UA77959C2 - Pharmaceutical formulation comprising iota-carrageenan and neutral gelling polymer, process for manufacture and use - Google Patents
Pharmaceutical formulation comprising iota-carrageenan and neutral gelling polymer, process for manufacture and use Download PDFInfo
- Publication number
- UA77959C2 UA77959C2 UA20031211097A UA20031211097A UA77959C2 UA 77959 C2 UA77959 C2 UA 77959C2 UA 20031211097 A UA20031211097 A UA 20031211097A UA 20031211097 A UA20031211097 A UA 20031211097A UA 77959 C2 UA77959 C2 UA 77959C2
- Authority
- UA
- Ukraine
- Prior art keywords
- carrageenan
- iota
- composition according
- mixture
- neutral
- Prior art date
Links
- 239000000679 carrageenan Substances 0.000 title claims abstract description 70
- 229920001525 carrageenan Polymers 0.000 title claims abstract description 70
- 229940113118 carrageenan Drugs 0.000 title claims abstract description 70
- 229920000642 polymer Polymers 0.000 title claims abstract description 66
- 230000007935 neutral effect Effects 0.000 title claims abstract description 42
- 238000000034 method Methods 0.000 title claims abstract description 15
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 6
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 13
- 239000000203 mixture Substances 0.000 claims abstract description 163
- 239000004480 active ingredient Substances 0.000 claims abstract description 40
- 239000003814 drug Substances 0.000 claims abstract description 26
- 230000002378 acidificating effect Effects 0.000 claims abstract description 6
- 229940079593 drug Drugs 0.000 claims description 21
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 13
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 10
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 6
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 6
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 3
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical group COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 claims description 2
- 229960002237 metoprolol Drugs 0.000 claims description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
- ZXIBCJHYVWYIKI-PZJWPPBQSA-N ximelagatran Chemical compound C1([C@@H](NCC(=O)OCC)C(=O)N2[C@@H](CC2)C(=O)NCC=2C=CC(=CC=2)C(\N)=N\O)CCCCC1 ZXIBCJHYVWYIKI-PZJWPPBQSA-N 0.000 claims 1
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- 238000005481 NMR spectroscopy Methods 0.000 description 38
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- 239000012267 brine Substances 0.000 description 12
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 12
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- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 description 6
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0102069A SE0102069D0 (sv) | 2001-06-21 | 2001-06-21 | Pharmaceutical formulation |
| SE0104049 | 2001-11-30 | ||
| SE0201660A SE0201660D0 (sv) | 2002-05-31 | 2002-05-31 | Pharmaceutical formulation |
| PCT/SE2002/001217 WO2003000293A1 (en) | 2001-06-21 | 2002-06-19 | Pharmaceutical formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA77959C2 true UA77959C2 (en) | 2007-02-15 |
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| UA20031211097A UA77959C2 (en) | 2001-06-21 | 2002-06-19 | Pharmaceutical formulation comprising iota-carrageenan and neutral gelling polymer, process for manufacture and use |
Country Status (31)
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|---|---|
| US (1) | US7700582B2 (pl) |
| EP (1) | EP1401502B1 (pl) |
| JP (1) | JP2005501024A (pl) |
| KR (1) | KR20040011542A (pl) |
| CN (1) | CN1518462A (pl) |
| AR (1) | AR034517A1 (pl) |
| AT (1) | ATE314093T1 (pl) |
| AU (1) | AU2002345463B2 (pl) |
| BG (1) | BG108516A (pl) |
| BR (1) | BR0210489A (pl) |
| CA (1) | CA2450449A1 (pl) |
| CO (1) | CO5550466A2 (pl) |
| CZ (1) | CZ299859B6 (pl) |
| DE (1) | DE60208369T2 (pl) |
| DK (1) | DK1401502T3 (pl) |
| EE (1) | EE200400028A (pl) |
| ES (1) | ES2254699T3 (pl) |
| HU (1) | HUP0400850A3 (pl) |
| IL (2) | IL159217A0 (pl) |
| IS (1) | IS2347B (pl) |
| MX (1) | MXPA03011546A (pl) |
| MY (1) | MY130332A (pl) |
| NO (1) | NO20035627D0 (pl) |
| NZ (1) | NZ530086A (pl) |
| PL (1) | PL366432A1 (pl) |
| RU (1) | RU2323006C2 (pl) |
| SI (1) | SI1401502T1 (pl) |
| SK (1) | SK286238B6 (pl) |
| UA (1) | UA77959C2 (pl) |
| WO (1) | WO2003000293A1 (pl) |
| ZA (1) | ZA200309316B (pl) |
Families Citing this family (23)
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| US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
| AR035216A1 (es) | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
| US9358214B2 (en) | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
| KR101132969B1 (ko) * | 2001-11-13 | 2012-04-09 | 아스텔라스세이야쿠 가부시키가이샤 | 용해성 약물 지속 방출 시스템 |
| SE0201659D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| SE0201661D0 (sv) * | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
| US8367111B2 (en) | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
| US7442387B2 (en) * | 2003-03-06 | 2008-10-28 | Astellas Pharma Inc. | Pharmaceutical composition for controlled release of active substances and manufacturing method thereof |
| US20050042289A1 (en) * | 2003-04-29 | 2005-02-24 | Yamanouchi Pharma Technologies, Inc. | Tablets and methods for modified release of hydrophylic and other active agents |
| US7781424B2 (en) * | 2003-05-27 | 2010-08-24 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| SE0303220D0 (sv) * | 2003-11-28 | 2003-11-28 | Astrazeneca Ab | New process |
| US8747895B2 (en) | 2004-09-13 | 2014-06-10 | Aptalis Pharmatech, Inc. | Orally disintegrating tablets of atomoxetine |
| US9884014B2 (en) | 2004-10-12 | 2018-02-06 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
| EP2417969A1 (en) | 2004-10-21 | 2012-02-15 | Aptalis Pharmatech, Inc. | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
| CA2584469A1 (en) * | 2004-10-26 | 2006-05-04 | Mcneil-Ppc, Inc. | Burst-release polymer composition and dosage forms comprising the same |
| US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
| TW200827336A (en) | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
| ME01239B (me) * | 2007-02-01 | 2013-06-20 | Takeda Pharmaceuticals Co | Čvrsti preparat koji sadrži alogliptin i pioglitazon |
| TW200900033A (en) * | 2007-06-21 | 2009-01-01 | Wen-Qing Li | Automatic brewing machine |
| US20090061000A1 (en) * | 2007-08-31 | 2009-03-05 | Astrazeneca Ab | Pharmaceutical formulation use 030 |
| DK2262486T3 (da) | 2008-08-01 | 2013-03-25 | Krka Tovarna Zdravil D D Novo Mesto | Quetiapin sammensætning |
| AR076907A1 (es) * | 2009-05-13 | 2011-07-20 | Wyeth Llc | Composiciones con liberacion rapida de farmaco |
| MX2012006240A (es) | 2009-12-02 | 2012-10-03 | Aptalis Pharma Ltd | Microcapsulas de fexofenadina y composiciones que contienen las mismas. |
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- 2002-06-19 UA UA20031211097A patent/UA77959C2/uk unknown
- 2002-06-19 AT AT02744027T patent/ATE314093T1/de not_active IP Right Cessation
- 2002-06-19 SI SI200230264T patent/SI1401502T1/sl unknown
- 2002-06-19 HU HU0400850A patent/HUP0400850A3/hu unknown
- 2002-06-19 EP EP02744027A patent/EP1401502B1/en not_active Expired - Lifetime
- 2002-06-19 KR KR10-2003-7016620A patent/KR20040011542A/ko not_active Application Discontinuation
- 2002-06-19 PL PL02366432A patent/PL366432A1/pl not_active IP Right Cessation
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- 2002-06-19 JP JP2003506935A patent/JP2005501024A/ja not_active Withdrawn
- 2002-06-19 CN CNA028125347A patent/CN1518462A/zh active Pending
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