UA78014C2 - Macrocyclic peptides active against hepatitis c virus - Google Patents
Macrocyclic peptides active against hepatitis c virus Download PDFInfo
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- UA78014C2 UA78014C2 UA20040807068A UA20040807068A UA78014C2 UA 78014 C2 UA78014 C2 UA 78014C2 UA 20040807068 A UA20040807068 A UA 20040807068A UA 20040807068 A UA20040807068 A UA 20040807068A UA 78014 C2 UA78014 C2 UA 78014C2
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- 238000001228 spectrum Methods 0.000 description 1
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- 229950006081 taribavirin Drugs 0.000 description 1
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- 235000002906 tartaric acid Nutrition 0.000 description 1
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- 229960005311 telbivudine Drugs 0.000 description 1
- IQFYYKKMVGJFEH-CSMHCCOUSA-N telbivudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1O[C@@H](CO)[C@H](O)C1 IQFYYKKMVGJFEH-CSMHCCOUSA-N 0.000 description 1
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- CBXCPBUEXACCNR-UHFFFAOYSA-N tetraethylammonium Chemical class CC[N+](CC)(CC)CC CBXCPBUEXACCNR-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
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- NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 description 1
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- 206010043778 thyroiditis Diseases 0.000 description 1
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
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- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002369711A CA2369711A1 (en) | 2002-01-30 | 2002-01-30 | Macrocyclic peptides active against the hepatitis c virus |
| PCT/CA2003/000089 WO2003064455A2 (en) | 2002-01-30 | 2003-01-24 | Macrocyclic peptides active against the hepatitis c virus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA78014C2 true UA78014C2 (en) | 2007-02-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20040807068A UA78014C2 (en) | 2002-01-30 | 2003-01-24 | Macrocyclic peptides active against hepatitis c virus |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20030181363A1 (es) |
| EP (1) | EP1472278B1 (es) |
| JP (1) | JP4040578B2 (es) |
| KR (1) | KR20040077899A (es) |
| CN (1) | CN1639187A (es) |
| AR (1) | AR038330A1 (es) |
| AT (1) | ATE414098T1 (es) |
| BR (1) | BR0307297A (es) |
| CA (1) | CA2369711A1 (es) |
| DE (1) | DE60324660D1 (es) |
| EA (1) | EA007738B1 (es) |
| EC (1) | ECSP045243A (es) |
| ES (1) | ES2316718T3 (es) |
| HR (1) | HRP20040689A2 (es) |
| MX (1) | MXPA04007462A (es) |
| NO (1) | NO20043591L (es) |
| NZ (1) | NZ534929A (es) |
| PE (1) | PE20030818A1 (es) |
| PL (1) | PL371007A1 (es) |
| RS (1) | RS67004A (es) |
| SA (1) | SA03230569B1 (es) |
| TW (1) | TW200307692A (es) |
| UA (1) | UA78014C2 (es) |
| UY (1) | UY27630A1 (es) |
| WO (1) | WO2003064455A2 (es) |
| ZA (1) | ZA200405639B (es) |
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| TR199901602T2 (xx) | 1996-10-18 | 1999-10-21 | Vertex Pharmaceuticals Incorporated | Serin proteazlar�n ve �zel olarak hepatit C vir�s� NS3 proteaz�n�n inhibit�rleri. |
| SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| JP3889708B2 (ja) | 2000-11-20 | 2007-03-07 | ブリストル−マイヤーズ スクイブ カンパニー | Ｃ型肝炎トリペプチド阻害剤 |
| US6867185B2 (en) * | 2001-12-20 | 2005-03-15 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
| AU2003299519A1 (en) | 2002-05-20 | 2004-05-04 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| ES2350201T3 (es) | 2002-05-20 | 2011-01-20 | Bristol-Myers Squibb Company | Sulfamidas heterocíclicas como inhibidores del virus de la hepatitis c. |
| MY140680A (en) | 2002-05-20 | 2010-01-15 | Bristol Myers Squibb Co | Hepatitis c virus inhibitors |
| WO2004043339A2 (en) | 2002-05-20 | 2004-05-27 | Bristol-Myers Squibb Company | Substituted cycloalkyl p1' hepatitis c virus inhibitors |
| US20050075279A1 (en) * | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
| US20050159345A1 (en) * | 2002-10-29 | 2005-07-21 | Boehringer Ingelheim International Gmbh | Composition for the treatment of infection by Flaviviridae viruses |
| US7176208B2 (en) * | 2003-04-18 | 2007-02-13 | Enanta Pharmaceuticals, Inc. | Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
| EP1654261B1 (en) | 2003-05-21 | 2007-11-14 | Boehringer Ingelheim International GmbH | Hepatitis c inhibitor compounds |
| ATE457995T1 (de) * | 2003-06-18 | 2010-03-15 | Tranzyme Pharma Inc | Makrozyklische motilin rezeptorantagonisten |
| PE20050374A1 (es) | 2003-09-05 | 2005-05-30 | Vertex Pharma | Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc |
| US7642235B2 (en) * | 2003-09-22 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
| PL1680137T3 (pl) * | 2003-10-14 | 2013-04-30 | F Hoffmann La Roche Ltd | Makrocykliczny kwas karboksylowy i związek acylosulfonamidowy jako inhibitor replikacji HCV |
| US7491794B2 (en) * | 2003-10-14 | 2009-02-17 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
| US7132504B2 (en) | 2003-11-12 | 2006-11-07 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7309708B2 (en) | 2003-11-20 | 2007-12-18 | Birstol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7135462B2 (en) | 2003-11-20 | 2006-11-14 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CA2539575C (en) | 2003-11-20 | 2015-01-20 | Boehringer Ingelheim International Gmbh | Method of removing transition metals, especially from metathesis reaction products |
| JP2007513200A (ja) * | 2003-12-08 | 2007-05-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 超臨界流体処理によるルテニウム副生物の除去 |
| EP1730167B1 (en) * | 2004-01-21 | 2011-01-12 | Boehringer Ingelheim International GmbH | Macrocyclic peptides active against the hepatitis c virus |
| DE602005019979D1 (en) | 2004-01-30 | 2010-04-29 | Medivir Ab | Hcv ns-3 serine protease inhibitoren |
| CN103304541A (zh) | 2004-02-20 | 2013-09-18 | 贝林格尔.英格海姆国际有限公司 | 病毒聚合酶抑制剂 |
| WO2005095403A2 (en) * | 2004-03-30 | 2005-10-13 | Intermune, Inc. | Macrocyclic compounds as inhibitors of viral replication |
| WO2005118620A2 (en) | 2004-05-27 | 2005-12-15 | New York University | Methods for preparing internally constraied peptides and peptidomimetics |
| WO2006020276A2 (en) * | 2004-07-16 | 2006-02-23 | Gilead Sciences, Inc. | Antiviral compounds |
| ATE512971T1 (de) | 2004-07-20 | 2011-07-15 | Boehringer Ingelheim Int | Peptidanaloga als hepatitis c-hemmer |
| UY29016A1 (es) | 2004-07-20 | 2006-02-24 | Boehringer Ingelheim Int | Analogos de dipeptidos inhibidores de la hepatitis c |
| EP1794178A1 (en) * | 2004-09-17 | 2007-06-13 | Boehringer Ingelheim International Gmbh | Process for preparing macrocyclic hcv protease inhibitors |
| US7189844B2 (en) * | 2004-09-17 | 2007-03-13 | Boehringer Ingelheim International Gmbh | Ring-closing metathesis process in supercritical fluid |
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| CA2583152A1 (en) * | 2004-10-21 | 2006-04-27 | Pfizer Inc. | Inhibitors of hepatitis c virus protease, and compositions and treatments using the same |
| MY141025A (en) | 2004-10-29 | 2010-02-25 | Vertex Pharma | Dose forms |
| DE102005002336A1 (de) * | 2005-01-17 | 2006-07-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Durchführung von kontinuierlichen Olefin-Ringschluss-Metathesen in komprimiertem Kohlendioxid |
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| US7592336B2 (en) | 2005-05-10 | 2009-09-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US7601686B2 (en) | 2005-07-11 | 2009-10-13 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
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| JP5249028B2 (ja) | 2005-07-25 | 2013-07-31 | インターミューン・インコーポレーテッド | Ｃ型肝炎ウイルス複製の新規大環状阻害剤 |
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| CA2643688A1 (en) | 2006-02-27 | 2007-08-30 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
| NZ571280A (en) | 2006-03-16 | 2011-10-28 | Vertex Pharma | Deuterated hepatitis C protease inhibitors |
| GB0609492D0 (en) * | 2006-05-15 | 2006-06-21 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| GB0612423D0 (en) | 2006-06-23 | 2006-08-02 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| RU2008152171A (ru) * | 2006-07-05 | 2010-08-10 | Интермьюн, Инк. (Us) | Новые ингибиторы вирусной репликации гепатита с |
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| EP2079480B1 (en) * | 2006-10-24 | 2013-06-05 | Merck Sharp & Dohme Corp. | Hcv ns3 protease inhibitors |
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| BRPI0718161A2 (pt) | 2006-10-27 | 2013-11-26 | Merck & Co Inc | Composto, composição farmacêutica, e, uso do composto. |
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| GB0625345D0 (en) | 2006-12-20 | 2007-01-31 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
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| AU2008219704A1 (en) | 2007-02-27 | 2008-09-04 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| AR066528A1 (es) * | 2007-05-10 | 2009-08-26 | Array Biopharma Inc | Peptidos inhibidores de la replicacion del virus de la hepatitis c |
| AR068794A1 (es) | 2007-06-29 | 2009-12-09 | Gilead Sciences Inc | Compuestos antivirales |
| AR067180A1 (es) * | 2007-06-29 | 2009-09-30 | Gilead Sciences Inc | Compuestos antivirales |
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| UA74546C2 (en) * | 1999-04-06 | 2006-01-16 | Boehringer Ingelheim Ca Ltd | Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition |
| US6608027B1 (en) * | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
| US6867185B2 (en) * | 2001-12-20 | 2005-03-15 | Bristol-Myers Squibb Company | Inhibitors of hepatitis C virus |
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2002
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- 2002-12-17 US US10/320,978 patent/US20030181363A1/en not_active Abandoned
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2003
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- 2003-01-24 BR BR0307297-5A patent/BR0307297A/pt not_active IP Right Cessation
- 2003-01-24 MX MXPA04007462A patent/MXPA04007462A/es unknown
- 2003-01-24 CN CNA038054841A patent/CN1639187A/zh active Pending
- 2003-01-24 JP JP2003564075A patent/JP4040578B2/ja not_active Expired - Fee Related
- 2003-01-24 AT AT03700743T patent/ATE414098T1/de active
- 2003-01-24 NZ NZ534929A patent/NZ534929A/en unknown
- 2003-01-24 UA UA20040807068A patent/UA78014C2/uk unknown
- 2003-01-24 EA EA200400886A patent/EA007738B1/ru not_active IP Right Cessation
- 2003-01-24 PL PL03371007A patent/PL371007A1/xx not_active Application Discontinuation
- 2003-01-24 EP EP03700743A patent/EP1472278B1/en not_active Expired - Lifetime
- 2003-01-24 ES ES03700743T patent/ES2316718T3/es not_active Expired - Lifetime
- 2003-01-24 WO PCT/CA2003/000089 patent/WO2003064455A2/en active Application Filing
- 2003-01-24 KR KR10-2004-7011682A patent/KR20040077899A/ko not_active Application Discontinuation
- 2003-01-24 DE DE60324660T patent/DE60324660D1/de not_active Expired - Lifetime
- 2003-01-28 TW TW092101813A patent/TW200307692A/zh unknown
- 2003-01-29 PE PE2003000095A patent/PE20030818A1/es not_active Application Discontinuation
- 2003-01-29 AR ARP030100252A patent/AR038330A1/es unknown
- 2003-01-29 UY UY27630A patent/UY27630A1/es not_active Application Discontinuation
- 2003-03-02 SA SA03230569A patent/SA03230569B1/ar unknown
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- 2004-07-15 ZA ZA200405639A patent/ZA200405639B/en unknown
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- 2004-08-20 EC EC2004005243A patent/ECSP045243A/es unknown
- 2004-08-27 NO NO20043591A patent/NO20043591L/no not_active Application Discontinuation
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| TW200307692A (en) | 2003-12-16 |
| NZ534929A (en) | 2006-08-31 |
| PL371007A1 (en) | 2005-06-13 |
| MXPA04007462A (es) | 2005-07-13 |
| KR20040077899A (ko) | 2004-09-07 |
| JP2005524632A (ja) | 2005-08-18 |
| ECSP045243A (es) | 2004-09-28 |
| ES2316718T3 (es) | 2009-04-16 |
| CA2369711A1 (en) | 2003-07-30 |
| EA200400886A1 (ru) | 2005-02-24 |
| ZA200405639B (en) | 2005-07-01 |
| HRP20040689A2 (en) | 2005-06-30 |
| DE60324660D1 (de) | 2008-12-24 |
| SA03230569B1 (ar) | 2007-03-05 |
| US20030181363A1 (en) | 2003-09-25 |
| CN1639187A (zh) | 2005-07-13 |
| AR038330A1 (es) | 2005-01-12 |
| EP1472278A2 (en) | 2004-11-03 |
| BR0307297A (pt) | 2004-12-21 |
| UY27630A1 (es) | 2003-08-29 |
| WO2003064455A3 (en) | 2004-02-05 |
| WO2003064455A2 (en) | 2003-08-07 |
| ATE414098T1 (de) | 2008-11-15 |
| PE20030818A1 (es) | 2003-10-30 |
| RS67004A (en) | 2006-10-27 |
| EA007738B1 (ru) | 2006-12-29 |
| EP1472278B1 (en) | 2008-11-12 |
| JP4040578B2 (ja) | 2008-01-30 |
| NO20043591L (no) | 2004-08-27 |
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