DE60014143D1 - Antimikrobielle 4-oxochinolizine mit 2-pyridongerüsten als teilstruktur - Google Patents

Antimikrobielle 4-oxochinolizine mit 2-pyridongerüsten als teilstruktur

Info

Publication number
DE60014143D1
DE60014143D1 DE60014143T DE60014143T DE60014143D1 DE 60014143 D1 DE60014143 D1 DE 60014143D1 DE 60014143 T DE60014143 T DE 60014143T DE 60014143 T DE60014143 T DE 60014143T DE 60014143 D1 DE60014143 D1 DE 60014143D1
Authority
DE
Germany
Prior art keywords
group
hydrogen atom
amino
oxochinolicine
scuffs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60014143T
Other languages
English (en)
Other versions
DE60014143T2 (de
Inventor
Ryoichi Fukumoto
Hiroyuki Kusakabe
Chong Chu
Hiroaki Kimura
Satoshi Yanagihara
Masatoshi Kato
Chisato Hirosawa
Seiji Ishiduka
Fusae Shizume
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sato Pharmaceutical Co Ltd
Original Assignee
Sato Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sato Pharmaceutical Co Ltd filed Critical Sato Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE60014143D1 publication Critical patent/DE60014143D1/de
Publication of DE60014143T2 publication Critical patent/DE60014143T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
DE60014143T 1999-10-19 2000-10-19 Antimikrobielle 4-oxochinolizine mit 2-pyridongerüsten als teilstruktur Expired - Fee Related DE60014143T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP29638399 1999-10-19
JP29638399 1999-10-19
PCT/JP2000/007256 WO2001029035A1 (fr) 1999-10-19 2000-10-19 Antimicrobiens 4-oxoquinolizine presentant des squelettes 2-pyridone en tant que structure partielle

Publications (2)

Publication Number Publication Date
DE60014143D1 true DE60014143D1 (de) 2004-10-28
DE60014143T2 DE60014143T2 (de) 2006-03-02

Family

ID=17832846

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60014143T Expired - Fee Related DE60014143T2 (de) 1999-10-19 2000-10-19 Antimikrobielle 4-oxochinolizine mit 2-pyridongerüsten als teilstruktur

Country Status (8)

Country Link
US (1) US6525066B2 (de)
EP (1) EP1227096B1 (de)
JP (1) JP4328049B2 (de)
AT (1) ATE277042T1 (de)
AU (1) AU7948900A (de)
DE (1) DE60014143T2 (de)
ES (1) ES2225237T3 (de)
WO (1) WO2001029035A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6846819B1 (en) 1999-10-08 2005-01-25 Affinium Pharmaceuticals, Inc. Fab I inhibitors
WO2002022614A1 (fr) * 2000-09-12 2002-03-21 Sankyo Company,Limited Derives de quinolizine
US7049310B2 (en) * 2001-04-06 2006-05-23 Affinium Pharmaceuticals, Inc. Fab I inhibitors
JP4101754B2 (ja) * 2001-09-28 2008-06-18 佐藤製薬株式会社 ２−ピリドン骨格を部分構造として有する４−オキソキノリジン抗菌剤
ES2518316T3 (es) * 2002-12-06 2014-11-05 Debiopharm International Sa Compuestos heterocíclicos, métodos de fabricación de los mismos y su uso en terapia
DE602004016831D1 (de) 2003-03-17 2008-11-13 Affinium Pharm Inc Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend
US20070275994A1 (en) * 2003-06-06 2007-11-29 Lohray Braj B Novel Antinfective Compounds
WO2007053131A2 (en) 2004-06-04 2007-05-10 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as antibiotic agents
JP2009518399A (ja) * 2005-12-05 2009-05-07 アフィニウム ファーマシューティカルズ， インク． Ｆａｂｉ阻害剤および抗菌剤としてのヘテロ環アクリルアミド化合物
CA2658506C (en) 2006-07-20 2016-01-26 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab 1 inhibitors
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
US8263613B2 (en) * 2007-02-16 2012-09-11 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab I inhibitors
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
WO2012047487A1 (en) * 2010-09-27 2012-04-12 Evolva Sa 2-pyridone antimicrobial compositions
ES2845551T3 (es) * 2011-02-01 2021-07-27 Emergent Product Dev Gaithersburg Inc 4-oxoquinolizinas antimicrobianas
RS58898B1 (sr) 2012-06-19 2019-08-30 Debiopharm Int Sa Prolek derivati (e)-n-metil-n-((3-metilbenzofuran-2-il)metil)-3-(7-okso-5,6,7,8-tetrahidro-1,8-naftiridin-3-il)akrilamida
TN2018000293A1 (en) 2016-02-26 2020-01-16 Debiopharm Int Sa Medicament for treatment of diabetic foot infections
CN110938028B (zh) * 2019-12-09 2022-03-04 南京杰运医药科技有限公司 一种(1r)-5-溴-2,3-二氢-1-甲基-1h-异吲哚的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9407806A (pt) * 1993-10-14 1997-08-19 Abbott Lab Composto processo de tratamento de uma infecção bacteriana em um paciente humano ou veterinário e intermediário sintético
EP0775702B1 (de) 1994-08-12 2003-07-23 Toyama Chemical Co., Ltd. Neue chinolon- oder naphthyridoncarbonsäurederivate oder deren salze
JP3833738B2 (ja) 1995-11-15 2006-10-18 第一製薬株式会社 置換アミノメチルピロリジン誘導体
WO2002022614A1 (fr) * 2000-09-12 2002-03-21 Sankyo Company,Limited Derives de quinolizine

Also Published As

Publication number Publication date
DE60014143T2 (de) 2006-03-02
ES2225237T3 (es) 2005-03-16
EP1227096A1 (de) 2002-07-31
WO2001029035A1 (fr) 2001-04-26
AU7948900A (en) 2001-04-30
EP1227096A4 (de) 2003-04-02
ATE277042T1 (de) 2004-10-15
JP4328049B2 (ja) 2009-09-09
US20020173517A1 (en) 2002-11-21
US6525066B2 (en) 2003-02-25
EP1227096B1 (de) 2004-09-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee