US20050241653A1 - Integrated surgical microscope and wavefront sensor - Google Patents

Integrated surgical microscope and wavefront sensor Download PDF

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US20050241653A1
US20050241653A1 US11/110,968 US11096805A US2005241653A1 US 20050241653 A1 US20050241653 A1 US 20050241653A1 US 11096805 A US11096805 A US 11096805A US 2005241653 A1 US2005241653 A1 US 2005241653A1
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eye
cornea
lens
surgical position
surgical
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Anthony Van Heugten
Daniel Durrie
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Novartis AG
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Wavetec Vision Systems Inc
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Publication of US20050241653A1 publication Critical patent/US20050241653A1/en
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Definitions

  • Refractive surgery and other corrective procedures are commonly performed on the human eye.
  • the refractive quality of the eye is altered.
  • the goal of refractive surgery typically is to correct a defective refractive condition of the eye, while not diminishing the overall refractive quality of the eye. In some cases, the goal is to actually improve the overall refractive quality of the eye.
  • Wavefront sensors generally provide the greatest detail about the refractive condition of, and additional information relating to, the eye. Wavefront sensors are generally standalone devices that operate in relatively large areas dedicated to the use of the wavefront sensors. With most existing wavefront sensors, the patient's eye is measured while the patient is in a sitting position.
  • measuring the refractive quality of the eye after the refractive surgery has been performed provides a quantification of the outcome of the surgery, it does not allow modifications to the surgery to be performed while the patient remains in the surgical position. If the outcome is not ideal, the patient may be relocated to the surgical area for a re-treatment, but in many cases a re-treatment may not be as effective as if the procedure had been performed to produce an ideal result the first time before the patient was moved from the surgical position. Additionally, moving a patient out of the sterile surgical field for diagnostic purposes, and then back into the surgical field, can be problematic.
  • the surgeon would have the opportunity to judge whether the procedure was producing desired results at the expected rate, and would be able to make adjustments or course corrections to the procedure midstream to improve the likelihood of achieving the desired outcome.
  • existing wavefront sensors and other measuring devices are generally relatively large and heavy, making them impracticable or impossible to suspend above a patient's head during surgery. As a result, a patient must be physically moved between wavefront measurement procedures and surgical correction procedures that are typically performed under a surgical microscope.
  • a wavefront sensor is integrated with a surgical microscope for allowing a doctor to make repeated measurements of a patient's eye while the patient remains in a surgical position.
  • the device includes a wavefront sensor optically aligned with a surgical microscope such that their fields of view at least partially overlap.
  • the optional inclusion of lightweight, compact diffractive optical components in the wavefront sensor allows the integrated device to be supported on a balancing mechanism above a patient's head during a surgical procedure. As a result, the need to reposition the device and/or the patient between measuring optical properties of the eye and performing surgical procedures on the eye is eliminated.
  • FIG. 1 is a side view of an integrated wavefront sensor and surgical microscope positioned above a patient's head.
  • FIG. 2 is a top view of the internal components of a wavefront sensor (with the cover removed) according to one embodiment.
  • FIG. 3 is a perspective view of an aberrated wave traveling through a grating, as well as wave images produced at the fist and second Talbot planes of the grating.
  • FIG. 4 is a side-view schematic diagram illustrating the operation of an integrated wavefront sensor and surgical microscope according to one embodiment.
  • FIG. 5 is a front-view schematic diagram of the operation of the integrated wavefront sensor and surgical microscope illustrated in FIG. 4 .
  • a surgical device 10 includes a surgical microscope 12 , or other suitable viewing device, attached to a wavefront sensor 14 , or other measuring device.
  • the surgical microscope 12 includes an eyepiece 16 , or other viewing mechanism, which includes one or more optical channels each having one or more optical lenses therein.
  • the eyepiece 16 is preferably binocular, or stereo, in that it includes two optical channels for allowing a doctor to view an eye 18 of a patient 20 using both of the doctor's eyes (as is best seen in FIG. 5 ). While a monocular eyepiece may alternatively be used, a binocular eyepiece is generally preferred because it provides a higher quality, more complete view to the doctor.
  • the surgical microscope 12 preferably further includes a light source 22 for providing visible light into the optical pathway of the eyepiece 16 , a focusing knob 24 for adjusting the focus of the microscope 12 , and an objective lens 26 , or other suitable lens, for focusing light beams.
  • the objective lens 26 is threaded onto the microscope 12 via internal threads on the lens 26 that match external threads on a body 25 of the microscope 12 .
  • the wavefront sensor 14 may be attached to the microscope 12 in any suitable manner, and is preferably removably attached to the microscope 12 .
  • the objective lens 26 may be removed from the microscope 12 , and the wavefront sensor 14 , which preferably includes an attachment portion with interior threads that match the exterior threads of the microscope body 25 , may be screwed onto the external threads of the microscope 12 .
  • the objective lens 26 may then be screwed back onto the external threads beneath the attachment portion of the wavefront sensor 14 .
  • One or more fasteners 28 may optionally be included to further (or alternatively) secure the wavefront sensor 14 to the microscope 12 .
  • the wavefront sensor 14 may alternatively be attached to the microscope via screws, bolts, pins, clamps, adhesive, or any other suitable fasteners or attachment means.
  • the wavefront sensor 14 includes a laser source 40 , or other light source, for creating a beam of light, preferably infrared light.
  • the beam of infrared light is preferably directed by a mirror 42 toward a beam splitter 44 or other suitable device.
  • An aperture-sharing element such as a combiner mirror 46 (shown in dashed lines in FIG. 1 ), a beam-splitter, or other similar device, reflects the beam of infrared light down into the eye 18 of the patient 20 .
  • the combiner mirror 46 preferably reflects infrared light while transmitting visible light so that a doctor can see the patient's eye 18 while looking through the combiner mirror 46 .
  • the combiner mirror 46 may alternatively be configured to reflect a portion of the visible light spectrum, and/or to transmit a portion of the infrared light spectrum, as described below.
  • the infrared light beam After the infrared light beam enters the eye 18 , it is reflected, as a wavefront, from the retina of the eye 18 toward the combiner mirror 46 .
  • the combiner mirror 46 redirects the light beam through the beam splitter 44 toward a first lens 48 .
  • the first lens 48 relays the infrared light beam off of mirrors 50 and 52 toward a second lens 54 , which directs the light beam onto a diffractive optical component, such as a first reticle or grating 56 .
  • the mirrors 42 , 50 , 52 are optionally included in the wavefront sensor 14 for re-directing the light beam to maintain it within a compact area, which facilitates the minimization of the overall size and length of the wavefront sensor 14 . A greater or lesser number of mirrors may be included in the wavefront sensor 14 .
  • the light beam is diffracted by the first grating 56 , as described in detail below, and preferably travels through another diffractive optical component, such as a second grating 58 , which further diffracts the light beam and creates a final image of the wavefront reflected from the eye 18 .
  • a camera 60 and/or another light detector or sensor, such as a CCD camera or other suitable device, then captures, records, and/or detects the final image of the eye 18 and converts it into a computer-readable format.
  • a computer may then measure and analyze the data to quantify characteristics of the wavefront, and thus, the refractive properties of the eye being examined.
  • the wavefront sensor 14 may of course include a greater or lesser number of components to meet the requirements of a given system. For example, a greater or lesser number of diffractive gratings or optical lenses may be included in the wavefront sensor 14 . Moreover, additional optical components, such as a camera lens, may optionally be included between the second refractive grating 58 and the camera 60 . Thus, the specific configuration of the wavefront sensor 14 illustrated in FIG. 2 is only one example a suitable wavefront sensor configuration.
  • the wavefront sensor 14 may be very compact and lightweight, and can produce higher resolution and more accurate alignment registration than a wavefront sensor using larger conventional refractive optics, such as a typical Hartmann-Shack wavefront sensor, as described below.
  • the wavefront sensor 14 preferably has a length Y that is less than 10 inches, more preferably less than nine inches, more preferably approximately 8.5 inches, and a width X that is preferably less than 5 inches, more preferably approximately 4.5 inches.
  • the wavefront sensor 14 preferably weighs less than five pounds, more preferably less than 3 pounds or less than 2 pounds.
  • the wavefront sensor 14 may of course be any other suitable size and/or weight.
  • the wavefront sensor 14 may be directly or indirectly attached to the surgical microscope 12 to form an integrated surgical device 10 .
  • the term “integrated” generally refers to the wavefront sensor 14 and the surgical microscope 12 being incorporated into a unit.
  • the integrated surgical device 10 may be attached to a balancing mechanism, hanging mechanism, or other suitable device or stand for suspending the integrated device 10 over a patient's head during surgery.
  • the balancing mechanism or other supporting device may be spring-loaded, counter-balanced, or otherwise balanced for supporting the integrated device 10 . Balancing mechanisms of this nature are commonly used to support and suspend surgical microscopes.
  • an attachment portion 30 of the surgical microscope 12 may be attached to the balancing mechanism via screws, pins, bolts, or other suitable fasteners, or the integrated device 10 may be attached to the balancing mechanism in any other suitable manner.
  • the wavefront sensor 14 may be added to an existing surgical microscope 12 that is already supported on a balancing mechanism. The field of view and the focal length of the microscope 12 and/or the wavefront sensor 14 may then be adjusted, if necessary, to optically align the devices relative to one another, as further described below.
  • refractive optical components are used to redirect a light beam as it passes through a material having a higher density than air, such as a glass refractive lens.
  • Diffractive optical components conversely, are used to bend a light beam as it encounters the sharp edges of an element, such as the gratings 56 , 58 , and only portions of the light beam occurring near the edges of the grating or other object are redirected.
  • Diffractive optical components, such as gratings are typically significantly smaller and weigh less than refractive optical components, such as refractive lenses.
  • the one or more diffractive gratings used in the wavefront sensor 14 may be made of any suitable material.
  • a preferred diffractive grating is made from a clear material, such as glass, and has equally spaced perpendicular lines etched or otherwise present on its surface.
  • the grating may include, for example, a repeating sequence of solid lines each having a width of approximately 12.5 microns, with each pair of lines separated by approximately 12.5 microns of clear glass (the lines and glass spaces on the grating may of course have any other suitable dimensions). The same sequence is repeated with lines running perpendicularly to the first set of lines, such that a pattern similar to that of a standard grid (i.e., a network of uniformly spaced horizontal and perpendicular lines) is formed.
  • a standard grid i.e., a network of uniformly spaced horizontal and perpendicular lines
  • This redirected light encounters light that has been redirected by one or more adjacent grating lines.
  • Talbot Effect a phenomenon known as the “Talbot Effect” occurs, and a series of dark and light zones form in a space within a predictable distance downstream from the grating, at locations referred to as Talbot planes. This phenomenon is described in detail in U.S. patent application Ser. No. 10/885,504, filed Jul. 6, 2004, as well as in “Fourier Transform Method For Automatic Processing of Moiré Deflectograms,” Quiroga et al., Opt. Eng. 38(6) pp.
  • the wavefront of light that passed through the grating is a flat, plane wave
  • the dark and light zones form a perfect replica of the grating, i.e., a virtual image of the grating.
  • the shape and size of the virtual image of the grating is distorted, as shown in FIG. 3 .
  • the virtual image may be observed by a camera or other light detector, and the images may be measured, typically by a computer, to accurately quantify the characteristics of the wavefront, and hence, the refractive properties of the eye being examined.
  • two or more gratings are aligned in series in the wavefront sensor.
  • the virtual image of the grating is modified to show less resolution, which can compensate for a camera having insufficient resolution.
  • the changes in the virtual image of the initial grating are visually converted into rotational movement, rather than just shrinkage or expansion, and the characteristics of the wavefront may be determined without change in size of the virtual image.
  • the virtual image created by the gratings contains, simultaneously, two sets of information.
  • the first set of information is the virtual image of the grating from which the refractive properties of the eye are characterized, as described above.
  • the second set of information is an almost complete image of the pupil of the eye, which is comprised of the light that passed untouched through the clear spaces of the grating, as well as light that reflected from the surface of the pupil, the sclera, the limbus, and/or other features of the eye if additional illumination is directed to illuminate these features.
  • This image essentially appears to be that of an eye being observed with a grid (i.e., a network of uniformly spaced horizontal and perpendicular lines) between the eye and the observer.
  • FIGS. 4 and 5 a schematic representation of a process for measuring characteristics of an eye is shown.
  • a surgeon (or other doctor) 105 looks through a surgical microscope 112 at the eye 125 of a patient.
  • the surgical microscope 112 preferably includes binocular, or stereo, optics such that it includes two optical viewing channels 116 , 118 (as shown in FIG. 5 ).
  • a monocular microscope may alternatively be used, however. Visible light reflecting from the patient's eye 125 travels along a light pathway 150 , passes through a combiner mirror 120 or similar device, and into the microscope 112 , so that the surgeon may view the patient's eye 125 along visual pathways 122 , 124 .
  • a wavefront sensor 114 generates an infrared light beam and projects it outwardly along a pathway 145 toward the combiner mirror 120 . While the combiner mirror 120 is shown located outside of the wavefront sensor 114 in the schematic representation of FIGS. 4 and 5 , it is understood that the combiner mirror 120 may be located inside the wavefront sensor 114 , as is shown in FIGS. 1 and 2 , or in any other suitable location where the optical pathways of the surgical microscope 112 and the wavefront sensor 114 meet.
