UA88008C2 - Water-soluble prodrugs - Google Patents

Water-soluble prodrugs

Info

Publication number
UA88008C2
UA88008C2 UAA200611517A UAA200611517A UA88008C2 UA 88008 C2 UA88008 C2 UA 88008C2 UA A200611517 A UAA200611517 A UA A200611517A UA A200611517 A UAA200611517 A UA A200611517A UA 88008 C2 UA88008 C2 UA 88008C2
Authority
UA
Ukraine
Prior art keywords
water
represented
group containing
soluble prodrugs
divalent group
Prior art date
Application number
UAA200611517A
Other languages
English (en)
Ukrainian (uk)
Inventor
Исао УМЕДА
Джун Охвада
Савако Озава
Original Assignee
Чугей Сейяку Кабусики Кайся
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Чугей Сейяку Кабусики Кайся filed Critical Чугей Сейяку Кабусики Кайся
Publication of UA88008C2 publication Critical patent/UA88008C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Целью этого изобретения является обеспечение водорастворимыми пролекарствами, которые могут быть введены парентерально и которые демонстрируют хорошую водорастворимость и небольшие межвидовые расхождения или индивидуальные отличия и быстро превращаются в активные формы химическим путем.Данным изобретением предлагаются водорастворимые пролекарства, представленные формулой (1), или их фармацевтически приемлемые соли или гидраты, или сольваты,, (1)гдеRпредставляет собой атом водорода или С 1-С6алкильную группу;W представляет собой двухвалентную группу, которая содержит третичную аминогруппу или сульфонильную группу; иY представляет собой остаток соединения, представленного Y-OH, которая содержит спиртовую гидроксильную группу.
UAA200611517A 2004-04-09 2005-04-08 Water-soluble prodrugs UA88008C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2004115713 2004-04-09

Publications (1)

Publication Number Publication Date
UA88008C2 true UA88008C2 (en) 2009-09-10

Family

ID=35124997

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200611517A UA88008C2 (en) 2004-04-09 2005-04-08 Water-soluble prodrugs

Country Status (18)

Country Link
US (1) US7910593B2 (ru)
EP (1) EP1757609B1 (ru)
JP (1) JP4823894B2 (ru)
KR (1) KR20070011457A (ru)
CN (1) CN1964979B (ru)
AU (1) AU2005230994A1 (ru)
BR (1) BRPI0509732A (ru)
CA (1) CA2563502A1 (ru)
HK (1) HK1100083A1 (ru)
IL (1) IL178465A0 (ru)
MX (1) MXPA06011679A (ru)
MY (1) MY145850A (ru)
NO (1) NO20065137L (ru)
NZ (1) NZ550665A (ru)
RU (1) RU2413731C2 (ru)
TW (1) TWI351284B (ru)
UA (1) UA88008C2 (ru)
WO (1) WO2005097803A1 (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04004882A (es) * 2001-11-23 2005-04-11 Chugai Pharmaceutical Co Ltd Metodo para la identificacion de enzimas que tienen como objetivo tumores.
WO2004073601A2 (en) * 2003-02-21 2004-09-02 Chugai Seiyaku Kabushiki Kaisha Process for the preparation of hexacyclic camptothecin derivatives
US8652484B2 (en) 2004-02-13 2014-02-18 Immunomedics, Inc. Delivery system for cytotoxic drugs by bispecific antibody pretargeting
US8435539B2 (en) * 2004-02-13 2013-05-07 Immunomedics, Inc. Delivery system for cytotoxic drugs by bispecific antibody pretargeting
CN1964979B (zh) 2004-04-09 2011-07-27 中外制药株式会社 新颖的水溶性前药
TW200744603A (en) 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
BRPI0617730A2 (pt) * 2005-10-19 2011-08-02 Chugai Pharmaceutical Co Ltd agente para prevenir ou tratar cáncer do páncreas, cáncer de ovário ou cáncer hepático contendo nova pró-fármaco hidrossolúvel
JP5466006B2 (ja) * 2006-09-03 2014-04-09 テックフィールズ バイオケム カンパニー リミテッド 非常に速い皮膚浸透率を有するアセトアミノフェン及び関連化合物の正荷電水溶性プロドラッグ
CN102665757A (zh) * 2009-12-09 2012-09-12 免疫医疗公司 通过双特异性抗体预靶向的用于细胞毒性药物的递送系统
CN104755482B (zh) * 2012-10-30 2017-04-26 内尔维阿诺医学科学有限公司 官能化的9‑溴‑喜树碱衍生物
RU2748260C2 (ru) * 2016-04-04 2021-05-21 Кемосентрикс, Инк. РАСТВОРИМЫЕ С5аR АНТАГОНИСТЫ
US20200207782A1 (en) 2017-09-22 2020-07-02 Sumitomo Dainippon Pharma Co., Ltd Chemically activated water-soluble prodrug
CN118221763A (zh) 2019-03-29 2024-06-21 免疫医疗有限公司 化合物及其缀合物

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4473692A (en) 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
EP0220601B1 (en) 1985-10-21 1991-12-11 Daiichi Seiyaku Co., Ltd. Pyranoindolizine derivatives and preparation process thereof
US4981968A (en) 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US4939255A (en) 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
US4975278A (en) 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
JPH0271836A (ja) 1988-09-05 1990-03-12 Agency Of Ind Science & Technol 繊維状極小分子集合体の製法
AU4128089A (en) 1988-09-15 1990-03-22 Rorer International (Overseas) Inc. Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
HU213136B (en) 1990-08-14 1997-02-28 Kyorin Seiyaku Kk Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them
JP3008226B2 (ja) 1991-01-16 2000-02-14 第一製薬株式会社 六環性化合物
NZ242117A (en) 1991-03-29 1994-11-25 Lilly Co Eli 4-phenylpiperidine derivatives and medicaments containing them
JP3359955B2 (ja) 1992-07-16 2002-12-24 第一製薬株式会社 抗腫瘍剤
US5840900A (en) * 1993-10-20 1998-11-24 Enzon, Inc. High molecular weight polymer-based prodrugs
GB9402934D0 (en) 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation
US5663177A (en) 1995-05-31 1997-09-02 Smithkline Beecham Corporation Water soluble camptothecin analogs
JP2967184B2 (ja) 1996-03-07 1999-10-25 工業技術院長 オリゴペプチド鎖のｃ端を両端にもつ双頭型脂質の製造方法
US6172230B1 (en) 1996-04-26 2001-01-09 Daiichi Pharmaceutical Co., Ltd. Process for the preparation of tetrahydro-indolizines
WO1998013059A1 (en) 1996-09-27 1998-04-02 Bristol-Myers Squibb Company Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells
UA57757C2 (ru) * 1996-12-20 2003-07-15 Сос'Єте Де Консей Де Решерш Е Даплікасьон С'Єнтіфік (С.К.Р.А.С.) Формы пролекарств и новые аналоги камптотецина, их применение в качестве лекарств
ATE329903T1 (de) 1997-02-14 2006-07-15 Bionumerik Pharmaceuticals Inc Hochgradig lipophile camptothecin-derivate
US6294344B1 (en) 1997-03-19 2001-09-25 The Board Of Trustees Of The University Of Arkansas Methods for the early diagnosis of ovarian cancer
GB9709421D0 (en) 1997-05-10 1997-07-02 Zeneca Ltd Chemical compounds
AU7582298A (en) 1997-05-19 1998-12-11 Johns Hopkins University School Of Medicine, The Tissue specific prodrug
DE69828287T2 (de) 1997-06-13 2005-12-15 Gryphon Therapeutics, Inc., South San Francisco Festphasige native chemische ligation von ungeschützten oder n-cystein-geschützten peptiden in wässrigen lösungen
GB9712370D0 (en) 1997-06-14 1997-08-13 Aepact Ltd Therapeutic systems
GB9715821D0 (en) 1997-07-25 1997-10-01 Pharmacia & Upjohn Spa Amidino-camptothecin derivatives
JP2001512830A (ja) 1997-08-08 2001-08-28 ニューバイオティックス インコーポレイテッド 生物療法耐性および化学療法耐性を克服するための方法および組成物
JP4102466B2 (ja) 1997-11-14 2008-06-18 株式会社アミノアップ化学 抗癌剤の副作用軽減剤
US6130039A (en) 1997-12-12 2000-10-10 Incyte Pharmaceuticals, Inc. Polynucleotide encoding human lysyl hydroxylase-like protein
IL137164A0 (en) 1998-01-23 2001-07-24 Newbiotics Inc Enzyme catalyzed therapeutic agents
GB2334256A (en) 1998-02-12 1999-08-18 Univ Montfort Hydroxylation activated prodrugs
EA008060B1 (ru) 1998-09-04 2007-02-27 Милленниум Фармасьютикалз, Инк. Антагонисты хемокинного рецептора и способы их применения
AU3281600A (en) 1999-02-27 2000-09-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transsduction mediated by tyrosine kinases
WO2000063418A1 (en) 1999-04-15 2000-10-26 The Regents Of The University Of California Protein transport assays
EE200100603A (et) 1999-05-14 2003-02-17 Imclone Systems Incorporated Inimese refraktaarsete kasvajate ravi epidermaalse kasvufaktori retseptori antagonistidega
US7413536B1 (en) 1999-09-14 2008-08-19 Xenoport, Inc. Substrates and screening methods for transport proteins
US6268375B1 (en) 1999-12-29 2001-07-31 Research Triangle Institute 10, 11-difluoromethylenedioxycamptothecin compounds with topoisomerase I inhibition
CZ298259B6 (cs) 2000-02-28 2007-08-08 Aventis Pharma S. A. Farmaceutická kombinace k lécení rakoviny obsahující CPT-11 a capecitabin
AU2001268653A1 (en) 2000-06-28 2002-01-08 Supergen, Inc. Combination hiv therapy including camptothecin
WO2002010741A2 (en) 2000-07-28 2002-02-07 Lion Bioscience Ag Regional intestinal permeability model
EP1387677A2 (en) 2000-11-07 2004-02-11 Dana-Farber Cancer Institute, Inc. Method of treating hematologic tumors and cancers using beta lapachone
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6803186B2 (en) 2001-03-02 2004-10-12 The Iams Company Compositions and methods for increasing amino acid absorption in mammals
WO2002100172A1 (en) 2001-06-11 2002-12-19 Xenoport, Inc. Administration of agents via the pept-2 transporter
MXPA04004882A (es) * 2001-11-23 2005-04-11 Chugai Pharmaceutical Co Ltd Metodo para la identificacion de enzimas que tienen como objetivo tumores.
BR0214615A (pt) 2001-11-30 2004-09-14 Chugai Pharmaceutical Co Ltd Composto hexacìclico
JP4664071B2 (ja) 2002-08-01 2011-04-06 エーザイ コーポレーション オブ ノース アメリカ グルタミンによるガンの改良治療
PA8578001A1 (es) 2002-08-07 2004-05-07 Warner Lambert Co Combinaciones terapeuticas de inhibidores de quinasa de erb b y terapias antineoplasicas
WO2004073601A2 (en) 2003-02-21 2004-09-02 Chugai Seiyaku Kabushiki Kaisha Process for the preparation of hexacyclic camptothecin derivatives
JP2005255643A (ja) 2004-03-15 2005-09-22 Masato Kusunoki 抗腫瘍効果増強方法および抗腫瘍効果増強剤
CN1964979B (zh) 2004-04-09 2011-07-27 中外制药株式会社 新颖的水溶性前药
NZ589252A (en) 2004-09-02 2012-06-29 Vertex Pharma Quinazolines useful as inhibitors of voltage-gated sodium channels
TWI389897B (zh) 2005-02-22 2013-03-21 Chugai Pharmaceutical Co Ltd 1- (2H) -isoquinolinone derivatives
TW200744603A (en) 2005-08-22 2007-12-16 Chugai Pharmaceutical Co Ltd Novel anticancer concomitant drug
BRPI0617730A2 (pt) * 2005-10-19 2011-08-02 Chugai Pharmaceutical Co Ltd agente para prevenir ou tratar cáncer do páncreas, cáncer de ovário ou cáncer hepático contendo nova pró-fármaco hidrossolúvel

