UA82089C2 - Аплидин для лечения множественной миеломы - Google Patents
Аплидин для лечения множественной миеломы Download PDFInfo
- Publication number
- UA82089C2 UA82089C2 UAA200509530A UA2005009530A UA82089C2 UA 82089 C2 UA82089 C2 UA 82089C2 UA A200509530 A UAA200509530 A UA A200509530A UA 2005009530 A UA2005009530 A UA 2005009530A UA 82089 C2 UA82089 C2 UA 82089C2
- Authority
- UA
- Ukraine
- Prior art keywords
- cells
- aplidine
- activity
- multiple myeloma
- patients
- Prior art date
Links
- 206010035226 Plasma cell myeloma Diseases 0.000 title claims abstract description 116
- UUSZLLQJYRSZIS-LXNNNBEUSA-N plitidepsin Chemical compound CN([C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@@H]1C)C(C)C)O)[C@@H](C)CC)C(=O)[C@@H]1CCCN1C(=O)C(C)=O UUSZLLQJYRSZIS-LXNNNBEUSA-N 0.000 title claims abstract description 100
- 108010049948 plitidepsin Proteins 0.000 title claims abstract description 97
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Изобретение касается применения аплидина для получения медикамента для лечения множественной миеломы.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45412503P | 2003-03-12 | 2003-03-12 | |
| PCT/GB2004/001062 WO2004080477A1 (en) | 2003-03-12 | 2004-03-12 | Aplidine for multiple myeloma treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA82089C2 true UA82089C2 (ru) | 2008-03-11 |
Family
ID=32990868
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200508279A UA83022C2 (ru) | 2003-03-12 | 2004-03-12 | Аплидин для комбинированной терапии лейкоза и лимфомы |
| UAA200509530A UA82089C2 (ru) | 2003-03-12 | 2004-12-03 | Аплидин для лечения множественной миеломы |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200508279A UA83022C2 (ru) | 2003-03-12 | 2004-03-12 | Аплидин для комбинированной терапии лейкоза и лимфомы |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7576188B2 (ru) |
| EP (1) | EP1620117A4 (ru) |
| JP (1) | JP2006519848A (ru) |
| KR (1) | KR20060002778A (ru) |
| CN (3) | CN101579520A (ru) |
| AU (1) | AU2004220451B2 (ru) |
| CA (1) | CA2516572A1 (ru) |
| MX (1) | MXPA05009741A (ru) |
| NO (1) | NO20053947L (ru) |
| NZ (1) | NZ541634A (ru) |
| RU (1) | RU2341283C2 (ru) |
| UA (2) | UA83022C2 (ru) |
| WO (1) | WO2004080421A2 (ru) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9803448D0 (en) | 1998-02-18 | 1998-04-15 | Pharma Mar Sa | Pharmaceutical formulation |
| PL200922B1 (pl) * | 1999-11-15 | 2009-02-27 | Pharma Mar Sa | Zastosowanie aplidyny do wytwarzania kompozycji farmaceutycznej |
| UA76718C2 (ru) | 2000-06-30 | 2006-09-15 | Фарма Мар, С.А. | Противоопухолевые производные аплидина |
| ATE299028T1 (de) | 2000-10-12 | 2005-07-15 | Pharma Mar Sa | Behandlung von krebserkrankungen mit aplidin in kombination mit carnitin oder acetylcarnitin |
| ES2312979T3 (es) | 2003-03-12 | 2009-03-01 | Dana-Farber Cancer Institute, Inc. | Aplidina para el tratamiento de mieloma multiple. |
| CN101579520A (zh) * | 2003-03-12 | 2009-11-18 | 达纳-法伯癌症协会有限公司 | 用于多发性骨髓瘤的治疗的aplidine |
| WO2007101235A2 (en) * | 2006-02-28 | 2007-09-07 | Pharma Mar, S.A. | Improved antitumoral treatments |
| ITMI20070817A1 (it) * | 2007-04-19 | 2008-10-20 | Farmacetika Ltd | Composizione farmaceutica comprendente l-carnitina ed un agente antagonista dei recettori adenosinici di membrana, loro derivati e/o sali farmaceuticamente accettabili, e uso degli stessi nella preparazione di farmaci con effetto non tossico di inibi |
| WO2008135793A1 (en) * | 2007-05-04 | 2008-11-13 | Pharma Mar S.A. | Combination of aplidine and carboplatin in anticancer treatments |
| US20100240595A1 (en) * | 2007-10-19 | 2010-09-23 | Pharma Mar ,S.A. | Improved Antitumoral Treatments |
| EP2262523A1 (en) * | 2008-03-07 | 2010-12-22 | Pharma Mar S.A. | Improved anticancer treatments |
| WO2010029158A1 (en) * | 2008-09-12 | 2010-03-18 | Pharma Mar, S.A. | Aplidine in the treatment of chronic myeloproliferative disorders |
| CN104706599B (zh) * | 2013-12-11 | 2020-10-02 | 中国海洋大学 | 一种携带膜海鞘素化合物的冻干粉针剂 |
| KR102511028B1 (ko) | 2016-03-15 | 2023-03-16 | 오리존 지노믹스 에스.에이. | 혈액 악성 종양의 치료를 위한 lsd1 억제제의 조합물 |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
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| US4950649A (en) * | 1980-09-12 | 1990-08-21 | University Of Illinois | Didemnins and nordidemnins |
| DE3161556D1 (en) | 1980-09-12 | 1984-01-05 | Univ Illinois | Novel antibiotics, derivatives thereof, processes for their extraction, and compositions containing them |
| US4493796A (en) * | 1980-09-12 | 1985-01-15 | Board Of Trustees, Univ. Of Ill. | Didemnins A, B, C, and derivatives thereof, as antiviral agents |
| IT1153974B (it) * | 1982-09-23 | 1987-01-21 | Erba Farmitalia | Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento |
| EP0220453B1 (de) * | 1985-09-20 | 1992-04-15 | Cernitin S.A. | Verwendung von Pflanzenpollenextrakten zur Herstellung von das Wachstum von Tumorzellen hemmenden pharmazeutischen Präparaten und Verfahren zu ihrer Herstellung |
| US4948791A (en) | 1989-04-10 | 1990-08-14 | The Board Of Trustees Of The University Of Illinois | Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum |
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| DE4120327A1 (de) | 1991-06-20 | 1992-12-24 | Basf Ag | Neue peptide, ihre herstellung und verwendung |
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| US5462726A (en) | 1993-12-17 | 1995-10-31 | Bristol-Myers Squibb Company | Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents |
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| PT956033E (pt) | 1996-10-24 | 2003-10-31 | Univ Illinois | SíNTESE TOTAL DE ANALOGOS AMINO HIP DE DIDEMNINA A |
| JP2001503746A (ja) | 1996-10-24 | 2001-03-21 | ザ・ボード・オブ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・イリノイ | ジデムニン類似体の半合成法 |
| US6034058A (en) * | 1997-04-15 | 2000-03-07 | Rinehart; Kenneth L. | Semi-synthetic alanyl dilemnin analogs |
| JP4327260B2 (ja) * | 1997-05-07 | 2009-09-09 | フアルマ・マル・エセ・ア | Ｌ型カルシウムチャンネルエンハンサーとしてのアプリジン |
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| PL200922B1 (pl) * | 1999-11-15 | 2009-02-27 | Pharma Mar Sa | Zastosowanie aplidyny do wytwarzania kompozycji farmaceutycznej |
| SE9904175D0 (sv) | 1999-11-18 | 1999-11-18 | Pharmacia & Upjohn Diag Ab | Assay device and use thereof |
| NZ521844A (en) | 2000-04-07 | 2004-07-30 | Univ Pennsylvania | Tamandarin and didemnin analogs having deoxo-proline residue or dehydro-proline residue and methods of making and use thereof |
| AU6836301A (en) * | 2000-06-20 | 2002-01-02 | Idec Pharma Corp | Treatment of b-cell associated diseases such as malignancies and autoimmune diseases using a cold anti-cd20 antibody/radiolabeled anti-cd22 antibody combination |
| UA76718C2 (ru) | 2000-06-30 | 2006-09-15 | Фарма Мар, С.А. | Противоопухолевые производные аплидина |
| ATE299028T1 (de) * | 2000-10-12 | 2005-07-15 | Pharma Mar Sa | Behandlung von krebserkrankungen mit aplidin in kombination mit carnitin oder acetylcarnitin |
| AU9402401A (en) | 2000-10-12 | 2002-04-22 | Pharma Mar Sa | Treatment of cancers |
| WO2002058688A1 (de) * | 2001-01-24 | 2002-08-01 | Mestex Ag | Verwendung von neurotoxischen substanzen für die herstellung eines mittels zur behandlung von gelenkschmerzen |
| ATA13422001A (de) | 2001-08-23 | 2003-09-15 | Plasser Bahnbaumasch Franz | Maschine zur bearbeitung einer gleisbettung |
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-
2004
- 2004-03-12 CN CNA2009100039994A patent/CN101579520A/zh active Pending
- 2004-03-12 JP JP2006507125A patent/JP2006519848A/ja active Pending
- 2004-03-12 CN CNB2004800051794A patent/CN100409895C/zh not_active Expired - Fee Related
- 2004-03-12 US US10/546,750 patent/US7576188B2/en not_active Expired - Fee Related
- 2004-03-12 UA UAA200508279A patent/UA83022C2/ru unknown
- 2004-03-12 CA CA002516572A patent/CA2516572A1/en not_active Abandoned
- 2004-03-12 RU RU2005126819/15A patent/RU2341283C2/ru not_active IP Right Cessation
- 2004-03-12 EP EP04720399A patent/EP1620117A4/en not_active Withdrawn
- 2004-03-12 AU AU2004220451A patent/AU2004220451B2/en not_active Ceased
- 2004-03-12 WO PCT/US2004/007606 patent/WO2004080421A2/en active Application Filing
- 2004-03-12 MX MXPA05009741A patent/MXPA05009741A/es unknown
- 2004-03-12 CN CN2004800067241A patent/CN1761480B/zh not_active Expired - Lifetime
- 2004-03-12 KR KR1020057015665A patent/KR20060002778A/ko not_active Application Discontinuation
- 2004-03-12 NZ NZ541634A patent/NZ541634A/en not_active IP Right Cessation
- 2004-12-03 UA UAA200509530A patent/UA82089C2/ru unknown
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2005
- 2005-08-24 NO NO20053947A patent/NO20053947L/no not_active Application Discontinuation
-
2009
- 2009-04-30 US US12/433,028 patent/US20090227490A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20060002778A (ko) | 2006-01-09 |
| CN101579520A (zh) | 2009-11-18 |
| EP1620117A2 (en) | 2006-02-01 |
| AU2004220451B2 (en) | 2010-01-21 |
| MXPA05009741A (es) | 2005-11-16 |
| US7576188B2 (en) | 2009-08-18 |
| NO20053947D0 (no) | 2005-08-24 |
| NZ541634A (en) | 2008-08-29 |
| CN1753684A (zh) | 2006-03-29 |
| WO2004080421A2 (en) | 2004-09-23 |
| RU2341283C2 (ru) | 2008-12-20 |
| US20090227490A1 (en) | 2009-09-10 |
| EP1620117A4 (en) | 2009-07-29 |
| RU2005126819A (ru) | 2006-01-20 |
| UA83022C2 (ru) | 2008-06-10 |
| NO20053947L (no) | 2005-12-07 |
| CN1761480A (zh) | 2006-04-19 |
| US20060178298A1 (en) | 2006-08-10 |
| CA2516572A1 (en) | 2004-09-23 |
| CN100409895C (zh) | 2008-08-13 |
| WO2004080421A3 (en) | 2005-06-09 |
| AU2004220451A1 (en) | 2004-09-23 |
| CN1761480B (zh) | 2012-09-26 |
| JP2006519848A (ja) | 2006-08-31 |
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