UA93888C2 - Протитуберкульозна композиція, яка містить сполуки оксазолу - Google Patents

Протитуберкульозна композиція, яка містить сполуки оксазолу

Info

Publication number
UA93888C2
UA93888C2 UAA200805407A UAA200805407A UA93888C2 UA 93888 C2 UA93888 C2 UA 93888C2 UA A200805407 A UAA200805407 A UA A200805407A UA A200805407 A UAA200805407 A UA A200805407A UA 93888 C2 UA93888 C2 UA 93888C2
Authority
UA
Ukraine
Prior art keywords
antituberculous
group
substituted
drugs
oxazole compounds
Prior art date
Application number
UAA200805407A
Other languages
English (en)
Russian (ru)
Inventor
Макото МАЦУМОТО
Хіроюкі Хасізуме
Тацуо Томісіге
Масанорі Кавасакі
Йосіхіко Шімокава
Original Assignee
Оцука Фармас'Ютікел Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37561307&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA93888(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Оцука Фармас'Ютікел Ко., Лтд. filed Critical Оцука Фармас'Ютікел Ко., Лтд.
Publication of UA93888C2 publication Critical patent/UA93888C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/06—Phenols the aromatic ring being substituted by nitro groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/133—Amines having hydroxy groups, e.g. sphingosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Винахід пропонує високопотужний протитуберкульозний лікарський засіб. Також йдеться про протитуберкульозний лікарський засіб, який містить сполуки оксазолу, представлені (І) загальною формулою (1): EMBED ISISServer (1) [де R1 представляє атом водню або С1-6алкільну групу, n представляє ціле число від 0 до 6, a R2 представляє загальну формулу (А) або подібні EMBED ISISServer , (A) де R3 представляє феноксигрупу (принаймні одну групу, вибрану з-поміж атома галогену, вибірково галогензаміщеної С1-6алкільної групи та вибірково галогензаміщеної С1-6алкоксигрупи, що може бути заміщена у фенільному кільці)або подібні], їх оптично активні форми або солі, та речовини (II), як, наприклад, первинні протитуберкульозні засоби.
UAA200805407A 2005-10-05 2006-10-04 Протитуберкульозна композиція, яка містить сполуки оксазолу UA93888C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005292461 2005-10-05
PCT/JP2006/320239 WO2007043542A1 (en) 2005-10-05 2006-10-04 Antituberculous composition comprising oxazole compounds

Publications (1)

Publication Number Publication Date
UA93888C2 true UA93888C2 (uk) 2011-03-25

Family

ID=37561307

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200805407A UA93888C2 (uk) 2005-10-05 2006-10-04 Протитуберкульозна композиція, яка містить сполуки оксазолу

Country Status (18)

Country Link
US (2) US8987304B2 (uk)
EP (2) EP1931425A1 (uk)
JP (2) JP5925065B2 (uk)
KR (1) KR101118942B1 (uk)
CN (2) CN101277740B (uk)
AR (1) AR056872A1 (uk)
AU (2) AU2006300320B2 (uk)
BR (1) BRPI0616659A8 (uk)
CA (2) CA2624497C (uk)
HK (1) HK1121082A1 (uk)
IL (1) IL189944A0 (uk)
PH (1) PH12015501098A1 (uk)
RU (2) RU2434632C2 (uk)
SG (1) SG165361A1 (uk)
TW (3) TW201434467A (uk)
UA (1) UA93888C2 (uk)
WO (1) WO2007043542A1 (uk)
ZA (1) ZA200802883B (uk)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2208705T3 (en) * 2007-09-20 2015-09-14 Kyowa Chem Ind Co Ltd Secondary calciumphosphatanhydrid particle and the process for preparing the
GB201012209D0 (en) * 2010-05-31 2010-09-08 Ge Healthcare Ltd In vivo imaging agent
RU2694056C2 (ru) 2013-07-26 2019-07-09 Санофи Противотуберкулезная стабильная фармацевтическая композиция в форме диспергируемой таблетки, содержащей гранулированный изониазид и гранулированный рифапентин, и способ ее приготовления
CA2918828A1 (en) 2013-07-26 2015-01-29 Sanofi Antitubercular composition comprising rifampicin, isoniazid, ethambutol and pyrazinamide and its process of preparation
US9822126B1 (en) 2014-10-21 2017-11-21 Council Of Scientific & Industrial Research Substituted 1,2,3-triazol-1-yl-methyl-2,3-dihydro-2-methyl-6-nitroimidazo[2,1-b]oxazoles as anti-mycobacterial agents and a process for the preparation thereof
RU2606839C1 (ru) * 2015-10-26 2017-01-10 Федеральное государственное бюджетное учреждение "Национальный исследовательский центр "Курчатовский институт" Лекарственный препарат противотуберкулезного действия на основе D-циклосерина в виде лиофилизата и способ получения лекарственного препарата
GB201519054D0 (en) * 2015-10-28 2015-12-09 Univ Dundee Composition
RU2627611C2 (ru) * 2015-10-30 2017-08-09 Акционерное общество "Фармасинтез" (АО "Фармасинтез") Противотуберкулезная фармацевтическая композиция, содержащая тиоацетазон
WO2019240104A1 (ja) 2018-06-11 2019-12-19 大塚製薬株式会社 デラマニド含有組成物
US20230381160A1 (en) * 2020-09-24 2023-11-30 Chien-Chang Lee Prophylatic use of calcium channel blockers in tuberculosis
KR102534846B1 (ko) 2021-12-14 2023-05-19 재단법인 환동해산업연구원 결핵균에 항균 활성을 가지는 해조류 추출물
US11977085B1 (en) 2023-09-05 2024-05-07 Elan Ehrlich Date rape drug detection device and method of using same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3911263A1 (de) 1989-04-07 1990-10-11 Saarstickstoff Fatol Gmbh Kombinationspraeparate
EP0648121B1 (en) 1993-05-05 1996-10-02 Palo Alto Medical Foundation Use of rifamycin derivatives for the manufacture of a medicament for the treatment of toxoplasmosis
RU2212335C1 (ru) * 2002-07-26 2003-09-20 Беляев Дмитрий Анатольевич Композиция для гидрофобизации древесины
AR041198A1 (es) * 2002-10-11 2005-05-04 Otsuka Pharma Co Ltd Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen
ES2314460T3 (es) * 2003-10-31 2009-03-16 Otsuka Pharmaceutical Co., Ltd. Compuestos de 2,3-dihidro-6-nitroimidazo (2,1-b)oxazol para el tratamiento de la tuberculosis.
TWI380975B (zh) * 2004-03-25 2013-01-01 Otsuka Pharma Co Ltd 製造胺基酚類化合物的方法

Also Published As

Publication number Publication date
EP2269694A3 (en) 2011-03-09
TW201233389A (en) 2012-08-16
IL189944A0 (en) 2008-08-07
BRPI0616659A8 (pt) 2018-05-08
RU2008117427A (ru) 2009-11-10
US20090275528A1 (en) 2009-11-05
US20150224099A1 (en) 2015-08-13
CN101277740A (zh) 2008-10-01
EP2269694A2 (en) 2011-01-05
AU2006300320B2 (en) 2010-08-26
ZA200802883B (en) 2009-09-30
SG165361A1 (en) 2010-10-28
KR20080052648A (ko) 2008-06-11
AU2006300320A1 (en) 2007-04-19
JP2012197312A (ja) 2012-10-18
CA2862193C (en) 2016-06-07
CA2862193A1 (en) 2007-04-19
WO2007043542A9 (en) 2008-05-08
JP2014132023A (ja) 2014-07-17
CA2624497C (en) 2014-11-18
US8987304B2 (en) 2015-03-24
BRPI0616659A2 (pt) 2012-12-25
AU2010241497A1 (en) 2010-12-09
JP5925065B2 (ja) 2016-05-25
EP1931425A1 (en) 2008-06-18
RU2434632C2 (ru) 2011-11-27
CN101277740B (zh) 2012-12-05
PH12015501098A1 (en) 2015-12-07
TW201434467A (zh) 2014-09-16
TW200744589A (en) 2007-12-16
RU2011129167A (ru) 2013-01-20
RU2560676C2 (ru) 2015-08-20
WO2007043542A1 (en) 2007-04-19
CA2624497A1 (en) 2007-04-19
HK1121082A1 (en) 2009-04-17
TWI368509B (en) 2012-07-21
KR101118942B1 (ko) 2012-02-27
CN102895230A (zh) 2013-01-30
AR056872A1 (es) 2007-10-31

Similar Documents

Publication Publication Date Title
PH12015501098A1 (en) Antituberculous composition comprising oxazole compounds
MY139244A (en) 2,3-dihydro-6-nitroimidazo [2,1-b] oxazole
AU2003273475A1 (en) N-(phenyl(piperidin-2-yl)methyl)benzamide derivatives, preparation thereof, and use thereof in therapy
EG24902A (en) Pyrimidine compounds and pests controlling composition containing the same
EP1775289A4 (en) NEW IMIDAZOLIDINE DERIVATIVES
MXPA04002647A (es) Antranilamidas artropodicidas.
RS54047B1 (en) PROCEDURE FOR OBTAINING 4-OXOCHINOLINE COMPOUNDS
HK1096549A1 (en) Imidazopyridine-derivatives as inducible no-synthase inhibitors
TW200731929A (en) Insecticidal 2-acylaminothiazole-4-carboxamides
TW200607808A (en) Pyrido-pyrimidine derivatives, preparation thereof and application thereof
MA32192B1 (fr) Composés dérivés d'azétidines, leur préparation et leur application en thérapeutique
WO2008129966A1 (ja) 有害生物防除組成物
DE60014143D1 (de) Antimikrobielle 4-oxochinolizine mit 2-pyridongerüsten als teilstruktur
MY138466A (en) Aminoalkoxyndoles as 5-ht6-receptor ligands for the treatment of cns-disorders
HK1096548A1 (en) Imidazopyridine-derivatives as inductible no-synthase inhibitors
TNSN08161A1 (en) 6-heteroarylpyridoindolone derivatives, their preparation and therapeutic use thereof
MY145368A (en) Aminoquinoxaline compounds and polyaminoquinoxaline compounds, and use thereof
HK1101667A1 (en) 5-iodotetrazoles
MY149301A (en) Epoxy compound and method for manufacturing the same
MX2022002898A (es) Compuesto de 7-oxa-3,4-diazabiciclo-[4.1.0]-4-hepten-2-ona y herbicida.
MXPA04009421A (es) Compuestos de tiazol-2-ilimina como inhibidores de la pde-7.
UA100489C2 (en) Anthranilamide insecticides
TW200606163A (en) Imidazopyridine compound
TW200626007A (en) Material for electroluminescent element and electroluminescent element
BR9812928A (pt) Novos derivados de 3-oxo-(2h) -1,2,4-triazina, processo de preparação de compostos quìmicos, e, composição farmacêutica