UA5576A1 - Спосіб отримання похідних 3,5-діаміно-1,2,4-триазіну або їх кислотно-адітивних солей - Google Patents

Спосіб отримання похідних 3,5-діаміно-1,2,4-триазіну або їх кислотно-адітивних солей

Info

Publication number
UA5576A1
UA5576A1 UA2932704A UA2932704A UA5576A1 UA 5576 A1 UA5576 A1 UA 5576A1 UA 2932704 A UA2932704 A UA 2932704A UA 2932704 A UA2932704 A UA 2932704A UA 5576 A1 UA5576 A1 UA 5576A1
Authority
UA
Ukraine
Prior art keywords
acid
diamino
triazine
derivatives
preparation
Prior art date
Application number
UA2932704A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Елан Сойер Девід
Джордж Бакстер Мартін
Реджинальд-Елфік Альберт
Айнслі Міллер Алістер
Original Assignee
Дзе Велкам Фаундейшн, Лимітед
Дзе Велкам Фаундейшн, Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10505597&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA5576(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Дзе Велкам Фаундейшн, Лимітед, Дзе Велкам Фаундейшн, Лимитед filed Critical Дзе Велкам Фаундейшн, Лимітед
Publication of UA5576A1 publication Critical patent/UA5576A1/uk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D253/00Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/061,2,4-Triazines
    • C07D253/0651,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/071,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075Two hetero atoms, in positions 3 and 5
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
UA2932704A 1979-06-01 1980-06-02 Спосіб отримання похідних 3,5-діаміно-1,2,4-триазіну або їх кислотно-адітивних солей UA5576A1 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7919257 1979-06-01

Publications (1)

Publication Number Publication Date
UA5576A1 true UA5576A1 (uk) 1994-12-28

Family

ID=10505597

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2932704A UA5576A1 (uk) 1979-06-01 1980-06-02 Спосіб отримання похідних 3,5-діаміно-1,2,4-триазіну або їх кислотно-адітивних солей

Country Status (30)

