NO20065137L - Vannloselig prolegemiddel - Google Patents
Vannloselig prolegemiddelInfo
- Publication number
- NO20065137L NO20065137L NO20065137A NO20065137A NO20065137L NO 20065137 L NO20065137 L NO 20065137L NO 20065137 A NO20065137 A NO 20065137A NO 20065137 A NO20065137 A NO 20065137A NO 20065137 L NO20065137 L NO 20065137L
- Authority
- NO
- Norway
- Prior art keywords
- water soluble
- soluble prodrug
- prodrug
- represented
- water
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Vannløselig prolegemiddel representert med generell formel (1), hvor R' er hydrogen eller C1-C6-alkyl, W er en toverdig gruppe som inneholder tertiært amino eller sulfonyl, og Y er en rest av en forbindelse som har en alkoholisk hydroksygruppe og er representert med Y-OH. Det beskrives også et farmasøytisk akseptabelt salt av prolegemidlet, eller et hydrat av dette, eller et solvat av begge.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004115713 | 2004-04-09 | ||
PCT/JP2005/006957 WO2005097803A1 (ja) | 2004-04-09 | 2005-04-08 | 新規水溶性プロドラッグ |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20065137L true NO20065137L (no) | 2006-12-21 |
Family
ID=35124997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20065137A NO20065137L (no) | 2004-04-09 | 2006-11-08 | Vannloselig prolegemiddel |
Country Status (18)
Country | Link |
---|---|
US (1) | US7910593B2 (no) |
EP (1) | EP1757609B1 (no) |
JP (1) | JP4823894B2 (no) |
KR (1) | KR20070011457A (no) |
CN (1) | CN1964979B (no) |
AU (1) | AU2005230994A1 (no) |
BR (1) | BRPI0509732A (no) |
CA (1) | CA2563502A1 (no) |
HK (1) | HK1100083A1 (no) |
IL (1) | IL178465A0 (no) |
MX (1) | MXPA06011679A (no) |
MY (1) | MY145850A (no) |
NO (1) | NO20065137L (no) |
NZ (1) | NZ550665A (no) |
RU (1) | RU2413731C2 (no) |
TW (1) | TWI351284B (no) |
UA (1) | UA88008C2 (no) |
WO (1) | WO2005097803A1 (no) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20050044570A (ko) * | 2001-11-23 | 2005-05-12 | 추가이 세이야쿠 가부시키가이샤 | 종양 표적 효소의 동정 방법 |
EP1599484A2 (en) * | 2003-02-21 | 2005-11-30 | Chugai Seiyaku Kabushiki Kaisha | Process for the preparation of hexacyclic camptothecin derivatives |
US8435539B2 (en) * | 2004-02-13 | 2013-05-07 | Immunomedics, Inc. | Delivery system for cytotoxic drugs by bispecific antibody pretargeting |
US8652484B2 (en) | 2004-02-13 | 2014-02-18 | Immunomedics, Inc. | Delivery system for cytotoxic drugs by bispecific antibody pretargeting |
BRPI0509732A (pt) | 2004-04-09 | 2007-09-25 | Chugai Pharmaceutical Co Ltd | pró-fármaco solúvel em água, composição farmacêutica, agente terapêutico, agente antifungo e uso do referido pró-fármaco |
TW200744603A (en) * | 2005-08-22 | 2007-12-16 | Chugai Pharmaceutical Co Ltd | Novel anticancer concomitant drug |
KR20080066039A (ko) * | 2005-10-19 | 2008-07-15 | 추가이 세이야쿠 가부시키가이샤 | 신규 수용성 프로드러그를 함유하는 췌장암, 난소암 또는 간암의 예방 또는 치료제 |
JP5466006B2 (ja) * | 2006-09-03 | 2014-04-09 | テックフィールズ バイオケム カンパニー リミテッド | 非常に速い皮膚浸透率を有するアセトアミノフェン及び関連化合物の正荷電水溶性プロドラッグ |
CN102665757A (zh) * | 2009-12-09 | 2012-09-12 | 免疫医疗公司 | 通过双特异性抗体预靶向的用于细胞毒性药物的递送系统 |
