UA80591C2 - C-6 modificated indazolilpyrrolotriazines, pharmaceutical composition upon their base and method of the treatment - Google Patents
C-6 modificated indazolilpyrrolotriazines, pharmaceutical composition upon their base and method of the treatment Download PDFInfo
- Publication number
- UA80591C2 UA80591C2 UAA200506891A UA2005006891A UA80591C2 UA 80591 C2 UA80591 C2 UA 80591C2 UA A200506891 A UAA200506891 A UA A200506891A UA 2005006891 A UA2005006891 A UA 2005006891A UA 80591 C2 UA80591 C2 UA 80591C2
- Authority
- UA
- Ukraine
- Prior art keywords
- ester
- carbamic acid
- indazol
- ethyl
- pyrrolo
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US43319002P | 2002-12-13 | 2002-12-13 | |
PCT/US2003/039542 WO2004054514A2 (en) | 2002-12-13 | 2003-12-12 | C-6 modified indazolylpyrrolotriazines |
Publications (1)
Publication Number | Publication Date |
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UA80591C2 true UA80591C2 (en) | 2007-10-10 |
Family
ID=32595133
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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UAA200506891A UA80591C2 (en) | 2002-12-13 | 2003-12-12 | C-6 modificated indazolilpyrrolotriazines, pharmaceutical composition upon their base and method of the treatment |
Country Status (27)
Country | Link |
---|---|
US (2) | US6916815B2 (ko) |
EP (1) | EP1569937B1 (ko) |
JP (1) | JP4511367B2 (ko) |
KR (1) | KR101073801B1 (ko) |
CN (2) | CN1726216A (ko) |
AR (1) | AR042450A1 (ko) |
AT (1) | ATE534648T1 (ko) |
AU (1) | AU2003300877B2 (ko) |
BR (1) | BR0316755A (ko) |
CA (1) | CA2509650C (ko) |
CO (1) | CO5570660A2 (ko) |
DK (1) | DK1569937T3 (ko) |
ES (1) | ES2374393T3 (ko) |
HR (1) | HRP20050535A2 (ko) |
IS (1) | IS7890A (ko) |
MX (1) | MXPA05006164A (ko) |
NO (1) | NO20052733L (ko) |
NZ (1) | NZ540338A (ko) |
PE (1) | PE20040805A1 (ko) |
PL (1) | PL377517A1 (ko) |
PT (1) | PT1569937E (ko) |
RS (1) | RS20050441A (ko) |
RU (1) | RU2356903C2 (ko) |
TW (1) | TW200420565A (ko) |
UA (1) | UA80591C2 (ko) |
WO (1) | WO2004054514A2 (ko) |
ZA (1) | ZA200504507B (ko) |
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US7625859B1 (en) * | 2000-02-16 | 2009-12-01 | Oregon Health & Science University | HER-2 binding antagonists |
US6867300B2 (en) | 2000-11-17 | 2005-03-15 | Bristol-Myers Squibb Company | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors |
US20090197852A9 (en) * | 2001-08-06 | 2009-08-06 | Johnson Robert G Jr | Method of treating breast cancer using 17-AAG or 17-AG or a prodrug of either in combination with a HER2 inhibitor |
MXPA04010379A (es) * | 2002-04-23 | 2005-02-17 | Squibb Bristol Myers Co | Compuestos de pirrolo-triazina anilina utiles como inhibidores de cinasa. |
DE60325469D1 (de) | 2002-04-23 | 2009-02-05 | Bristol Myers Squibb Co | Als kinase inhibitoren geeignete arylketonpyrrolotriazin-verbindungen |
TWI329112B (en) * | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
WO2004018478A2 (en) | 2002-08-23 | 2004-03-04 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
TW200420565A (en) * | 2002-12-13 | 2004-10-16 | Bristol Myers Squibb Co | C-6 modified indazolylpyrrolotriazines |
EP1590335A4 (en) | 2003-02-05 | 2006-03-08 | Bristol Myers Squibb Co | PROCESS FOR THE PRODUCTION OF PYRROLOTRIAZINKINASE INHIBITORS |
EP2633866A3 (en) * | 2003-10-17 | 2013-12-18 | Novo Nordisk A/S | Combination therapy |
US7102001B2 (en) * | 2003-12-12 | 2006-09-05 | Bristol-Myers Squibb Company | Process for preparing pyrrolotriazine |
US20060014741A1 (en) * | 2003-12-12 | 2006-01-19 | Dimarco John D | Synthetic process, and crystalline forms of a pyrrolotriazine compound |
MY145634A (en) * | 2003-12-29 | 2012-03-15 | Bristol Myers Squibb Co | Pyrrolotriazine compounds as kinase inhibitors |
US7064203B2 (en) * | 2003-12-29 | 2006-06-20 | Bristol Myers Squibb Company | Di-substituted pyrrolotriazine compounds |
US7102002B2 (en) * | 2004-06-16 | 2006-09-05 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
TW200600513A (en) * | 2004-06-30 | 2006-01-01 | Bristol Myers Squibb Co | A method for preparing pyrrolotriazine compounds |
US7253167B2 (en) * | 2004-06-30 | 2007-08-07 | Bristol-Myers Squibb Company | Tricyclic-heteroaryl compounds useful as kinase inhibitors |
US7102003B2 (en) * | 2004-07-01 | 2006-09-05 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds |
US7504521B2 (en) | 2004-08-05 | 2009-03-17 | Bristol-Myers Squibb Co. | Methods for the preparation of pyrrolotriazine compounds |
TW200618803A (en) | 2004-08-12 | 2006-06-16 | Bristol Myers Squibb Co | Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors |
WO2006042002A2 (en) * | 2004-10-05 | 2006-04-20 | Oregon Health And Science University | Compositions and methods for treating disease |
US7151176B2 (en) * | 2004-10-21 | 2006-12-19 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds |
US8034326B2 (en) * | 2005-04-18 | 2011-10-11 | Novo Nordisk A/S | IL-21 variants |
US7402582B2 (en) * | 2005-07-01 | 2008-07-22 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith |
US7405213B2 (en) * | 2005-07-01 | 2008-07-29 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith |
WO2007035428A1 (en) | 2005-09-15 | 2007-03-29 | Bristol-Myers Squibb Company | Met kinase inhibitors |
US7547782B2 (en) | 2005-09-30 | 2009-06-16 | Bristol-Myers Squibb Company | Met kinase inhibitors |
US7514435B2 (en) * | 2005-11-18 | 2009-04-07 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
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MX2008011136A (es) | 2006-03-07 | 2008-09-08 | Squibb Bristol Myers Co | Compuestos de profamarco de pirrolotriazina anilina utiles como inhibidores de cinasa. |
CA2666426A1 (en) | 2006-10-26 | 2008-05-02 | Novo Nordisk A/S | Il-21 variants |
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US20090132842A1 (en) * | 2007-11-15 | 2009-05-21 | International Business Machines Corporation | Managing Computer Power Consumption In A Computer Equipment Rack |
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KR20100132999A (ko) | 2008-04-04 | 2010-12-20 | 길리애드 사이언시즈, 인코포레이티드 | 스테아로일 CoA 불포화 효소 억제제로서 사용하기 위한 트리아졸로피리디논 유도체 |
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WO2009126311A1 (en) * | 2008-04-11 | 2009-10-15 | The University Of Texas, M.D. Anderson Cancer Center | Radiosensitization of tumors with indazolpyrrolotriazines for radiotherapy |
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JP2012520314A (ja) * | 2009-03-11 | 2012-09-06 | アムビト ビオスシエンセス コルポラチオン | 癌治療のためのインダゾリルアミノピロロトリアジンとタキサンの併用 |
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US9724352B2 (en) | 2012-05-31 | 2017-08-08 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Pyrrolo[2,1-F[1,2,4]triazine compounds, preparation methods and applications thereof |
CN103450204B (zh) | 2012-05-31 | 2016-08-17 | 中国科学院上海药物研究所 | 吡咯[2,1-f][1,2,4]并三嗪类化合物,其制备方法及用途 |
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MXPA04010379A (es) | 2002-04-23 | 2005-02-17 | Squibb Bristol Myers Co | Compuestos de pirrolo-triazina anilina utiles como inhibidores de cinasa. |
DE60325469D1 (de) | 2002-04-23 | 2009-02-05 | Bristol Myers Squibb Co | Als kinase inhibitoren geeignete arylketonpyrrolotriazin-verbindungen |
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TW200420565A (en) * | 2002-12-13 | 2004-10-16 | Bristol Myers Squibb Co | C-6 modified indazolylpyrrolotriazines |
US7102001B2 (en) * | 2003-12-12 | 2006-09-05 | Bristol-Myers Squibb Company | Process for preparing pyrrolotriazine |
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2003
- 2003-12-08 TW TW092134601A patent/TW200420565A/zh unknown
- 2003-12-12 RS YUP-2005/0441A patent/RS20050441A/sr unknown
- 2003-12-12 EP EP03813396A patent/EP1569937B1/en not_active Expired - Lifetime
- 2003-12-12 WO PCT/US2003/039542 patent/WO2004054514A2/en active Application Filing
- 2003-12-12 CN CNA200380105906XA patent/CN1726216A/zh active Pending
- 2003-12-12 CA CA002509650A patent/CA2509650C/en not_active Expired - Fee Related
- 2003-12-12 JP JP2004560804A patent/JP4511367B2/ja not_active Expired - Fee Related
- 2003-12-12 BR BR0316755-0A patent/BR0316755A/pt not_active IP Right Cessation
- 2003-12-12 UA UAA200506891A patent/UA80591C2/uk unknown
- 2003-12-12 RU RU2005120650/04A patent/RU2356903C2/ru not_active IP Right Cessation
- 2003-12-12 DK DK03813396.3T patent/DK1569937T3/da active
- 2003-12-12 AT AT03813396T patent/ATE534648T1/de active
- 2003-12-12 ES ES03813396T patent/ES2374393T3/es not_active Expired - Lifetime
- 2003-12-12 MX MXPA05006164A patent/MXPA05006164A/es active IP Right Grant
- 2003-12-12 KR KR1020057010549A patent/KR101073801B1/ko not_active IP Right Cessation
- 2003-12-12 NZ NZ540338A patent/NZ540338A/en not_active IP Right Cessation
- 2003-12-12 PT PT03813396T patent/PT1569937E/pt unknown
- 2003-12-12 PE PE2003001275A patent/PE20040805A1/es not_active Application Discontinuation
- 2003-12-12 AR ARP030104592A patent/AR042450A1/es unknown
- 2003-12-12 CN CN200910246410A patent/CN101723948A/zh active Pending
- 2003-12-12 PL PL377517A patent/PL377517A1/pl not_active Application Discontinuation
- 2003-12-12 AU AU2003300877A patent/AU2003300877B2/en not_active Ceased
- 2003-12-15 US US10/736,476 patent/US6916815B2/en not_active Expired - Fee Related
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2005
- 2005-06-01 ZA ZA200504507A patent/ZA200504507B/en unknown
- 2005-06-02 US US11/143,279 patent/US7148220B2/en not_active Expired - Fee Related
- 2005-06-07 NO NO20052733A patent/NO20052733L/no not_active Application Discontinuation
- 2005-06-10 IS IS7890A patent/IS7890A/is unknown
- 2005-06-10 HR HR20050535A patent/HRP20050535A2/hr not_active Application Discontinuation
- 2005-06-13 CO CO05057043A patent/CO5570660A2/es not_active Application Discontinuation
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