EA200401330A1 - Железосодержащие соединения декстрина для лечения железодефицитной анемии - Google Patents

Железосодержащие соединения декстрина для лечения железодефицитной анемии

Info

Publication number
EA200401330A1
EA200401330A1 EA200401330A EA200401330A EA200401330A1 EA 200401330 A1 EA200401330 A1 EA 200401330A1 EA 200401330 A EA200401330 A EA 200401330A EA 200401330 A EA200401330 A EA 200401330A EA 200401330 A1 EA200401330 A1 EA 200401330A1
Authority
EA
Eurasian Patent Office
Prior art keywords
molecular weight
iron
average molecular
daltons
dextrin
Prior art date
Application number
EA200401330A
Other languages
English (en)
Other versions
EA006720B1 (ru
Inventor
Ханс Берг Андреасен
Ларс Христенсен
Original Assignee
Фармакосмос Холдинг А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармакосмос Холдинг А/С filed Critical Фармакосмос Холдинг А/С
Publication of EA200401330A1 publication Critical patent/EA200401330A1/ru
Publication of EA006720B1 publication Critical patent/EA006720B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
    • C08B30/12—Degraded, destructured or non-chemically modified starch, e.g. mechanically, enzymatically or by irradiation; Bleaching of starch
    • C08B30/18—Dextrin, e.g. yellow canari, white dextrin, amylodextrin or maltodextrin; Methods of depolymerisation, e.g. by irradiation or mechanically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

Настоящее изобретение раскрывает железосодержащее соединение декстрина для лечения железодефицитной анемии, содержащее гидрированный декстрин, имеющий среднемассовую молекулярную массу, равную или меньшую чем 3000 Да, и среднечисловую молекулярную массу, равную или большую чем 400 Дальтон, в устойчивой ассоциации с оксогидроксидом железа. Так как молекулярная масса декстрина должна находиться в узком интервале, еще один важный признак изобретения состоит в том, что 10% фракция декстринов, имеющих наивысшую молекулярную массу, имеет среднюю молекулярную массу, меньшую чем 4500 Дальтон, и в том, что 90% декстринов имеют молекулярную массу, меньшую чем 3000 Дальтон. Далее является важным, что 10% фракция, имеющая самую низкую молекулярную массу, имеет среднемассовую молекулярную массу, равную 340 Дальтон или более.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200401330A 2002-04-09 2003-04-08 Железосодержащие соединения декстрина для лечения железодефицитной анемии EA006720B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200200512 2002-04-09
PCT/DK2003/000228 WO2003087164A1 (en) 2002-04-09 2003-04-08 Iron dextrin compounds for the treatment of iron deficiency anaemia

Publications (2)

Publication Number Publication Date
EA200401330A1 true EA200401330A1 (ru) 2005-02-24
EA006720B1 EA006720B1 (ru) 2006-04-28

Family

ID=28459423

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401330A EA006720B1 (ru) 2002-04-09 2003-04-08 Железосодержащие соединения декстрина для лечения железодефицитной анемии

Country Status (24)

Country Link
US (1) US20030191090A1 (ru)
EP (1) EP1492821B1 (ru)
JP (1) JP4520748B2 (ru)
KR (1) KR20040104560A (ru)
CN (1) CN1309741C (ru)
AR (1) AR039396A1 (ru)
AT (1) ATE335008T1 (ru)
AU (1) AU2003226923B2 (ru)
BR (1) BR0308773A (ru)
CA (1) CA2480365A1 (ru)
DE (1) DE60307249T2 (ru)
DK (1) DK1492821T3 (ru)
EA (1) EA006720B1 (ru)
ES (1) ES2270070T3 (ru)
HK (1) HK1069589A1 (ru)
MX (1) MXPA04009770A (ru)
NO (1) NO20044131L (ru)
NZ (1) NZ535761A (ru)
PL (1) PL373403A1 (ru)
PT (1) PT1492821E (ru)
SI (1) SI1492821T1 (ru)
UA (1) UA79452C2 (ru)
WO (1) WO2003087164A1 (ru)
ZA (1) ZA200407658B (ru)