EP2914600A2 (en) * | 2012-10-30 | 2015-09-09 | Nerviano Medical Sciences S.r.l. | Functionalized 9-bromo-camptothecin derivatives |
MA44629A (fr) | 2016-04-04 | 2021-03-24 | Chemocentryx Inc | Antagonistes de c5ar solubles |
WO2019059344A1 (ja) | 2017-09-22 | 2019-03-28 | 大日本住友製薬株式会社 | 化学活性化型水溶性プロドラッグ |
RS63715B1 (sr) | 2019-03-29 | 2022-11-30 | Medimmune Ltd | Jedinjenja i njihovi konjugati |
Family Cites Families (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4473692A (en) | 1981-09-04 | 1984-09-25 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives and process for preparing same |
DE3682874D1 (de) | 1985-10-21 | 1992-01-23 | Daiichi Seiyaku Co | Pyranoindolizinderivate und verfahren zu ihrer herstellung. |
US4981968A (en) | 1987-03-31 | 1991-01-01 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
US4939255A (en) | 1987-06-24 | 1990-07-03 | Daiichi Pharmaceutical Co., Ltd. | Hexa-cyclic camptothecin derivatives |
US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
JPH0271836A (ja) * | 1988-09-05 | 1990-03-12 | Agency Of Ind Science & Technol | 繊維状極小分子集合体の製法 |
AU4128089A (en) | 1988-09-15 | 1990-03-22 | Rorer International (Overseas) Inc. | Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same |
HU213136B (en) | 1990-08-14 | 1997-02-28 | Kyorin Seiyaku Kk | Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them |
JP3008226B2 (ja) | 1991-01-16 | 2000-02-14 | 第一製薬株式会社 | 六環性化合物 |
ZA922180B (en) | 1991-03-29 | 1993-09-27 | Lilly Co Eli | Piperidine derivatives |
JP3359955B2 (ja) | 1992-07-16 | 2002-12-24 | 第一製薬株式会社 | 抗腫瘍剤 |
US5840900A (en) * | 1993-10-20 | 1998-11-24 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
GB9402934D0 (en) | 1994-02-16 | 1994-04-06 | Erba Carlo Spa | Camptothecin derivatives and process for their preparation |
US5663177A (en) | 1995-05-31 | 1997-09-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs |
JP2967184B2 (ja) * | 1996-03-07 | 1999-10-25 | 工業技術院長 | オリゴペプチド鎖のc端を両端にもつ双頭型脂質の製造方法 |
US6172230B1 (en) | 1996-04-26 | 2001-01-09 | Daiichi Pharmaceutical Co., Ltd. | Process for the preparation of tetrahydro-indolizines |
CA2264227A1 (en) | 1996-09-27 | 1998-04-02 | Raymond A. Firestone | Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells |
UA57757C2 (uk) | 1996-12-20 | 2003-07-15 | Сос'Єте Де Консей Де Решерш Е Даплікасьон С'Єнтіфік (С.К.Р.А.С.) | Аналоги камптотецину, спосіб їх отримання (варіанти) і фармацевтична композиція |
PT1017675E (pt) | 1997-02-14 | 2006-09-29 | Bionumerik Pharmaceuticals Inc | Derivados da camtotecina altamente lipofilos |
US6294344B1 (en) | 1997-03-19 | 2001-09-25 | The Board Of Trustees Of The University Of Arkansas | Methods for the early diagnosis of ovarian cancer |
GB9709421D0 (en) | 1997-05-10 | 1997-07-02 | Zeneca Ltd | Chemical compounds |
AU7582298A (en) | 1997-05-19 | 1998-12-11 | Johns Hopkins University School Of Medicine, The | Tissue specific prodrug |
DE69837170T2 (de) | 1997-06-13 | 2007-11-22 | Amylin Pharmaceuticals, Inc., San Diego | Festphasige native chemische Ligation von ungeschützten oder n-cystein-geschützten Peptiden in wässrigen Lösungen |