Also Published As

Publication number Publication date
RU2413731C2 (ru) 2011-03-10
IL178465A0 (en) 2007-02-11
CA2563502A1 (en) 2005-10-20
CN1964979A (zh) 2007-05-16
TW200600088A (en) 2006-01-01
US20080015157A1 (en) 2008-01-17
WO2005097803A1 (ja) 2005-10-20
JPWO2005097803A1 (ja) 2008-02-28
EP1757609A4 (en) 2010-09-01
HK1100083A1 (en) 2007-09-07
US7910593B2 (en) 2011-03-22
AU2005230994A1 (en) 2005-10-20
CN1964979B (zh) 2011-07-27
MY145850A (en) 2012-04-30
NZ550665A (en) 2010-05-28
EP1757609B1 (en) 2013-10-16
MXPA06011679A (es) 2007-01-23
KR20070011457A (ko) 2007-01-24
TWI351284B (en) 2011-11-01
BRPI0509732A (pt) 2007-09-25
RU2006139644A (ru) 2008-05-20
EP1757609A1 (en) 2007-02-28
JP4823894B2 (ja) 2011-11-24
NO20065137L (no) 2006-12-21

Similar Documents

Publication Publication Date Title
UA88008C2 (en) Water-soluble prodrugs
EA017861B9 (ru) Способ получения 4-оксохинолинового соединения
DE602005014936D1 (en) Phosphoramidatderivate
AU2006304874A8 (en) Pyrimidinones as casein kinase II (CK2) modulators
UA94833C2 (en) Substituted bicyclolactams
WO2005094329A8 (en) Compouns, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor
TW200730496A (en) Oxime ester photoinitiators
MY140987A (en) Specific glucocorticosteroid compound having anti-inflammatory activity
MY141194A (en) Process for the synthesis of ivabradine and its pharmaceutically acceptable acid addition salts
TNSN08191A1 (en) Kinase inhibitors
WO2006113509A3 (en) Quinobenzoxazine analogs and methods of using thereof
WO2006113552A8 (en) Cyanoarylamines
WO2007014054A3 (en) Benzenesulfonamide inhibitor of ccr2 chemokine receptor
WO2007099548A3 (en) Novel 11 beta - hydroxyandrosta-4-ene-3-ones
WO2008047951A3 (en) An alzheimer' s disease progression inhibitor containing heterocyclic compound
MY145788A (en) Antitumoral dihydropyran-2-one compounds
WO2004091504A3 (en) Substituted quinobenzoxazine analogs
WO2007012626A3 (de) Neues verfahren zur herstellung von tiotropiumsalzen
WO2006083841A3 (en) Therapeutic esters
MY138826A (en) 2,7-substituted indoles
WO2007014839A3 (en) Cathepsin k inhibitors
TW200613308A (en) Cyclobutanetetracarboxylate compound and preparation method thereof
UA93529C2 (ru) Соли и смеси 9-оксоакридин-10-уксусной кислоты c 1-алкиламино-1-дезоксиполиолами
AP2002002466A0 (en) 3-heterocycliylpropanohydroxamic acid PCP INHIBITORS.
WO2006026034A3 (en) Processes for the preparation of isothiazole derivatives