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DE10249552A1 (de) 2002-10-23 2004-05-13 Vifor (International) Ag Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel
WO2005087216A2 (de) * 2004-03-12 2005-09-22 Eberhard-Karls-Universität Tübingen Behandlung von anämischen zuständen durch inhibierung der erythrozytenapoptose
JP4550543B2 (ja) * 2004-10-07 2010-09-22 松谷化学工業株式会社 鉄、マグネシウム又は亜鉛成分に対する食品用マスキング剤
ES2333814T3 (es) 2005-02-09 2010-03-01 Vifor (International) Ag Uso de compuestos de complejo de hierro (iii).
EP1757299A1 (de) * 2005-08-25 2007-02-28 Vifor (International) Ag Eisen(III)-Komplexverbindungen zur Behandlung von Eisenmangel-Zuständen bei Patienten mit chronisch-entzündlicher Darmerkrankung
EP1790356A1 (de) * 2005-11-24 2007-05-30 Vifor (International) Ag Präparat, umfassend Eisen(III)-Komplexverbindungen und redoxaktive Substanz(en)
WO2007081744A2 (en) 2006-01-06 2007-07-19 Luitpold Pharmaceuticals, Inc. Methods and compositions for administration of iron
US20080132465A1 (en) * 2006-12-05 2008-06-05 Vincent Windisch Apparatus and method for isolating iron components from serum
PT2411053T (pt) * 2009-03-25 2017-02-15 Pharmacosmos Holding As Composto oligossacarídico de ferro estável
CN102451185A (zh) * 2010-10-19 2012-05-16 长春纳米生技公司 金属离子纳米簇组合物
WO2012104204A1 (en) 2011-01-31 2012-08-09 Vifor (International) Ag Iron-carbohydrate complex compounds for the intravenous therapy of malaria
CN103946019B (zh) * 2011-10-13 2016-10-05 维达西姆公司 铁-纤维组合物、其制备和用途
WO2014138016A1 (en) 2013-03-08 2014-09-12 Vidasym, Inc. Metal ion-functional fiber component complex compositions, preparation and uses thereof
EP2997968A1 (en) 2014-09-22 2016-03-23 Ioulia Tseti Iron (III) hydroxide complexes with activated glucose syrups and process for preparing same
US10258647B2 (en) 2015-09-01 2019-04-16 Particle Dynamics International, Llc Iron-polysaccharide complexes and methods for the preparation thereof
WO2018198135A1 (en) * 2017-04-26 2018-11-01 Mylan Laboratories Ltd. Improved process for the preparation of iron complex
CN107519198A (zh) * 2017-07-21 2017-12-29 南通市第人民医院 一种右旋糖酐铁注射液及其制备方法
EP3932535A1 (en) 2020-07-01 2022-01-05 Vifor Fresenius Medical Care Renal Pharma, Ltd. Manufacturing method for polynuclear iron compounds stabilized by carbohydrates and/or humic acid
KR20240041957A (ko) * 2021-08-03 2024-04-01 파르마코스모스 홀딩 에이/에스 반려동물의 철 결핍증 치료방법에서 피하 사용을 위한 철 착화합물

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DE1293144B (de) * 1964-11-04 1969-04-24 Hausmann Ag Labor Verfahren zur Herstellung von Komplexverbindungen des Eisens mit Sorbit, Gluconsaeure und einem Oligosaccharid
GB1183940A (en) * 1966-10-22 1970-03-11 Fisons Pharmaceuticals Ltd Ferric Hydroxide Complexes
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JPS6039681B2 (ja) * 1976-01-01 1985-09-07 日本臓器製薬株式会社 デキストリン・クエン酸・第二鉄多核複合体及び該複合体を含有する非経口用鉄剤
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Also Published As

Publication number Publication date
PL373403A1 (en) 2005-08-22
AR039396A1 (es) 2005-02-16
ES2270070T3 (es) 2007-04-01
KR20040104560A (ko) 2004-12-10
US20030191090A1 (en) 2003-10-09
MXPA04009770A (es) 2004-12-13
NO20044131L (no) 2004-09-29
ATE335008T1 (de) 2006-08-15
AU2003226923B2 (en) 2006-08-17
JP4520748B2 (ja) 2010-08-11
EA006720B1 (ru) 2006-04-28
BR0308773A (pt) 2005-02-09
CA2480365A1 (en) 2003-10-23
CN1646568A (zh) 2005-07-27
JP2005530863A (ja) 2005-10-13
SI1492821T1 (sl) 2006-12-31
HK1069589A1 (en) 2005-05-27
PT1492821E (pt) 2006-12-29
CN1309741C (zh) 2007-04-11
DE60307249T2 (de) 2007-03-15
ZA200407658B (en) 2006-07-26
DE60307249D1 (de) 2006-09-14
EP1492821A1 (en) 2005-01-05
DK1492821T3 (da) 2006-11-27
NZ535761A (en) 2007-09-28
AU2003226923A1 (en) 2003-10-27
UA79452C2 (en) 2007-06-25
WO2003087164A1 (en) 2003-10-23
EP1492821B1 (en) 2006-08-02

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU