UA82177C2 - Полипептиды фактора коагуляции vii человека - Google Patents

Полипептиды фактора коагуляции vii человека Download PDF

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Publication number
UA82177C2
UA82177C2 UA2004031982A UA2004031982A UA82177C2 UA 82177 C2 UA82177 C2 UA 82177C2 UA 2004031982 A UA2004031982 A UA 2004031982A UA 2004031982 A UA2004031982 A UA 2004031982A UA 82177 C2 UA82177 C2 UA 82177C2
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UA
Ukraine
Prior art keywords
factor
polypeptide
amino acid
replaced
sequence
Prior art date
Application number
UA2004031982A
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English (en)
Ukrainian (uk)
Inventor
Эгон Перссон
Оле Вильстед Ольсен
Original Assignee
Ново Нордиск Хэлс Кеа Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Ново Нордиск Хэлс Кеа Аг filed Critical Ново Нордиск Хэлс Кеа Аг
Publication of UA82177C2 publication Critical patent/UA82177C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Заявленное изобретение относится к новым вариантам фактора VII коагуляции человека, имеющим коагуляционную активность, а также полинуклеотидным конструктам, которые кодируют такие варианты векторов и клеток-хозяев, которые содержат и экспрессируют полинуклеотид, фармацевтическим композициям, применению.
UA2004031982A 2001-09-27 2002-09-26 Полипептиды фактора коагуляции vii человека UA82177C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200101413 2001-09-27
PCT/DK2002/000635 WO2003027147A2 (en) 2001-09-27 2002-09-26 Human coagulation factor vii polypeptides

Publications (1)

Publication Number Publication Date
UA82177C2 true UA82177C2 (ru) 2008-03-25

Family

ID=8160736

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2004031982A UA82177C2 (ru) 2001-09-27 2002-09-26 Полипептиды фактора коагуляции vii человека

Country Status (19)

Country Link
EP (1) EP1432794B1 (ru)
JP (1) JP4537059B2 (ru)
KR (1) KR20040039444A (ru)
CN (1) CN1602354A (ru)
AT (1) ATE532858T1 (ru)
AU (1) AU2002333211B2 (ru)
BR (1) BR0212818A (ru)
CA (1) CA2461003A1 (ru)
CZ (1) CZ2004427A3 (ru)
ES (1) ES2376694T3 (ru)
HU (1) HUP0500060A3 (ru)
IL (1) IL160897A0 (ru)
MX (1) MXPA04002833A (ru)
NO (1) NO20041700L (ru)
PL (1) PL368619A1 (ru)
RU (1) RU2325401C2 (ru)
UA (1) UA82177C2 (ru)
WO (1) WO2003027147A2 (ru)
ZA (1) ZA200402262B (ru)

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Also Published As

Publication number Publication date
IL160897A0 (en) 2004-08-31
CZ2004427A3 (cs) 2004-08-18
WO2003027147A2 (en) 2003-04-03
CA2461003A1 (en) 2003-04-03
JP2005509413A (ja) 2005-04-14
HUP0500060A3 (en) 2010-01-28
RU2004112768A (ru) 2006-01-10
EP1432794A2 (en) 2004-06-30
ATE532858T1 (de) 2011-11-15
JP4537059B2 (ja) 2010-09-01
EP1432794B1 (en) 2011-11-09
PL368619A1 (en) 2005-04-04
NO20041700L (no) 2004-04-26
KR20040039444A (ko) 2004-05-10
CN1602354A (zh) 2005-03-30
ES2376694T3 (es) 2012-03-16
BR0212818A (pt) 2004-10-05
AU2002333211B2 (en) 2008-05-08
ZA200402262B (en) 2004-06-02
WO2003027147A3 (en) 2003-11-27
HUP0500060A2 (hu) 2005-04-28
MXPA04002833A (es) 2004-07-15
RU2325401C2 (ru) 2008-05-27

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