UA79452C2 - Iron-dextrin compounds for treatment of iron deficiency anaemia - Google Patents
Iron-dextrin compounds for treatment of iron deficiency anaemia Download PDFInfo
- Publication number
- UA79452C2 UA79452C2 UA20041008114A UA20041008114A UA79452C2 UA 79452 C2 UA79452 C2 UA 79452C2 UA 20041008114 A UA20041008114 A UA 20041008114A UA 20041008114 A UA20041008114 A UA 20041008114A UA 79452 C2 UA79452 C2 UA 79452C2
- Authority
- UA
- Ukraine
- Prior art keywords
- iron
- dextrin
- molecular weight
- daltons
- solution
- Prior art date
Links
- 229920001353 Dextrin Polymers 0.000 title claims abstract description 119
- 239000004375 Dextrin Substances 0.000 title claims abstract description 119
- 150000001875 compounds Chemical class 0.000 title claims abstract description 39
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 title claims abstract description 10
- 235000019425 dextrin Nutrition 0.000 claims abstract description 77
- 229910021519 iron(III) oxide-hydroxide Inorganic materials 0.000 claims abstract description 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 151
- 229910052742 iron Inorganic materials 0.000 claims description 76
- 239000000243 solution Substances 0.000 claims description 56
- 239000000203 mixture Substances 0.000 claims description 41
- 239000007864 aqueous solution Substances 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 32
- 239000008194 pharmaceutical composition Substances 0.000 claims description 20
- 229920002472 Starch Polymers 0.000 claims description 15
- 239000012528 membrane Substances 0.000 claims description 15
- 235000019698 starch Nutrition 0.000 claims description 15
- 239000008107 starch Substances 0.000 claims description 15
- 238000002347 injection Methods 0.000 claims description 11
- 239000007924 injection Substances 0.000 claims description 11
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical group OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 10
- 238000005194 fractionation Methods 0.000 claims description 9
- 230000007062 hydrolysis Effects 0.000 claims description 9
- 238000006460 hydrolysis reaction Methods 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 7
- 241001465754 Metazoa Species 0.000 claims description 6
- 238000005984 hydrogenation reaction Methods 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- CUPCBVUMRUSXIU-UHFFFAOYSA-N [Fe].OOO Chemical compound [Fe].OOO CUPCBVUMRUSXIU-UHFFFAOYSA-N 0.000 claims description 5
- 150000002505 iron Chemical class 0.000 claims description 5
- 230000002265 prevention Effects 0.000 claims description 5
- 229910000033 sodium borohydride Inorganic materials 0.000 claims description 5
- 239000012279 sodium borohydride Substances 0.000 claims description 5
- 235000013343 vitamin Nutrition 0.000 claims description 5
- 239000011782 vitamin Substances 0.000 claims description 5
- 229940088594 vitamin Drugs 0.000 claims description 5
- 229930003231 vitamin Natural products 0.000 claims description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 229910052802 copper Inorganic materials 0.000 claims description 4
- 239000010949 copper Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 235000016709 nutrition Nutrition 0.000 claims description 4
- 239000003381 stabilizer Substances 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 235000014413 iron hydroxide Nutrition 0.000 claims description 3
- NCNCGGDMXMBVIA-UHFFFAOYSA-L iron(ii) hydroxide Chemical compound [OH-].[OH-].[Fe+2] NCNCGGDMXMBVIA-UHFFFAOYSA-L 0.000 claims description 3
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 2
- 125000003172 aldehyde group Chemical group 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 239000010941 cobalt Substances 0.000 claims description 2
- 229910017052 cobalt Inorganic materials 0.000 claims description 2
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 2
- 239000003995 emulsifying agent Substances 0.000 claims description 2
- 150000001261 hydroxy acids Chemical class 0.000 claims description 2
- 238000007911 parenteral administration Methods 0.000 claims description 2
- 239000006072 paste Substances 0.000 claims description 2
- 150000003839 salts Chemical group 0.000 claims description 2
- 239000011669 selenium Substances 0.000 claims description 2
- 229910052711 selenium Inorganic materials 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000011701 zinc Substances 0.000 claims description 2