  • the combiner mirror 120 is preferably transparent to visible light but reflective to infrared light so that it reflects the infrared light beam toward the patient's eye 125 .
  • the wavefront sensor 114 and the microscope 112 preferably share a common aperture through the combiner mirror 120 .
  • a beam splitter that transmits and reflects both a portion of the visible light and a portion of the infrared light may be used in place of the combiner mirror 120 . Using such a beam splitter would allow the wavefront sensor 114 to operate at a wavelength other than that of the infrared light, such as at a wavelength in the visible spectrum.
  • the combiner mirror 120 may be configured to reflect a portion of the visible light spectrum, allowing the wavefront sensor 114 to operate in a wavelength range within the visible spectrum, yet prevent that particular wavelength from entering the microscope 112 .
  • the combiner mirror 120 may be a narrow pass/reflect combiner, which reflects only a defined wavelength of light having a lower and upper range, thereby allowing the wavefront sensor 114 to operate within the visible light spectrum. The defined visible light spectrum would then be selectively blocked from returning to the microscope 112 , while all light above or below the lower and upper ranges would be freely transmitted.
  • the combiner mirror 120 reflects the light beam along pathway 150 toward the patient's eye 125 .
  • the infrared light enters the patient's eye 125 and is reflected as a wavefront back along light pathway 150 toward the combiner mirror 120 , which reflects the wavefront along light pathway 145 into the wavefront sensor 114 .
  • the wavefront sensor 114 measures the wavefront using the process described above, or using a similar process.
  • the wavefront sensor 114 may have the same configuration and components as the wavefront sensor 14 illustrated in FIG. 2 , or it may have an alternative configuration and may include alternative components.
  • the wavefront sensor 114 and the microscope 112 are each preferably focused at a point occurring at plane 135 , such that a field of view 155 of the wavefront sensor 114 at least partially overlaps a field of 160 of the microscope 112 .
  • the patient's eye 125 is preferably located within the overlapping portion of the fields of view 155 , 160 .
  • the wavefront sensor 114 and the microscope 112 are focused at substantially the same point, such that the center of each field of view 155 , 160 is located at approximately the same point, in the same plane 135 , preferably at or near the center of the patient's eye 125 .
  • the surgeon 105 may look through the microscope 112 directly into the visual axis of the patient's eye 125 while the wavefront sensor 114 takes measurements of the eye 125 .
  • the patient does not have to change the gaze angle of the patient's eye 125 at any time during the viewing and measurement processes. This can be very advantageous, especially when the surgical procedure being performed prevents the patient from seeing clearly, or at all, such that it is nearly impossible for the patient to accurately adjust the gaze angle of the patient's eye 125 according to a surgeon's instructions.
  • the integrated wavefront sensor and surgical microscope described herein provides several advantages. First, it allows a surgeon or other doctor to directly view a patient's eye while the wavefront sensor performs measurements of the refractive characteristics or other optical properties of the patient's eye. As a result, a surgeon can view the results of a given step of a surgical procedure without having to move the patient, the patient's eye, or the device. Indeed, the gaze angle of the patient's eye does not need to change at all during the viewing and measuring steps, and the surgeon's view may be directly aligned with, as opposed to offset from, the visual axis of the patient's eye.
  • the integrated device may be very compact. Accordingly, the lightweight integrated device can be suspended on a balancing device, or other supporting mechanism, above the head of a patient lying in the supine surgical position, while the surgeon views the patient's eye through the surgical microscope of the integrated device.
  • the integrated surgical device 10 is preferably not integrated with or otherwise attached to a refractive laser device or other refractive surgical tool.
  • the integrated surgical device 10 is preferably used primarily for viewing and measuring purposes, while one or more surgical tools used to perform corrective eye procedures are physically separate from the integrated device. Lightweight or otherwise compact surgical tools, however, may optionally be incorporated into the surgical device 10 .
  • the wavefront sensor 14 and the surgical microscope 12 also preferably do not share an optical pathway to the patient's eye 18 with any other surgical devices.
  • the wavefront sensor and the surgical microscope are preferably (although, not necessarily) separate components that are removably attached to one another, they may each include their own optical components, including any lenses. Thus, the wavefront sensor and the surgical microscope do not need to share a lens, thus providing several advantages and general design flexibility over integrated surgical systems that require one or more lenses to be shared between two or more optical components.
  • Some surgical systems for example, use a common optical lens to focus light beams from both a wavefront sensor and a refractive laser device.
  • a common optical lens By sharing a lens in this manner, the flexibility to select or design the lens for only a single specific function is lost, as is the ability to design the best possible lens for the overall system application.
  • compromises must be made to meet the requirements of each component that shares the lens.
  • Antireflective coatings are commonly applied to lenses so that they can function optimally within a certain wavelength. If the laser being used is of a different wavelength than the wavefront sensor illumination beam, however, a common antireflective coating cannot be selected that will work optimally for each of the wavelengths. The same holds true for the wavelength of the wavefront sensor illumination beam in comparison to that of the visible light used to provide visibility through a microscope. Because the surgical device 10 described herein does not require that a lens be shared between the wavefront sensor and the surgical microscope, different antireflective coatings may be applied to the lenses of each of these components, thus allowing for optimal coatings to be selected for each component.
  • Another disadvantage of sharing a common lens between two or more optical components is the inability to select an optimal focal length, or power, of the lens for each component involved.
  • a long focal length lens is desirable in a wavefront sensor to provide sufficient working space for a doctor between the wavefront sensor and the patient.
  • a shorter focal length lens is desirable to more tightly focus the laser energy into a shorter plane.
  • a system that shares a common lens for these components must compromise or settle on a common focal length, which will not be optimal for one or both of the components.
  • an advantageous feature of the surgical device 10 is that it does not require a lens to be shared by the wavefront sensor 14 and the surgical microscope 12 .
  • the surgical device 10 may be used to improve and/or enhance a variety of corrective procedures performed on the eye.
  • corrective eye procedures may be enhanced by using the surgical device 10 .
  • Cataract surgery generally involves replacing the natural lens of an eye after the natural lens has become unclear.
  • Existing methods typically require measuring the physical dimensions of the eye with ultrasound, followed by calculating the refractive power of the artificial lens, or other replacement lens, to be inserted. Because the natural lens is unclear, these measurements are often difficult to make. Additionally, variations in the structures of the eye that cannot typically be measured using existing techniques may degrade the calculation.
  • the integrated surgical device 10 facilitates measurement of the eye's refractive power before and/or immediately after the natural lens is removed, without movement of the patient or the patient's eye, such that the true refractive power of the eye can be more accurately determined. For example, if it is determined that 42 diopters of power are needed for a patient to see clearly at a predetermined distance, and after the natural lens is removed the eye has only 22 diopters of power, then it can easily and accurately be determined that 20 diopters of power must be introduced to the eye via the new lens being inserted.
  • the patient typically has to be moved from the surgical table to a measurement device to make the refractive measurements. Because the patient is typically sedated, and there may be an incision in the patient's eye, and there are sterility requirements to maintain, it is not practical to move the patient between surgical steps.
  • the integrated surgical device 10 which is preferably suspended above the patient's head, conversely, a surgeon may view the patient's eye through the surgical microscope 12 while the wavefront sensor 14 makes measurements of the eye with the natural lens removed. Accordingly, the patient, as well as the patient's eye, is able to remain motionless in the surgical position during the entire corrective process.
  • a further challenge associated with cataract surgery is that once the replacement lens is inserted into the eye, the replacement lens must be aligned to ensure that it is properly oriented and positioned. If, for example, the replacement lens is not correctly centered, or is not perpendicular to the optical axis of the eye, or if the cylindrical portion (if astigmatic correction to the replacement lens is also being performed) is not oriented to the correct axis, refractive aberrations may be introduced, and the surgical outcome will therefore be degraded.
  • the integrated surgical device 10 allows the surgeon to make refractive measurements of the eye, after the replacement lens has been inserted, which may be used to guide any required repositioning of the replacement lens.
  • viscoelastic cushioning fluids are typically injected into the eye to protect endothelium cells and other structures, and should be completely removed after the surgery is completed.
  • the wavefront sensor 14 may be used to identify any remaining viscoelastic pockets (as wave distortions), and can therefore assist the surgeon in removing all of the viscoelastic fluid.
  • astigmatisms may also be reduced during the lens replacement procedure by means other than using a replacement lens with a cylinder component.
  • the location and size of any entry wound could be adjusted, the position of a paracentesis incision could be adjusted, as could any additional lamellar, radial, or arcuate cuts made, all while the surgeon receives feedback from the wavefront sensor 14 that may guide corrections made during the procedure.
  • the replacement lens may be replaced or repaired before the membrane that previously contained the natural lens shrinks and tightens onto the replacement lens.
  • a process of introducing relaxing incisions into various locations of the eye, which causes the cornea to flatten out in predictable directions, is often used to eliminate astigmatism of the cornea.
  • Such a procedure is often performed at the end of cataract surgery, for example, to eliminate an astigmatism that was induced by the main cataract incision, or that had previously existed.
  • the amount of flattening generally varies from patient to patient, however, and is therefore very difficult to precisely predict.
  • the wavefront sensor 14 can make measurements during the surgical procedure to guide the position, depth, and length of incisions made by the surgeon to achieve desired results.
  • Corneal transplant surgery in which a small central portion, typically 8 to 10 mm in diameter, of the cornea is cut from a donor's eye and grafted into a correspondingly-sized hole cut into a recipient's cornea, may also be improved by using the integrated surgical device 10 .
  • refractive errors are typically difficult to measure. Refractive errors may be introduced if, for example, the donor's corneal tissue is not properly centered, rotated, or oriented in the recipient's cornea, or if the sutures are too tight, too loose, or not evenly tightened. If the recipient's eye is measured after the healing process has completed, refractive errors are difficult, if not impossible, to correct.
  • a surgeon may measure refractive changes in the eye while placing and suturing the donor graft. Indeed, the recipient may remain lying on the surgical table, and the surgeon may look directly into the visual axis of the recipient's eye, while the refractive measurements are being taken. Accordingly, the recipient does not need to be moved at any point during the transplant procedure. Additionally, the donor cornea may be measured by the wavefront sensor to locate its optical axis to assist with better cutting and/or placement of the cornea.
  • the integrated surgical device 10 may also be used to enhance LASIK (Laser-Assisted In Situ Keratomileusis) refractive surgery, or other laser-assisted surgical procedures.
  • LASIK Laser-Assisted In Situ Keratomileusis
  • Several variations of laser vision surgery require that a flap be cut from the surface of the cornea to expose the stroma of the cornea to laser treatment.
  • the laser reshapes the stroma to a desired contour, after which the flap is replaced over the reshaped stroma. If the flap is not precisely repositioned at its original location, if foreign matter is trapped inside the flap, if a wrinkle is introduced during repositioning, and/or if a host of other repositioning errors occur, then the visual outcome of the procedure will be degraded.
  • the integrated surgical device 10 allows a surgeon to measure the refractive or optical properties of the eye while the surgeon directly observes the eye, and while the flap is being repositioned, so that any positioning errors or other problems can quickly be corrected.
  • the integrated surgical device 10 may also be used during a Conductive Keratoplasty (“CK”) procedure.
  • CK is a refractive surgical procedure in which highly localized energy pulses, such as heat pulses or radio frequency pulses, are applied to the collagen or stroma of the cornea to reshape the cornea to correct for refractive errors, particularly hyperopia.
  • Current methods typically require that the eye be measured with a conventional refractive device, which provides information regarding how many energy pulses are required to reshape the cornea as desired and identifies which regions of the cornea should receive pulses.
  • the patient is then moved to a surgical location where the energy pulses, typically 8 or more, are applied to the cornea, after which the patient is moved back to the measurement device so that the eye may be re-measured.
  • the outcome of such a procedure is generally the result of a best prediction, and the actual outcome is rarely exactly as desired due to variability in the response of each individual cornea. If the cornea is under-corrected, more pulses may be added later, but if the cornea is over-corrected, it is difficult, and sometimes impossible, to reverse the over-correction.
  • the eye's refractive condition may be measured after each pulse is applied (preferably after a certain minimum number of pulses have been applied, for example, after 6 pulses have been applied, since a complete correction will typically not occur until at least a certain minimum number of pulses have been applied), and the surgeon may therefore make guided corrections during the surgical procedure.
  • the surgeon may, for example, alter the position, size, quantity, and/or energy of the pulses applied if measurements taken between successive pulses dictate that such steps should be taken.
  • the placement of the pulses is critically important, and the wavefront sensor may be used to help guide the placement of each energy pulse.
  • a procedure for positioning an inlay in a cornea along the eye's visual axis may also be aided by using the integrated surgical device 10 .
  • a procedure for positioning an inlay in a cornea along the eye's visual axis may also be aided by using the integrated surgical device 10 .
  • an opaque disk or similar structure with a small central aperture is placed in the cornea and trapped inside the flap.
  • the inserted disk creates the effect of a smaller aperture, resulting in the depth of view of the eye being increased. It is, however, extremely difficult to center the disk about the eye's visual axis.
  • the wavefront sensor 14 can make measurements to determine the exact location of the eye's visual axis while the surgeon directly views the eye, which aids the surgeon in precisely positioning the disk in the proper central location.
  • the corneal inlay's central aperture may be cut into the inlay by the laser after it has been placed in the eye.
  • the precise measurements of the wavefront sensor, coupled with the precise control of the laser placement may result in a more accurate aperture position than if it were manually positioned.
  • the integrated surgical device 10 may also be used to control corneal distortion during placement of inserts into the cornea.
  • myopia for example, the cornea is too steep and must be flattened.
  • slices are cut into the cornea, after which tiny, curved strips are slid into the stroma of the cornea to exert a straightening force on the cornea that flattens the cornea.
  • the wavefront sensor 14 can make measurements of the eye while the doctor directly views the eye, allowing the doctor to monitor the degree of flattening and to adjust the process (e.g., to add more or different inserts) midstream.
  • the integrated surgical device 10 may further be used to measure and view the eye during a procedure for adjusting the tension of the ciliary muscle and/or the ciliary process of the eye.
  • rings or other devices are inserted into the sclera just beyond the limbus of the eye to exert a radially outwardly pulling force on the ciliary muscle.
  • the goal of this procedure is to expand the relaxed diameter of the ciliary muscle, which in turn provides added tension in the ciliary muscle and removes some of the slack that has developed therein over the years.
  • the wavefront sensor 14 can take measurements of the eye while the tensioning procedure is being performed under the surgical microscope 12 , thus guiding the amount of tensioning required to achieve desired results.
  • Another corrective procedure involves removing tissue from the cornea, via mechanical slicing or another method, to modify the shape of the cornea.
  • mechanical tissue removal an incision is made in the side of the cornea to provide a split in the stroma of the cornea.
  • a shallow spoon-shaped device is then guided into the split, and a blade is used to remove tissue below the spoon's edge plane, resulting in less corneal tissue thickness centrally than peripherally, and thus, corneal flattening (i.e., reduction in myopia).
  • the wavefront sensor 14 can make measurements during the surgical procedure to guide the process and aid the surgeon in determining how much tissue, at which locations, should be removed.
  • the natural lens of the eye may also be modified to correct refractive defects in the natural lens. Some defects that may occur over time include small opacities, protein buildup, and size increases in the lens.
  • One method of modifying the natural lens involves removing tissue from the lens to correct vision loss associated with these and other defects. Even a small amount of material removal, however, can result in a large change in refraction.
  • the wavefront sensor 14 can make measurements during the surgical procedure to guide the process and aid the surgeon in determining how much lens tissue, at which locations, should be removed.
  • Optical properties of the natural lens may also be modified by introducing chemicals, or changing blood sugar levels, in a patient's system.
  • Using the integrated surgical device 10 during such a procedure allows a surgeon to measure the amount of change resulting from the introduction of one or more chemicals, which can aid the surgeon in reaching a desired outcome.
  • the integrated surgical device 10 may also be used to aid in controlling or influencing the resulting shape of a lens that is injected into the eye as a liquid and that cures into a solid.
  • a lens is commonly referred to as a “form in the bag” lens.
  • Extreme precision is required to attain the desired resultant shape of the lens using such a procedure.
  • the shape and index of refraction of the lens can be manipulated.
  • Using the integrated surgical device 10 allows a surgeon looking through the microscope 12 to obtain wavefront data about the lens as it is being formed so that proper course corrections can be made during the curing process.
  • Advancements have been made in the ability to modify or tune the characteristics of an artificial lens after the lens has been inserted into the eye and the eye has healed.
  • a surgeon viewing the eye through the microscope 12 can make modifications to the artificial lens while the wavefront sensor 14 makes measurements that can guide the procedure.
  • the integrated surgical device 10 allows a surgeon to view the eye while making wavefront measurements, which aids the surgeon in selecting an appropriate lens and in positioning the lens in the correct central location along the visual axis of the eye. Additionally, the integrated surgical device 10 can verify the overall success or failure of the procedure, which allows the surgeon to make adjustments, while the patient remains on the surgical table, if the outcome is not ideal. This not only improves efficiency, but also allows re-accessing of an incision before it has healed, such that a new incision is not required to make corrections after a non-ideal outcome.
  • the wavefront sensor 14 of the integrated surgical device 10 may be used to measure the eye before the procedure to help determine a minimum amount of material to add, and may also be used to measure the eye after the material is inserted. The wavefront sensor 14 may then be used to measure the eye at various points of the procedure, which is performed under the surgical microscope 12 , to ensure that the correct amount of material is removed.
  • a patient's eye is measured with a wavefront sensor at a first location, a treatment is calculated and/or planned based on the measurements, and the patient is then moved to a second location where the actual treatment is performed.
  • the eye is measured while the patient is sitting upright, but the treatment is performed while the patient is lying facing upward in a supine position.
  • the patient's eyes rotate, or “cyclotort.”
  • dye marks are typically placed on the eye while the patient is in the upright position so that the amount of cyclotortion can be measured.
  • the wavefront measurements may be taken while the patient lies in the supine position, with the cyclotortion present, and while the doctor is viewing the eye. Accordingly, the intermediate step of marking the cornea and compensating for the rotation is not required. The elimination of this step improves the efficiency of the process, and the precision of the orientation of the wavefront registration to the eye is enhanced.
  • the integrated surgical device 10 may be used to enhance any vision correction procedure by providing a surgeon the ability to view the eye simultaneously with making wavefront measurements of the eye.
  • the surgeon may make wavefront measurements while the patient remains lying in the surgical position, and may course adjustments to a procedure midstream without having to move the patient between surgical steps.
  • wavefront sensor 14 could include a greater or lesser number of components arranged in any conceivable configuration.
  • the invention therefore, should not be limited, except by the following claims and their equivalents.

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Cited By (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070171519A1 (en) * 2004-07-16 2007-07-26 Ralf Wolleschensky Microscope with heightened resolution and linear scanning
US20080062384A1 (en) * 2006-09-08 2008-03-13 Akkolens International B.V. Device and method for measuring the optical properties of an eye in combination with an operating microscope
DE102008034490A1 (de) 2008-07-24 2010-02-04 Carl Zeiss Meditec Ag Augenchirurgiesystem und Verfahren zur Vorbereitung und Durchführung einer Augenoperation
US20100061604A1 (en) * 2008-09-11 2010-03-11 Carl Zeiss Surgical Gmbh Medical systems and methods
US20100076423A1 (en) * 2008-09-19 2010-03-25 Avedro, Inc. Eye therapy system
DE102008047400A1 (de) 2008-09-16 2010-04-29 Carl Zeiss Surgical Gmbh Augenchirurgie-Messsystem
EP2184005A1 (en) 2008-10-22 2010-05-12 SensoMotoric Instruments Gesellschaft für innovative Sensorik mbH Method and apparatus for image processing for computer-aided eye surgery
US20100157246A1 (en) * 2008-12-23 2010-06-24 Carl Zeiss Surgical Gmbh Ophthalmic surgical system
US7883505B2 (en) 2004-04-20 2011-02-08 Wavetec Vision Systems, Inc. Integrated surgical microscope and wavefront sensor
DE102009037841A1 (de) * 2009-08-18 2011-02-24 Carl Zeiss Surgical Gmbh Wellenfrontanalysesystem und optisches System mit Mikroskop und Wellenfrontanalysesystem
US7988291B2 (en) 2003-04-10 2011-08-02 Wavetec Vision Systems, Inc. Intraoperative estimation of intraocular lens power
US20110190739A1 (en) * 2010-01-29 2011-08-04 Lensar, Inc. Servo controlled docking force device for use in ophthalmic applications
US8049873B2 (en) 2008-03-19 2011-11-01 Carl Zeiss Meditec Ag Surgical microscopy system having an optical coherence tomography facility
WO2012047307A1 (en) * 2010-09-30 2012-04-12 Curveright Llc Corneal treatment system and method
US20120197102A1 (en) * 2011-01-27 2012-08-02 Nidek Co., Ltd. Ophthalmic surgical microscope
USRE43702E1 (en) 2004-07-16 2012-10-02 Carl Zeiss Microimaging Gmbh Microscope with heightened resolution and linear scanning
US8337550B2 (en) 2006-07-11 2012-12-25 Refocus Ocular, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
US8342688B1 (en) 2009-06-15 2013-01-01 Casimir Andrew Swinger Multifocal capable ophthalmic aberrometer
US8459795B2 (en) 2008-09-16 2013-06-11 Carl Zeiss Meditec Ag Measuring system for ophthalmic surgery
US8500283B1 (en) 2009-04-02 2013-08-06 Casimir A. Swinger Microscope-attachable aberrometer
US8545023B2 (en) 2009-07-14 2013-10-01 Wavetec Vision Systems, Inc. Ophthalmic surgery measurement system
US8550624B2 (en) 2008-11-06 2013-10-08 Wavetec Vision Systems, Inc. Optical angular measurement system for ophthalmic applications and method for positioning of a toric intraocular lens with increased accuracy
EP2676645A1 (en) * 2009-07-24 2013-12-25 Lensar, Inc. Laser system for reducing astigmatism induced from cataract therapy
US8619405B2 (en) 2007-10-31 2013-12-31 Wavetec Vision Systems, Inc. Wavefront sensor
US8652131B2 (en) 2007-07-19 2014-02-18 Avedro, Inc. Eye therapy system
US20140058365A1 (en) * 2007-12-17 2014-02-27 Josef F. Bille System and Method for Using Compensating Incisions in Intrastromal Refractive Surgery
US8712536B2 (en) 2009-04-02 2014-04-29 Avedro, Inc. Eye therapy system
US8708491B2 (en) 2008-07-25 2014-04-29 Lensar, Inc. Method and system for measuring an eye
US8758332B2 (en) 2009-07-24 2014-06-24 Lensar, Inc. Laser system and method for performing and sealing corneal incisions in the eye
US8764187B2 (en) 2009-07-14 2014-07-01 Wavetec Vision Systems, Inc. Determination of the effective lens position of an intraocular lens using aphakic refractive power
US8801186B2 (en) 2010-10-15 2014-08-12 Lensar, Inc. System and method of scan controlled illumination of structures within an eye
US8876290B2 (en) 2009-07-06 2014-11-04 Wavetec Vision Systems, Inc. Objective quality metric for ocular wavefront measurements
US8882757B2 (en) 2008-11-11 2014-11-11 Avedro, Inc. Eye therapy system
US8911496B2 (en) 2006-07-11 2014-12-16 Refocus Group, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
US8915594B2 (en) 2011-11-25 2014-12-23 Md Lasers & Instruments, Inc. Refraction system for facilitating contact lens fitting
US8992516B2 (en) 2007-07-19 2015-03-31 Avedro, Inc. Eye therapy system
US9072462B2 (en) 2012-09-27 2015-07-07 Wavetec Vision Systems, Inc. Geometric optical power measurement device
US20150196428A1 (en) * 2007-03-13 2015-07-16 Optimedica Corporation Method and apparatus for creating ocular surgical and relaxing incisions
US9180051B2 (en) 2006-01-20 2015-11-10 Lensar Inc. System and apparatus for treating the lens of an eye
US20150335478A1 (en) * 2014-05-23 2015-11-26 Novartis Ag Measuring module including an interface for coupling to a laser device
US9329309B2 (en) 2012-02-27 2016-05-03 E-Vision Smart Optics, Inc. Electroactive lens with multiple depth diffractive structures
US9545338B2 (en) * 2006-01-20 2017-01-17 Lensar, Llc. System and method for improving the accommodative amplitude and increasing the refractive power of the human lens with a laser
US9555111B2 (en) 2012-03-29 2017-01-31 Cxl Ophthalmics, Llc Ocular cross-linking system and method for sealing corneal wounds
US9566301B2 (en) 2012-03-29 2017-02-14 Cxl Ophthalmics, Llc Compositions and methods for treating or preventing diseases associated with oxidative stress
US9622911B2 (en) 2010-09-30 2017-04-18 Cxl Ophthalmics, Llc Ophthalmic treatment device, system, and method of use
US9662010B2 (en) 2014-09-19 2017-05-30 Carl Zeiss Meditec Ag Optical system, comprising a microscopy system and an OCT system
AU2015204392B2 (en) * 2007-03-13 2017-06-22 Amo Development, Llc Apparatus for creating ocular surgical and relaxing incisions
US10463541B2 (en) 2011-03-25 2019-11-05 Lensar, Inc. System and method for correcting astigmatism using multiple paired arcuate laser generated corneal incisions
US10575986B2 (en) 2012-03-29 2020-03-03 Cxl Ophthalmics, Llc Ophthalmic treatment solution delivery devices and delivery augmentation methods
US10758416B2 (en) 2010-01-08 2020-09-01 Amo Development, Llc Method and system for modifying eye tissue and intraocular lenses
US10864114B2 (en) 2010-01-08 2020-12-15 Amo Development, Llc Method and system for modifying eye tissue and intraocular lenses

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8506083B2 (en) 2011-06-06 2013-08-13 Clarity Medical Systems, Inc. Compact wavefront sensor module and its attachment to or integration with an ophthalmic instrument
US8262646B2 (en) 2006-01-20 2012-09-11 Lensar, Inc. System and method for providing the shaped structural weakening of the human lens with a laser
US8820929B2 (en) * 2006-01-20 2014-09-02 Clarity Medical Systems, Inc. Real-time measurement/display/record/playback of wavefront data for use in vision correction procedures
US8777413B2 (en) 2006-01-20 2014-07-15 Clarity Medical Systems, Inc. Ophthalmic wavefront sensor operating in parallel sampling and lock-in detection mode
US9889043B2 (en) 2006-01-20 2018-02-13 Lensar, Inc. System and apparatus for delivering a laser beam to the lens of an eye
DE102006038911A1 (de) * 2006-08-18 2008-02-21 Carl Zeiss Surgical Gmbh Ophthalmoskopie-Vorsatzmodul und Operationsmikroskop mit Ophthalmoskopie-Vorsatzzmodul
ES2655204T3 (es) * 2007-09-06 2018-02-19 Alcon Lensx, Inc. Fijación de objetivo precisa de foto-disrupción quirúrgica
US8333474B2 (en) 2007-10-19 2012-12-18 Wavetec Vision Systems, Inc. Optical instrument alignment system
US8500723B2 (en) 2008-07-25 2013-08-06 Lensar, Inc. Liquid filled index matching device for ophthalmic laser procedures
US9168175B2 (en) * 2008-09-04 2015-10-27 Vladimir Feingold Method for laser cutting a corneal pocket
US8382745B2 (en) 2009-07-24 2013-02-26 Lensar, Inc. Laser system and method for astigmatic corrections in association with cataract treatment
JP2013500086A (ja) 2009-07-24 2013-01-07 レンサー， インク． Ｌａｄａｒを利用した手順を眼の水晶体に実施するシステムおよび方法
EP2456384B1 (en) 2009-07-24 2023-09-20 LENSAR, Inc. System for providing laser shot patterns to the lens of an eye
US8617146B2 (en) 2009-07-24 2013-12-31 Lensar, Inc. Laser system and method for correction of induced astigmatism
US8556425B2 (en) 2010-02-01 2013-10-15 Lensar, Inc. Purkinjie image-based alignment of suction ring in ophthalmic applications
USD694890S1 (en) 2010-10-15 2013-12-03 Lensar, Inc. Laser system for treatment of the eye
USD695408S1 (en) 2010-10-15 2013-12-10 Lensar, Inc. Laser system for treatment of the eye
US8337018B2 (en) * 2010-12-10 2012-12-25 Wavelight Gmbh Surgical microscope
US10219690B2 (en) 2011-03-15 2019-03-05 Adventus Technologies, Inc. Ophthalmic refractor and method of ophthalmic refractor signal analysis
DE102011088039B4 (de) * 2011-12-08 2020-01-16 Leica Microsystems (Schweiz) Ag Operationsmikroskopsystem für die Ophthalmologie und zugehörige Detektionseinheit
JP5996097B2 (ja) 2012-04-30 2016-09-21 クラリティ メディカル システムズ インコーポレイテッド 並行サンプリングおよびロックイン検出モードで作動する眼科用波面センサ
US9332899B2 (en) * 2012-11-06 2016-05-10 Clarity Medical Systems, Inc. Electronic eye marking/registration
CN103576310B (zh) * 2013-03-15 2016-01-27 江苏大学 一种辅助近视、散光人员裸眼使用显微镜的装置
KR101995878B1 (ko) 2013-07-02 2019-07-03 메사츄세츠 인스티튜트 어브 테크놀로지 눈 처방을 결정하는 장치 및 방법
DE102013110425A1 (de) * 2013-09-20 2015-04-09 Karl Storz Gmbh & Co. Kg Okular
CN105813543B (zh) 2013-10-10 2018-09-14 诺华股份有限公司 用于iol屈光力估计值的校正值
DK3102151T3 (en) 2014-02-03 2019-03-04 Hanna Shammas PROCEDURE FOR DETERMINING INTRAOCULAR LENS POWER
US9585561B2 (en) 2014-07-25 2017-03-07 Novartis Ag Ophthalmic surgical microscope with adaptive optics for optical wavefront compensation
DE102014014093B4 (de) * 2014-09-23 2018-10-11 Carl Zeiss Meditec Ag Augenchirurgiesystem und Verfahren zum Betreiben eines Augenchirurgiesystems
WO2016076171A1 (ja) * 2014-11-12 2016-05-19 シャープ株式会社 エレクトロルミネッセンス装置、及び製造方法
CN104614848A (zh) * 2015-02-11 2015-05-13 衡雪源 神经外科多人电子手术显微镜
NZ773818A (en) 2015-03-16 2022-07-29 Magic Leap Inc Methods and systems for diagnosing and treating health ailments
JP6505539B2 (ja) * 2015-07-27 2019-04-24 株式会社トプコン 眼科用顕微鏡
KR20220040511A (ko) 2016-04-08 2022-03-30 매직 립, 인코포레이티드 가변 포커스 렌즈 엘리먼트들을 가진 증강 현실 시스템들 및 방법들
IL268630B2 (en) 2017-02-23 2023-09-01 Magic Leap Inc Display system with variable power reflector
CN108056892A (zh) * 2018-01-15 2018-05-22 青岛市市立医院 一种一体式眼科临床辅助装置
WO2021033561A1 (ja) * 2019-08-16 2021-02-25 株式会社トプコン 眼科装置及び眼科システム
US12121218B2 (en) * 2020-05-11 2024-10-22 Welch Allyn, Inc. Configuring optical light path having beam overlap on image sensor
US20220031512A1 (en) 2020-07-31 2022-02-03 Alcon Inc. Systems and methods for eye cataract removal
CN111772921A (zh) * 2020-08-11 2020-10-16 曹志君 一种眼科白内障手术用多功能剥离钳
EP4098176B1 (en) 2021-06-01 2026-02-25 Wavesense Engineering GmbH Optical apparatus
EP4226844A1 (en) * 2022-02-11 2023-08-16 Leica Instruments (Singapore) Pte. Ltd. Apparatus and method for an imaging device
AU2023343279A1 (en) 2022-09-16 2025-02-13 Alcon Inc. Methods and systems for determining intraocular lens parameters for ophthalmic surgery using an emulated finite elements analysis model

Citations (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172662A (en) * 1976-09-08 1979-10-30 Carl Zeiss Stiftung Eyepiece for measurement of lengths and angles by a microscope
US4911711A (en) * 1986-12-05 1990-03-27 Taunton Technologies, Inc. Sculpture apparatus for correcting curvature of the cornea
US5206672A (en) * 1990-09-05 1993-04-27 Nestle S.A. Surgical optometer
US5329322A (en) * 1992-05-26 1994-07-12 Yancey Don R Palm size autorefractor and fundus topographical mapping instrument
US5455645A (en) * 1994-04-11 1995-10-03 Lacrimedics, Inc. Refractometer for measuring spherical refractive errors
US5493109A (en) * 1994-08-18 1996-02-20 Carl Zeiss, Inc. Optical coherence tomography assisted ophthalmologic surgical microscope
US5796463A (en) * 1996-11-27 1998-08-18 The Regents Of The University Of California Apparatus and method for improving the operation of an autorefractor
US5800533A (en) * 1996-03-18 1998-09-01 Harry C. Eggleston Adjustable intraocular lens implant with magnetic adjustment facilities
US5861937A (en) * 1997-05-30 1999-01-19 Nidek Co., Ltd. Ophthalmic apparatus
US5963300A (en) * 1998-02-17 1999-10-05 Amt Technologies, Corp. Ocular biometer
US5968095A (en) * 1995-05-09 1999-10-19 Pharmacia & Upjohn Groningen Bv Method of selecting an intraocular lens to be implanted into an eye
US6042232A (en) * 1999-01-21 2000-03-28 Leica Microsystems Inc. Automatic optometer evaluation method using data over a wide range of focusing positions
US6271915B1 (en) * 1996-11-25 2001-08-07 Autonomous Technologies Corporation Objective measurement and correction of optical systems using wavefront analysis
US6275718B1 (en) * 1999-03-23 2001-08-14 Philip Lempert Method and apparatus for imaging and analysis of ocular tissue
US6299618B1 (en) * 1999-02-12 2001-10-09 Takeshi Sugiura Intraocular lens insertion device
US20020016629A1 (en) * 2000-03-20 2002-02-07 Sandstedt Christian A. Application of wavefront sensor to lenses capable of post-fabrication power modification
US6382794B1 (en) * 1999-09-27 2002-05-07 Carl Zeiss, Inc. Method and apparatus for mapping a corneal contour and thickness profile
US6394605B1 (en) * 2001-05-23 2002-05-28 Alcon Universal Ltd. Fogging method for a wavefront sensor
US6409345B1 (en) * 2000-08-08 2002-06-25 Tracey Technologies, Llc Method and device for synchronous mapping of the total refraction non-homogeneity of the eye and its refractive components
US20020082629A1 (en) * 2000-10-20 2002-06-27 Bausch & Lomb Incorporated Method and system for improving vision
US20020105617A1 (en) * 2000-05-23 2002-08-08 Sverker Norrby Methods of obtaining ophthalmic lenses providing the eye with reduced aberrations
US20020107567A1 (en) * 2000-11-29 2002-08-08 Thomas Terwee Device for use in eye surgery
US20020118349A1 (en) * 2000-12-27 2002-08-29 Nikon Corporation Position detecting method and unit, optical characteristic measuring method and unit, exposure apparatus, and device manufacturing method
US20020135736A1 (en) * 2000-12-08 2002-09-26 Visx, Inc. Direct wavefront-based corneal ablation treatment program
US20030009156A1 (en) * 2001-06-05 2003-01-09 Adaptive Optics Associates, Inc. Method of treating the human eye with a wavefront sensor-based ophthalmic instrument
US6508812B1 (en) * 2000-03-13 2003-01-21 Memphis Eye & Cataract Associates Ambulatory Surgery Center Control system for high resolution high speed digital micromirror device for laser refractive eye surgery
US6550917B1 (en) * 2000-02-11 2003-04-22 Wavefront Sciences, Inc. Dynamic range extension techniques for a wavefront sensor including use in ophthalmic measurement
US6585723B1 (en) * 1998-09-04 2003-07-01 Nidek Co., Ltd. Corneal surgery apparatus
US6588902B2 (en) * 2000-09-28 2003-07-08 Nidek Co., Ltd. Ophthalmic apparatus
US6601956B1 (en) * 1998-11-13 2003-08-05 Benedikt Jean Method and apparatus for the simultaneous determination of surface topometry and biometry of the eye
US20030174281A1 (en) * 2000-10-20 2003-09-18 Herekar Satish Venkatesh System and method for performing optical corrective procedures with real-time feedback
US6626538B1 (en) * 2000-07-12 2003-09-30 Peter N. Arrowsmith Method for determining the power of an intraocular lens used for the treatment of myopia
US6626535B2 (en) * 2000-12-29 2003-09-30 Bausch & Lomb Incorporated Lens-eye model and method for predicting in-vivo lens performance
US6685319B2 (en) * 2000-09-21 2004-02-03 Visx, Incorporated Enhanced wavefront ablation system
US6736510B1 (en) * 2003-02-04 2004-05-18 Ware Tec Vision Systems, Inc. Ophthalmic talbot-moire wavefront sensor
US6761454B2 (en) * 2002-02-13 2004-07-13 Ophthonix, Inc. Apparatus and method for determining objective refraction using wavefront sensing
US20040156014A1 (en) * 2002-11-29 2004-08-12 Piers Patricia Ann Multifocal ophthalmic lens
US6781681B2 (en) * 2001-12-10 2004-08-24 Ophthonix, Inc. System and method for wavefront measurement
US20040176753A1 (en) * 2001-06-26 2004-09-09 Manfred Dick Method and device for representing an operative field during laser operations
US20040189938A1 (en) * 2003-03-25 2004-09-30 Eagan Barry T. Moire aberrometer
US20040223214A1 (en) * 2003-05-09 2004-11-11 3M Innovative Properties Company Scanning laser microscope with wavefront sensor
US6836374B2 (en) * 2002-11-20 2004-12-28 Powervision, Inc. Lens system and methods for power adjustment
US20040263785A1 (en) * 2003-06-16 2004-12-30 Visx, Inc. Methods and devices for registering optical measurement datasets of an optical system
US20050105044A1 (en) * 2003-11-14 2005-05-19 Laurence Warden Lensometers and wavefront sensors and methods of measuring aberration
US6905641B2 (en) * 2000-09-26 2005-06-14 Calhoun Vision, Inc. Delivery system for post-operative power adjustment of adjustable lens
US20050203422A1 (en) * 2004-02-10 2005-09-15 Jay Wei Optical apparatus and methods for performing eye examinations
US20050225725A1 (en) * 2003-11-14 2005-10-13 Laurence Warden Ophthalmic diagnostic instrument
US20050243276A1 (en) * 2004-04-20 2005-11-03 Wavetec Vision Systems, Inc. Integrated surgical microscope and wavefront sensor
US6997555B2 (en) * 1999-12-03 2006-02-14 Carl Zeiss Meditec Ag Method for determining vision defects and for collecting data for correcting vision defects of the eye by interaction of a patient with an examiner and apparatus therefor
US7018376B2 (en) * 2001-01-29 2006-03-28 Intralase Corp. Ocular fixation and stabilization device for ophthalmic surgical applications
US7034949B2 (en) * 2001-12-10 2006-04-25 Ophthonix, Inc. Systems and methods for wavefront measurement
US7490940B2 (en) * 2002-02-13 2009-02-17 Ophthonix, Inc. Method for determining objective refraction using wavefront sensing
US20090103050A1 (en) * 2007-10-19 2009-04-23 Wavetec Vision Systems, Inc. Optical instrument alignment system
US7556378B1 (en) * 2003-04-10 2009-07-07 Tsontcho Ianchulev Intraoperative estimation of intraocular lens power

Family Cites Families (187)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1209451A (en) 1967-01-16 1970-10-21 Int Research & Dev Co Ltd Improvements in and relating to apparatus for measuring parts of the human eye
US3947186A (en) 1975-03-17 1976-03-30 Bradford Howland Eye-test lens and method
US4019813A (en) 1976-01-19 1977-04-26 Baylor College Of Medicine Optical apparatus for obtaining measurements of portions of the eye
DE2616139C3 (de) 1976-04-13 1979-03-22 Optische Werke G. Rodenstock, 8000 Muenchen Augenuntersuchungsgerät zur Messung der retinalen Sehschärfe
JPS53111697A (en) 1977-03-11 1978-09-29 Asahi Optical Co Ltd Optical system of objective automatic ophthalmoscope
US4293198A (en) 1977-09-21 1981-10-06 Canon Kabushiki Kaisha Eye refractometer
JPS5542624A (en) 1978-09-20 1980-03-26 Canon Kk Automatic eye refraction measuring system
JPS5586437A (en) 1978-12-22 1980-06-30 Nippon Chemical Ind Objective eye refractive power measuring device
JPS55125844A (en) 1979-03-20 1980-09-29 Canon Kk Optic refractometer
JPS55160538A (en) 1979-06-02 1980-12-13 Nippon Chemical Ind Objective eye refraction device
JPS5652032A (en) 1979-10-05 1981-05-09 Canon Kk Eye refrating force measuring apparatus
US4650301A (en) 1980-10-31 1987-03-17 Humphrey Instruments, Inc. Objective refractor for the eye
US4640596A (en) 1980-10-31 1987-02-03 Humphrey Instruments, Inc. Objective refractor for the eye
US4669835A (en) 1980-10-31 1987-06-02 Humphrey Instruments, Inc. Objective refractor for the eye
IL63264A (en) 1980-11-04 1986-07-31 Israel Atomic Energy Comm Topographical mapping system and method
US4541697A (en) 1981-03-03 1985-09-17 Randwal Instrument Co., Inc. Ophthalmic testing devices
DE3204876C2 (de) 1982-02-12 1986-10-16 Helmut Dr.rer.nat. 8000 München Krueger Vorrichtung zur Bestimmung des Refraktionszustandes des menschlichen Auges
US5374193A (en) 1983-01-25 1994-12-20 Trachtman; Joseph N. Methods and apparatus for use in alpha training, EMG training and dichotic learning
US4692003A (en) 1983-11-07 1987-09-08 Adachi Iwao P Real-time analysis keratometer
US4669466A (en) 1985-01-16 1987-06-02 Lri L.P. Method and apparatus for analysis and correction of abnormal refractive errors of the eye
US4710193A (en) 1986-08-18 1987-12-01 David Volk Accommodating intraocular lens and lens series and method of lens selection
US4964715A (en) 1987-02-17 1990-10-23 Richards William D Comparative surgical keratometer
US4995716A (en) * 1989-03-09 1991-02-26 Par Technology Corporation Method and apparatus for obtaining the topography of an object
DE3919181C1 (https=) 1989-06-12 1990-09-06 Heine Optotechnik Gmbh & Co Kg, 8036 Herrsching, De
US4984883A (en) 1989-07-21 1991-01-15 Joseph Winocur Translation insensitive keratometer using moire deflectometry
US5080477A (en) 1989-08-28 1992-01-14 Yoshi Adachi Surface topographer
DE4003698C2 (de) 1990-02-07 1994-09-08 Wild Heerbrugg Ag Wellenfrontsensor
US5157427A (en) 1990-04-16 1992-10-20 Allergan Humphrey Objective refractor
JPH0431813A (ja) * 1990-05-28 1992-02-04 Nikon Corp 中間変倍用ズームレンズを備えた顕微鏡
WO1992001417A1 (en) 1990-07-19 1992-02-06 Horwitz Larry S Vision measurement and correction
US5258791A (en) 1990-07-24 1993-11-02 General Electric Company Spatially resolved objective autorefractometer
JP2942321B2 (ja) 1990-08-10 1999-08-30 株式会社ニデック 徹照像撮影装置
JP3165144B2 (ja) 1990-10-26 2001-05-14 株式会社ニデック 双眼倒像鏡式レーザ治療装置
US5164750A (en) 1990-11-08 1992-11-17 Yoshi Adachi Aspheric surface topographer
US5208619A (en) 1990-11-16 1993-05-04 Allergan Humphrey Automatic refractor, lensmeter and keratometer utilizing Badal optics
JPH04200436A (ja) 1990-11-29 1992-07-21 Canon Inc 眼科装置
US5684561A (en) 1992-05-26 1997-11-04 Daphne Eye Technologies Device and method for evaluation of refraction of the eye
US5841511A (en) 1992-06-02 1998-11-24 Eyesys Technologies, Inc. Method of corneal analysis using a checkered placido apparatus
US5282852A (en) 1992-09-02 1994-02-01 Alcon Surgical, Inc. Method of calculating the required power of an intraocular lens
US5307097A (en) 1992-11-05 1994-04-26 Kera-Metrics, Inc. Corneal topography system including single-direction shearing of holograph grating in orthogonal directions
DE4310561A1 (de) * 1993-03-26 1994-09-29 Klaus Prof Dipl Phys Dietrich Vorrichtung und Verfahren zur Bestimmung von Sehschärfe, Refraktion und zur Beobachtung der Augenoberfläche
IL112395A (en) 1995-01-19 1998-09-24 Rotlex 1994 Ltd Optical device and a method of utilizing such device for optically examining objects
US5968094A (en) 1995-09-18 1999-10-19 Emmetropia, Inc. Compound intraocular lens
JP3592416B2 (ja) 1995-10-31 2004-11-24 晃敏 吉田 眼内物質の測定装置
JP3683059B2 (ja) 1995-12-13 2005-08-17 晃敏 吉田 眼球から発生する光による眼内物質の測定装置
US6043885A (en) 1996-07-12 2000-03-28 Essilor International Fringe deflectometry apparatus and method
FR2753544B1 (fr) 1996-09-17 1998-11-27 Thomson Csf Systeme de controle de faisceau lumineux
JP3630884B2 (ja) 1996-10-25 2005-03-23 株式会社ニデック 眼科検査装置
US20010041884A1 (en) 1996-11-25 2001-11-15 Frey Rudolph W. Method for determining and correcting vision
US5777719A (en) 1996-12-23 1998-07-07 University Of Rochester Method and apparatus for improving vision and the resolution of retinal images
JPH1124434A (ja) 1997-06-30 1999-01-29 Ricoh Co Ltd 駆動接離機構
US6096077A (en) 1997-08-20 2000-08-01 Thinoptx, Inc. Deformable intraocular corrective lens
JP3313309B2 (ja) 1997-08-21 2002-08-12 株式会社トプコン 眼科装置
JP3763958B2 (ja) 1998-01-20 2006-04-05 株式会社ニデック 眼科装置
US6007204A (en) 1998-06-03 1999-12-28 Welch Allyn, Inc. Compact ocular measuring system
US6251101B1 (en) 1998-06-26 2001-06-26 Visx, Incorporated Surgical laser system microscope with separated ocular and objective lenses
US6004313A (en) 1998-06-26 1999-12-21 Visx, Inc. Patient fixation system and method for laser eye surgery
BR9913130A (pt) * 1998-08-19 2001-05-08 Autonomous Technologies Corp Aparelho e método para medir defeitos de visão de um olho humano
US6598975B2 (en) 1998-08-19 2003-07-29 Alcon, Inc. Apparatus and method for measuring vision defects of a human eye
GB9820664D0 (en) * 1998-09-23 1998-11-18 Isis Innovation Wavefront sensing device
US7303281B2 (en) 1998-10-07 2007-12-04 Tracey Technologies, Llc Method and device for determining refractive components and visual function of the eye for vision correction
UA67870C2 (uk) 2002-10-04 2004-07-15 Сергій Васильович Молебний Спосіб вимірювання хвильових аберацій ока
JP4769923B2 (ja) 1998-12-10 2011-09-07 カール ツァイス メディテック アクチエンゲゼルシャフト 眼内レンズの計算に好適な、眼の軸方向長さ及び／又は角膜の曲率及び／又は前房深さを非接触的に測定するための一体化装置
DE19857001A1 (de) 1998-12-10 2000-06-15 Zeiss Carl Jena Gmbh Anordnung und Verfahren zur berührungslosen Messung der Achslänge, der Hornhautkrümmung und/oder der Vorderkammertiefe des Auges
JP2000197607A (ja) 1998-12-30 2000-07-18 Canon Inc 検眼装置
US6050687A (en) 1999-06-11 2000-04-18 20/10 Perfect Vision Optische Geraete Gmbh Method and apparatus for measurement of the refractive properties of the human eye
US6262328B1 (en) 1999-06-11 2001-07-17 Westinghouse Savannah River Company Container and method for absorbing and reducing hydrogen concentration
US6002484A (en) * 1999-06-18 1999-12-14 Rozema; Jos J. Phase contrast aberroscope
US6086204A (en) 1999-09-20 2000-07-11 Magnante; Peter C. Methods and devices to design and fabricate surfaces on contact lenses and on corneal tissue that correct the eye's optical aberrations
AU1085801A (en) * 1999-10-14 2001-04-23 Iridex Corporation Therapeutic use of long-pulse laser photocoagulation in combination with other treatment modalities
US6264328B1 (en) 1999-10-21 2001-07-24 University Of Rochester Wavefront sensor with off-axis illumination
ES2199095T3 (es) * 1999-10-21 2007-03-16 Technolas Gmbh Ophthalmologische Systeme Reconocimiento y seguimiento del iris para el tratamiento optico.
