US20030065002A1 - Abuse-resistant controlled-release opioid dosage form - Google Patents

Abuse-resistant controlled-release opioid dosage form Download PDF

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Publication number
US20030065002A1
US20030065002A1 US10/143,111 US14311102A US2003065002A1 US 20030065002 A1 US20030065002 A1 US 20030065002A1 US 14311102 A US14311102 A US 14311102A US 2003065002 A1 US2003065002 A1 US 2003065002A1
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United States
Prior art keywords
opioid
antagonist
pharmaceutical composition
naloxone
composition according
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Abandoned
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US10/143,111
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English (en)
Inventor
Frank Caruso
Huai-Hung Kao
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Purdue Pharma LP
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Endo Pharmaceuticals Inc
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Application filed by Endo Pharmaceuticals Inc filed Critical Endo Pharmaceuticals Inc
Priority to US10/143,111 priority Critical patent/US20030065002A1/en
Assigned to ENDO PHARMACEUTICALS, INC. reassignment ENDO PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CARUSO, FRANK S., KAO, HUAI-HUNG
Publication of US20030065002A1 publication Critical patent/US20030065002A1/en
Priority to US11/901,232 priority patent/US20080069881A1/en
Priority to US13/494,431 priority patent/US20120252832A1/en
Priority to US13/777,537 priority patent/US20130172382A1/en
Priority to US14/067,821 priority patent/US9084729B2/en
Priority to US14/136,443 priority patent/US8969369B2/en
Assigned to PURDUE PHARMA reassignment PURDUE PHARMA ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ENDO PHARMACEUTICALS INC.
Priority to US14/205,204 priority patent/US9056051B2/en
Assigned to PURDUE PHARMA L.P. reassignment PURDUE PHARMA L.P. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: PURDUE PHARMA
Priority to US14/725,369 priority patent/US9161937B2/en
Priority to US14/725,379 priority patent/US9168252B2/en
Priority to US14/859,200 priority patent/US9283221B2/en
Priority to US14/859,195 priority patent/US9283216B2/en
Priority to US15/015,019 priority patent/US9345701B1/en
Priority to US15/014,995 priority patent/US9358230B1/en
Priority to US15/159,465 priority patent/US9511066B2/en
Priority to US15/159,737 priority patent/US9480685B2/en
Priority to US15/280,541 priority patent/US20170014405A1/en
Priority to US15/280,621 priority patent/US20170014406A1/en
Priority to US15/898,018 priority patent/US20180185353A1/en
Priority to US15/898,069 priority patent/US20180169090A1/en
Priority to US16/222,720 priority patent/US20190111051A1/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • the present invention relates to controlled-release analgesic pharmaceutical formulations. More specifically, the invention relates to abuse-deterring controlled-release analgesic tablets.
  • Opioid compounds have long been known both for their powerful analgesic properties, and for their strong potential for abuse. While highly effective at controlling pain, opioids can also be addictive. Abuse of opioids, particularly heroin, but also including morphine, codeine, oxycodone, hydromorphone, oxymorphone, and others, is a problem in modem society. Opioid addicts can obtain drugs from a variety of illicit sources. These street drugs are of questionable quality. Therefore, to potential abusers, prescription pharmaceutical opioids can be particularly attractive as a drug source because of their high purity and dependable dosage.
  • Abusers extract the pharmaceutical opioid, and other constituents, from the tablets. To do so, the tablets are crushed and often dissolved. The result may be further treated before it is ultimately injected or snorted to achieve a “high”. This type of intravenous or intranasal abuse is well documented.
  • opioid antagonists have been used to block the euphoria associated with opioid abuse, and to induce withdrawal symptoms in addicts.
  • opioid antagonists One opioid antagonist used previously, and even now, is naloxone.
  • Naloxone is a powerful antagonist of the opioid receptor. Naloxone is highly effective when taken parenterally, but poorly effective when taken orally because of its metabolism in the liver and, thus, has a high oral:parenteral potency ratio. When injected in humans, amounts as small as 0.2-0.4 mg can block the opioid receptors and prevent the user from experiencing the drug's effects, whether analgesia or mood alteration, euphoria.
  • naloxone Because of the high oral:parenteral potency ratio ( ⁇ 100) the antagonist action of oral doses of naloxone is much lower than the action of injections of naloxone. Because antagonists such as naloxone are less effective when taken orally, they have not been used to deter oral abuse and have been limited to deterring parenteral or intranasal abuse.
  • Oxycontin® a controlled release oxycodone tablet from Purdue Pharma
  • Oxycontin® is available in strengths as high as 160 mg oxycodone per tablet.
  • the high opioid content makes these tablets especially attractive to abusers.
  • Illegal trade in controlled release opioid tablets is becoming more prevalent.
  • an abuser may crush the tablet and extract the opioid compound by dissolution for injection, or intranasal administration.
  • the abuser can achieve a euphoric effect from the drug by simply taking the drug orally, after chewing the tablet or grinding it to break the controlled release matrix and converting it to an immediate release product. Therefore, it would be desirable to have a formulation which would prevent the oral abuse of controlled release tablets if crushed to convert it to an immediate release product, without significantly affecting the analgesic action of opioid compounds in the intact controlled release tablet.
  • WO 01/58447 discloses pharmaceutical combinations of opioid agonists and antagonists in a controlled release matrix.
  • the antagonist is present and released in amounts, over time, that attenuate or reduce the side effects of the opioid agonist, yet in amounts insufficient to block the opioid effect.
  • the preferred antagonist is Naltrexone, which is highly effective when administered orally or parenterally.
  • the antagonist is released only in very small amounts, 100-1000 times less than the opioid.
  • WO '447 is silent with respect to including an anti-abusive amount of antagonist in the dose to prevent abuse.
  • the intravenous use of small amounts of naloxone, 0.25 or 1 ⁇ g kg ⁇ 1 hr ⁇ 1 is also disclosed as having attenuating effects.
  • WO '447 does not present release rates for the antagonist in its CR formulation, but directs those skilled in the art to the Crain patents (U.S. Pat. Nos. 5,767,125; 5,580,876; 5,512,578; and 5,472,943).
  • the Crain patents collectively disclose instant release formulations with “ultra-low” doses of certain antagonists to selectively block only the excitatory opioid receptors to attenuate opioid side effects, without blocking inhibitory receptors, which would lead to opioid blocking. These doses are on the order of pico-molar amounts.
  • Crain '578 suggests that only naltrexone is useful in oral administration and that 1 ⁇ g doses are sufficient for attenuating opioid side effects by selectively blocking the excitatory opioid receptors and leaving the inhibitory opioid receptors free for receiving the opioid agonist (which may be administered in lower than normal doses with similar analgesic effect).
  • the normal oral dose of naltrexone is about 50 mg versus “ultra low” does of 1 ⁇ g of naltrexone described in Crain '578 patent.
  • Abuse-resistant, controlled release opioid tablets are a combination containing an opioid antagonist having a high oral:parenteral potency ratio (i.e. oral:parenteral>1), such as naloxone, at a level insufficient to block the opioid effects or to attenuate the opioid side-effects in the controlled release formulation administered over an extended period, but above that needed to suppress the euphoric effect of the opioid if administered all at once. If the combination tablet is crushed to break the controlled release properties, the opioid and opioid antagonist is released as an immediate release product in a single dose, and the antagonist blocks the euphoric effects of the agonist.
  • the opioid antagonist is contained in a controlled-release matrix and released over time, with the opioid agonist.
  • the present invention employs the principle that certain opioid antagonists are ineffective in low oral doses. Therefore, one can administer a low oral dose over a long period of time (controlled release) from a tablet containing a large, orally effective amount of antagonist, without adversely affecting the action of the opioid. However, if the antagonist is administered all at once, it will block the opioid effect and may induce withdrawal in dependent individuals.
  • controlled release or “CR” when used herein, is intended to refer to tablets intended to release an active pharmaceutical ingredient over an extended period of time, usually over 4 hours, generally 8-12 or up to 24 hours.
  • One method of determining this is to check the intended dosing schedule. Any tablet intended to be taken less frequently than once every four hours should be considered controlled release regardless of labeling as controlled release, sustained release, extended release, etc. Often, these tablets contain polymeric matrices which may be cross-linked. Examples of such controlled release formulations are the Contin® system, produced by Purdue Fredrick Pharmaceuticals, or the TimerX® system by Pennwest Pharmaceuticals.
  • Other controlled release polymers can also be used, such as methacrylate (Eudragit®), hydroxylpropyl methylcellulose (HPMC), or Carbopol®.
  • the present invention may be used with these or other controlled release formulations.
  • the tablet of the present invention contains an opioid agonist in a controlled release matrix, along with an opioid antagonist.
  • the antagonist is present at such a level, and dispensed at such a rate, that it will not block the action of the opioid agonist when an intact controlled release tablet is taken orally. Crushing the tablet will release sufficient antagonist all at once as an immediate release formulation to block the opioid response and also, induce abstinence.
  • Antagonists need to reach an effective dose to work, so their slow release coupled with fast metabolism means they are maintained at ineffective, low levels in normal, recommended, therapeutic, non-abusive use. This low level of antagonist can be released over a long time period without affecting the therapeutic action of the opioid agonist.
  • the antagonist does not accumulate to blocking levels, since it is metabolized before it can accumulate to such levels.
  • the level of antagonist should be varied with the opioid dosage of the tablet.
  • the oral:parenteral potency ratio, and the release rates the levels of antagonists employed will vary. Regardless, there should be sufficient antagonist to block the opioid effect (high) and induce withdrawal in dependent individuals, if the tablet is crushed, converting the formulation to immediate release. Under normal conditions, the release rate is not sufficient for blocking the opioid effect nor suitable for selectively blocking the excitatory opioid receptors to attenuate opioid side effects.
  • the presently preferred antagonist it is believed that 15 mg (immediate release) should begin to block the opioid receptors and initiate withdrawal.
  • the opioid agonist can be any agonist in general use as an analgesic, including, but not limited to, morphine, oxycodone, levorphenol, meperdine, hydrocodone, codeine, dihydrocodeine, hydromorphone, propoxyphene, methadone, and oxymorphone.
  • any addictive opioid in a controlled release dosage form is the target of the present invention.
  • controlled release oxycodone has recently been the target of abuse, and would therefore make a good candidate for use in the present invention.
  • the release rate of the opioid agonist is established to achieve the desired analgesic effect.
  • Potency of the antagonist is measured as the oral:parenteral potency ratio, which indicates the amount of antagonist required orally to achieve an equivalent effect to an effective parenteral dose.
  • an antagonist having an oral:parenteral potency ratio of 10:1 requires 10 times the parenteral dose to be effective orally.
  • the opioid antagonists used herein will have greater antagonistic effect when administered parenterally than when administered orally (oral:parenteral potency ratio>1). Accordingly, the desired antagonists block the opioid effect and induce withdrawal when administered at relatively low levels parenterally or intranasally. At the same time, these antagonists require relatively large levels to be effective when administered orally for recommended, therapeutic use. Thus, effective parenteral/intranasal doses are ineffective when administered orally.
  • the oral:parenteral potency ratio is at least approximately 10:1, more preferably at least approximately 25:1, and most preferably at least approximately 100:1 as is the case with Naloxone.
  • opioid antagonists having substantially greater effectiveness when administered by injection than when administered orally include, but are not limited to: naloxone; naltrexone; N-cyclo propylmethyl-7,8-dihydro-14-hydroxynormorphinone or 21 cyclopropyl z, -(1-hydroxy-1-methylethyl)-6,14-endo-ethano-tetrahydrooripavine (or diphenorphine); and the pharmaceutically-acceptable salts thereof.
  • opioid antagonists such as naloxone
  • opioid antagonists can block opioid receptors and reduce or eliminate the effect of opioids.
  • Such antagonists are useful in treating opioid overdoses and to help treat addiction, in some cases.
  • the antagonists By blocking opioid receptors, the antagonists reverse and block the response to opioids.
  • the high oral:parenteral potency ratio antagonists, such as naloxone, while very effective when injected, are significantly less effective when taken orally. Therefore, a dosage form designed for oral administration can have a significant amount of opioid antagonist, without adversely affecting the therapeutic efficacy of the opioid. Similarly, these levels of antagonists do not attenuate the side effects of the opioid.
  • Such an antagonist would be effective in deterring intravenous or intranasal abuse when present in low levels, but would be ineffective in deterring oral abuse.
  • the antagonist would also reduce or inhibit the therapeutic efficacy of the drug.
  • a tablet containing an orally effective amount of antagonists in a CR formulation releasing ineffective amounts of antagonist under normal use would be effective against both oral and parenteral abuse, without minimizing the effectiveness of the opioid under normal use.
  • the amount of antagonist in the composition will depend on the relative strength of the antagonist, the amount and strength of the opioid, the release rate of the antagonist, and the oral:parenteral potency ratio. In any event, the combination of antagonist type, oral:parenteral potency ratio, quantity, and release rate do not result in blockage of the opioid effect or attenuation of its side effects, when administered orally in its intended, intact dosage form.
  • Strengths of controlled release opioid tablets vary with the particular opioid used. In the case of oxycodone, strengths of 10, 20, 40, 80, and 160 mg may be used in a controlled release formula.