- 229910052725 zinc Inorganic materials 0.000 claims description 2
- 239000002585 base Substances 0.000 claims 2
- 239000006185 dispersion Substances 0.000 claims 2
- 125000003158 alcohol group Chemical group 0.000 claims 1
- 239000003637 basic solution Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
- FBAFATDZDUQKNH-UHFFFAOYSA-M iron chloride Chemical group [Cl-].[Fe] FBAFATDZDUQKNH-UHFFFAOYSA-M 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000012876 topography Methods 0.000 claims 1
- IEECXTSVVFWGSE-UHFFFAOYSA-M iron(3+);oxygen(2-);hydroxide Chemical compound [OH-].[O-2].[Fe+3] IEECXTSVVFWGSE-UHFFFAOYSA-M 0.000 abstract description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 16
- 229920002307 Dextran Polymers 0.000 description 14
- 210000004379 membrane Anatomy 0.000 description 11
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 150000001720 carbohydrates Chemical class 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 231100000419 toxicity Toxicity 0.000 description 6
- 230000001988 toxicity Effects 0.000 description 6
- 206010022971 Iron Deficiencies Diseases 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- 235000000346 sugar Nutrition 0.000 description 5
- 241000282412 Homo Species 0.000 description 4
- 208000007502 anemia Diseases 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- -1 iron-dextran compound Chemical class 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 208000003455 anaphylaxis Diseases 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 230000029087 digestion Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 210000000936 intestine Anatomy 0.000 description 3
- 150000002506 iron compounds Chemical class 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 239000012258 stirred mixture Substances 0.000 description 3
- 150000008163 sugars Chemical class 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000002052 anaphylactic effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- FWZTTZUKDVJDCM-CEJAUHOTSA-M disodium;(2r,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;iron(3+);oxygen(2-);hydroxide;trihydrate Chemical compound O.O.O.[OH-].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[Na+].[Na+].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3].O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 FWZTTZUKDVJDCM-CEJAUHOTSA-M 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 229960004887 ferric hydroxide Drugs 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 238000005227 gel permeation chromatography Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 150000003138 primary alcohols Chemical class 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- WVYWICLMDOOCFB-UHFFFAOYSA-N 4-methyl-2-pentanol Chemical compound CC(C)CC(C)O WVYWICLMDOOCFB-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 206010065973 Iron Overload Diseases 0.000 description 1
- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 229930194936 Tylosin Natural products 0.000 description 1
- 239000004182 Tylosin Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 231100000693 bioaccumulation Toxicity 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000011097 chromatography purification Methods 0.000 description 1
- 239000013066 combination product Substances 0.000 description 1
- 229940127555 combination product Drugs 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000010981 drying operation Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- UCNNJGDEJXIUCC-UHFFFAOYSA-L hydroxy(oxo)iron;iron Chemical compound [Fe].O[Fe]=O.O[Fe]=O UCNNJGDEJXIUCC-UHFFFAOYSA-L 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229940032961 iron sucrose Drugs 0.000 description 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical group Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
- VRIVJOXICYMTAG-IYEMJOQQSA-L iron(ii) gluconate Chemical class [Fe+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O VRIVJOXICYMTAG-IYEMJOQQSA-L 0.000 description 1
- MVZXTUSAYBWAAM-UHFFFAOYSA-N iron;sulfuric acid Chemical class [Fe].OS(O)(=O)=O MVZXTUSAYBWAAM-UHFFFAOYSA-N 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 238000009304 pastoral farming Methods 0.000 description 1
- 235000021395 porridge Nutrition 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 125000000075 primary alcohol group Chemical group 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 description 1
- 229960004059 tylosin Drugs 0.000 description 1
- 235000019375 tylosin Nutrition 0.000 description 1
- 239000004552 water soluble powder Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
- C08B30/12—Degraded, destructured or non-chemically modified starch, e.g. mechanically, enzymatically or by irradiation; Bleaching of starch
- C08B30/18—Dextrin, e.g. yellow canari, white dextrin, amylodextrin or maltodextrin; Methods of depolymerisation, e.g. by irradiation or mechanically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200200512 | 2002-04-09 | ||
| PCT/DK2003/000228 WO2003087164A1 (en) | 2002-04-09 | 2003-04-08 | Iron dextrin compounds for the treatment of iron deficiency anaemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA79452C2 true UA79452C2 (en) | 2007-06-25 |
Family
ID=28459423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20041008114A UA79452C2 (en) | 2002-04-09 | 2003-08-04 | Iron-dextrin compounds for treatment of iron deficiency anaemia |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20030191090A1 (ru) |
| EP (1) | EP1492821B1 (ru) |
| JP (1) | JP4520748B2 (ru) |
| KR (1) | KR20040104560A (ru) |
| CN (1) | CN1309741C (ru) |
| AR (1) | AR039396A1 (ru) |
| AT (1) | ATE335008T1 (ru) |
| AU (1) | AU2003226923B2 (ru) |
| BR (1) | BR0308773A (ru) |
| CA (1) | CA2480365A1 (ru) |
| DE (1) | DE60307249T2 (ru) |
| DK (1) | DK1492821T3 (ru) |
| EA (1) | EA006720B1 (ru) |
| ES (1) | ES2270070T3 (ru) |
| HK (1) | HK1069589A1 (ru) |
| MX (1) | MXPA04009770A (ru) |
| NO (1) | NO20044131L (ru) |
| NZ (1) | NZ535761A (ru) |
| PL (1) | PL373403A1 (ru) |
| PT (1) | PT1492821E (ru) |
| SI (1) | SI1492821T1 (ru) |
| UA (1) | UA79452C2 (ru) |
| WO (1) | WO2003087164A1 (ru) |
| ZA (1) | ZA200407658B (ru) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10249552A1 (de) | 2002-10-23 | 2004-05-13 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| WO2005087216A2 (de) * | 2004-03-12 | 2005-09-22 | Eberhard-Karls-Universität Tübingen | Behandlung von anämischen zuständen durch inhibierung der erythrozytenapoptose |
| JP4550543B2 (ja) * | 2004-10-07 | 2010-09-22 | 松谷化学工業株式会社 | 鉄、マグネシウム又は亜鉛成分に対する食品用マスキング剤 |
| WO2006084782A1 (de) | 2005-02-09 | 2006-08-17 | Vifor (International) Ag | Verwendung von eisen(iii)-komplexverbindungen |
| EP1757299A1 (de) * | 2005-08-25 | 2007-02-28 | Vifor (International) Ag | Eisen(III)-Komplexverbindungen zur Behandlung von Eisenmangel-Zuständen bei Patienten mit chronisch-entzündlicher Darmerkrankung |
| EP1790356A1 (de) * | 2005-11-24 | 2007-05-30 | Vifor (International) Ag | Präparat, umfassend Eisen(III)-Komplexverbindungen und redoxaktive Substanz(en) |
| CN101365458B (zh) | 2006-01-06 | 2012-09-05 | 卢特波尔德药品公司 | 用于铁给药的方法和组合物 |
| US20080132465A1 (en) * | 2006-12-05 | 2008-06-05 | Vincent Windisch | Apparatus and method for isolating iron components from serum |
| NZ595597A (en) | 2009-03-25 | 2013-05-31 | Pharmacosmos Holding As | A stable iron oligosaccharide compound |
| CN106176808A (zh) * | 2010-10-19 | 2016-12-07 | 长春纳米生技公司 | 金属离子纳米簇组合物 |
| WO2012104204A1 (en) | 2011-01-31 | 2012-08-09 | Vifor (International) Ag | Iron-carbohydrate complex compounds for the intravenous therapy of malaria |
| AU2013201308B2 (en) * | 2011-10-13 | 2015-01-29 | Alebund Pharmaceuticals (Hong Kong) Limited | Iron-fiber composition, preparation and uses thereof |
| CN105007759B (zh) | 2013-03-08 | 2018-11-20 | 上海礼邦医药科技有限公司 | 金属离子-功能性纤维组分络合物组合物、其制备及用途 |
| EP2997968A1 (en) | 2014-09-22 | 2016-03-23 | Ioulia Tseti | Iron (III) hydroxide complexes with activated glucose syrups and process for preparing same |
| US10258647B2 (en) | 2015-09-01 | 2019-04-16 | Particle Dynamics International, Llc | Iron-polysaccharide complexes and methods for the preparation thereof |
| WO2018198135A1 (en) * | 2017-04-26 | 2018-11-01 | Mylan Laboratories Ltd. | Improved process for the preparation of iron complex |
| CN107519198A (zh) * | 2017-07-21 | 2017-12-29 | 南通市第人民医院 | 一种右旋糖酐铁注射液及其制备方法 |
| EP3932535A1 (en) | 2020-07-01 | 2022-01-05 | Vifor Fresenius Medical Care Renal Pharma, Ltd. | Manufacturing method for polynuclear iron compounds stabilized by carbohydrates and/or humic acid |
| JP2024529536A (ja) * | 2021-08-03 | 2024-08-06 | ファーマコスモス ホールディング エー／エス | コンパニオンアニマルの鉄欠乏症の治療における皮下使用のための鉄錯体化合物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1293144B (de) * | 1964-11-04 | 1969-04-24 | Hausmann Ag Labor | Verfahren zur Herstellung von Komplexverbindungen des Eisens mit Sorbit, Gluconsaeure und einem Oligosaccharid |
| GB1183940A (en) * | 1966-10-22 | 1970-03-11 | Fisons Pharmaceuticals Ltd | Ferric Hydroxide Complexes |
| ES360433A1 (es) * | 1968-11-20 | 1970-11-16 | Rocador Sa | Procedimiento para la fabricacion de un compuesto de hierrotrivalente apropiado para administracion por via oral. |
| US3686397A (en) * | 1970-05-18 | 1972-08-22 | Mueller Arthur | Parenteral iron preparations |
| JPS6039681B2 (ja) * | 1976-01-01 | 1985-09-07 | 日本臓器製薬株式会社 | デキストリン・クエン酸・第二鉄多核複合体及び該複合体を含有する非経口用鉄剤 |
| DE3422249A1 (de) * | 1984-06-15 | 1985-12-19 | Pfeifer & Langen, 5000 Köln | Wasserloesliches eisendextran und verfahren zu seiner herstellung |
| JPS6128502A (ja) * | 1985-04-06 | 1986-02-08 | Nippon Zoki Pharmaceut Co Ltd | デキストリン・ヒドロキシカルボン酸・第二鉄多核複合体の製造方法 |
| US5102652A (en) * | 1986-07-03 | 1992-04-07 | Advanced Magnetics Inc. | Low molecular weight carbohydrates as additives to stabilize metal oxide compositions |
| US4827945A (en) * | 1986-07-03 | 1989-05-09 | Advanced Magnetics, Incorporated | Biologically degradable superparamagnetic materials for use in clinical applications |
| DK172860B1 (da) * | 1998-03-25 | 1999-08-16 | Pharmacosmos Holding As | Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman |
-
2003
- 2003-04-08 CN CNB038079682A patent/CN1309741C/zh not_active Expired - Fee Related
- 2003-04-08 NZ NZ535761A patent/NZ535761A/en not_active IP Right Cessation
- 2003-04-08 DK DK03746252T patent/DK1492821T3/da active
- 2003-04-08 AU AU2003226923A patent/AU2003226923B2/en not_active Ceased
- 2003-04-08 JP JP2003584119A patent/JP4520748B2/ja not_active Expired - Fee Related
- 2003-04-08 AR ARP030101220A patent/AR039396A1/es not_active Application Discontinuation
- 2003-04-08 BR BR0308773-5A patent/BR0308773A/pt not_active IP Right Cessation
- 2003-04-08 KR KR10-2004-7015844A patent/KR20040104560A/ko not_active Application Discontinuation
- 2003-04-08 PL PL03373403A patent/PL373403A1/xx unknown
- 2003-04-08 US US10/408,251 patent/US20030191090A1/en not_active Abandoned
- 2003-04-08 SI SI200330490T patent/SI1492821T1/sl unknown
- 2003-04-08 WO PCT/DK2003/000228 patent/WO2003087164A1/en active IP Right Grant
- 2003-04-08 PT PT03746252T patent/PT1492821E/pt unknown
- 2003-04-08 EA EA200401330A patent/EA006720B1/ru not_active IP Right Cessation
- 2003-04-08 DE DE60307249T patent/DE60307249T2/de not_active Expired - Lifetime
- 2003-04-08 EP EP03746252A patent/EP1492821B1/en not_active Expired - Lifetime
- 2003-04-08 ES ES03746252T patent/ES2270070T3/es not_active Expired - Lifetime
- 2003-04-08 MX MXPA04009770A patent/MXPA04009770A/es active IP Right Grant
- 2003-04-08 CA CA002480365A patent/CA2480365A1/en not_active Abandoned
- 2003-04-08 AT AT03746252T patent/ATE335008T1/de active
- 2003-08-04 UA UA20041008114A patent/UA79452C2/uk unknown
-
2004
- 2004-09-22 ZA ZA200407658A patent/ZA200407658B/en unknown
- 2004-09-29 NO NO20044131A patent/NO20044131L/no not_active Application Discontinuation
-
2005
- 2005-03-11 HK HK05102115A patent/HK1069589A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60307249T2 (de) | 2007-03-15 |
| DK1492821T3 (da) | 2006-11-27 |
| ES2270070T3 (es) | 2007-04-01 |
| PL373403A1 (en) | 2005-08-22 |
| PT1492821E (pt) | 2006-12-29 |
| US20030191090A1 (en) | 2003-10-09 |
| KR20040104560A (ko) | 2004-12-10 |
| ATE335008T1 (de) | 2006-08-15 |
| CN1309741C (zh) | 2007-04-11 |
| SI1492821T1 (sl) | 2006-12-31 |
| CA2480365A1 (en) | 2003-10-23 |
| EP1492821A1 (en) | 2005-01-05 |
| CN1646568A (zh) | 2005-07-27 |
| JP2005530863A (ja) | 2005-10-13 |
| BR0308773A (pt) | 2005-02-09 |
| AU2003226923B2 (en) | 2006-08-17 |
| NZ535761A (en) | 2007-09-28 |
| WO2003087164A1 (en) | 2003-10-23 |
| HK1069589A1 (en) | 2005-05-27 |
| JP4520748B2 (ja) | 2010-08-11 |
| AR039396A1 (es) | 2005-02-16 |
| EP1492821B1 (en) | 2006-08-02 |
| ZA200407658B (en) | 2006-07-26 |
| DE60307249D1 (de) | 2006-09-14 |
| EA200401330A1 (ru) | 2005-02-24 |
| EA006720B1 (ru) | 2006-04-28 |
| AU2003226923A1 (en) | 2003-10-27 |
| MXPA04009770A (es) | 2004-12-13 |
| NO20044131L (no) | 2004-09-29 |
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