US20070181503A1 - Affinity particle and affinity separation method - Google Patents

Affinity particle and affinity separation method Download PDF

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Publication number
US20070181503A1
US20070181503A1 US11/580,000 US58000005A US2007181503A1 US 20070181503 A1 US20070181503 A1 US 20070181503A1 US 58000005 A US58000005 A US 58000005A US 2007181503 A1 US2007181503 A1 US 2007181503A1
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US
United States
Prior art keywords
particles
affinity
group
groups
ligands
Prior art date
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Abandoned
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US11/580,000
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English (en)
Inventor
Katsuyuki Maeno
Kazuyuki Miyazawa
Akira Ishikubo
Kazuhiko Ishihara
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Shiseido Co Ltd
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Shiseido Co Ltd
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Filing date
Publication date
Application filed by Shiseido Co Ltd filed Critical Shiseido Co Ltd
Assigned to SHISEIDO COMPANY, LTD. reassignment SHISEIDO COMPANY, LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ISHIKUBO, AKIRA, MAENO, KATSUYUKI, MIYAZAWA, KAZUYUKI, ISHIHARA, KAZUHIKO
Publication of US20070181503A1 publication Critical patent/US20070181503A1/en
Abandoned legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3257—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such
    • B01J20/3259—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one of the heteroatoms nitrogen, oxygen or sulfur together with at least one silicon atom, these atoms not being part of the carrier as such comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulfur with at least one silicon atom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3285—Coating or impregnation layers comprising different type of functional groups or interactions, e.g. different ligands in various parts of the sorbent, mixed mode, dual zone, bimodal, multimodal, ionic or hydrophobic, cationic or anionic, hydrophilic or hydrophobic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/58—Use in a single column
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
US11/580,000 2004-05-24 2005-05-18 Affinity particle and affinity separation method Abandoned US20070181503A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2004-153253 2004-05-24
JP2004153253 2004-05-24
JP2005138560A JP3922648B2 (ja) 2004-05-24 2005-05-11 アフィニティー粒子及びアフィニティー分離方法
JP2005-138560 2005-05-11
PCT/JP2005/009088 WO2005113135A1 (ja) 2004-05-24 2005-05-18 アフィニティー粒子及びアフィニティー分離方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2005/009088 A-371-Of-International WO2005113135A1 (ja) 2004-05-24 2005-05-18 アフィニティー粒子及びアフィニティー分離方法

Related Child Applications (1)

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US12/495,936 Continuation US8551332B2 (en) 2004-05-24 2009-07-01 Affinity particle and affinity separation method

Publications (1)

Publication Number Publication Date
US20070181503A1 true US20070181503A1 (en) 2007-08-09

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Family Applications (3)

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US11/580,000 Abandoned US20070181503A1 (en) 2004-05-24 2005-05-18 Affinity particle and affinity separation method
US12/490,216 Abandoned US20090321357A1 (en) 2004-05-24 2009-06-23 Affinity Particle And Affinity Separation Method
US12/495,936 Expired - Fee Related US8551332B2 (en) 2004-05-24 2009-07-01 Affinity particle and affinity separation method

Family Applications After (2)

Application Number Title Priority Date Filing Date
US12/490,216 Abandoned US20090321357A1 (en) 2004-05-24 2009-06-23 Affinity Particle And Affinity Separation Method
US12/495,936 Expired - Fee Related US8551332B2 (en) 2004-05-24 2009-07-01 Affinity particle and affinity separation method

Country Status (5)

Country Link
US (3) US20070181503A1 (ja)
EP (1) EP1759761B1 (ja)
JP (1) JP3922648B2 (ja)
KR (1) KR101155655B1 (ja)
WO (1) WO2005113135A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060060533A1 (en) * 2002-11-25 2006-03-23 Kazuyuki Miyazawa Method of modifying surface of material
US20070284297A1 (en) * 2006-06-09 2007-12-13 Marcello Gatti Apparatus for the purification of organic molecules and relevant method of manufacture
US20090149667A1 (en) * 2007-12-05 2009-06-11 Dai Nippon Printing Co., Ltd. Method of producing substance immobilizing carrier
US20110021756A1 (en) * 2008-03-19 2011-01-27 Katsuyuki Maeno Method of manufacturing an affinity particle, affinity particle, and separation method
US9347031B2 (en) 2009-06-15 2016-05-24 Shiseido Company, Ltd. Container for forming a cell aggregate and a method for forming a cell aggregate

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101065387B (zh) * 2004-11-29 2012-05-30 株式会社资生堂 含磷酰胆碱基的化合物及其制备方法
JP5391265B2 (ja) * 2009-03-02 2014-01-15 株式会社 資生堂 バイオチップの製造方法
KR101283446B1 (ko) * 2010-11-10 2013-07-08 재단법인대구경북과학기술원 포스포콜린에 의해 표면개질된 자성나노입자, 그의 제조 방법, 및 그를 이용한 단백질 분리방법
JP5095855B2 (ja) * 2010-12-13 2012-12-12 株式会社 資生堂 細胞凝集塊の形成方法
US10077376B2 (en) 2014-01-31 2018-09-18 Siemens Healthcare Diagnostics Inc. Paramagnetic supports for use as assay reagents
CN110586022A (zh) * 2019-09-18 2019-12-20 沈阳航空航天大学 一种用酸碱改性的多孔氮化硼从纺织工业废水中去除脂肪酸的方法
CN115073515B (zh) * 2022-06-29 2024-03-01 南京威尔药业科技有限公司 一种快速分离磷脂各组分的方法

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4298500A (en) * 1980-05-05 1981-11-03 Varian Associates, Inc. Mixed phase chromatographic compositions
US4415631A (en) * 1980-06-27 1983-11-15 Akzo Porous inorganic support material coated with an organic stationary phase, for use in chromatography, and process for its preparation
US4767670A (en) * 1987-01-21 1988-08-30 E. I. Du Pont De Nemours And Company Chromatographic supports for separation of oligonucleotides
US5045190A (en) * 1988-11-08 1991-09-03 Carbonell Ruben G Chromatography apparatus
US5137627A (en) * 1989-03-02 1992-08-11 Supelco, Inc. Deactivated supports for liquid chromatographic separation of silanophiles
US5141806A (en) * 1989-10-31 1992-08-25 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Microporous structure with layered interstitial surface treatment, and method and apparatus for preparation thereof
US5277813A (en) * 1988-06-17 1994-01-11 S.A.C. Corporation Shielded stationary phases
US5374755A (en) * 1992-07-17 1994-12-20 Millipore Corporation Liquid chromatography stationary phases with reduced silanol interactions
US5431807A (en) * 1992-10-21 1995-07-11 Cornell Research Foundation, Inc. Multimodal chromatographic separation media and process for using same
US5438000A (en) * 1992-11-12 1995-08-01 Nippon Paint Co., Ltd. Serum separation sealant
US20020005380A1 (en) * 2000-05-31 2002-01-17 Takaya Sato Bioreactor carrier, process for producing the carrier and method for using the same
US6884345B1 (en) * 1998-11-09 2005-04-26 Knut Irgum Chromatography method and a column material useful in said method
US20060060533A1 (en) * 2002-11-25 2006-03-23 Kazuyuki Miyazawa Method of modifying surface of material
US7125488B2 (en) * 2004-02-12 2006-10-24 Varian, Inc. Polar-modified bonded phase materials for chromatographic separations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59169532A (ja) * 1983-03-17 1984-09-25 Asahi Chem Ind Co Ltd Ｃ反応性蛋白の吸着材
JPH0833380B2 (ja) * 1986-12-03 1996-03-29 東ソー株式会社 液体クロマトグラフイ−用充てん剤
GB9301702D0 (en) * 1993-01-28 1993-03-17 Biocompatibles Ltd New materials
JPH0826076A (ja) * 1994-07-19 1996-01-30 Asmo Co Ltd 車両用雨滴除去装置
JP3884510B2 (ja) * 1996-10-14 2007-02-21 日本油脂株式会社 固定化免疫学的活性物質の保存時安定化方法
EP0991943A1 (de) 1997-06-18 2000-04-12 Innova Gesellschaft Zur Entwicklung Und Vermarktung Innovativer Produkte MBH Magnetische partikel mit biologisch aktiven rezeptoren
US6258264B1 (en) * 1998-04-10 2001-07-10 Transgenomic, Inc. Non-polar media for polynucleotide separations
JP4680361B2 (ja) * 2000-09-22 2011-05-11 一彦 石原 分離・回収方法
JP4434517B2 (ja) * 2001-06-11 2010-03-17 Ｊｕｎｋｅｎ Ｍｅｄｉｃａｌ株式会社 吸着材

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4298500A (en) * 1980-05-05 1981-11-03 Varian Associates, Inc. Mixed phase chromatographic compositions
US4415631A (en) * 1980-06-27 1983-11-15 Akzo Porous inorganic support material coated with an organic stationary phase, for use in chromatography, and process for its preparation
US4767670A (en) * 1987-01-21 1988-08-30 E. I. Du Pont De Nemours And Company Chromatographic supports for separation of oligonucleotides
US5277813A (en) * 1988-06-17 1994-01-11 S.A.C. Corporation Shielded stationary phases
US5045190A (en) * 1988-11-08 1991-09-03 Carbonell Ruben G Chromatography apparatus
US5137627A (en) * 1989-03-02 1992-08-11 Supelco, Inc. Deactivated supports for liquid chromatographic separation of silanophiles
US5141806A (en) * 1989-10-31 1992-08-25 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Microporous structure with layered interstitial surface treatment, and method and apparatus for preparation thereof
US5374755A (en) * 1992-07-17 1994-12-20 Millipore Corporation Liquid chromatography stationary phases with reduced silanol interactions
US5431807A (en) * 1992-10-21 1995-07-11 Cornell Research Foundation, Inc. Multimodal chromatographic separation media and process for using same
US5438000A (en) * 1992-11-12 1995-08-01 Nippon Paint Co., Ltd. Serum separation sealant
US6884345B1 (en) * 1998-11-09 2005-04-26 Knut Irgum Chromatography method and a column material useful in said method
US20020005380A1 (en) * 2000-05-31 2002-01-17 Takaya Sato Bioreactor carrier, process for producing the carrier and method for using the same
US20060060533A1 (en) * 2002-11-25 2006-03-23 Kazuyuki Miyazawa Method of modifying surface of material
US7125488B2 (en) * 2004-02-12 2006-10-24 Varian, Inc. Polar-modified bonded phase materials for chromatographic separations

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060060533A1 (en) * 2002-11-25 2006-03-23 Kazuyuki Miyazawa Method of modifying surface of material
US7560023B2 (en) * 2002-11-25 2009-07-14 Shiseido Company, Ltd. Method of modifying surface of material
US20070284297A1 (en) * 2006-06-09 2007-12-13 Marcello Gatti Apparatus for the purification of organic molecules and relevant method of manufacture
US20090149667A1 (en) * 2007-12-05 2009-06-11 Dai Nippon Printing Co., Ltd. Method of producing substance immobilizing carrier
US8293933B2 (en) 2007-12-05 2012-10-23 Dai Nippon Printing Co., Ltd. Method of producing substance immobilizing carrier
US20110021756A1 (en) * 2008-03-19 2011-01-27 Katsuyuki Maeno Method of manufacturing an affinity particle, affinity particle, and separation method
US9347031B2 (en) 2009-06-15 2016-05-24 Shiseido Company, Ltd. Container for forming a cell aggregate and a method for forming a cell aggregate

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EP1759761B1 (en) 2011-07-27
KR20070053650A (ko) 2007-05-25
EP1759761A1 (en) 2007-03-07
KR101155655B1 (ko) 2012-06-13
WO2005113135A1 (ja) 2005-12-01
EP1759761A4 (en) 2008-11-05
US20100137133A1 (en) 2010-06-03
JP2006007204A (ja) 2006-01-12
US8551332B2 (en) 2013-10-08
JP3922648B2 (ja) 2007-05-30

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