US6199986B1 (en) 1999-10-21 2001-03-13 University Of Rochester Rapid, automatic measurement of the eye's wave aberration
ES2390397T3 (es) * 1999-10-21 2012-11-12 Technolas Perfect Vision Gmbh Perfil corneal personalizado
US6419671B1 (en) 1999-12-23 2002-07-16 Visx, Incorporated Optical feedback system for vision correction
AU778319B2 (en) * 1999-12-23 2004-11-25 Shevlin Technologies Limited A display device
US6439720B1 (en) 2000-01-27 2002-08-27 Aoptics, Inc. Method and apparatus for measuring optical aberrations of the human eye
US7455407B2 (en) 2000-02-11 2008-11-25 Amo Wavefront Sciences, Llc System and method of measuring and mapping three dimensional structures
US6659613B2 (en) 2000-03-27 2003-12-09 Board Of Regents, The University Of Texas System Methods and systems for measuring local scattering and aberration properties of optical media
WO2001078585A2 (en) 2000-04-19 2001-10-25 Alcon Universal Ltd. Wavefront sensor for objective measurement of an optical system and associated methods
JP4515687B2 (ja) 2000-04-19 2010-08-04 アルコン・レフラクティヴ・ホライズンズ・インク． 眼のレジストレーション及び乱視のアライメント制御システム及び方法
US6338559B1 (en) 2000-04-28 2002-01-15 University Of Rochester Apparatus and method for improving vision and retinal imaging
US6460997B1 (en) 2000-05-08 2002-10-08 Alcon Universal Ltd. Apparatus and method for objective measurements of optical systems using wavefront analysis
WO2001085045A1 (en) * 2000-05-09 2001-11-15 Memphis Eye & Cataract Associates Ambulatory Surgery Center (Dba Meca Laser And Surgery Center) Method and system for control of high resolution high speed digital micromirror device for laser refractive eye surgery
US6382795B1 (en) 2000-05-20 2002-05-07 Carl Zeiss, Inc. Method and apparatus for measuring refractive errors of an eye
US6382793B1 (en) 2000-05-20 2002-05-07 Carl Zeiss, Inc. Method and apparatus for measuring a wavefront
DE10042751A1 (de) 2000-08-31 2002-03-14 Thomas Hellmuth System zur berührungslosen Vermessung der optischen Abbildungsqualität eines Auges
EP1324689B1 (en) 2000-10-10 2006-08-02 University of Rochester Determination of ocular refraction from wavefront aberration data
US6827444B2 (en) 2000-10-20 2004-12-07 University Of Rochester Rapid, automatic measurement of the eye's wave aberration
SE0004829D0 (sv) 2000-12-22 2000-12-22 Pharmacia Groningen Bv Methods of obtaining ophthalmic lenses providing the eye with reduced aberrations
DE10103763C2 (de) 2001-01-27 2003-04-03 Zeiss Carl Meditec Ag Verfahren und Vorrichtung zur subjektiven Bestimmung von Abbildungsfehlern höherer Ordnung
US20020133228A1 (en) 2001-03-13 2002-09-19 Sarver Edwin J. Adjustable intraocular lens
US20040167622A1 (en) 2001-03-26 2004-08-26 Sunalp Murad A. Temporary refractive intraocular lens and methods of use
JP4694025B2 (ja) 2001-04-18 2011-06-01 株式会社トプコン 眼特性測定装置
BR0209122A (pt) 2001-04-18 2004-07-27 Bausch & Lomb Refração manifesta objetiva
EP1390802A1 (en) 2001-04-27 2004-02-25 Novartis AG Automatic lens design and manufacturing system
JP4618527B2 (ja) * 2001-04-27 2011-01-26 日立オートモティブシステムズ株式会社 気圧式倍力装置
US6561648B2 (en) 2001-05-23 2003-05-13 David E. Thomas System and method for reconstruction of aberrated wavefronts
US7044604B1 (en) 2001-07-11 2006-05-16 Arrowsmith Peter N Method for determining the power of an intraocular lens used for the treatment of myopia
US6693280B2 (en) * 2001-08-03 2004-02-17 Sensir Technologies, L.L.C. Mid-infrared spectrometer attachment to light microscopes
FR2828396B1 (fr) 2001-08-12 2004-05-07 Samuel Henri Bucourt Dispositif de mesure des aberrations d'un systeme de type oeil
US6634751B2 (en) 2001-09-10 2003-10-21 Bausch & Lomb Incorporated Intraocular lens derivation system
US6575572B2 (en) 2001-09-21 2003-06-10 Carl Zeiss Ophthalmic Systems, Inc. Method and apparatus for measuring optical aberrations of an eye
US6554429B1 (en) 2001-10-15 2003-04-29 Alcon, Inc. Method for determining accommodation
DE10154194A1 (de) 2001-11-07 2003-05-22 Asclepion Meditec Ag Verfahren und Vorrichtung zur Messung des Dynamischen Verhaltens eines optischen Systems
US6739721B2 (en) 2001-12-11 2004-05-25 Bausch And Lomb, Inc Method and apparatus for calibrating and certifying accuracy of a wavefront sensing device
US6637884B2 (en) 2001-12-14 2003-10-28 Bausch & Lomb Incorporated Aberrometer calibration
US6736509B2 (en) 2001-12-21 2004-05-18 Bausch And Lomb, Inc. Aberrometer illumination apparatus and method
DE10202509A1 (de) * 2002-01-23 2003-07-31 Leica Microsystems Ophthalmo-Operationsmikroskop
WO2003062743A1 (en) * 2002-01-24 2003-07-31 Nano-Or Technologies (Israel) Ltd. Improved spatial wavefront analysis and 3d measurement
US7130835B2 (en) 2002-03-28 2006-10-31 Bausch & Lomb Incorporated System and method for predictive ophthalmic correction
US7077522B2 (en) 2002-05-03 2006-07-18 University Of Rochester Sharpness metric for vision quality
WO2003102498A1 (en) * 2002-05-30 2003-12-11 Visx, Inc. “tracking torsional eye orientation and position”
EP1511978A4 (en) 2002-05-31 2008-03-05 Wavefront Sciences Inc METHOD AND SYSTEM FOR DETECTING AND ANALYZING THE WAVE FRONT OF AN OPTICAL TRANSMISSION SYSTEM
DE10227120A1 (de) * 2002-06-15 2004-03-04 Carl Zeiss Jena Gmbh Mikroskop, insbesondere Laserscanningmikroskop mit adaptiver optischer Einrichtung
US6786603B2 (en) 2002-09-25 2004-09-07 Bausch & Lomb Incorporated Wavefront-generated custom ophthalmic surfaces
CN2572937Y (zh) * 2002-10-08 2003-09-17 黄长征 具有屈光检测功能的眼科手术显微镜
US7406263B2 (en) * 2002-10-17 2008-07-29 Aoptix Technologies Combined wavefront sensor and data detector for a free space optical communications system with adaptive optics
SE0203564D0 (sv) 2002-11-29 2002-11-29 Pharmacia Groningen Bv Multifocal opthalmic lens
US6658282B1 (en) 2002-12-19 2003-12-02 Bausch & Lomb Incorporated Image registration system and method
MXPA05010791A (es) 2003-04-09 2005-12-15 Visx Inc Analizador de calibracion de frente de onda y metodos de uso del mismo.
DE602004032529D1 (de) 2003-04-11 2011-06-16 Bausch & Lomb System und methode zur erfassung von daten eines auges
US7357509B2 (en) 2003-04-28 2008-04-15 University Of Rochester Metrics to predict subjective impact of eye's wave aberration
DE10344781A1 (de) 2003-09-23 2005-04-14 Carl Zeiss Meditec Ag Verfahren zur Bestimmung einer Intraokularlinse
JP4233426B2 (ja) 2003-09-30 2009-03-04 株式会社ニデック 眼屈折力測定装置
CA2544183A1 (en) 2003-10-28 2005-05-19 Welch Allyn, Inc. Digital documenting ophthalmoscope
US20050117117A1 (en) 2003-12-02 2005-06-02 Dan Bourla Intraoperative biometry
WO2005057252A2 (en) 2003-12-02 2005-06-23 Wavetec Vision Systems, Inc. Interactive refractor incorporating wavefront sensing and adaptive optics
US7070276B2 (en) 2003-12-04 2006-07-04 Rensselaer Polytechnic Institute Apparatus and method for accommodative stimulation of an eye and simultaneous ipsilateral accommodative imaging
US7857451B2 (en) 2003-12-12 2010-12-28 Indiana University Research And Technology Corporation System and method for optimizing clinical optic prescriptions
US7336371B1 (en) 2004-01-29 2008-02-26 Carl Zeiss Smt Ag Apparatus and method for measuring the wavefront of an optical system
US7490938B2 (en) 2004-02-09 2009-02-17 Robert Adam Latkany Method, device and computer program for selecting an intraocular lens for an aphakic eye that has previously been subjected to refractive surgery
JP2005237901A (ja) * 2004-03-01 2005-09-08 Nidek Co Ltd 眼科装置
US7476248B2 (en) 2004-04-06 2009-01-13 Alcon, Inc. Method of calculating the required lens power for an opthalmic implant
EP1758531A1 (en) 2004-04-09 2007-03-07 Roger F. Steinert Laser system for vision correction
US7461938B2 (en) 2004-06-30 2008-12-09 Ophthonix, Inc. Apparatus and method for determining sphere and cylinder components of subjective refraction using objective wavefront measurement
US20060007395A1 (en) * 2004-07-06 2006-01-12 Mayo William T System and method for wavefront measurement
JP4492858B2 (ja) 2004-07-20 2010-06-30 株式会社ニデック 眼科装置及び眼内屈折力分布算出プログラム
JP4609838B2 (ja) * 2004-08-10 2011-01-12 株式会社ニデック 角膜手術装置
DE102004055683B4 (de) 2004-10-26 2006-09-07 Carl Zeiss Surgical Gmbh Augenchirurgie-Mikroskopiesystem und Verfahren hierzu
SE0402769D0 (sv) 2004-11-12 2004-11-12 Amo Groningen Bv Method of selecting intraocular lenses
US20060126018A1 (en) 2004-12-10 2006-06-15 Junzhong Liang Methods and apparatus for wavefront sensing of human eyes
US20060126019A1 (en) 2004-12-10 2006-06-15 Junzhong Liang Methods and systems for wavefront analysis
US20060135952A1 (en) 2004-12-21 2006-06-22 Curatu Eugene O Corrective intraocular lens and associated methods
CN100585449C (zh) 2005-01-27 2010-01-27 伦斯勒理工学院 可适应性扫描光学显微镜
KR100686093B1 (ko) 2005-02-03 2007-02-23 엘지전자 주식회사 영상기기 및 그의 채널 운용 방법
FR2881520B1 (fr) 2005-02-03 2007-10-12 Lyuboshenko Igor Obtention d'une image de phase a partir d'une image d'intensite
US8439502B2 (en) 2005-03-09 2013-05-14 Advanced Vision Engineering, Inc Algorithms and methods for determining aberration-induced vision symptoms in the eye from wave aberration
US7537344B2 (en) 2005-03-09 2009-05-26 Advanced Vision Engineering, Inc Methods for specifying image quality of human eyes from wavefront measurements
PL2062553T3 (pl) 2005-04-05 2011-01-31 Alcon Inc Optymalne współczynniki kształtu IOL dla soczewek oftalmicznych
US7441901B2 (en) 2005-06-14 2008-10-28 Advanced Vision Engineering, Inc. Multitask vision architecture for refractive vision corrections
US20060279699A1 (en) 2005-06-14 2006-12-14 Advanced Vision Engineering, Inc Wavefront fusion algorithms for refractive vision correction and vision diagnosis
KR101248492B1 (ko) 2005-07-29 2013-04-03 알콘 리프랙티브호리존스, 인코포레이티드 안과용 장치의 위치결정 시스템 및 관련 방법
US20070024808A1 (en) 2005-07-29 2007-02-01 Alcon Refractivehorizons, Inc. Ophthalmic device lateral positioning system and associated methods
WO2007035334A2 (en) 2005-09-19 2007-03-29 Advanced Vision Engineering, Inc. Methods and apparatus for comprehensive vision diagnosis
JP5085858B2 (ja) 2005-09-27 2012-11-28 株式会社ニデック 眼屈折力測定装置
US20070083261A1 (en) 2005-10-07 2007-04-12 Colvard David M Method of maintaining the preoperative dimensions of the eye in an intraocular lens placement procedure
US7445335B2 (en) 2006-01-20 2008-11-04 Clarity Medical Systems, Inc. Sequential wavefront sensor
US8100530B2 (en) 2006-01-20 2012-01-24 Clarity Medical Systems, Inc. Optimizing vision correction procedures
US7475989B2 (en) 2006-03-14 2009-01-13 Amo Manufacturing Usa, Llc Shack-Hartmann based integrated autorefraction and wavefront measurements of the eye
US7616330B2 (en) 2006-04-07 2009-11-10 AMO Wavefront Sciences, LLP Geometric measurement system and method of measuring a geometric characteristic of an object
ES2617061T3 (es) 2006-04-11 2017-06-15 Cognoptix, Inc Procesamiento de imágenes oculares
US20080033546A1 (en) 2006-05-31 2008-02-07 Junzhong Liang Methods and apparatus for improving vision
US20080004610A1 (en) 2006-06-30 2008-01-03 David Miller System for calculating IOL power
NL2000221C2 (nl) 2006-09-08 2008-03-11 Akkolens Int Bv Inrichting en werkwijze voor het meten van de optische eigenschappen van een oog in combinatie met een operatiemicroscoop.