  • the amount of opioid antagonist (such as naloxone) in such a tablet may also vary from about 2 mg to 40 mg or more.
  • Higher dose opioid tablets should contain an effective amount of antagonist without accumulation.
  • the amount of naloxone, opioid antagonist used can range from 5 to 40 mg.
  • the ratio of opioid to opioid antagonist varies from 1:3 to 4:1, since a 160 mg opioid tablet may contain 80 mg opioid antagonist.
  • the ratio can vary, it is preferable to select one ratio for all tablet strengths. Physicians prefer to titrate patients using several low dose tablets which add up to the desired dosage. This is easiest if a constant ratio is maintained. Thus, a constant ratio across tablet strengths is useful even though that ratio can be any appropriate ratio in the range set forth above.
  • compositions of the invention contain sufficient antagonist to be effective orally and, therefore, necessarily contain a parenterally or intranasally effective blocking amount. Accordingly, parenteral and intranasal abuse are not discussed here.
  • Abusers may “chew” a single large dose tablet to achieve instant release of an abusive dose of opioid.
  • Compositions containing these abusive amounts of opioid should contain enough antagonist to block oral abuse by “chewing.”
  • Two or more lower dose tablets may be “chewed” together to achieve an abusive dose.
  • each tablet itself does not contain an orally, effective amount of antagonist, when combined to an abusive dose, the combined antagonist should be orally effective. That is if, for example, a 10 mg tablet is not sufficient to achieve a high, it need not contain the full orally effective amount of antagonist. If two 10 mg tablets are sufficient for a high, they then should contain a combined amount of antagonist which is effective orally for blocking the opioid effect.
  • two or more high-dose tablets could be taken orally, without crushing, to achieve a “high.” Such a combination would take advantage of the CR properties to sustain a high for the entire dosage period up to 12 hours. This type of abuse is uncommon since most abusers want the instant high or rush afforded by the immediate release of the crushed tablets. Such a combination, according to one embodiment of the invention, should also release a blocking amount of antagonist when taken orally without chewing. This arrangement would also prevent the dire effects of accidental overdose. Although this type of arrangement would be beneficial in many situations, it could limit a prescribing doctor's options, and therefore, may not be appropriate in all situations. Tablets according to this embodiment are not preferred, but are certainly within the scope of the invention.
  • Tablets according to the invention may take into consideration any of the above abusive regimes individually or any combination thereof.
  • the tablet contains 1) an amount of antagonist which is orally effective for blocking the opioid effect and 2) that the antagonist is available, normally, only at levels that are ineffective to block the opioid effect or to attenuate the opioid side-effects.
  • One of the ways to achieve this is to control the release rate of the antagonist.
  • the release rate of the antagonist is best thought of in terms of a percent of the release rate of the opioid agonist. The rate is controlled between approximately 100%-0% of the release rate of the opioid, preferably 100%-25%.
  • Table 1 shows release rates of opioid and antagonist as % released. In the case of 0%, the antagonist is never released unless the tablet is crushed. But, that is the subject of another application.
  • the short half-life (about one hour) ensures that the Naloxone does not accumulate to blocking levels, even when released at the same rate as the opioid.
  • the unreleased portion remaining after 10-12 hours passes to the large intestine where the absorption rate is much slower than in the stomach and small intestine. Accordingly, the amount of antagonist released beyond 10-12 hours does not contribute to any blocking or attenuating effect.
  • Release rates are a percentage of agonist or antagonist with respect to its total content in the composition.
  • the tablets may be made by any traditional method of manufacture of controlled release tablets. Two principal processes are wet process (including wet granulation) and dry process (including direct mixing and roller compaction process.) Exemplary compositions for those processes are reproduced below. TABLE 2 Preferred Naloxone Ranges for Differing Strengths of Oxycodone Tablets Oxycodone (mg) 10 20 40 80 160 Naloxone (mg) 2-10 4-20 8-40 16-80 20-160
  • the doses for controlled release tablets may be 10, 20, or 40 mg and the naloxone dose ranges may be the same as set forth for oxycodone.
  • compositions may also be used.
  • tablets according to the present invention will have the following compositions: Material Quantity (%) Oxycodone Hydrochloride, USP 2.000-35.000 Naloxone 2.000-20.000 Microcrystalline Cellulose, NF (Avicel PH102) 10.000-50.000 Ammonio Methacrylate Copolymer, NF (Eudragit RSPO) 30.000-70.000 Colloidal Silicon Dioxide, NF (Cab-O-Sil) 0-5.000 Sodium Lauryl Sulfate, NF 0-5.000 Magnesium Hydroxide, USP 0-2.000 Povidone, USP 0-15.000 Stearic Acid, NF 0-5.000 Magnesium Stearate, NF 0-5.000
  • Dissolution was conducted according to USP XXIV Apparatus 3 (Reciprocating Cylinder) for Formulation 1-3.
  • the apparatus 3 is to simulate the gastrointestinal conditions of human.
  • the 1 st hour is at pH 1.2 of 0.1N HCl.
  • the 2nd and 3rd hours are at pH 4.5 of 10 mM of potassium phosphate monobasic.
  • the conditions after the 3 rd hours are at pH 6.8 of 10 mM of potassium phosphate monobasic.
  • All dissolution vessels contain 250 mL of dissolution solution.
  • the dip rate is set at 10 dips per minute.
  • the bath temperature is set at 37.5° C.
  • HPLC parameters are set as follows: Column—Inertsil ODS 3, 50 mm ⁇ 4.6 mm, 3 ⁇ m particle size. Mobile phase: 80% 30 mM sodium hexanesulfonate pH 3.0+/ ⁇ 1, 20% acetonitrile. Injection volume is 75 ⁇ L. Column temperature is 35° C., Flow rate is set at 1.0 mL/min. Wavelength is set at 225 nm. Run time is 5.5 minutes.
  • Dissolution results for Formulation 1-3 were as follows: Formulation 1 Tablet not Crushed Tablet Crushed % Oxycodone % Naloxone % Oxycodone % Naloxone Time Dissolved Dissolved Dissolved Dissolved Dissolved 0 0.0 0.0 0.0 0.0 1 29.8 27.8 88.2 94.6 2 47.8 45.4 3 59.8 57.4 4 68.5 65.9 8 91.1 87.5 12 100.7 97.9
  • Formulation 2 Tablet not Crushed Tablet Crushed % Oxycodone % Naloxone % Oxycodone % Naloxone Time Dissolved Dissolved Dissolved Dissolved Dissolved 0 0.0 0.0 0.0 0.0 1 40.1 37.0 104.9 102.8 2 63.2 60.3 3 77.3 75.3 4 86.5 85.2 8 105.6 106.1 12 110.5 112.6
  • Example 3 which has the highest initial release rate of antagonist, only makes about 5 mg naloxone available in the first hour. Due to the short half-life of naloxone, and the slow release rate, the antagonist does not accumulate in the body to a level that blocks the opioid effect. On the other hand, in the crushed tablet, substantially all of the antagonist is available in the first hour. Thus, an opioid blocking amount of antagonist is readily available to deter oral and other forms of abuse. Regardless of the antagonist used, the combination of the antagonist content, the release rate, and the antagonist half-life achieves the goals of the invention to block the opioid effect when administered as for instant release, yet not blocking the opioid effect when administered as intended and recommended as a controlled release formulation.
US10/143,111 2001-05-11 2002-05-10 Abuse-resistant controlled-release opioid dosage form Abandoned US20030065002A1 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
US10/143,111 US20030065002A1 (en) 2001-05-11 2002-05-10 Abuse-resistant controlled-release opioid dosage form
US11/901,232 US20080069881A1 (en) 2001-05-11 2007-09-14 Abuse-resistant controlled-release opioid dosage form
US13/494,431 US20120252832A1 (en) 2001-05-11 2012-06-12 Abuse-resistant controlled-release opioid dosage form
US13/777,537 US20130172382A1 (en) 2001-05-11 2013-02-26 Abuse-resistant controlled-release opioid dosage form
US14/067,821 US9084729B2 (en) 2001-05-11 2013-10-30 Abuse-resistant controlled-release opioid dosage form
US14/136,443 US8969369B2 (en) 2001-05-11 2013-12-20 Abuse-resistant controlled-release opioid dosage form
US14/205,204 US9056051B2 (en) 2001-05-11 2014-03-11 Abuse-resistant controlled-release opioid dosage form
US14/725,369 US9161937B2 (en) 2001-05-11 2015-05-29 Abuse-resistant controlled-release opioid dosage form
US14/725,379 US9168252B2 (en) 2001-05-11 2015-05-29 Abuse-resistant controlled-release opioid dosage form
US14/859,200 US9283221B2 (en) 2001-05-11 2015-09-18 Abuse-resistant controlled-release opioid dosage form
US14/859,195 US9283216B2 (en) 2001-05-11 2015-09-18 Abuse-resistant controlled-release opioid dosage form
US15/015,019 US9345701B1 (en) 2001-05-11 2016-02-03 Abuse-resistant controlled-release opioid dosage form
US15/014,995 US9358230B1 (en) 2001-05-11 2016-02-03 Abuse-resistant controlled-release opioid dosage form
US15/159,737 US9480685B2 (en) 2001-05-11 2016-05-19 Abuse-resistant controlled-release opioid dosage form
US15/159,465 US9511066B2 (en) 2001-05-11 2016-05-19 Abuse-resistant controlled-release opioid dosage form
US15/280,621 US20170014406A1 (en) 2001-05-11 2016-09-29 Abuse-resistant controlled-release opioid dosage form
US15/280,541 US20170014405A1 (en) 2001-05-11 2016-09-29 Abuse-resistant controlled-release opioid dosage form
US15/898,018 US20180185353A1 (en) 2001-05-11 2018-02-15 Abuse-resistant controlled-release opioid dosage form
US15/898,069 US20180169090A1 (en) 2001-05-11 2018-02-15 Abuse-resistant controlled-release opioid dosage form
US16/222,720 US20190111051A1 (en) 2001-05-11 2018-12-17 Abuse-resistant controlled-release opioid dosage form

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US13/494,431 Abandoned US20120252832A1 (en) 2001-05-11 2012-06-12 Abuse-resistant controlled-release opioid dosage form
US13/777,537 Abandoned US20130172382A1 (en) 2001-05-11 2013-02-26 Abuse-resistant controlled-release opioid dosage form
US14/067,821 Expired - Fee Related US9084729B2 (en) 2001-05-11 2013-10-30 Abuse-resistant controlled-release opioid dosage form
US14/136,443 Expired - Fee Related US8969369B2 (en) 2001-05-11 2013-12-20 Abuse-resistant controlled-release opioid dosage form
US14/205,204 Expired - Fee Related US9056051B2 (en) 2001-05-11 2014-03-11 Abuse-resistant controlled-release opioid dosage form
US14/725,369 Expired - Fee Related US9161937B2 (en) 2001-05-11 2015-05-29 Abuse-resistant controlled-release opioid dosage form
US14/725,379 Expired - Fee Related US9168252B2 (en) 2001-05-11 2015-05-29 Abuse-resistant controlled-release opioid dosage form
US14/859,200 Expired - Fee Related US9283221B2 (en) 2001-05-11 2015-09-18 Abuse-resistant controlled-release opioid dosage form
US14/859,195 Expired - Fee Related US9283216B2 (en) 2001-05-11 2015-09-18 Abuse-resistant controlled-release opioid dosage form
US15/015,019 Expired - Lifetime US9345701B1 (en) 2001-05-11 2016-02-03 Abuse-resistant controlled-release opioid dosage form
US15/014,995 Expired - Lifetime US9358230B1 (en) 2001-05-11 2016-02-03 Abuse-resistant controlled-release opioid dosage form
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US15/159,737 Expired - Lifetime US9480685B2 (en) 2001-05-11 2016-05-19 Abuse-resistant controlled-release opioid dosage form
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US13/777,537 Abandoned US20130172382A1 (en) 2001-05-11 2013-02-26 Abuse-resistant controlled-release opioid dosage form
US14/067,821 Expired - Fee Related US9084729B2 (en) 2001-05-11 2013-10-30 Abuse-resistant controlled-release opioid dosage form
US14/136,443 Expired - Fee Related US8969369B2 (en) 2001-05-11 2013-12-20 Abuse-resistant controlled-release opioid dosage form
US14/205,204 Expired - Fee Related US9056051B2 (en) 2001-05-11 2014-03-11 Abuse-resistant controlled-release opioid dosage form
US14/725,369 Expired - Fee Related US9161937B2 (en) 2001-05-11 2015-05-29 Abuse-resistant controlled-release opioid dosage form
US14/725,379 Expired - Fee Related US9168252B2 (en) 2001-05-11 2015-05-29 Abuse-resistant controlled-release opioid dosage form
US14/859,200 Expired - Fee Related US9283221B2 (en) 2001-05-11 2015-09-18 Abuse-resistant controlled-release opioid dosage form
US14/859,195 Expired - Fee Related US9283216B2 (en) 2001-05-11 2015-09-18 Abuse-resistant controlled-release opioid dosage form
US15/015,019 Expired - Lifetime US9345701B1 (en) 2001-05-11 2016-02-03 Abuse-resistant controlled-release opioid dosage form
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