WO2011099764A3 - Novel pyrimidine derivative for inhibiting the growth of cancer cells - Google Patents
Novel pyrimidine derivative for inhibiting the growth of cancer cells Download PDFInfo
- Publication number
- WO2011099764A3 WO2011099764A3 PCT/KR2011/000858 KR2011000858W WO2011099764A3 WO 2011099764 A3 WO2011099764 A3 WO 2011099764A3 KR 2011000858 W KR2011000858 W KR 2011000858W WO 2011099764 A3 WO2011099764 A3 WO 2011099764A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- growth
- cancer cells
- pyrimidine derivative
- inhibiting
- novel pyrimidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
The present invention provides a novel pyrimidine derivative or pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising same, which can effectively inhibit the growth of cancer cells induced by the overexpression of EGFR including subtypes and also prevents the development of drug resistance caused by the mutation of EGFR tyrosine kinase including subtypes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020100011979A KR101301533B1 (en) | 2010-02-09 | 2010-02-09 | Novel pyrimidine derivatives for inhibiting cancer cell growth |
KR10-2010-0011979 | 2010-02-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011099764A2 WO2011099764A2 (en) | 2011-08-18 |
WO2011099764A3 true WO2011099764A3 (en) | 2012-01-05 |
Family
ID=44368289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2011/000858 WO2011099764A2 (en) | 2010-02-09 | 2011-02-09 | Novel pyrimidine derivative for inhibiting the growth of cancer cells |
Country Status (2)
Country | Link |
---|---|
KR (1) | KR101301533B1 (en) |
WO (1) | WO2011099764A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104529800A (en) * | 2014-12-08 | 2015-04-22 | 重庆威鹏药业有限公司 | Preparation method of trans-4-dimethylaminocrotonic acid and its salt |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE059230T2 (en) | 2011-06-10 | 2022-10-28 | Merck Patent Gmbh | Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity |
WO2014093230A2 (en) * | 2012-12-10 | 2014-06-19 | Merck Patent Gmbh | Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity |
CA2917667A1 (en) | 2013-07-09 | 2015-01-15 | Dana-Farber Cancer Institute, Inc. | Kinase inhibitors for the treatment of disease |
AU2016325143B2 (en) * | 2015-09-18 | 2020-08-13 | Kaken Pharmaceutical Co., Ltd. | Biaryl derivative and medicine containing same |
RS64908B1 (en) | 2015-11-17 | 2023-12-29 | Merck Patent Gmbh | Methods for treating multiple sclerosis using pyrimidine and pyridine compounds with btk inhibitory activity |
EP3426637B1 (en) | 2016-03-11 | 2022-02-09 | Angel Pharmaceutical Co., Ltd. | Compounds and methods for modulating bruton's tyrosine kinase |
JP6469272B2 (en) * | 2017-03-01 | 2019-02-13 | 科研製薬株式会社 | A pharmaceutical comprising a biaryl derivative or a salt thereof |
TWI809967B (en) * | 2021-07-06 | 2023-07-21 | 石 全 | Crystalline forms of (s, e)-4-(dimethylamino)-n-(3-(4-(2-hydroxy-1-phenylethylamino)-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl)but-2-enamide free base |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020132822A1 (en) * | 2000-10-26 | 2002-09-19 | Noe Mark C. | Pyrimidine-2,4,6-trione metalloproteinase inhibitors |
US20070270421A1 (en) * | 2004-02-27 | 2007-11-22 | Tomohiro Matsushima | Novel pyridine Derivative and Pyrimidine Derivative (1) |
US20090227587A1 (en) * | 2003-10-31 | 2009-09-10 | Warner-Lambert Company Llc | Pyrimidines as inhibitors of phosphoinositide-3-kinases (PI3K) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050070712A1 (en) | 2003-09-26 | 2005-03-31 | Christi Kosogof | Pyrimidine derivatives as ghrelin receptor modulators |
-
2010
- 2010-02-09 KR KR1020100011979A patent/KR101301533B1/en not_active IP Right Cessation
-
2011
- 2011-02-09 WO PCT/KR2011/000858 patent/WO2011099764A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020132822A1 (en) * | 2000-10-26 | 2002-09-19 | Noe Mark C. | Pyrimidine-2,4,6-trione metalloproteinase inhibitors |
US20090227587A1 (en) * | 2003-10-31 | 2009-09-10 | Warner-Lambert Company Llc | Pyrimidines as inhibitors of phosphoinositide-3-kinases (PI3K) |
US20070270421A1 (en) * | 2004-02-27 | 2007-11-22 | Tomohiro Matsushima | Novel pyridine Derivative and Pyrimidine Derivative (1) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104529800A (en) * | 2014-12-08 | 2015-04-22 | 重庆威鹏药业有限公司 | Preparation method of trans-4-dimethylaminocrotonic acid and its salt |
CN104529800B (en) * | 2014-12-08 | 2017-01-25 | 重庆威鹏药业有限公司 | Preparation method of trans-4-dimethylaminocrotonic acid and its salt |
Also Published As
Publication number | Publication date |
---|---|
KR101301533B1 (en) | 2013-09-04 |
WO2011099764A2 (en) | 2011-08-18 |
KR20110092517A (en) | 2011-08-18 |
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