, chloroform, toluene, N-methylpyrrolidone, N,N-dimethylformamide, dimethylsulfoxide, chlorobenzene or the like can be used.
  • a base also can be used, specifically, for example, an organic base such as pyridine, triethylamine and diisopropylethylamine, and an inorganic base such as potassium carbonate, cesium carbonate and sodium hydride can be used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the process is a process for reducing the compound (7f) to produce the compound (7g).
  • the methods similar to those in ⁇ Process 1A-11> can be used.
  • the process is a process for protecting amino of the compound (7g) to produce the compound (7h).
  • the methods similar to those in ⁇ Process 1B-6> can be used.
  • the process is a process for alkylating the compound (7h) to produce the compound (7i).
  • the methods similar to those in ⁇ Process 1A-13> can be used.
  • the process is a process for deprotecting the compound (7i) to produce the compound (7j).
  • the methods similar to those in ⁇ Process 1A-5> can be used.
  • the process is a process for alkylating the compound (7g) to produce the compound (7j).
  • the methods similar to those in ⁇ Process 1A-12> can be used.
  • R 1c represents C 1-6 alkoxy, and R 1c may be substituted with a substituent selected from Substituent Group A or Substituent Group B, and if R 1c has a hydroxyl, or primary or secondary amino substituent group, the substituent group may be protected by a suitable protecting group; and the other symbols represent the same meanings as defined above.
  • These processes are processes for producing the compound (7k), (7l), (7m), (7n) or (7o) from the compound (1l), (1m), (1k), (1j) or (1n), respectively.
  • the compound (1l), (1m), (1k), (1j) or (1n) can be reacted with a chlorocarbonic acid ester, a chlorocarbonic acid thioester, a dialkyl dicarbonate or the like to produce the compound (7k), (7l), (7m), (7n) or (7o).
  • a base also can be used, that is, an organic base such as pyridine, triethylamine and diisopropylethylamine, and an inorganic base such as potassium carbonate, cesium carbonate and sodium hydroxide can be used.
  • reaction temperature is between 0° C. and a reflux temperature.
  • reaction time is between 10 minutes and 30 hours.
  • the process is a process for reducing the compound (7k) to produce the compound (7l).
  • the methods similar to those in ⁇ Process 1A-11> can be used.
  • the process is a process for protecting amino of the compound (7l) to produce the compound (7m).
  • the methods similar to those in ⁇ Process 1B-6> can be used.
  • the process is a process for alkylating the compound (7m) to produce the compound (7n).
  • the methods similar to those in ⁇ Process 1A-13> can be used.
  • the process is a process for deprotecting the compound (7n) to produce the compound (7o).
  • the methods similar to those in ⁇ Process 1A-5> can be used.
  • the process is a process for alkylating the compound (7l) to produce the compound (7o).
  • the methods similar to those in ⁇ Process 1A-12> can be used.
  • Y 2 represents sulfinyl or sulfonyl; and the other symbols represents that same meanings as defined above.
  • the process is a process for producing the compound (I-A) of the present invention from the compound (8a), that is, the above intermediate (XI).
  • R 1 or R 9 does not contain hydroxyl, primary or secondary amino, and when Y is a group except a group represented by the formula —NH—:
  • Method 1 Using a compound represented by the formula Ar—OC( ⁇ O)—Cl, wherein Ar represents the same meaning as defined above, a compound represented by the formula Ar—OC( ⁇ S)—Cl, wherein Ar represents the same meaning as defined above, or the like, the compound (8a) can be converted to a carbamic acid ester derivative or a carbamic acid thioester derivative, which is then reacted with an amine to produce the compound (I-A) of the present invention. Alternatively, the compound (8a) can be reacted with a carbamate derivative, a thiocarbamate derivative, an isocyanate derivative or an isothiocyanate derivative to convert to the compound (I-A) of the present invention.
  • chloroform, toluene, N-methylpyrrolidone, N,N-dimethylformamide, dimethyl sulfoxide, chlorobenzene or the like can be used.
  • a mixed solvent of the above solvent and water also can be used.
  • a base also can be used, and specifically, an organic base such as pyridine, triethylamine and diisopropylethylamine, and an inorganic base such as potassium carbonate, cesium carbonate, sodium hydride and sodium hydroxide can be used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the compound (8a) can be reacted with an acyl halide, a carboxylic anhydride, a thioacyl halide or the like to produce the compound (I-A) of the present invention.
  • the compound (8a) can be reacted with a carboxylic acid in the presence of a condensing agent such as (1H-1,2,3-benzotriazol-1-yloxy)(tri(dimethylamino))phosphonium hexafluorophosphate to produce the compound (I-A) of the present invention.
  • a condensing agent such as (1H-1,2,3-benzotriazol-1-yloxy)(tri(dimethylamino))phosphonium hexafluorophosphate
  • tetrahydrofuran, chloroform, toluene, N-methylpyrrolidone, N,N-dimethylformamide, dimethyl sulfoxide, chlorobenzene or the like can be used.
  • a base also can be used, and specifically, an organic base such as pyridine, triethylamine and diisopropylethylamine, and an inorganic base such as potassium carbonate, cesium carbonate and sodium hydride can be used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the compound (8a) can be reacted with a chlorocarbonic acid ester, a chlorocarbonic acid thioester or a dialkyldicarbonate to produce the compound (I-A) of the present invention.
  • a base also can be used, that is, an organic base such as pyridine, triethylamine and diisopropylethylamine, and an inorganic base such as potassium carbonate, cesium carbonate and sodium hydroxide can be used.
  • As the solvent tetrahydrofuran, chloroform, dichloroethane, N,N-dimethylformamide, dimethyl sulfoxide, chlorobenzene or the like can be used.
  • a mixed solvent of the above solvent and water also can be used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • R 1 or R 9 contains hydroxyl, primary or secondary amino, or when Y 1 is a group represented by the formula —NH—:
  • the process is a process for producing the compound (I-A) of the present invention from the compound (8b), that is, the above intermediate (XII).
  • R 1 or R 9 does not contain hydroxyl, primary or secondary amino, and when Y is a group except a group represented by the formula —NH—:
  • the compound (8b) can be reacted with an acyl isothiocyanate to produce the compound (I-A) of the present invention.
  • an acid such as camphor sulfonic acid can also be added.
  • the solvent a mixed solvent of toluene-methanol, a mixed solvent of toluene-ethanol, acetonitrile, N,N-dimethylformamide, tetrahydrofuran or the like can be used.
  • the reaction temperature is between room temperature and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the compound (8b) can be reacted with an acyl isocyanate to produce the compound (I-A) of the present invention.
  • an acyl isocyanate As the solvent, N,N-dimethylformamide, tetrahydrofuran or the like can be used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the compound (8b) can be condensed with the compound (3n) to produce the compound (I-A) of the present invention.
  • a condensing agent 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, (1H-1,2,3-benzotriazol-1-yloxy)(tri(dimethylamino))phosphonium hexafluorophosphate or the like can be used.
  • An organic base such as triethylamine also can be used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the compound (8b) can be reacted with N-(chlorocarbonyl)isocyanate or phenyl isocyanateformate, and then reacted with an amine to provide the compound (I-A) of the present invention.
  • a base such as diisopropylamine and triethylamine also may be used.
  • the solvent dichloromethane, dichloroethane, tetrahydrofuran or the like can be used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the compound (8b) can be reacted with the compound (6b) to produce the compound (I-A) of the present invention.
  • the solvent N,N-dimethylformamide, dimethyl sulfoxide, N-methylpyrrolidone, tetrahydrofuran or the like can be used.
  • a base such as sodium hydride, pyridine and triethylamine also may be suitably used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • the compound (8b) can be condensed with the compound (3k), R 103 of the resultant compound is then deprotected, followed by condensing with an amine or a salt thereof to produce the compound (I-A) of the present invention.
  • condensation with an amine or a salt thereof general condensation of a carboxylic acid with an amine can be used.
  • the solvent N,N-dimethylformamide and tetrahydrofuran can be used, and as the condensing agent, carbonyl diimidazole, dicyclohexyl carbodiimide, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and (1H-1,2,3-benzotriazol-1-yloxy)(tri(dimethylamino))phosphonium hexafluorophosphate can be used.
  • a base such as triethylamine can also be suitably used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • R 1 or R 9 contains hydroxyl, primary or secondary amino, or when Y 1 is a group represented by the formula —NH—:
  • the process is a process for oxidation of the compound (I-B) of the present invention to the compound (I-C) of the present invention.
  • oxidizing agent hydrogen peroxide, peracetic acid, metaperiodic acid salt, 3-chloroperbenzoic acid or the like can be used.
  • solvent methanol, water, dichloromethane, chloroform or the like can be used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 30 hours.
  • L 3 represents chlorine or bromine;
  • X 101 represents chlorine, bromine or iodine;
  • R 10b represents halogen, cyano, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl or a group represented by the formula —CO—R 12 , wherein R 12 represents the same meaning as defined above;
  • R 10d represents C 1-6 alkyl;
  • R 10e represents hydrogen or C 1-4 alkyl;
  • R 10f , R 10g and R 10h may be the same or different and each represents hydrogen or C 1-4 alkyl, with the proviso that the total carbon number of R 10f , R 10g and R 10h is 0 or more to 4 or less;
  • R 10k represents C 1-6 alkyl; and the other symbols represent the same meanings as defined above.
  • the process is a process for chlorinating, brominating or iodinating the 5-position of the compound (9a) to produce the compound (9b).
  • a halogenating agent such as iodine, N-iodosuccinimide, bromine, N-bromosuccinimide and N-chlorosuccinimide can be used.
  • the solvent for example, N,N-dimethylformamide, dimethyl sulfoxide, dichloromethane and acetonitrile can be used.
  • the reaction temperature is between 0° C. and a reflux temperature.
  • the reaction time is between 10 minutes and 48 hours.
  • the process is a process for converting X 101 of the compound (9b) to cyano to produce the compound (9c).
  • X 101 is preferably iodine or bromine when L 3 is chlorine, and X 101 is preferably iodine when L 3 is bromine.
  • a palladium catalyst such as tetrakis(triphenylphosphine)palladium(0) and dichlorobis(triphenylphosphine)palladium(II)
  • 0.5-0.6 equivalent of zinc cyanide is used relative to the compound (9b)
  • 1.0-1.2 equivalent of potassium cyanide or trimethylsilyl cyanide is used relative to the compound (9b).
  • the solvent for example, N,N-dimethylformamide, dioxane or tetrahydrofuran can be used.
  • the reaction temperature is between room temperature and a reflux temperature.
  • the reaction time is between 10 minutes and 10 hours.
  • the process is a process for producing the compound (9d) from the compound (9c). Hydrolysis using an inorganic base such as potassium carbonate and a hydrogen peroxide can be used. As the solvent, dimethyl sulfoxide or the like can be used. The reaction temperature is between 0° C. and a reflux temperature. The reaction time is between 10 minutes and 10 hours. A method of heating under reflux in a solvent such as toluene and tetrahydrofuran in the presence of potassium trimethylsilanolate, as described in Tetrahedron Lett., 41, 3747(2000), also can be used. The reaction time is between 10 minutes and 60 hours.
  • the process is a process for producing the compound (9e) from the compound (9b).
  • a method of reacting with (1-ethoxyvinyl)tributyltin in the presence of a palladium catalyst such as dichlorobis(triphenylphosphine)palladium(II) and tetrakis(triphenylphosphine)palladium(0) can be used.
  • a salt such as lithium chloride may be added.
  • tetrahydrofuran, N,N-dimethylformamide, N-methylpyrrolidone or the like can be used.
  • the reaction temperature is between room temperature and a reflux temperature.
  • the reaction time is between 10 minutes and 60 hours.
  • Tetrahedron, 53 (14), 5159 (1997) can be mentioned.
  • the process is a process for producing the compound (9f) from the compound (9b).
  • a method of reacting an alcohol represented by the formula R 10d —OH with carbon monoxide in the presence of a palladium catalyst such as dichlorobis(triphenylphosphine)palladium(II) can be used.
  • a palladium catalyst such as dichlorobis(triphenylphosphine)palladium(II)
  • a base such as triethylamine and diisopropylethylamine may be added.
  • an alcohol represented by the formula R 10a —OH, tetrahydrofuran, N,N-dimethylformamide, N-methylpyrrolidone, dimethyl sulfoxide or the like can be used.
  • the reaction temperature is between room temperature and a reflux temperature.
  • the reaction time is between 10 minutes and 60 hours.
  • the process is a process for producing the compound (9g) from the compound (9b).
  • the compound (9b) can be reacted with an acetylene derivative in the presence of a palladium catalyst such as dichlorobis(triphenylphosphine)palladium(II) to produce the compound (9g).
  • a palladium catalyst such as dichlorobis(triphenylphosphine)palladium(II) to produce the compound (9g).
  • a palladium catalyst such as dichlorobis(triphenylphosphine)palladium(II)
  • an organic base such as triethylamine or an inorganic base such as potassium carbonate and sodium hydroxide may be added.
  • a monovalent copper halide may coexist.
  • reaction temperature is between room temperature and a reflux temperature.
  • reaction time is between 10 minutes and 60 hours.
  • the process is a process for producing the compound (9h) from the compound (9b).
  • the compound (9b) can be reacted with a trialkylvinyltin derivative in the presence of a palladium catalyst such as dichlorobis(triphenylphosphine)palladium(II) to produce the compound (9h).
  • a palladium catalyst such as dichlorobis(triphenylphosphine)palladium(II)
  • hexamethylphosphoramide or the like may be added.
  • the solvent tetrahydrofuran, N,N-dimethylformamide, N-methylpyrrolidone, dimethyl sulfoxide or the like can be used.
  • the reaction temperature is between room temperature and a reflux temperature.
  • the reaction time is between 10 minutes and 60 hours.
  • Tetrahedron, 53 (14), 5159 (1997) can be mentioned.
  • the process is a process for producing the compound (9k) from the compound (9b).
  • a method of reacting with carbon monoxide in the presence of a palladium catalyst such as dichlorobis(triphenylphosphine)palladium(II), and sodium formate, as described in Bull. Chem. Soc. Jpn., 67 (8), 2329 (1994), can be used.
  • a palladium catalyst such as dichlorobis(triphenylphosphine)palladium(II), and sodium formate, as described in Bull. Chem. Soc. Jpn., 67 (8), 2329 (1994)
  • the solvent tetrahydrofuran, N,N-dimethylformamide, N-methylpyrrolidone, dimethyl sulfoxide or the like can be used.
  • the reaction temperature is between room temperature and a reflux temperature.
  • the reaction time is between 10 minutes and 60 hours.
  • the process is a process for producing the compound (9m) from the compound (9b).
  • a method of reacting with a reagent prepared from alkyl magnesium halide and zinc(II)chloride in the presence of a palladium catalyst such as dichlorobis(triphenylphosphine)palladium(II), as described in J. Org. Chem., 2001, 66 (20), 605, can be used.
  • a palladium catalyst such as dichlorobis(triphenylphosphine)palladium(II), as described in J. Org. Chem., 2001, 66 (20), 605
  • a palladium catalyst such as dichlorobis(triphenylphosphine)palladium(II)
  • As the solvent tetrahydrofuran or the like can be used.
  • the reaction temperature is between room temperature and a reflux temperature.
  • the reaction time is between 10 minutes and 60 hours.
  • a method of reacting with tetraalkyltin in the presence of a palladium catalyst such as dichlorobis(triphenylphosphine)palladium(II), as described in Tetrahedron Lett. 1996, 37 (14), 2409-2412, can be used.
  • a palladium catalyst such as dichlorobis(triphenylphosphine)palladium(II), as described in Tetrahedron Lett. 1996, 37 (14), 2409-2412
  • the solvent toluene or the like can be used.
  • the reaction temperature is between room temperature and a reflux temperature.
  • the reaction time is between 10 minutes and 60 hours.
  • the “leaving group” may be any group generally known as a leaving group in organic synthesis, and is not particularly limited. Specifically for example, it includes halogen such as chlorine, bromine and iodine; nitro; alkylsulfonyloxy such as methanesulfonyloxy, trifluoromethanesulfonyloxy and ethanesulfonyloxy; arylsulfonyloxy such as benzenesulfonyloxy and p-toluenesulfonyloxy; and alkanoyloxy such as acetoxy and trifluoroacetoxy.
  • halogen such as chlorine, bromine and iodine
  • nitro alkylsulfonyloxy such as methanesulfonyloxy, trifluoromethanesulfonyloxy and ethanesulfonyloxy
  • arylsulfonyloxy such as benzenes
  • the amino-protecting group may be any group generally known as an amino-protecting group in organic synthesis, and is not particularly limited. Specifically for example, it includes substituted or unsubstituted acyl such as formyl, acetyl, chloroacetyl, dichloroacetyl, propionyl, phenylacetyl, phenoxyacetyl and thienylacetyl; alkoxycarbonyl such as t-butoxycarbonyl; substituted or unsubstituted benzyloxycarbonyl such as benzyloxycarbonyl and 4-nitrobenzyloxycarbonyl; substituted or unsubstituted alkyl such as methyl, t-butyl and 2,2,2-trichloroethyl; substituted benzyl such as trityl, 4-methoxybenzyl, 4-nitrobenzyl and diphenylmethyl; alkylcarbonyloxyalkyl such as pivaloyloxymethyl; alkyl
  • These protecting groups can be deprotected by a conventional method such as hydrolysis and reduction depending on the kind of the protecting group used.
  • the hydroxyl-protecting group may be any group generally known as a hydroxyl-protecting group in organic synthesis, and is not particularly limited. Specifically for example, it includes alkylsilyl such as trimethylsilyl and t-butyldimethylsilyl; alkoxymethyl such as methoxymethyl and 2-methoxyethoxymethyl; tetrahydropyranyl; substituted or unsubstituted benzyl such as benzyl, 4-methoxybenzyl, 2,4-dimethoxybenzyl, 2-nitrobenzyl, 4-nitrobenzyl and trityl; alkenyl such as allyl; and acyl such as formyl and acetyl.
  • alkylsilyl such as trimethylsilyl and t-butyldimethylsilyl
  • alkoxymethyl such as methoxymethyl and 2-methoxyethoxymethyl
  • tetrahydropyranyl substituted or unsubstituted benzy
  • These protecting groups can be deprotected by a conventional method such as hydrolysis and reduction depending on the kind of the protecting group used.
  • the carboxyl-protecting group may be any group generally known as a carboxyl-protecting group in organic synthesis, and is not particularly limited.
  • a carboxyl-protecting group in organic synthesis, and is not particularly limited.
  • it includes substituted or unsubstituted alkyl such as methyl, ethyl, i-propyl, t-butyl, 2-iodoethyl and 2,2,2-trichloroethyl; alkoxymethyl such as methoxymethyl, ethoxymethyl and i-butoxymethyl; acyloxymethyl such as butylyloxymethyl and pivaloyloxymethyl; alkoxycarbonyloxyethyl such as 1-methoxycarbonyloxyethyl and 1-ethoxycarbonyloxyethyl; and substituted or unsubstituted benzyl such as benzyl, 4-methoxybenzyl, 2-nitrobenzyl and 4-nitrobenzyl.
  • These protecting groups can be deprotected by a conventional method such as hydrolysis and reduction depending on the kind of the protecting group used.
  • each of the starting materials and various reagents may be a salt, a hydrate or a solvate, varies depending on a starting material, a solvent and the like to be used, and is not limited to a particular one as long as it does not inhibit a reaction.
  • a solvent to be used varies depending on a starting material, a reagent and the like, and is not limited to a particular one as long as it does not inhibit a reaction and can dissolve the starting material to some extent.
  • the compound (I) according to the present invention if provided as a free form, can be converted to a form of a salt or a hydrate which the forgoing may form by a conventional method.
  • the compound (I) according to the present invention if provided as the form of a salt or a hydrate of the compound (I), can be converted to a free form of the compound (I) by a conventional method.
  • the compound (I) according to the present invention and the various isomers (such as geometric isomers and optical isomers) of the compound (I) according to the present invention can be purified and isolated by a conventional separation means, including recrystallization, diastereomer salt method, enzyme separation method, and various chromatographies such as thin-layer chromatography, column chromatography and gas chromatography.
  • the compound (I) of the present invention is generally mixed with an appropriate additive and formulated to use as a medicament. But the compound of the present invention may be used alone without any additive.
  • the above additives include excipients, binders, lubricants, disintegrators, coloring agents, taste correctives, emulsifiers, surfactants, dissolving aids, suspending agents, isotonizing agents, buffering agents, antiseptics, antioxidants, stabilizers, absorption accelerators and the like. These also may be appropriately combined to use if desired.
  • excipients include, for example, lactose, white soft sugar, glucose, corn starch, mannitol, sorbitol, starch, alpha starch, dextrin, crystalline cellulose, soft silicic anhydride, aluminum silicate, calcium silicate, magnesium aluminometasilicate and calcium hydrogenphosphate.
  • the binders include, for example, polyvinyl alcohol, methylcellulose, ethylcellulose, gum arabic, tragacanth, gelatin, shellac, hydroxypropylmethylcellulose, hydroxypropylcellulose, carboxymethylcellulose sodium, polyvinylpyrrolidone and macrogol.
  • the disintegrators includes, for example, crystalline cellulose, agar, gelatin, calcium carbonate, sodium hydrogencarbonate, calcium citrate, dextrin, pectin, low-substituted hydroxypropylcellulose, carboxymethylcellulose, carboxymethylcellulose calcium, croscarmellose sodium, carboxymethyl starch and carboxymethyl starch sodium.
  • the coloring agents include, for example, those approved for addition to pharmaceuticals, such as iron sesquioxide, yellow iron sesquioxide, carmine, caramel, ⁇ -carotene, titanium oxide, talc, riboflavin sodium phosphate, yellow aluminum lake and the like.
  • the taste correctives include cocoa powder, menthol, aromatic powders, mentha oil, borneol, powdered cinnamon bark and the like.
  • the emulsifiers or surfactants include, for example, stearyl triethanolamine, sodium lauryl sulfate, lauryl aminopropionic acid, lecitin, glycerin monostearate, sucrose fatty acid esters and glycerin fatty acid esters.
  • the dissolving aids include, for example, polyethylene glycol, propylene glycol, benzyl benzoate, ethanol, cholesterol, triethanolamine, sodium carbonate, sodium citrate, polysorbate 80 and nicotinamide.
  • the suspending agents include, for example, hydrophilic polymers such as polyvinyl alcohol, polyvinylpyrrolidone, methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose and hydroxypropylcellulose, in addition to the above surfactants.
  • hydrophilic polymers such as polyvinyl alcohol, polyvinylpyrrolidone, methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose and hydroxypropylcellulose, in addition to the above surfactants.
  • the isotonizing agents include, for example, glucose, sodium chloride, mannitol and sorbitol.
  • the buffering agents include, for example, buffer solutions of phosphate, acetate, carbonate and citrate.
  • the antiseptics include, for example, methylparaben, propylparaben, chlorobutanol, benzyl alcohol, phenetyl alcohol, dehydroacetic acid and sorbic acid.
  • the antioxidants include, for example, sulfite, ascorbic acid and ⁇ -tocopherol.
  • the stabilizers include those commonly used in pharmaceuticals.
  • the absorption accelerators include those commonly used in pharmaceuticals.
  • the formulation may be in an oral form such as tablets, powders, granules, capsules, syrups, lozenges and inhalants; an external application form such as suppositories, ointment, eye salve, tape, eye drops, nose drops, ear drops, pap and lotion; and an injection.
  • An oral formulation may be formulated by combining appropriately the above additives, and may be coated on the surface if necessary.
  • An external application may be formulated by combining appropriately the above additives, particularly excipients, binders, taste correctives, emulsifiers, surfactants, dissolving aids, suspending agents, isotonizing agents, antiseptics, antioxidants, stabilizers and absorption accelerators.
  • An injection may be formulated by combining appropriately the above additives, particularly emulsifiers, surfactants, dissolving aids, suspending agents, isotonizing agents, buffering agents, antiseptics, antioxidants, stabilizers and absorption accelerators.
  • additives particularly emulsifiers, surfactants, dissolving aids, suspending agents, isotonizing agents, buffering agents, antiseptics, antioxidants, stabilizers and absorption accelerators.
  • the dose of the compound according to the present invention for the pharmaceutical use varies depending on symptoms and age of the patients, but it will ordinary be 0.1 mg to 10 g (preferably 1 mg to 2 g) for an oral formulation, 0.01 mg to 10 g (preferably 0.1 mg to 2 g) for an external application, and 0.01 mg to 10 g (preferably 0.1 mg to 2 g) for an injection, which is administrated once or divided over two to four times a day.
  • the compound according to the present invention can be produced, for example, by the methods described in the below Production Examples and Examples. But these Examples are for illustrative purposes, and the compound according to the present invention is not limited to the following specific Examples in any case.
  • YMC SIL-60-400/230W was used as silica gel for purification unless otherwise described.
  • ODS column WakopakR Combi ODS Column, or YMC Combi ODS-A
  • Chlorocarbonylacetic acid methyl ester (5.00 g) was dissolved in tetrahydrofuran (100 ml) under a nitrogen atmosphere, and triethylamine (5.58 ml) and 4-fluoroaniline (3.79 ml) were added thereto in an ice water bath, followed by raising the temperature up to room temperature and stirring for 4 hrs. The reaction mixture was partitioned between ethyl acetate and 1 N HCl.
  • the organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate, water and brine in this order, dried over anhydrous sodium sulfate, concentrated under a reduced pressure, and dried in vacuum to provide the titled compound (8.02 g, quantitatively) as pale brown crystals.
  • N-(4-fluorophenyl)malonic acid methyl ester (8.02 g) was dissolved in ethanol (80 ml), and lithium hydroxide monohydrate (3.19 g) was added thereto, followed by stirring for 3 hrs and 30 min.
  • To the reaction mixture was added 1 N HCl (84 ml), followed by evaporating ethanol under a reduced pressure.
  • the residue was salted out and extracted with ethyl acetate-tetrahydrofuran (1:1).
  • the organic layer was dried over anhydrous sodium sulfate, and concentrated under a reduced pressure.
  • diethyl ether-hexane (1:1) was added to suspend. A solid was filtered off and dried under aeration to provide the titled compound (7.06 g, 94%) as pale brown powder.
  • Chlorocarbonylacetic acid methyl ester (1.00 g) was dissolved in tetrahydrofuran (20 ml) under a nitrogen atmosphere, and triethylamine (1.12 ml) and 2,4-difluoroaniline (0.82 ml) were added thereto in an ice water bath, followed by raising the temperature up to room temperature and stirring for 3 hrs and 40 min. Triethylamine (0.56 ml) and 2,4-difluoroaniline (0.39 ml) were added further thereto, followed by stirring at room temperature overnight.
  • Triethylamine (0.25 ml) and 2,4-difluoroaniline (0.17 ml) were added further thereto, followed by stirring at room temperature for 3 hrs.
  • Triethylamine (0.25 ml) and 2,4-difluoroaniline (0.17 ml) were added further thereto, followed by stirring at room temperature for 1 hr and 20 min.
  • the reaction mixture was partitioned between ethyl acetate and 1 N HCl. The organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate, water and brine in this order, dried over anhydrous sodium sulfate, and concentrated under a reduced pressure.
  • N-(2,4-difluorophenyl)malonic acid methyl ester (1.14 g) was dissolved in ethanol (10 ml), and lithium hydroxide monohydrate (417 mg) was added thereto, followed by stirring for 3 hrs and 30 min.
  • To the reaction mixture was added 1 N HCl (20 ml), followed by evaporating ethanol under a reduced pressure.
  • the residue was salted out and extracted with ethyl acetate-tetrahydrofuran (1:1).
  • the organic layer was dried over anhydrous sodium sulfate, and concentrated under a reduced pressure.
  • diethyl ether-hexane (1:1) to suspend.
  • a solid was filtered off and dried under aeration to provide the titled compound (1.01 g, 94.5%) as a pale purple solid.
  • 4-fluorobenzylamine (1.252 g) was dissolved in tetrahydrofuran (30 ml) under a nitrogen atmosphere, and triethylamine (2.6 ml) and ethyl chlorooxalate (1.4 ml) were added dropwise therein while cooling in an ice water bath, followed by stirring at room temperature for 30 min.
  • the reaction mixture was partitioned between ethyl acetate and a saturated aqueous solution of sodium hydrogencarbonate.
  • the organic layer was washed with water, 1 N HCl, water, and brine in this order, and dried over anhydrous sodium sulfate.
  • N-(4-fluorobenzyl)oxalamide ethyl ester (1.85 g) was dissolved in methanol (20 ml)-water (5 ml), and lithium hydroxide monohydrate (671 mg) was added thereto, followed by stirring at room temperature for 30 min.
  • To the reaction mixture was added 2 N HCl (10 ml).
  • Methanol was evaporated under a reduced pressure to give a residue, which was partitioned between ethyl acetate and water.
  • the organic layer was washed with water and brine in this order, and dried over anhydrous sodium sulfate.
  • the solvent was evaporated under a reduced pressure to give a residue, to which diethyl ether-hexane was added to precipitate crystals.
  • the crystals were filtered off and dried under aeration to provide the titled compound (1.346 g, 83%) as white crystals.
  • the reaction mixture was cooled in an ice bath, and then supplied with water (2.0 mL), an 5 N aqueous solution of sodium hydroxide (2.0 mL) and water (10.0 mL), followed by stirring in an ice bath for 1 hr.
  • the insoluble portion was filtered and washed with tetrahydrofuran to give a filtrate, which was concentrated under a reduced pressure to provide a crude product of the titled compound (9.2 g, 72.3%) as a pale yellow oil.
  • aqueous layer was also concentrated under a reduced pressure to give a residue, to which tetrahydrofuran (100 mL) was added to filter an insoluble portion.
  • the filtrate was combined with the above residue, and concentrated under a reduced pressure to give a residue (549 mg).
  • This residue was dissolved in tetrahydrofuran (10 mL), and then lithium aluminium hydride (107 mg) was gradually added thereto while cooling in an ice bath and stirring, followed by stirring under a nitrogen atmosphere at room temperature for 30 min and heating to stir at 65° C. for 2 hrs.
  • the reaction mixture was cooled in an ice bath, and then water (0.11 mL), a 5 N aqueous solution of sodium hydroxide (0.11 mL) and water (0.55 mL) in this order were added thereto, followed by stirring in an ice bath for 1 hr.
  • the insoluble portion was filtered, and washed with tetrahydrofuran to give a filtrate, which was concentrated under a reduced pressure to provide a crude product of the titled compound (1.63 g, 26.3%) as a yellow oil.
  • 2-Amino-4-chloropyridine (8.00 g) was dissolved in N-methylpyrrolidone (65 ml), and then 2-fluoro-4-nitrophenol (19.55 g) and N,N-diisopropylethylamine (43.36 ml) were added thereto, followed by stirring at 160° C. for 41 hrs.
  • the reaction mixture was cooled down to room temperature, and partitioned between ethyl acetate-tetrahydrofuran (1:1) and a 2 N aqueous solution of sodium hydroxide. The organic layer was washed with water and brine in this order. The aqueous layer was extracted again with ethyl acetate.
  • 2-Amino-4-(2-fluoro-4-nitrophenoxy)pyridine (187 mg) was dissolved in tetrahydrofuran (4 ml) under a nitrogen atmosphere, and then triethylamine (0.21 ml) and phenyl chloroformate (0.188 ml) were added dropwise thereto while cooling in an ice bath, followed by stirring at room temperature for 20 min.
  • To the reaction mixture were added N,N-dimethylformamide (2 ml) and 4-(pyrrolidin-1-yl)piperidine (609 mg) at room temperature, followed by stirring overnight.
  • the reaction mixture was partitioned between ethyl acetate and water. The organic layer was washed with brine, and dried over anhydrous sodium sulfate.
  • 2-Amino-4-(2-fluoro-4-nitrophenoxy)pyridine (249 mg) was dissolved in tetrahydrofuran (5 ml) under a nitrogen atmosphere, and then triethylamine (0.21 ml) and phenyl chloroformate (0.19 ml) were added dropwise thereto while cooling in an ice water bath, followed by stirring at room temperature for 15 min. To the reaction mixture was added 2 M solution of dimethylamine in methanol (4.0 ml), followed by stirring for 2 days.
  • 2-Amino-4-(2-fluoro-4-nitrophenoxy)pyridine (347 mg) was dissolved in tetrahydrofuran (7.5 ml) under a nitrogen atmosphere, and then triethylamine (0.314 ml) and phenyl chloroformate (0.282 ml) were added dropwise thereto while cooling in an ice water bath, followed by stirring at room temperature for 10 min.
  • To the reaction mixture was added 2 M solution of methylamine in tetrahydrofuran (7.5 ml), followed by stirring for 2 days.
  • the reaction mixture was partitioned between ethyl acetate and a saturated aqueous solution of sodium hydrogencarbonate.
  • 2-Phenylacetyl chloride (0.481 ml) was dissolved in acetonitrile (30 ml) under a nitrogen atmosphere, and then potassium thiocyanate (707 mg) was added thereto at 50° C., followed by stirring at the same temperature for 1.5 hrs. After acetonitrile was evaporated under a reduced pressure, toluene (20 ml) and a saturated aqueous solution of sodium hydrogencarbonate (20 ml) were added, followed by stirring for 25 min.
  • the toluene layer (12 ml) was added in a solution of 2-amino-4-(4-amino-2-fluorophenoxy)pyridine (400 mg) in ethanol (10 ml) at room temperature, followed by stirring for 1 hr.
  • the reaction mixture was concentrated under a reduced pressure to give a residue, which was then purified by silica gel column chromatography (eluent; ethyl acetate). Fractions containing the target compound were concentrated under a reduced pressure to give a residue, to which diethyl ether (10 ml) was added to precipitate crystals, followed by diluting with hexane (50 ml). The crystals were filtered off and dried under aeration to provide the titled compound (298 mg, 41%) as white crystals.
  • the reaction mixture was cooled down to room temperature, and partitioned between ethyl acetate and a 1 N aqueous solution of sodium hydroxide.
  • the organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate, water and brine in this order, and dried over anhydrous sodium sulfate.
  • N-(3-Fluoro-4- ⁇ 2-[(pyrrolidine-1-carbonyl)amino]pyridin-4-yloxy ⁇ phenyl)malonic acid benzyl ester (546 mg) was dissolved in tetrahydrofuran (15 ml)-methanol (15 ml), and then 10% palladium carbon (236 mg) was added thereto under a nitrogen atmosphere, followed by replacing with hydrogen inside the system and stirring for 1 hr. After replacing with nitrogen inside the system, the catalyst was filtered and washed with methanol. The filtrate was concentrated under a reduced pressure and dried in vacuum to provide the titled compound (354.4 mg, 79.3%).
  • the reaction mixture was partitioned between ethyl acetate and a saturated aqueous solution of ammonium chloride.
  • the organic layer was washed with a saturated aqueous solution of ammonium chloride, water and brine in this order, and dried over anhydrous sodium sulfate.
  • the solvent was evaporated under a reduced pressure to give a residue, which was purified by silica gel column chromatography (Fuji Silysia NH, eluent; ethyl acetate).
  • the resultant fractions were concentrated under a reduced pressure, and dried in vacuum to provide the titled compound (245 mg, 75.5%) as a yellow solid.
  • reaction mixture was concentrated under a reduced pressure to give a residue, to which N,N-dimethylformamide (6.0 ml) and N,N-diethyl-N′-methyl-1,3-propanediamine (606 mg, 4.2 mmol) were added, followed by stirring at room temperature for 4 hrs and 45 min.
  • ethyl acetate 150 ml
  • washed with a saturated aqueous solution of sodium hydrogencarbonate was dried over anhydrous sodium sulfate.
  • reaction mixture was cooled down to room temperature, and then 4-(4-amino-2-fluorophenoxy)pyridin-2-ylamine (160 mg, 0.912 mmol) was then added thereto, followed by stirring at room temperature for 59.5 hrs.
  • the reaction mixture was partitioned between water (50 ml) and ethyl acetate (100 ml). The organic layer was washed with brine, and dried over sodium sulfate.
  • Boc-isonipecotic acid (554 mg, 2.42 mmol), triethylamine (0.673 ml, 4.83 mmol), and benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (1.07 g, 2.42 mmol) were further added thereto, followed by stirring at room temperature for 3 hrs.
  • Boc-isonipecotic acid (554 mg, 2.42 mmol), triethylamine (0.673 ml, 4.83 mmol), and benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (1.07 g, 2.42 mmol) were added thereto, followed by stirring at room temperature for 3 days.
  • ethyl acetate 150 ml
  • washed with a saturated aqueous solution of sodium hydrogencarbonate was dried over anhydrous sodium sulfate.
  • the mixture was dissolved in methanol (50 ml) again, and then 10% palladium carbon (100 mg) was added thereto, followed by stirring under a hydrogen atmosphere at room temperature for 2 hrs.
  • the catalyst was filtered.
  • the filtrate was concentrated under a reduced pressure to give a residue, which was then filtered by silica gel.
  • the filtrate was concentrate under a reduced pressure to provide the titled compound (185 mg) as a yellow oil.
  • Boc-isonipecotic acid (93.5 mg, 0.408 mmol), triethylamine (0.0853 ml, 0.612 mmol) and benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (180 mg, 0.408 mmol) were further added thereto, followed by stirring at room temperature for 32.5 hrs.
  • ethyl acetate (50 ml) tetrahydrofuran (50 ml) and a saturated aqueous solution of sodium hydrogencarbonate (50 ml) to partition.
  • 2-Amino-4-chloropyridine (2.57 g) was dissolved in dimethylsulfoxide (30 ml), and then 2-chloro-4-nitrophenol (6.94 g) and N,N-diisopropylethylamine (14 ml) were added thereto, followed by stirring at 160° C. for 6 days.
  • the reaction mixture was cooled down to room temperature, and partitioned between ethyl acetate and a 1 N aqueous solution of sodium hydroxide.
  • the organic layer was washed with a 1 N aqueous solution of sodium hydroxide and brine in this order, and dried over anhydrous sodium sulfate.
  • 2-Amino-4-(2-chloro-4-nitrophenoxy)pyridine (574 mg) was dissolved in tetrahydrofuran (10 ml) under a nitrogen atmosphere, and then triethylamine (0.602 ml) and phenyl chloroformate (0.542 ml) were added dropwise thereto while cooling in an ice bath, followed by stirring at room temperature for 10 min.
  • the reaction mixture was partitioned between ethyl acetate and a saturated aqueous solution of sodium hydrogencarbonate.
  • the organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate and brine in this order, and dried over anhydrous sodium sulfate.
  • the reaction mixture was cooled down to room temperature, and filtered through celite to remove an insoluble portion, which was washed with ethyl acetate-tetrahydrofuran (1:1) and water.
  • the organic layer of the filtrate was separated, washed with water and brine in this order, dried over anhydrous sodium sulfate.
  • the solvent was evaporated under a reduced pressure to give a residue, which was purified by silica gel column chromatography (eluent; ethyl acetate) to provide the titled compound (227 mg) as pale yellow powder.
  • the reaction mixture was cooled down to room temperature, and filtered through celite to remove an insoluble portion, which was washed with ethyl acetate-tetrahydrofuran (1:1) and water.
  • the organic layer of the filtrate was separated, washed with water and brine in this order, dried over anhydrous sodium sulfate.
  • the organic layer was washed with a saturated aqueous solution of ammonium chloride, water, a saturated aqueous solution of sodium hydrogencarbonate and brine in this order, and dried over anhydrous sodium sulfate.
  • the solvent was evaporated under a reduced pressure to give a residue, to which ethanol (20 ml)-water (5 ml) was added to dissolve, and then electrolytic iron powder (400 mg) and ammonium chloride (800 mg) were added thereto, followed by heating under reflux for 2 hr.
  • the reaction mixture was cooled down to room temperature, and filtered through celite to remove an insoluble portion, which was washed with ethyl acetate-tetrahydrofuran (1:1) and water.
  • reaction mixture was concentrated under a reduced pressure to give a residue, to which N,N-dimethylformamide (18.9 ml) and morpholine (1.42 ml) were added, followed by stirring at room temperature for 5 hrs.
  • the combined organic layer was washed with brine, and dried over anhydrous sodium sulfate.
  • reaction mixture was concentrated under a reduced pressure to give a residue, to which N,N-dimethylformamide (20 ml) and pyrrolidine (1.36 ml) were added, followed by stirring at room temperature for 0.5 hr.
  • the reaction mixture was partitioned between ethyl acetate (150 ml) and water (100 ml). The organic layer was washed with brine, and dried over anhydrous sodium sulfate.
  • 2-Amino-4-(4-amino-3-chlorophenoxy)pyridine (707 mg) as disclosed in WO 02/32872 was dissolved in tetrahydrofuran (15 ml) under a nitrogen atmosphere, and then triethylamine (0.523 ml) and phenyl chloroformate (0.470 ml) were added dropwise thereto while cooling in an ice bath, followed by raising the temperature gradually to room temperature while stirring. After 6 hrs, the reaction mixture was partitioned between ethyl acetate and a saturated aqueous solution of sodium hydrogencarbonate. The organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate and brine in this order, and dried over anhydrous sodium sulfate.
  • 2-Amino-4-(4-amino-3-chlorophenoxy)pyridine (236 mg) as disclosed in WO 02/32872 was dissolved in tetrahydrofuran (10 ml) under a nitrogen atmosphere, and then triethylamine (0.21 ml) and phenyl chloroformate (0.188 ml) were added dropwise thereto while cooling in an ice bath, followed by raising the temperature gradually to room temperature and stirring overnight. To the reaction mixture were added N,N-dimethylformamide (2 ml) and N,N-diethylamine (0.5 ml), followed by further stirring for 1 day. The reaction mixture was partitioned between ethyl acetate and water.
  • 2-Amino-4-(4-amino-3-chlorophenoxy)pyridine (236 mg) as disclosed in WO 02/32872 was dissolved in tetrahydrofuran (10 ml) under a nitrogen atmosphere, and then triethylamine (0.21 ml) and phenyl chloroformate (0.188 ml) were added dropwise thereto while cooling in an ice bath, followed by raising the temperature gradually to room temperature and stirring overnight. To the reaction mixture were added N,N-dimethylformamide (2 ml) and morpholine (0.5 ml), followed by further stirring for 1 day. The reaction mixture was partitioned between ethyl acetate and water.
  • 2-Amino-4-(4-amino-3-chlorophenoxy)pyridine (236 mg) as disclosed in WO 02/32872 was dissolved in tetrahydrofuran (10 ml) under a nitrogen atmosphere, and then triethylamine (0.21 ml) and phenyl chloroformate (0.188 ml) were added dropwise thereto while cooling in an ice bath, followed by stirring at room temperature for 1.5 hrs. To the reaction mixture were added N,N-dimethylformamide (2 ml) and 1-methylpiperazine (0.555 ml), followed by further stirring for 1 day. The reaction mixture was partitioned between ethyl acetate and water.
  • 2-Amino-4-(4-amino-3-chlorophenoxy)pyridine (471 mg) as disclosed in WO 02/32872 was dissolved in N,N-dimethylformamide (10 ml) under a nitrogen atmosphere, and then triethylamine (0.523 ml), 1-(t-butoxycarbonyl)piperidine-4-carboxylic acid (573 mg), and (1H-1,2,3-benzotriazol-1-yloxy)[tri(dimethylamino)]phosphonium hexafluorophosphate (1106 mg) were added thereto at room temperature, followed by stirring for 2.5 hrs.
  • Triethylamine 0.523 ml
  • 1-(t-butoxycarbonyl)piperidine-4-carboxylic acid 573 mg
  • (1H-1,2,3-benzotriazol-1-yloxy)[tri(dimethylamino)]phosphonium hexafluorophosphate (1106 mg) were further added thereto, followed by stirring overnight.
  • the reaction mixture was partitioned between ethyl acetate and water.
  • the organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate and brine in this order, and dried over anhydrous sodium sulfate.
  • the reaction mixture was partitioned between ethyl acetate and water. The organic layer was washed with brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under a reduced pressure to give a residue, to which diethyl ether-hexane (1:2) was added to precipitate crystals. The crystals were filtered off, and dried under aeration to provide the titled compound (121 mg, 79%) as pale brown crystals.
  • the titled compound was obtained as pale brown powder (146 mg, 46%) from 2-amino-4-(4-amino-3-chlorophenoxy)pyridine (236 mg) as disclosed in WO 02/32872 and cyclopropylamine.
  • the titled compound was obtained as colorless oil (154.7 mg, 41%) from 2-amino-4-(4-amino-3-chlorophenoxy)pyridine (236 mg) as disclosed in WO 02/32872 and 2-(N,N-diethylamino)ethylamine.
  • the titled compound was obtained as white powder (137.8 mg, 33%) from 2-amino-4-(4-amino-3-chlorophenoxy)pyridine (236 mg) as disclosed in WO 02/32872 and 4-(pyrrolidin-1-yl)piperidine.
  • reaction mixture was cooled down to room temperature, and partitioned between ethyl acetate and a 1 N aqueous solution of sodium hydroxide.
  • the organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate, water and brine in this order, and dried over anhydrous sodium sulfate.
  • 2-Amino-4-(4-amino-3-chlorophenoxy)pyridine 250 mg was dissolved in tetrahydrofuran (5 ml) under a nitrogen atmosphere, and then triethylamine (0.185 ml) and phenyl chlorothioformate (0.184 ml) were added dropwise thereto while cooling in an ice bath, followed by stirring at room temperature for 2.5 hrs. To the reaction mixture were further added triethylamine (0.074 ml) and phenyl chlorothioformate (0.073 ml), followed by stirring at room temperature for 40 min. To the reaction mixture was added pyrrolidine (0.530 ml), followed by stirring overnight.
  • 4-(4-Amino-3-chlorophenoxy)pyridin-2-ylamine 750 mg, 3.18 mmol was dissolved in tetrahydrofuran (30 ml), and then triethylamine (0.444 ml, 4.77 mmol) was added thereto.
  • Phenyl chloroformate 0.399 ml, 4.77 mmol was added dropwise thereto while ice-cooling, followed by stirring at room temperature for 4 hrs and 45 min.
  • Triethylamine (0.222 ml) and phenyl chloroformate (0.200 ml) were further added thereto while ice-cooling, followed by stirring for 40 min.
  • Triethylamine (0.111 ml) and phenyl chloroformate (0.100 ml) were further added thereto, followed by stirring for 40 min.
  • the reaction mixture was concentrated under a reduced pressure to give a residue, to which N,N-dimethylformamide (10 ml) and 3-(morpholin-4-yl)propylamine (2.32 ml, 15.9 mmol) were added, followed by stirring at room temperature for 2 hrs.
  • the reaction mixture was partitioned between ethyl acetate (50 ml) and water (20 ml). The organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate, and dried over anhydrous sodium sulfate.
  • 4-(4-Amino-3-chlorophenoxy)pyridin-2-ylamine 750 mg, 3.18 mmol was dissolved in tetrahydrofuran (30 ml), and then triethylamine (0.444 ml, 4.77 mmol) was added thereto.
  • Phenyl chloroformate 0.399 ml, 4.77 mmol was added dropwise thereto while ice-cooling, followed by stirring at room temperature for 4 hrs and 45 min.
  • Triethylamine (0.222 ml) and phenyl chloroformate (0.200 ml) were further added thereto, followed by stirring for 40 min.
  • Triethylamine (0.111 ml) and phenyl chloroformate (0.100 ml) were further added thereto, followed by stirring for 40 min.
  • the reaction mixture was concentrated under a reduced pressure to give a residue, to which N,N-dimethylformamide (10 ml) and 3-(1-methylpiperazin-4-yl)propylamine (2.32 ml, 15.9 mmol) were added, followed by stirring at room temperature for 2 hrs.
  • the reaction mixture was partitioned between ethyl acetate (50 ml) and water (20 ml). The organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate, and dried over anhydrous sodium sulfate.
  • 4-(4-Amino-3-chlorophenoxy)pyridin-2-ylamine 750 mg, 3.18 mmol was dissolved in tetrahydrofuran (30 ml), and then triethylamine (0.444 ml, 4.77 mmol) was added thereto.
  • Phenyl chloroformate 0.399 ml, 4.77 mmol was added dropwise thereto while ice-cooling, followed by stirring at room temperature for 3.5 hrs.
  • Triethylamine (0.444 ml) and phenyl chloroformate (0.399 ml) were further added thereto while ice-cooling, followed by stirring for 15 min.
  • N,N-dimethylformamide (6.0 ml) and piperidine (1.5 ml) were added thereto, followed by stirring at room temperature for 5.5 hrs.
  • the reaction mixture was concentrated under a reduced pressure, and then N,N-dimethylformamide (4.0 ml) and piperidine (1.0 ml) were added thereto, followed by stirring at room temperature for 36 hrs.
  • the reaction mixture was partitioned between ethyl acetate and water. The organic layer was washed with brine, and dried over anhydrous sodium sulfate.
  • 4-(4-Amino-3-chlorophenoxy)pyridin-2-ylamine 750 mg, 3.18 mmol was dissolved in tetrahydrofuran (30 ml), and then triethylamine (0.444 ml, 4.77 mmol) was added thereto.
  • Phenyl chloroformate 0.399 ml, 4.77 mmol was added dropwise thereto while ice-cooling, followed by stirring at room temperature for 5 hrs.
  • Triethylamine (0.222 ml) and phenyl chloroformate (0.200 ml) were further added thereto while ice-cooling, followed by stirring for 40 min.
  • Triethylamine (0.111 ml) and phenyl chloroformate (0.100 ml) were further added thereto while ice-cooling, followed by stirring for 30 min.
  • the reaction mixture was concentrated under a reduced pressure to give a residue, to which N,N-dimethylformamide (10 ml), azetidine hydrochloride (1.49 g, 15.9 mmol) and triethylamine (2.66 ml, 19.1 mmol) were added thereto, followed by stirring at room temperature for 3 hrs.
  • To the reaction mixture were added ethyl acetate (50 ml) and water (20 ml), and was further added a saturated aqueous solution of sodium hydrogencarbonate to partition.
  • 4-(4-Amino-3-chlorophenoxy)pyridin-2-ylamine 750 mg, 3.18 mmol was dissolved in tetrahydrofuran (30 ml), and then triethylamine (0.444 ml, 4.77 mmol) was added thereto.
  • Phenyl chloroformate 0.399 ml, 4.77 mmol was added dropwise thereto while ice-cooling, followed by stirring at room temperature for 5 hrs.
  • Triethylamine (0.222 ml) and phenyl chloroformate (0.200 ml) were further added thereto, followed by stirring for 40 min.
  • Triethylamine (0.111 ml) and phenyl chloroformate (0.100 ml) were further added thereto, followed by stirring for 30 min.
  • the reaction mixture was concentrated under a reduced pressure to give a residue, to which N,N-dimethylformamide (10 ml) and 3-(diethylamino)propylamine (2.49 ml, 15.9 mmol) were added, followed by stirring at room temperature for 3 hrs.
  • ethyl acetate (50 ml) and water (20 ml) were added a saturated aqueous solution of sodium hydrogencarbonate to partition.
  • the organic layer was washed with brine, and dried over anhydrous sodium sulfate.
  • the solvent was evaporated to give a residue, which was then dried in vacuum to provide the titled compound (645 mg, 1.65 mmol, 51.8%) as a pale yellow solid.
  • the reaction mixture was partitioned between ethyl acetate (60 ml) and water (60 ml). The organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated under a reduced pressure. The resultant residue was dissolved in ethanol (20 ml), and then electrolytic iron powder (505 mg, 9.04 mmol), ammonium chloride (967 ml, 18.1 mmol) and water (5 ml) were added thereto, followed by stirring to heat at 80° C. for 2 hrs. The reaction mixture was cooled down to room temperature, and filtered to remove an insoluble portion.
  • the reaction mixture was partitioned between ethyl acetate (60 ml) and water (60 ml). The organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated under a reduced pressure. The resultant residue was dissolved in ethanol (20 ml), and then electrolytic iron powder (505 mg, 9.04 mmol), ammonium chloride (967 ml, 18.1 mmol) and water (5 ml) were added thereto, followed by stirring to heat at 80° C. for 2 hrs. The reaction mixture was cooled down to room temperature, and filtered to remove an insoluble portion.
  • 1,4-Diaminobenzene (1.081 g) was dissolved in tetrahydrofuran (50 ml) under a nitrogen atmosphere while stirring, and then triethylamine (2.01 ml) and benzyl chloroformate (1.71 ml) were added dropwise thereto while cooling in an ice-bath, followed by raising the temperature gradually up to room temperature. After 7 hrs, to the reaction mixture was added a saturated aqueous solution of sodium hydrogencarbonate, followed by extracting with ethyl acetate. The organic layer was washed with brine, and dried over anhydrous sodium sulfate.
  • 6-Amino-4-chloropyrimidine (259 mg) was dissolved in 2-ethoxyethanol (10 ml), and then benzyl N-(4-aminophenyl)carbamate (533 mg) and 2 N HCl (2 ml) were added thereto, followed by stirring at 120° C. overnight.
  • the reaction mixture was cooled down to room temperature, and partitioned between ethyl acetate and a saturated aqueous solution of sodium hydrogencarbonate. The organic layer was washed with brine, and dried over anhydrous sodium sulfate.
  • Benzyl N-[4-(6-aminopyrimidin-4-ylamino)phenyl]carbamate (313 mg) was dissolved in tetrahydrofuran (10 ml) under a nitrogen atmosphere, and then triethylamine (0.78 ml) and phenyl chloroformate (0.35 ml) were added dropwise thereto while cooling in an ice bath, followed by stirring at room temperature for 30 min. To the reaction mixture were added pyrrolidine (1.0 ml) and N,N-dimethylformamide (2 ml), followed by further stirring at room temperature overnight. The reaction mixture was partitioned between ethyl acetate and water.
  • Benzyl N- ⁇ 4-[6-(pyrrolidin-1-ylcarbonyl)aminopyrimidin-4-ylamino]phenyl]carbamate (210 mg) was dissolved in tetrahydrofuran (5 ml)-methanol (5 ml), and then 10% palladium carbon (200 mg) was added thereto under a nitrogen atmosphere, followed by replacing with hydrogen inside the system and stirring for 5 hrs. After replacing with nitrogen inside the system, the reaction mixture was filtered to remove the catalyst, which was washed with tetrahydrofuran and ethanol in this order. The filtrate was concentrated under a reduced pressure to give a residue, to which hexane-ethyl acetate was added to precipitate crystals. The crystals were filtered, and dried under aeration to provide the titled compound (103 mg, 71%) as white crystals.
  • Benzyl N-[4-(2-aminopyridin-4-ylamino)phenyl]carbamate (321 mg) was dissolved in tetrahydrofuran (10 ml) under a nitrogen atmosphere, and then triethylamine (0.803 ml) and phenyl chloroformate (0.36 ml) were added dropwise thereto while cooling in an ice bath, followed by stirring at room temperature for 1 hr. To the reaction mixture were added pyrrolidine (0.8 ml) and N,N-dimethylformamide (2 ml), followed by stirring further at room temperature overnight. The reaction mixture was partitioned between ethyl acetate and water.
  • the organic layer was washed with brine, and dried over anhydrous sodium sulfate.
  • the solvent was evaporated under a reduced pressure to give a residue (950 mg), which was then dissolved in dimethyl sulfoxide (5.0 ml), and then a 5 N aqueous solution of sodium hydroxide (1.0 ml) was added thereto, followed by stirring at 100° C. for 30 min.
  • the reaction mixture was cooled down to room temperature, and partitioned between ethyl acetate and water.
  • the organic layer was washed with water and brine in this order, and dried over anhydrous sodium sulfate.
  • 2-Fluoro-4-nitrophenol (1.736 g) was dissolved in dimethyl sulfoxide (10 ml), and then sodium hydride (400 mg) was added thereto, followed by stirring for 20 min. Then, 4-amino-6-chloropyrimidine (648 mg) was added thereto, followed by stirring at 100° C. for 45 min. The reaction mixture was heated up to 120° C., followed by stirring for 1 hr and 25 min. Then, the reaction mixture was heated up to 140° C., followed by stirring overnight. The reaction mixture was cooled down to room temperature, and then a 1 N aqueous solution of sodium hydroxide (10 ml) was added thereto, followed by stirring and extracting with ethyl acetate.

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WO2011099764A3 (en) * 2010-02-09 2012-01-05 Hanmi Holdings Co., Ltd. Novel pyrimidine derivative for inhibiting the growth of cancer cells
KR101301533B1 (ko) 2010-02-09 2013-09-04 한미사이언스 주식회사 암세포 성장 억제 효과를 갖는 신규 피리미딘 유도체
US8637672B2 (en) 2010-04-29 2014-01-28 Deciphera Pharmaceuticals, Llc Cyclopropyl dicarboxamides and analogs exhibiting anti-cancer and anti-proliferative activities

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