US20040116328A1 - Condensed imidazole derivatives - Google Patents

Condensed imidazole derivatives Download PDF

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Publication number
US20040116328A1
US20040116328A1 US10/457,002 US45700203A US2004116328A1 US 20040116328 A1 US20040116328 A1 US 20040116328A1 US 45700203 A US45700203 A US 45700203A US 2004116328 A1 US2004116328 A1 US 2004116328A1
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US
United States
Prior art keywords
group
formula
compound
represented
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/457,002
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English (en)
Inventor
Seiji Yoshikawa
Eita Emori
Fumiyoshi Matsuura
Richard Clark
Hironori Ikuta
Kazunobu Kira
Nobuyuki Yasuda
Tadashi Nagakura
Kazuto Yamazaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Assigned to EISAI CO., LTD. reassignment EISAI CO., LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CLARK, RICHARD, EMORI, EITA, IKUTA, HIRONORI, KIRA, KAZUNOBU, MATSUURA, FUMIYOSHI, NAGAKURA, TADASHI, YAMAZAKI, KAZUTO, YASUDA, NOBUYUKI, YOSHIKAWA, SEIJI
Assigned to EISAI CO., LTD. reassignment EISAI CO., LTD. CORRECTION OF ASSIGNEE ADDRESS ON NOTICE OF RECORDATION FOR ASSIGNMENT RECORDED 10/31/03 AT REEL/FRAME 014099/0045 Assignors: CLARK, RICHARD, EMORI, EITA, IKUTA, HIRONORI, KIRA, KAZUNOBU, MATSUURA, FUMIYOSHI, NAGAKURA, TADASHI, YAMAZAKI, KAZUTO, YASUDA, NOBUYUKI, YOSHIKAWA, SEIJI
Publication of US20040116328A1 publication Critical patent/US20040116328A1/en
Priority to US11/212,407 priority Critical patent/US20060063787A1/en
Priority to US12/199,982 priority patent/US7772226B2/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
US10/457,002 2002-06-06 2003-06-06 Condensed imidazole derivatives Abandoned US20040116328A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US11/212,407 US20060063787A1 (en) 2002-06-06 2005-08-26 Condensed imidazole derivatives
US12/199,982 US7772226B2 (en) 2002-06-06 2008-08-28 Condensed imidazole derivatives

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2002166069 2002-06-06
JP2002-166069 2002-06-06
JP2002-209373 2002-07-18
JP2002209373 2002-07-18
JP2002-307750 2002-10-23
JP2002307750 2002-10-23

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/212,407 Continuation US20060063787A1 (en) 2002-06-06 2005-08-26 Condensed imidazole derivatives

Publications (1)

Publication Number Publication Date
US20040116328A1 true US20040116328A1 (en) 2004-06-17

Family

ID=29740540

Family Applications (4)

Application Number Title Priority Date Filing Date
US10/516,971 Abandoned US20060100199A1 (en) 2002-06-06 2003-06-03 Novel condensed imidazole derivatives
US10/457,002 Abandoned US20040116328A1 (en) 2002-06-06 2003-06-06 Condensed imidazole derivatives
US11/212,407 Abandoned US20060063787A1 (en) 2002-06-06 2005-08-26 Condensed imidazole derivatives
US12/199,982 Expired - Fee Related US7772226B2 (en) 2002-06-06 2008-08-28 Condensed imidazole derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US10/516,971 Abandoned US20060100199A1 (en) 2002-06-06 2003-06-03 Novel condensed imidazole derivatives

Family Applications After (2)

Application Number Title Priority Date Filing Date
US11/212,407 Abandoned US20060063787A1 (en) 2002-06-06 2005-08-26 Condensed imidazole derivatives
US12/199,982 Expired - Fee Related US7772226B2 (en) 2002-06-06 2008-08-28 Condensed imidazole derivatives

Country Status (19)

Country Link
US (4) US20060100199A1 (US20040116328A1-20040617-C00038.png)
EP (1) EP1514552A4 (US20040116328A1-20040617-C00038.png)
JP (2) JP3675813B2 (US20040116328A1-20040617-C00038.png)
KR (1) KR100985160B1 (US20040116328A1-20040617-C00038.png)
CN (2) CN100469778C (US20040116328A1-20040617-C00038.png)
AU (1) AU2003241960B2 (US20040116328A1-20040617-C00038.png)
BR (1) BR0311697A (US20040116328A1-20040617-C00038.png)
CA (1) CA2485641C (US20040116328A1-20040617-C00038.png)
HK (2) HK1078869A1 (US20040116328A1-20040617-C00038.png)
IL (1) IL165178A0 (US20040116328A1-20040617-C00038.png)
IS (1) IS7625A (US20040116328A1-20040617-C00038.png)
MX (1) MXPA04012226A (US20040116328A1-20040617-C00038.png)
NO (1) NO20050054L (US20040116328A1-20040617-C00038.png)
NZ (1) NZ536794A (US20040116328A1-20040617-C00038.png)
PL (1) PL374007A1 (US20040116328A1-20040617-C00038.png)
RU (1) RU2297418C9 (US20040116328A1-20040617-C00038.png)
TW (1) TWI273104B (US20040116328A1-20040617-C00038.png)
WO (1) WO2003104229A1 (US20040116328A1-20040617-C00038.png)
ZA (1) ZA200500041B (US20040116328A1-20040617-C00038.png)

Cited By (99)

* Cited by examiner, † Cited by third party
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US20040082570A1 (en) * 2002-02-25 2004-04-29 Eisai Co., Ltd. Xanthine derivative and DPPIV inhibitor
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US20040122228A1 (en) * 2002-08-22 2004-06-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg New purine derivatives, the preparation thereof and their use as pharmaceutical compositions
US20040138215A1 (en) * 2002-11-21 2004-07-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
US20040138214A1 (en) * 2002-11-08 2004-07-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
US20040166125A1 (en) * 2002-08-22 2004-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivatives, their preparation and their use in pharmaceutical compositions
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WO2004111051A1 (de) * 2003-06-18 2004-12-23 Boehringer Ingelheim International Gmbh Imidazopyridazinon- und imidazopyridonderivate, deren herstellung und deren verwendung als arzneimittel
US20050020574A1 (en) * 2002-12-03 2005-01-27 Boehringer Ingelheim Pharma Gmbh Co. Kg New substituted imidazo-pyridinones and imidazo-pyridazinones, the preparation thereof and their use as pharmaceutical compositions
US20050070706A1 (en) * 2003-08-13 2005-03-31 Syrrx, Inc. Dipeptidyl peptidase inhibitors
WO2005058901A1 (de) * 2003-12-17 2005-06-30 Boehringer Ingelheim International Gmbh Neue 2-(piperazin-1-yl)- und 2-([1,4]diazepan-1-yl)- imidazo[4,5-d]pyridazin-4-one, deren herstellung und deren verwendung als arzneimittel zur bekämpfung von diabetes mellitus
US20050143377A1 (en) * 2003-12-23 2005-06-30 Boehringer Ingelheim International Gmbh Bicyclic imidazole derivatives, the preparation thereof and their use as pharmaceutical compositions
WO2005061505A1 (en) * 2003-12-16 2005-07-07 Pfizer Products Inc. Bicyclic imidazolyl pyrimidin-4-one cannabinoid receptor ligands and uses thereof
US20050171093A1 (en) * 2003-12-17 2005-08-04 Boehringer Ingelheim International Gmbh New piperazin-1-yl and 2-([1,4]diazepan-1-yl)-imidazo[4,5-d]-pyridazin-4-ones, the preparation thereof and their use as pharmaceutial compositions
US20050187227A1 (en) * 2004-02-23 2005-08-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-[3-Amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical composition
US20050203095A1 (en) * 2004-03-13 2005-09-15 Boehringer Ingelheim International Gmbh Imidazopyridazinediones, their preparation and their use as pharmaceutical compositions
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US20060004074A1 (en) * 2004-06-24 2006-01-05 Boehringer Ingelheim International Gmbh New imidazoles and triazoles, their preparation, and their use as pharmaceutical compositions
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US20060094722A1 (en) * 2002-09-26 2006-05-04 Eisai Co., Ltd. Combination drug
US20060111362A1 (en) * 2002-12-04 2006-05-25 Eisai Co., Ltd. 1,3-Dihydroimidazole ring compound
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US20070098781A1 (en) * 2005-08-11 2007-05-03 Loeffler Bernd M Modified release compositions for DPP-IV inhibitors
US20070219178A1 (en) * 2003-12-04 2007-09-20 Eisai Co., Ltd. Preventive or therapeutic agents for multiple sclerosis
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US20060100199A1 (en) 2006-05-11
RU2004139111A (ru) 2005-08-10
EP1514552A4 (en) 2008-04-02
US20060063787A1 (en) 2006-03-23
KR20050005544A (ko) 2005-01-13
AU2003241960B2 (en) 2009-07-30
US20090018331A1 (en) 2009-01-15
CN1931859A (zh) 2007-03-21
JP2005145951A (ja) 2005-06-09
IS7625A (is) 2005-01-04
PL374007A1 (en) 2005-09-19
KR100985160B1 (ko) 2010-10-05
IL165178A0 (en) 2005-12-18

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