US7478908B2 (en) 2006-09-27 2009-01-20 Bausch & Lomb Incorporated Apparatus and method for determining a position of an eye
US20080084541A1 (en) 2006-10-06 2008-04-10 Ming Lai Ophthalmic system and method
AU2007317262B2 (en) 2006-11-09 2011-10-20 Amo Wavefront Sciences, Llc. Method and apparatus for obtaining the distance from an optical measurement instrument to and object under test
WO2008141304A2 (en) 2007-05-11 2008-11-20 Amo Manufacturing Usa, Llc Combined wavefront and topography systems and methods
US7832864B2 (en) 2007-06-15 2010-11-16 The Arizona Board Of Regents On Behalf Of The University Of Arizona Inverse optical design
US7976163B2 (en) 2007-06-27 2011-07-12 Amo Wavefront Sciences Llc System and method for measuring corneal topography
US8414123B2 (en) 2007-08-13 2013-04-09 Novartis Ag Toric lenses alignment using pre-operative images
US20090096987A1 (en) 2007-10-10 2009-04-16 Ming Lai Eye Measurement Apparatus and a Method of Using Same
US7594729B2 (en) 2007-10-31 2009-09-29 Wf Systems, Llc Wavefront sensor
US8128228B2 (en) 2007-12-19 2012-03-06 Wf Systems Llc Devices and methods for measuring axial distances
US8480659B2 (en) 2008-07-25 2013-07-09 Lensar, Inc. Method and system for removal and replacement of lens material from the lens of an eye
US8657445B2 (en) 2008-09-11 2014-02-25 Iol Innovations Aps System and method for determining and predicting IOL power in situ
WO2010035139A2 (en) 2008-09-29 2010-04-01 Sifi Diagnostic Spa Systems and methods for designing and implanting customized biometric intraocular lens
US8550624B2 (en) 2008-11-06 2013-10-08 Wavetec Vision Systems, Inc. Optical angular measurement system for ophthalmic applications and method for positioning of a toric intraocular lens with increased accuracy
DE102008062908B4 (de) 2008-12-23 2011-01-20 Carl Zeiss Ag Augenchirurgiesystem
US8876290B2 (en) 2009-07-06 2014-11-04 Wavetec Vision Systems, Inc. Objective quality metric for ocular wavefront measurements
CN104367299B (zh) 2009-07-14 2017-09-15 波技术视觉系统公司 眼科手术测量系统
EP2453822B1 (en) 2009-07-14 2014-08-20 WaveTec Vision Systems, Inc. Determination of the effective lens position of an intraocular lens using aphakic refractive power
DE102009037841B4 (de) 2009-08-18 2020-01-23 Carl Zeiss Meditec Ag Optisches System mit Wellenfrontanalysesystem und Baugruppe mit Wellenfrontanalysesystem für ein Mikroskop mit Mikroskopchassis
CA2880482C (en) 2012-09-27 2020-03-10 Applied Medical Resources Corporation Surgical training model for laparoscopic procedures
US9072462B2 (en) 2012-09-27 2015-07-07 Wavetec Vision Systems, Inc. Geometric optical power measurement device
JP2014079517A (ja) 2012-10-18 2014-05-08 Canon Inc 眼科装置

Patent Citations (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172662A (en) * 1976-09-08 1979-10-30 Carl Zeiss Stiftung Eyepiece for measurement of lengths and angles by a microscope
US4911711A (en) * 1986-12-05 1990-03-27 Taunton Technologies, Inc. Sculpture apparatus for correcting curvature of the cornea
US5206672A (en) * 1990-09-05 1993-04-27 Nestle S.A. Surgical optometer
US5329322A (en) * 1992-05-26 1994-07-12 Yancey Don R Palm size autorefractor and fundus topographical mapping instrument
US5455645A (en) * 1994-04-11 1995-10-03 Lacrimedics, Inc. Refractometer for measuring spherical refractive errors
US5493109A (en) * 1994-08-18 1996-02-20 Carl Zeiss, Inc. Optical coherence tomography assisted ophthalmologic surgical microscope
US5968095A (en) * 1995-05-09 1999-10-19 Pharmacia & Upjohn Groningen Bv Method of selecting an intraocular lens to be implanted into an eye
US5800533A (en) * 1996-03-18 1998-09-01 Harry C. Eggleston Adjustable intraocular lens implant with magnetic adjustment facilities
US6271915B1 (en) * 1996-11-25 2001-08-07 Autonomous Technologies Corporation Objective measurement and correction of optical systems using wavefront analysis
US5796463A (en) * 1996-11-27 1998-08-18 The Regents Of The University Of California Apparatus and method for improving the operation of an autorefractor
US5861937A (en) * 1997-05-30 1999-01-19 Nidek Co., Ltd. Ophthalmic apparatus
US5963300A (en) * 1998-02-17 1999-10-05 Amt Technologies, Corp. Ocular biometer
US6585723B1 (en) * 1998-09-04 2003-07-01 Nidek Co., Ltd. Corneal surgery apparatus
US6601956B1 (en) * 1998-11-13 2003-08-05 Benedikt Jean Method and apparatus for the simultaneous determination of surface topometry and biometry of the eye
US6042232A (en) * 1999-01-21 2000-03-28 Leica Microsystems Inc. Automatic optometer evaluation method using data over a wide range of focusing positions
US6299618B1 (en) * 1999-02-12 2001-10-09 Takeshi Sugiura Intraocular lens insertion device
US6275718B1 (en) * 1999-03-23 2001-08-14 Philip Lempert Method and apparatus for imaging and analysis of ocular tissue
US6382794B1 (en) * 1999-09-27 2002-05-07 Carl Zeiss, Inc. Method and apparatus for mapping a corneal contour and thickness profile
US6997555B2 (en) * 1999-12-03 2006-02-14 Carl Zeiss Meditec Ag Method for determining vision defects and for collecting data for correcting vision defects of the eye by interaction of a patient with an examiner and apparatus therefor
US6550917B1 (en) * 2000-02-11 2003-04-22 Wavefront Sciences, Inc. Dynamic range extension techniques for a wavefront sensor including use in ophthalmic measurement
US6508812B1 (en) * 2000-03-13 2003-01-21 Memphis Eye & Cataract Associates Ambulatory Surgery Center Control system for high resolution high speed digital micromirror device for laser refractive eye surgery
US20020016629A1 (en) * 2000-03-20 2002-02-07 Sandstedt Christian A. Application of wavefront sensor to lenses capable of post-fabrication power modification
US20020105617A1 (en) * 2000-05-23 2002-08-08 Sverker Norrby Methods of obtaining ophthalmic lenses providing the eye with reduced aberrations
US6626538B1 (en) * 2000-07-12 2003-09-30 Peter N. Arrowsmith Method for determining the power of an intraocular lens used for the treatment of myopia
US6409345B1 (en) * 2000-08-08 2002-06-25 Tracey Technologies, Llc Method and device for synchronous mapping of the total refraction non-homogeneity of the eye and its refractive components
US6685319B2 (en) * 2000-09-21 2004-02-03 Visx, Incorporated Enhanced wavefront ablation system
US6905641B2 (en) * 2000-09-26 2005-06-14 Calhoun Vision, Inc. Delivery system for post-operative power adjustment of adjustable lens
US6588902B2 (en) * 2000-09-28 2003-07-08 Nidek Co., Ltd. Ophthalmic apparatus
US20020082629A1 (en) * 2000-10-20 2002-06-27 Bausch & Lomb Incorporated Method and system for improving vision
US6908196B2 (en) * 2000-10-20 2005-06-21 Wavefront Sciences, Inc. System and method for performing optical corrective procedures with real-time feedback
US6926710B2 (en) * 2000-10-20 2005-08-09 Bausch And Lomb Incorporated Method and system for improving vision
US20030174281A1 (en) * 2000-10-20 2003-09-18 Herekar Satish Venkatesh System and method for performing optical corrective procedures with real-time feedback
US20020107567A1 (en) * 2000-11-29 2002-08-08 Thomas Terwee Device for use in eye surgery
US20020135736A1 (en) * 2000-12-08 2002-09-26 Visx, Inc. Direct wavefront-based corneal ablation treatment program
US20020118349A1 (en) * 2000-12-27 2002-08-29 Nikon Corporation Position detecting method and unit, optical characteristic measuring method and unit, exposure apparatus, and device manufacturing method
US6626535B2 (en) * 2000-12-29 2003-09-30 Bausch & Lomb Incorporated Lens-eye model and method for predicting in-vivo lens performance
US7018376B2 (en) * 2001-01-29 2006-03-28 Intralase Corp. Ocular fixation and stabilization device for ophthalmic surgical applications
US6394605B1 (en) * 2001-05-23 2002-05-28 Alcon Universal Ltd. Fogging method for a wavefront sensor
US7448752B2 (en) * 2001-06-05 2008-11-11 Northrop Grumman Corporation Method of treating the human eye with a wavefront sensor-based ophthalmic instrument
US7350920B2 (en) * 2001-06-05 2008-04-01 Bruce Martin Levine Wavefront sensing apparatus with adaptive optics
US20030009156A1 (en) * 2001-06-05 2003-01-09 Adaptive Optics Associates, Inc. Method of treating the human eye with a wavefront sensor-based ophthalmic instrument
US6609794B2 (en) * 2001-06-05 2003-08-26 Adaptive Optics Associates, Inc. Method of treating the human eye with a wavefront sensor-based ophthalmic instrument
US6572230B2 (en) * 2001-06-05 2003-06-03 Metrologic Instruments, Inc. Ophthalmic instrument having an integral wavefront sensor and display device that displays a graphical representation of high order aberrations of the human eye measured by the wavefront sensor
US7066928B2 (en) * 2001-06-26 2006-06-27 Carl Zeiss Meditec Ag Method and device for representing an operative field during laser operations
US20040176753A1 (en) * 2001-06-26 2004-09-09 Manfred Dick Method and device for representing an operative field during laser operations
US6781681B2 (en) * 2001-12-10 2004-08-24 Ophthonix, Inc. System and method for wavefront measurement
US7034949B2 (en) * 2001-12-10 2006-04-25 Ophthonix, Inc. Systems and methods for wavefront measurement
US7490940B2 (en) * 2002-02-13 2009-02-17 Ophthonix, Inc. Method for determining objective refraction using wavefront sensing
US6761454B2 (en) * 2002-02-13 2004-07-13 Ophthonix, Inc. Apparatus and method for determining objective refraction using wavefront sensing
US6836374B2 (en) * 2002-11-20 2004-12-28 Powervision, Inc. Lens system and methods for power adjustment
US20040156014A1 (en) * 2002-11-29 2004-08-12 Piers Patricia Ann Multifocal ophthalmic lens
US6736510B1 (en) * 2003-02-04 2004-05-18 Ware Tec Vision Systems, Inc. Ophthalmic talbot-moire wavefront sensor
US20040189938A1 (en) * 2003-03-25 2004-09-30 Eagan Barry T. Moire aberrometer
US7556378B1 (en) * 2003-04-10 2009-07-07 Tsontcho Ianchulev Intraoperative estimation of intraocular lens power
US8313196B2 (en) * 2003-04-10 2012-11-20 Wavetec Vision Systems, Inc. Intraoperative estimation of intraocular lens power
US20100042210A1 (en) * 2003-04-10 2010-02-18 Tsontcho Ianchulev Intraoperative Estimation of Intraocular Lens Power
US20100036386A1 (en) * 2003-04-10 2010-02-11 Tsontcho Ianchulev Intraoperative Estimation of Intraocular Lens Power
US20100030225A1 (en) * 2003-04-10 2010-02-04 Tsontcho Ianchulev Intraoperative Estimation of Intraocular Lens Power
US7057806B2 (en) * 2003-05-09 2006-06-06 3M Innovative Properties Company Scanning laser microscope with wavefront sensor
US20040223214A1 (en) * 2003-05-09 2004-11-11 3M Innovative Properties Company Scanning laser microscope with wavefront sensor
US20040263785A1 (en) * 2003-06-16 2004-12-30 Visx, Inc. Methods and devices for registering optical measurement datasets of an optical system
US20050105044A1 (en) * 2003-11-14 2005-05-19 Laurence Warden Lensometers and wavefront sensors and methods of measuring aberration
US7425067B2 (en) * 2003-11-14 2008-09-16 Ophthonix, Inc. Ophthalmic diagnostic instrument
US20050225725A1 (en) * 2003-11-14 2005-10-13 Laurence Warden Ophthalmic diagnostic instrument
US20050203422A1 (en) * 2004-02-10 2005-09-15 Jay Wei Optical apparatus and methods for performing eye examinations
US20050243276A1 (en) * 2004-04-20 2005-11-03 Wavetec Vision Systems, Inc. Integrated surgical microscope and wavefront sensor
US7883505B2 (en) * 2004-04-20 2011-02-08 Wavetec Vision Systems, Inc. Integrated surgical microscope and wavefront sensor
US20090103050A1 (en) * 2007-10-19 2009-04-23 Wavetec Vision Systems, Inc. Optical instrument alignment system

Cited By (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9168127B2 (en) 2003-04-10 2015-10-27 Wavetec Vision Systems, Inc. Intraoperative estimation of intraocular lens power
US7988291B2 (en) 2003-04-10 2011-08-02 Wavetec Vision Systems, Inc. Intraoperative estimation of intraocular lens power
US8313196B2 (en) 2003-04-10 2012-11-20 Wavetec Vision Systems, Inc. Intraoperative estimation of intraocular lens power
US9445890B2 (en) 2003-04-10 2016-09-20 Wavetec Vision Systems, Inc. Intraoperative estimation of intraocular lens power
US8632185B2 (en) 2003-04-10 2014-01-21 Wavetec Vision Systems, Inc. Intraoperative estimation of intraocular lens power
US9107612B2 (en) 2004-04-20 2015-08-18 Wavetec Vision Systems, Inc. Integrated surgical microscope and wavefront sensor
US8475439B2 (en) 2004-04-20 2013-07-02 Wavetec Vision Systems, Inc. Integrated surgical microscope and wavefront sensor
US9420949B2 (en) 2004-04-20 2016-08-23 Wavetec Vision Systems, Inc. Integrated surgical microscope and wavefront sensor
US8394083B2 (en) 2004-04-20 2013-03-12 Wavetec Vision Systems, Inc. Integrated surgical microscope and wavefront sensor
US7883505B2 (en) 2004-04-20 2011-02-08 Wavetec Vision Systems, Inc. Integrated surgical microscope and wavefront sensor
US20070171519A1 (en) * 2004-07-16 2007-07-26 Ralf Wolleschensky Microscope with heightened resolution and linear scanning
US7468834B2 (en) * 2004-07-16 2008-12-23 Carl Zeiss Microimaging Gmbh Microscope with heightened resolution and linear scanning
USRE43702E1 (en) 2004-07-16 2012-10-02 Carl Zeiss Microimaging Gmbh Microscope with heightened resolution and linear scanning
US9545338B2 (en) * 2006-01-20 2017-01-17 Lensar, Llc. System and method for improving the accommodative amplitude and increasing the refractive power of the human lens with a laser
US9180051B2 (en) 2006-01-20 2015-11-10 Lensar Inc. System and apparatus for treating the lens of an eye
US8409277B2 (en) 2006-07-11 2013-04-02 Refocus Ocular, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
US9687339B2 (en) 2006-07-11 2017-06-27 Refocus Group, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
US9700406B2 (en) 2006-07-11 2017-07-11 Refocus Group, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
US11273028B2 (en) 2006-07-11 2022-03-15 Refocus Group Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
US9486310B2 (en) 2006-07-11 2016-11-08 Refocus Group, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
US9504559B2 (en) 2006-07-11 2016-11-29 Refocus Group, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
US9717588B2 (en) 2006-07-11 2017-08-01 Refocus Group, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
US9452044B2 (en) 2006-07-11 2016-09-27 Refocus Group, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
US9730785B2 (en) 2006-07-11 2017-08-15 Refocus Group, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
US9498324B2 (en) 2006-07-11 2016-11-22 Refocus Group, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
US8911496B2 (en) 2006-07-11 2014-12-16 Refocus Group, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
US8337550B2 (en) 2006-07-11 2012-12-25 Refocus Ocular, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
US10485653B2 (en) 2006-07-11 2019-11-26 Refocus Group, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
US10285804B2 (en) 2006-07-11 2019-05-14 Refocus Group, Inc. Scleral prosthesis for treating presbyopia and other eye disorders and related devices and methods
US20080062384A1 (en) * 2006-09-08 2008-03-13 Akkolens International B.V. Device and method for measuring the optical properties of an eye in combination with an operating microscope
US7850308B2 (en) 2006-09-08 2010-12-14 Akkolens International B.V. Device and method for measuring the optical properties of an eye in combination with an operating microscope
US10925720B2 (en) 2007-03-13 2021-02-23 Amo Development, Llc Method and apparatus for creating ocular surgical and relaxing incisions
US10376356B2 (en) * 2007-03-13 2019-08-13 Optimedica Corporation Method and apparatus for creating ocular surgical and relaxing incisions
US10405970B2 (en) 2007-03-13 2019-09-10 Optimedica Corporation Method and apparatus for creating ocular surgical and relaxing incisions
US10709548B2 (en) * 2007-03-13 2020-07-14 Amo Development, Llc Method and apparatus for creating ocular surgical and relaxing incisions
US20150196428A1 (en) * 2007-03-13 2015-07-16 Optimedica Corporation Method and apparatus for creating ocular surgical and relaxing incisions
US20150196429A1 (en) * 2007-03-13 2015-07-16 Optimedica Corporation Method and apparatus for creating ocular surgical and relaxing incisions
AU2015204392B2 (en) * 2007-03-13 2017-06-22 Amo Development, Llc Apparatus for creating ocular surgical and relaxing incisions
US11931243B2 (en) 2007-03-13 2024-03-19 Amo Development, Llc Method and apparatus for creating ocular surgical and relaxing incisions
US8992516B2 (en) 2007-07-19 2015-03-31 Avedro, Inc. Eye therapy system
US8652131B2 (en) 2007-07-19 2014-02-18 Avedro, Inc. Eye therapy system
US8619405B2 (en) 2007-10-31 2013-12-31 Wavetec Vision Systems, Inc. Wavefront sensor
US9295381B2 (en) 2007-10-31 2016-03-29 Wavetec Vision Systems, Inc. Wavefront sensor
US20140058365A1 (en) * 2007-12-17 2014-02-27 Josef F. Bille System and Method for Using Compensating Incisions in Intrastromal Refractive Surgery
US8049873B2 (en) 2008-03-19 2011-11-01 Carl Zeiss Meditec Ag Surgical microscopy system having an optical coherence tomography facility
US8708488B2 (en) 2008-07-24 2014-04-29 Carl Zeiss Meditec Ag Eye surgery system and methods of preparing and performing an eye surgery
US20110122365A1 (en) * 2008-07-24 2011-05-26 Carl Zeiss Surgical Gmbh Eye Surgery System and Methods of Preparing and Performing an Eye Surgery
DE102008034490B4 (de) 2008-07-24 2018-12-20 Carl Zeiss Meditec Ag Augenchirurgiesystem und Verfahren zur Vorbereitung und Durchführung einer Augenoperation
DE102008034490A1 (de) 2008-07-24 2010-02-04 Carl Zeiss Meditec Ag Augenchirurgiesystem und Verfahren zur Vorbereitung und Durchführung einer Augenoperation
US8708491B2 (en) 2008-07-25 2014-04-29 Lensar, Inc. Method and system for measuring an eye
US9320438B2 (en) 2008-09-11 2016-04-26 Carl Zeiss Meditec Ag Medical systems and methods
US9351644B2 (en) 2008-09-11 2016-05-31 Carl Zeiss Meditec Ag Medical systems and methods
US9357931B2 (en) 2008-09-11 2016-06-07 Carl Zeiss Meditec Ag Medical systems and methods
US9129366B2 (en) 2008-09-11 2015-09-08 Carl Zeiss Meditec Ag Medical systems and methods
US20100061604A1 (en) * 2008-09-11 2010-03-11 Carl Zeiss Surgical Gmbh Medical systems and methods
US8144958B2 (en) 2008-09-11 2012-03-27 Carl Zeiss Meditec Ag Medical systems and methods
US8459795B2 (en) 2008-09-16 2013-06-11 Carl Zeiss Meditec Ag Measuring system for ophthalmic surgery
DE102008047400B9 (de) * 2008-09-16 2011-01-05 Carl Zeiss Surgical Gmbh Augenchirurgie-Messsystem
DE102008047400A1 (de) 2008-09-16 2010-04-29 Carl Zeiss Surgical Gmbh Augenchirurgie-Messsystem
DE102008047400B4 (de) * 2008-09-16 2010-07-01 Carl Zeiss Surgical Gmbh Augenchirurgie-Messsystem
CN102215738A (zh) * 2008-09-16 2011-10-12 卡尔蔡司外科器械有限责任公司 眼外科测量系统
WO2010031540A3 (de) * 2008-09-16 2010-05-27 Carl Zeiss Surgical Gmbh Augenchirurgie-messsystem
US20100076423A1 (en) * 2008-09-19 2010-03-25 Avedro, Inc. Eye therapy system
US8398628B2 (en) * 2008-09-19 2013-03-19 Avedro, Inc. Eye therapy system
EP2184005A1 (en) 2008-10-22 2010-05-12 SensoMotoric Instruments Gesellschaft für innovative Sensorik mbH Method and apparatus for image processing for computer-aided eye surgery
US9307904B2 (en) 2008-11-06 2016-04-12 Wavetec Vision Systems, Inc. Optical angular measurement system for ophthalmic applications and method for positioning of a toric intraocular lens with increased accuracy
US8550624B2 (en) 2008-11-06 2013-10-08 Wavetec Vision Systems, Inc. Optical angular measurement system for ophthalmic applications and method for positioning of a toric intraocular lens with increased accuracy
WO2010054268A3 (en) * 2008-11-06 2016-03-31 Wavetec Vision Systems, Inc. Optical angular measurement system for ophthalmic applications and method for positioning of a toric intraocular lens with increased accuracy
US8882757B2 (en) 2008-11-11 2014-11-11 Avedro, Inc. Eye therapy system
US20100157246A1 (en) * 2008-12-23 2010-06-24 Carl Zeiss Surgical Gmbh Ophthalmic surgical system
US7845798B2 (en) 2008-12-23 2010-12-07 Carl Zeiss Surgical Gmbh Ophthalmic surgical system
US8500283B1 (en) 2009-04-02 2013-08-06 Casimir A. Swinger Microscope-attachable aberrometer
US8712536B2 (en) 2009-04-02 2014-04-29 Avedro, Inc. Eye therapy system
US8342688B1 (en) 2009-06-15 2013-01-01 Casimir Andrew Swinger Multifocal capable ophthalmic aberrometer
US8876290B2 (en) 2009-07-06 2014-11-04 Wavetec Vision Systems, Inc. Objective quality metric for ocular wavefront measurements
US9603516B2 (en) 2009-07-06 2017-03-28 Wavetec Vision Systems, Inc. Objective quality metric for ocular wavefront measurements
US9554697B2 (en) 2009-07-14 2017-01-31 Wavetec Vision Systems, Inc. Determination of the effective lens position of an intraocular lens using aphakic refractive power
US8545023B2 (en) 2009-07-14 2013-10-01 Wavetec Vision Systems, Inc. Ophthalmic surgery measurement system
US9259149B2 (en) 2009-07-14 2016-02-16 Wavetec Vision Systems, Inc. Ophthalmic surgery measurement system
US8764187B2 (en) 2009-07-14 2014-07-01 Wavetec Vision Systems, Inc. Determination of the effective lens position of an intraocular lens using aphakic refractive power
US8758332B2 (en) 2009-07-24 2014-06-24 Lensar, Inc. Laser system and method for performing and sealing corneal incisions in the eye
EP2676645A1 (en) * 2009-07-24 2013-12-25 Lensar, Inc. Laser system for reducing astigmatism induced from cataract therapy
US8891164B2 (en) 2009-08-18 2014-11-18 Carl Zeiss Meditec Ag System for wavefront analysis and optical system having a microscope and a system for wavefront analysis
DE102009037841B4 (de) 2009-08-18 2020-01-23 Carl Zeiss Meditec Ag Optisches System mit Wellenfrontanalysesystem und Baugruppe mit Wellenfrontanalysesystem für ein Mikroskop mit Mikroskopchassis
DE102009037841A1 (de) * 2009-08-18 2011-02-24 Carl Zeiss Surgical Gmbh Wellenfrontanalysesystem und optisches System mit Mikroskop und Wellenfrontanalysesystem
US10864114B2 (en) 2010-01-08 2020-12-15 Amo Development, Llc Method and system for modifying eye tissue and intraocular lenses
US10758416B2 (en) 2010-01-08 2020-09-01 Amo Development, Llc Method and system for modifying eye tissue and intraocular lenses
US11058583B2 (en) 2010-01-08 2021-07-13 Amo Development, Llc Method and system for modifying eye tissue and intraocular lenses
US20110190739A1 (en) * 2010-01-29 2011-08-04 Lensar, Inc. Servo controlled docking force device for use in ophthalmic applications
US9622911B2 (en) 2010-09-30 2017-04-18 Cxl Ophthalmics, Llc Ophthalmic treatment device, system, and method of use
WO2012047307A1 (en) * 2010-09-30 2012-04-12 Curveright Llc Corneal treatment system and method
US11033429B2 (en) 2010-09-30 2021-06-15 Cxl Ophthalmics, Llc Ophthalmic treatment device, system, and method of use
US11135090B2 (en) 2010-09-30 2021-10-05 Cxl Ophthalmics, Llc Ophthalmic treatment device, system, and method of use
US12156834B2 (en) 2010-09-30 2024-12-03 Cxl Ophthalmics, Llc Ophthalmic treatment device, system, and method of use
US10285857B2 (en) 2010-09-30 2019-05-14 Cxl Ophthalmics, Llc Ophthalmic treatment device, system, and method of use
US8801186B2 (en) 2010-10-15 2014-08-12 Lensar, Inc. System and method of scan controlled illumination of structures within an eye
US20120197102A1 (en) * 2011-01-27 2012-08-02 Nidek Co., Ltd. Ophthalmic surgical microscope
US10463541B2 (en) 2011-03-25 2019-11-05 Lensar, Inc. System and method for correcting astigmatism using multiple paired arcuate laser generated corneal incisions
US8985768B2 (en) 2011-11-25 2015-03-24 Ming Lai Integrated refractor
US8915594B2 (en) 2011-11-25 2014-12-23 Md Lasers & Instruments, Inc. Refraction system for facilitating contact lens fitting
US9329309B2 (en) 2012-02-27 2016-05-03 E-Vision Smart Optics, Inc. Electroactive lens with multiple depth diffractive structures
US10054725B2 (en) 2012-02-27 2018-08-21 E-Vision Smart Optics, Inc. Electroactive lens with multiple depth diffractive structures
US10729716B2 (en) 2012-03-29 2020-08-04 Cxl Ophthalmics, Llc Compositions and methods for treating or preventing diseases associated with oxidative stress
US10575986B2 (en) 2012-03-29 2020-03-03 Cxl Ophthalmics, Llc Ophthalmic treatment solution delivery devices and delivery augmentation methods
US11497766B2 (en) 2012-03-29 2022-11-15 Cxl Ophthalmics, Llc Compositions and methods for treating or preventing diseases associated with oxidative stress
US9566301B2 (en) 2012-03-29 2017-02-14 Cxl Ophthalmics, Llc Compositions and methods for treating or preventing diseases associated with oxidative stress
US9555111B2 (en) 2012-03-29 2017-01-31 Cxl Ophthalmics, Llc Ocular cross-linking system and method for sealing corneal wounds
US10092594B2 (en) 2012-03-29 2018-10-09 Cxl Ophthalmics, Llc Compositions and methods for treating or preventing diseases associated with oxidative stress
US11931291B2 (en) 2012-03-29 2024-03-19 Epion Therapeutics, Inc. Ophthalmic treatment solution delivery devices and delivery augmentation methods
US9339180B2 (en) 2012-09-27 2016-05-17 Wavetec Vision Systems, Inc. Geometric optical power measurement device
US9072462B2 (en) 2012-09-27 2015-07-07 Wavetec Vision Systems, Inc. Geometric optical power measurement device
KR101833860B1 (ko) * 2014-05-23 2018-03-02 웨이브라이트 게엠베하 레이저 디바이스에 결합하기 위한 인터페이스를 포함하는 측정 모듈
US20150335478A1 (en) * 2014-05-23 2015-11-26 Novartis Ag Measuring module including an interface for coupling to a laser device
US9795512B2 (en) * 2014-05-23 2017-10-24 Novartis Ag Measuring module including an interface for coupling to a laser device
RU2659014C2 (ru) * 2014-05-23 2018-06-26 Уэйвлайт Гмбх Измерительный модуль, содержащий интерфейс для соединения с лазерным прибором
US9662010B2 (en) 2014-09-19 2017-05-30 Carl Zeiss Meditec Ag Optical system, comprising a microscopy system and an OCT system
US10092179B2 (en) 2014-09-19 2018-10-09 Carl Zeiss Meditec Ag System for optical coherence tomography, comprising a zoomable kepler system

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US9107612B2 (en) 2015-08-18
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US20050243276A1 (en) 2005-11-03
US7883505B2 (en) 2011-02-08
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US20110267579A1 (en) 2011-11-03
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US20130021574A1 (en) 2013-01-24
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