GB9712370D0 (en) | 1997-06-14 | 1997-08-13 | Aepact Ltd | Therapeutic systems |
GB9715821D0 (en) | 1997-07-25 | 1997-10-01 | Pharmacia & Upjohn Spa | Amidino-camptothecin derivatives |
JP2001512830A (ja) | 1997-08-08 | 2001-08-28 | ニューバイオティックス インコーポレイテッド | 生物療法耐性および化学療法耐性を克服するための方法および組成物 |
JP4102466B2 (ja) | 1997-11-14 | 2008-06-18 | 株式会社アミノアップ化学 | 抗癌剤の副作用軽減剤 |
US6130039A (en) | 1997-12-12 | 2000-10-10 | Incyte Pharmaceuticals, Inc. | Polynucleotide encoding human lysyl hydroxylase-like protein |
ES2172303T3 (es) | 1998-01-23 | 2002-09-16 | Newbiotics Inc | Agentes terapeuticos obtenidos por catalisis enzimatica. |
GB2334256A (en) | 1998-02-12 | 1999-08-18 | Univ Montfort | Hydroxylation activated prodrugs |
WO2003045942A2 (en) | 1998-09-04 | 2003-06-05 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
AU3281600A (en) | 1999-02-27 | 2000-09-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transsduction mediated by tyrosine kinases |
WO2000063418A1 (en) * | 1999-04-15 | 2000-10-26 | The Regents Of The University Of California | Protein transport assays |
PL365999A1 (en) | 1999-05-14 | 2005-01-24 | Imclone Systems Incorporated | Treatment of refractory human tumors with epidermal growth factor receptor antagonists |
US7413536B1 (en) * | 1999-09-14 | 2008-08-19 | Xenoport, Inc. | Substrates and screening methods for transport proteins |
US6268375B1 (en) | 1999-12-29 | 2001-07-31 | Research Triangle Institute | 10, 11-difluoromethylenedioxycamptothecin compounds with topoisomerase I inhibition |
CZ298259B6 (cs) | 2000-02-28 | 2007-08-08 | Aventis Pharma S. A. | Farmaceutická kombinace k lécení rakoviny obsahující CPT-11 a capecitabin |
AU2001268653A1 (en) * | 2000-06-28 | 2002-01-08 | Supergen, Inc. | Combination hiv therapy including camptothecin |
EP1358612A2 (en) * | 2000-07-28 | 2003-11-05 | LION Bioscience AG | Regional intestinal permeability model |
WO2002058694A2 (en) | 2000-11-07 | 2002-08-01 | Dana-Farber Cancer Institute, Inc. | Method of treating hematologic tumors and cancers using beta lapachone |
US6350756B1 (en) * | 2001-01-18 | 2002-02-26 | California Pacific Medical Center | Camptothecin derivatives |
EP1409711A4 (en) * | 2001-03-02 | 2005-08-10 | Iams Company | COMPOSITIONS AND METHODS FOR INCREASING AMINO ACID ABSORPTION OF MAMMALS |
EP1406493A4 (en) * | 2001-06-11 | 2006-06-14 | Xenoport Inc | ADMINISTRATION OF MEDIUM BY THE PEPT-2 TRANSPORTER |
KR20050044570A (ko) | 2001-11-23 | 2005-05-12 | 추가이 세이야쿠 가부시키가이샤 | 종양 표적 효소의 동정 방법 |
BR0214615A (pt) | 2001-11-30 | 2004-09-14 | Chugai Pharmaceutical Co Ltd | Composto hexacìclico |
WO2004012662A2 (en) * | 2002-08-01 | 2004-02-12 | Aesgen, Inc. | Improved treatment of cancer with glutamine |
PA8578001A1 (es) | 2002-08-07 | 2004-05-07 | Warner Lambert Co | Combinaciones terapeuticas de inhibidores de quinasa de erb b y terapias antineoplasicas |
EP1599484A2 (en) | 2003-02-21 | 2005-11-30 | Chugai Seiyaku Kabushiki Kaisha | Process for the preparation of hexacyclic camptothecin derivatives |
JP2005255643A (ja) | 2004-03-15 | 2005-09-22 | Masato Kusunoki | 抗腫瘍効果増強方法および抗腫瘍効果増強剤 |
BRPI0509732A (pt) | 2004-04-09 | 2007-09-25 | Chugai Pharmaceutical Co Ltd | pró-fármaco solúvel em água, composição farmacêutica, agente terapêutico, agente antifungo e uso do referido pró-fármaco |
DE602005015231D1 (de) | 2004-09-02 | 2009-08-13 | Vertex Pharma | Als ionenkanalmodulatoren geeignete chinazoline |
TWI389897B (zh) | 2005-02-22 | 2013-03-21 | Chugai Pharmaceutical Co Ltd | 1- (2H) -isoquinolinone derivatives |
TW200744603A (en) | 2005-08-22 | 2007-12-16 | Chugai Pharmaceutical Co Ltd | Novel anticancer concomitant drug |
KR20080066039A (ko) * | 2005-10-19 | 2008-07-15 | 추가이 세이야쿠 가부시키가이샤 | 신규 수용성 프로드러그를 함유하는 췌장암, 난소암 또는 간암의 예방 또는 치료제 |
-
2005
- 2005-04-08 BR BRPI0509732-0A patent/BRPI0509732A/pt not_active IP Right Cessation
- 2005-04-08 WO PCT/JP2005/006957 patent/WO2005097803A1/ja active Application Filing
- 2005-04-08 UA UAA200611517A patent/UA88008C2/ru unknown
- 2005-04-08 KR KR1020067023380A patent/KR20070011457A/ko not_active Application Discontinuation
- 2005-04-08 CA CA002563502A patent/CA2563502A1/en not_active Abandoned
- 2005-04-08 RU RU2006139644/04A patent/RU2413731C2/ru not_active IP Right Cessation
- 2005-04-08 TW TW094111144A patent/TWI351284B/zh not_active IP Right Cessation
- 2005-04-08 JP JP2006512137A patent/JP4823894B2/ja not_active Expired - Fee Related
- 2005-04-08 EP EP05728811.0A patent/EP1757609B1/en not_active Not-in-force
- 2005-04-08 NZ NZ550665A patent/NZ550665A/en unknown
- 2005-04-08 CN CN2005800190556A patent/CN1964979B/zh not_active Expired - Fee Related
- 2005-04-08 US US11/547,036 patent/US7910593B2/en not_active Expired - Fee Related
- 2005-04-08 AU AU2005230994A patent/AU2005230994A1/en not_active Abandoned
- 2005-04-08 MX MXPA06011679A patent/MXPA06011679A/es active IP Right Grant
- 2005-04-09 MY MYPI20051586A patent/MY145850A/en unknown
-
2006
- 2006-10-05 IL IL178465A patent/IL178465A0/en unknown
- 2006-11-08 NO NO20065137A patent/NO20065137L/no not_active Application Discontinuation
-
2007
- 2007-07-25 HK HK07108060.1A patent/HK1100083A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BRPI0509732A (pt) | 2007-09-25 |
EP1757609A1 (en) | 2007-02-28 |
JPWO2005097803A1 (ja) | 2008-02-28 |
US20080015157A1 (en) | 2008-01-17 |
US7910593B2 (en) | 2011-03-22 |
JP4823894B2 (ja) | 2011-11-24 |
RU2006139644A (ru) | 2008-05-20 |
AU2005230994A1 (en) | 2005-10-20 |
MXPA06011679A (es) | 2007-01-23 |
MY145850A (en) | 2012-04-30 |
CN1964979A (zh) | 2007-05-16 |
CA2563502A1 (en) | 2005-10-20 |
HK1100083A1 (en) | 2007-09-07 |
CN1964979B (zh) | 2011-07-27 |
RU2413731C2 (ru) | 2011-03-10 |
TWI351284B (en) | 2011-11-01 |
NZ550665A (en) | 2010-05-28 |
IL178465A0 (en) | 2007-02-11 |
KR20070011457A (ko) | 2007-01-24 |
EP1757609A4 (en) | 2010-09-01 |
EP1757609B1 (en) | 2013-10-16 |
WO2005097803A1 (ja) | 2005-10-20 |
TW200600088A (en) | 2006-01-01 |
UA88008C2 (en) | 2009-09-10 |
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Legal Events
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |