US20030108917A1 - Method for manufacturing hydrogel biochip by using star-like polyethylene glycol derivative having epoxy group - Google Patents

Method for manufacturing hydrogel biochip by using star-like polyethylene glycol derivative having epoxy group Download PDF

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Publication number
US20030108917A1
US20030108917A1 US10/231,829 US23182902A US2003108917A1 US 20030108917 A1 US20030108917 A1 US 20030108917A1 US 23182902 A US23182902 A US 23182902A US 2003108917 A1 US2003108917 A1 US 2003108917A1
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US
United States
Prior art keywords
probe
biochip
exon
substrate
star
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/231,829
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English (en)
Inventor
Nam Huh
Mi-Jung Song
Jong-Myeon Park
Ga-Young Park
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Samsung Electronics Co Ltd
Original Assignee
Samsung Electronics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR10-2002-0048128A external-priority patent/KR100450822B1/ko
Application filed by Samsung Electronics Co Ltd filed Critical Samsung Electronics Co Ltd
Assigned to SAMSUNG ELECTRONICS CO., LTD. reassignment SAMSUNG ELECTRONICS CO., LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HUH, NAM, PARK, GA-YOUNG, PARK, JONG-MYEON, SONG, MI-JUNG
Publication of US20030108917A1 publication Critical patent/US20030108917A1/en
Priority to US11/510,931 priority Critical patent/US7695910B2/en
Abandoned legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00576—Chemical means fluorophore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00644—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being present in discrete locations, e.g. gel pads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00677—Ex-situ synthesis followed by deposition on the substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00729—Peptide nucleic acids [PNA]
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
US10/231,829 2001-09-01 2002-08-30 Method for manufacturing hydrogel biochip by using star-like polyethylene glycol derivative having epoxy group Abandoned US20030108917A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/510,931 US7695910B2 (en) 2001-09-01 2006-08-28 Method for manufacturing hydrogel biochip by using star-like polyethylene glycol derivative having epoxy group

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR2001-53687 2001-09-01
KR20010053687 2001-09-01
KR10-2002-0048128A KR100450822B1 (ko) 2001-09-01 2002-08-14 에폭시기를 갖는 방사형 폴리에틸렌글리콜 유도체를이용한 하이드로 젤 바이오칩의 제조방법
KR2002-48128 2002-08-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/510,931 Division US7695910B2 (en) 2001-09-01 2006-08-28 Method for manufacturing hydrogel biochip by using star-like polyethylene glycol derivative having epoxy group

Publications (1)

Publication Number Publication Date
US20030108917A1 true US20030108917A1 (en) 2003-06-12

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
US10/231,829 Abandoned US20030108917A1 (en) 2001-09-01 2002-08-30 Method for manufacturing hydrogel biochip by using star-like polyethylene glycol derivative having epoxy group
US11/510,931 Expired - Fee Related US7695910B2 (en) 2001-09-01 2006-08-28 Method for manufacturing hydrogel biochip by using star-like polyethylene glycol derivative having epoxy group

Family Applications After (1)

Application Number Title Priority Date Filing Date
US11/510,931 Expired - Fee Related US7695910B2 (en) 2001-09-01 2006-08-28 Method for manufacturing hydrogel biochip by using star-like polyethylene glycol derivative having epoxy group

Country Status (5)

Country Link
US (2) US20030108917A1 (zh)
EP (1) EP1421216A4 (zh)
JP (1) JP3883539B2 (zh)
CN (1) CN1217009C (zh)
WO (1) WO2003020978A1 (zh)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060040274A1 (en) * 2004-08-19 2006-02-23 Biocept, Inc. Microarrays utilizing hydrogels
US20070106239A1 (en) * 2003-12-19 2007-05-10 Basf Aktiengesellschaft A German Corporation Swellable hydrogel-forming polymers having a low fraction of fines
EP1801238A1 (en) 2005-12-20 2007-06-27 Samsung Electronics Co., Ltd. Microarray substrate, method of manufacturing the same, microarray using the microarray substrate, and method of analyzing target biomolecule using the microarray
US20080000308A1 (en) * 2006-06-08 2008-01-03 Canon Kabushiki Kaisha Measuring probe and production process thereof
US20080280782A1 (en) * 2004-02-16 2008-11-13 Samsung Electronics Co., Ltd. Method for noncovalently immobilizing a biomolecule on a solid substrate and microarray produced according to the method
DE102007008499B4 (de) * 2006-02-22 2014-10-16 Uchrezhdenie Rossiiskoi Akademii Nauk Institut Molekulyarnoi Biologii Im.V.A. Engelgardta Ran (Imb Ran), Verfahren zur Immobilisierung von Hydrogelen über unmodifizierten Polymermaterialien, Biochip auf Basis von unmodifizierten Polymermaterialien und Verfahren zu seiner Herstellung

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DE10360394A1 (de) * 2003-12-19 2005-07-14 Basf Ag Quellbare hydrogelbildende Polymere mit geringem Feinstaubanteil
KR100653975B1 (ko) * 2004-11-30 2006-12-05 한국과학기술원 집코드 방식을 이용한 ｐｎａ 칩 및 이의 제작방법
KR100766750B1 (ko) * 2004-12-13 2007-10-17 주식회사 엘지생명과학 바이오칩의 제조방법
CN100334229C (zh) * 2005-06-17 2007-08-29 东南大学 基于凝胶固定核酸的dna微阵列芯片制备方法
KR100729953B1 (ko) * 2005-10-14 2007-06-20 주식회사 엘지생명과학 플라즈마 공정을 이용한 플라스틱 기판의 제조 방법 및그에 의해 제조된 플라스틱 기판
JP4862412B2 (ja) * 2006-01-31 2012-01-25 住友ベークライト株式会社 バイオチップの製造方法
JPWO2008018355A1 (ja) * 2006-08-08 2009-12-24 シャープ株式会社 バイオセンサ及びその製造方法並びに当該バイオセンサを用いた検出方法
US20110059859A1 (en) * 2008-05-09 2011-03-10 Zhiping Liu Molecule Detecting System
GB0818609D0 (en) * 2008-10-10 2008-11-19 Univ Hull apparatus and method
EP2281632B1 (en) * 2009-07-02 2013-11-13 Amic AB Capillary driven assay device and its manufacture
CN102520151A (zh) * 2011-12-09 2012-06-27 东南大学 一种准三维生物芯片的制备方法
JPWO2015147147A1 (ja) * 2014-03-26 2017-04-13 国立大学法人北海道大学 生物学的試料をハイドロゲルで高速固定する方法及びそのための装置
CN110368503B (zh) * 2018-04-13 2021-10-29 上海市第十人民医院 Peg核交联星型高分子纳米造影剂及其制备方法和应用

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US5741700A (en) * 1993-08-11 1998-04-21 University Of Chicago Method of immobilizing water-soluble bioorganic compounds on a capillary-porous carrier
US5744305A (en) * 1989-06-07 1998-04-28 Affymetrix, Inc. Arrays of materials attached to a substrate
US5770721A (en) * 1993-08-11 1998-06-23 University Of Chicago Method of manufacturing a matrix for the detection of mismatches
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US20020064546A1 (en) * 1996-09-13 2002-05-30 J. Milton Harris Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
US20040023413A1 (en) * 2001-11-26 2004-02-05 Molecular Reflections, Inc. Microscale immobilization of molecules using a hydrogel and methods of use thereof
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Publication number Priority date Publication date Assignee Title
US5744305A (en) * 1989-06-07 1998-04-28 Affymetrix, Inc. Arrays of materials attached to a substrate
US5552270A (en) * 1991-03-18 1996-09-03 Institut Molekulyarnoi Biologii Imeni V.A. Methods of DNA sequencing by hybridization based on optimizing concentration of matrix-bound oligonucleotide and device for carrying out same
US5741700A (en) * 1993-08-11 1998-04-21 University Of Chicago Method of immobilizing water-soluble bioorganic compounds on a capillary-porous carrier
US5770721A (en) * 1993-08-11 1998-06-23 University Of Chicago Method of manufacturing a matrix for the detection of mismatches
US5736257A (en) * 1995-04-25 1998-04-07 Us Navy Photoactivatable polymers for producing patterned biomolecular assemblies
US5847019A (en) * 1995-04-25 1998-12-08 The United States Of America As Represented By The Secretary Of The Navy Photoactivatable polymers for producing patterned biomolecular assemblies
US20020064546A1 (en) * 1996-09-13 2002-05-30 J. Milton Harris Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
US6762019B2 (en) * 1997-09-30 2004-07-13 Surmodics, Inc. Epoxide polymer surfaces
US6046305A (en) * 1997-12-12 2000-04-04 Macromed, Inc. Heterofunctionalized star-shaped poly(ethylene gycols) for protein modification
US20040023413A1 (en) * 2001-11-26 2004-02-05 Molecular Reflections, Inc. Microscale immobilization of molecules using a hydrogel and methods of use thereof

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070106239A1 (en) * 2003-12-19 2007-05-10 Basf Aktiengesellschaft A German Corporation Swellable hydrogel-forming polymers having a low fraction of fines
US7553903B2 (en) * 2003-12-19 2009-06-30 Basf Aktiengesellschaft Swellable hydrogel-forming polymers having a low fraction of fines
US20080280782A1 (en) * 2004-02-16 2008-11-13 Samsung Electronics Co., Ltd. Method for noncovalently immobilizing a biomolecule on a solid substrate and microarray produced according to the method
US7611889B2 (en) 2004-02-16 2009-11-03 Samsung Electronics Co., Ltd. Method for noncovalently immobilizing a biomolecule on a solid substrate and microarray produced according to the method
US7687259B2 (en) 2004-02-16 2010-03-30 Samsung Electronics Co., Ltd. Method for noncovalently immobilizing a biomolecule on a solid substrate and microarray produced according to the method
US20060040274A1 (en) * 2004-08-19 2006-02-23 Biocept, Inc. Microarrays utilizing hydrogels
US7595157B2 (en) 2004-08-19 2009-09-29 Biocept, Inc. Microarrays utilizing hydrogels
EP1801238A1 (en) 2005-12-20 2007-06-27 Samsung Electronics Co., Ltd. Microarray substrate, method of manufacturing the same, microarray using the microarray substrate, and method of analyzing target biomolecule using the microarray
US20070190541A1 (en) * 2005-12-20 2007-08-16 Jong-Myeon Park Microarray substrate, methods of manufacturing and use
DE102007008499B4 (de) * 2006-02-22 2014-10-16 Uchrezhdenie Rossiiskoi Akademii Nauk Institut Molekulyarnoi Biologii Im.V.A. Engelgardta Ran (Imb Ran), Verfahren zur Immobilisierung von Hydrogelen über unmodifizierten Polymermaterialien, Biochip auf Basis von unmodifizierten Polymermaterialien und Verfahren zu seiner Herstellung
US20080000308A1 (en) * 2006-06-08 2008-01-03 Canon Kabushiki Kaisha Measuring probe and production process thereof
US7811829B2 (en) * 2006-06-08 2010-10-12 Canon Kabushiki Kaisha Measuring probe and production process thereof

Also Published As

Publication number Publication date
US20070020676A1 (en) 2007-01-25
WO2003020978A1 (en) 2003-03-13
CN1217009C (zh) 2005-08-31
EP1421216A1 (en) 2004-05-26
JP2004522175A (ja) 2004-07-22
EP1421216A4 (en) 2006-05-17
CN1483083A (zh) 2004-03-17
JP3883539B2 (ja) 2007-02-21
US7695910B2 (en) 2010-04-13
WO2003020978B1 (en) 2004-04-08

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