Country Link
US (2) US4486354A (cg-RX-API-DMAC10.html)
EP (2) EP0021121B1 (cg-RX-API-DMAC10.html)
JP (2) JPS5625169A (cg-RX-API-DMAC10.html)
AR (1) AR227521A1 (cg-RX-API-DMAC10.html)
AT (1) AT370097B (cg-RX-API-DMAC10.html)
AU (2) AU530999B2 (cg-RX-API-DMAC10.html)
BG (1) BG60427B2 (cg-RX-API-DMAC10.html)
CA (1) CA1112643A (cg-RX-API-DMAC10.html)
CS (1) CS234018B2 (cg-RX-API-DMAC10.html)
CZ (1) CZ384891A3 (cg-RX-API-DMAC10.html)
DD (1) DD151309A5 (cg-RX-API-DMAC10.html)
DK (1) DK153787C (cg-RX-API-DMAC10.html)
ES (1) ES491998A0 (cg-RX-API-DMAC10.html)
FI (1) FI67844C (cg-RX-API-DMAC10.html)
GE (1) GEP19960470B (cg-RX-API-DMAC10.html)
GR (1) GR68380B (cg-RX-API-DMAC10.html)
HU (1) HU182086B (cg-RX-API-DMAC10.html)
IE (1) IE49823B1 (cg-RX-API-DMAC10.html)
IL (1) IL60201A (cg-RX-API-DMAC10.html)
IT (1) IT1147087B (cg-RX-API-DMAC10.html)
MX (1) MX9202962A (cg-RX-API-DMAC10.html)
MY (1) MY8500062A (cg-RX-API-DMAC10.html)
NL (1) NL950007I2 (cg-RX-API-DMAC10.html)
NZ (1) NZ193890A (cg-RX-API-DMAC10.html)
PL (1) PL124029B1 (cg-RX-API-DMAC10.html)
SU (1) SU1055331A3 (cg-RX-API-DMAC10.html)
UA (1) UA5576A1 (cg-RX-API-DMAC10.html)
YU (1) YU145680A (cg-RX-API-DMAC10.html)
ZA (1) ZA803250B (cg-RX-API-DMAC10.html)
ZW (1) ZW12980A1 (cg-RX-API-DMAC10.html)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024351B1 (en) * 1979-08-16 1984-10-31 The Wellcome Foundation Limited Solid pharmaceutical formulation containing substitued phenyl-triazines
GB8328757D0 (en) * 1983-10-27 1983-11-30 Wellcome Found Chemical compounds
DE3600891A1 (de) * 1986-01-15 1987-07-16 Bayer Ag 1,8-verbrueckte 4-chinolon-3-carbonsaeuren und diese enthaltende arzneimittel
GB8613183D0 (en) * 1986-05-30 1986-07-02 Wellcome Found Triazine salt
US4972496A (en) * 1986-07-25 1990-11-20 Grid Systems Corporation Handwritten keyboardless entry computer system
FI895821A7 (fi) 1988-12-07 1990-06-08 The Wellcome Foundation Ltd Farmaseuttisesti aktivisia CNS-yhdisteitä
US5136080A (en) * 1989-12-04 1992-08-04 Burroughs Wellcome Co. Nitrile compounds
GB9012312D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
GB9012311D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
GB9124807D0 (en) * 1991-11-22 1992-01-15 Wellcome Found Pharmaceutical formulations
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
IE77165B1 (en) * 1991-01-30 1997-12-03 Wellcome Found Water-dispersible tablet containing acyclovir
GB9203483D0 (en) * 1992-02-19 1992-04-08 Wellcome Found Anti-inflammatory compounds
DK0644763T3 (da) * 1992-06-12 1997-07-28 Wellcome Found Anvendelse af 3,5-diamino-6-(2,3-dichlorphenyl)-1,2,4-triacin-isethionat til behandlingen og forebyggelsen af afhængighed, tolerance og sensitivering af medikamenter
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
FR2699077B1 (fr) * 1992-12-16 1995-01-13 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
US6133299A (en) * 1993-02-25 2000-10-17 Warner-Lambert Company Methods for treating neurodegenerative diseases and disorders using N-(2,6-disubstituted aromatic)-N'-pyridinyl ureas and other anticonvulsant compounds
US5866597A (en) * 1993-03-19 1999-02-02 Glaxo Wellcome Inc. Use of triazine compounds for the treatment of memory and learning disorders
GB9305693D0 (en) * 1993-03-19 1993-05-05 Wellcome Found Therapeutic triazine compounds and use
GB9305692D0 (en) * 1993-03-19 1993-05-05 Wellcome Found Therapeutic triazine compounds and use
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
GB9317146D0 (en) * 1993-08-18 1993-10-06 Wellcome Found Therapeutic combinations
GB9424766D0 (en) * 1994-12-07 1995-02-08 Wellcome Found Pharmaceutical composition
PT800520E (pt) * 1994-12-30 2002-11-29 Wellcome Found Processo para a preparacao de lamotrigina
GB9426448D0 (en) * 1994-12-30 1995-03-01 Wellcome Found Process
GB9512854D0 (en) * 1995-06-23 1995-08-23 Wellcome Found Novel formulation
GB9518027D0 (en) * 1995-09-05 1995-11-08 Wellcome Found Pharmacologically active compound
FR2741879A1 (fr) * 1995-12-05 1997-06-06 Esteve Labor Dr Derives de fluorophenyl-triazines et pyrimidines, leur preparation et leur application en tant que medicament
US6202491B1 (en) 1997-07-22 2001-03-20 Skf Condition Monitoring, Inc. Digital vibration coupling stud
GB9726987D0 (en) * 1997-12-22 1998-02-18 Glaxo Group Ltd Compounds
US6124500A (en) * 1998-03-09 2000-09-26 Rohm And Haas Company Process for synthesizing benzoic acids
GB9812413D0 (en) 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
PL348865A1 (en) * 1998-12-14 2002-06-17 Torrent Pharmaceuticals Ltd An improved process for the preparation of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
IN183150B (cg-RX-API-DMAC10.html) * 1998-12-14 1999-09-25 Torrent Pharmaceuticals Ltd
US20020055177A1 (en) * 1999-03-10 2002-05-09 Glaxo Wellcome Inc. Compound and its use
EP1169060B1 (en) * 1999-04-09 2005-08-31 Euro-Celtique S.A. Sodium channel blocker compositions and the use thereof
GB9907965D0 (en) * 1999-04-09 1999-06-02 Glaxo Group Ltd Medical use
US6639072B1 (en) 2000-01-03 2003-10-28 Rpg Life Sciences Limited Process for the preparation of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, commonly known as lamotrigine
IL134730A (en) * 2000-02-25 2003-10-31 Chemagis Ltd Process for preparing substituted benzoyl cyanide amidinohydrazones
CN1477976A (zh) 2000-11-30 2004-02-25 �Ʒ� Gaba激动剂与醛糖还原酶抑制剂的组合
PL365927A1 (en) 2000-11-30 2005-01-10 Pfizer Products Inc. Combination of gaba agonists and sorbitol dehydrogenase inhibitors
EP1390355A4 (en) * 2001-02-27 2005-02-23 Teva Pharma NEW CRYSTALLINE FORMS OF LAMOTRIGIN AND METHOD FOR THE PRODUCTION THEREOF
WO2003020273A2 (en) * 2001-09-03 2003-03-13 Newron Pharmaceuticals Spa Pharmaceutical composition comprising gabapentin or an analogue thereof and an $g(a)-aminoamide and its analgesic use
CA2366521C (en) 2001-12-24 2007-03-06 Brantford Chemicals Inc. A new and efficient process for the preparation of lamotrigine and related 3,5-diamino-6-substituted-1,2,4-triazines
AU2003217676B2 (en) 2002-02-22 2009-06-11 Takeda Pharmaceutical Company Limited Active agent delivery systems and methods for protecting and administering active agents
WO2003090693A2 (en) * 2002-04-23 2003-11-06 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing lamotrigine particles of defined morphology
US7939102B2 (en) * 2002-06-07 2011-05-10 Torrent Pharmaceuticals Ltd. Controlled release formulation of lamotrigine
US8637512B2 (en) 2002-07-29 2014-01-28 Glaxo Group Limited Formulations and method of treatment
HU225667B1 (en) 2002-09-20 2007-05-29 Richter Gedeon Nyrt Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
ES2209639B1 (es) 2002-10-31 2005-08-01 Vita Cientifica, S.L. Procedimiento para la obtencion de un compuesto farmaceuticamente activo y obtencion de su intermedio.
EP1603889A1 (en) * 2003-03-17 2005-12-14 Hetero Drugs Limited Novel crystalline forms of lamotrigine
AU2003230193A1 (en) 2003-03-27 2004-10-18 Hetero Drugs Limited Novel crystalline forms of candesartan cilexetil
AU2004237951A1 (en) * 2003-05-16 2004-11-25 Pfizer Products Inc. Therapeutic combinations of atypical antipsychotics with GABA modulators, anticonvulsants or benzodiazapines
WO2004103340A1 (en) * 2003-05-20 2004-12-02 Ranbaxy Laboratories Limited Water dispersible tablets of lamotrigine
GB2395483A (en) * 2003-07-03 2004-05-26 Jubilant Organosys Ltd Crystalline lamotrigine and its monohydrate
DK1691811T3 (da) 2003-12-11 2014-10-20 Sunovion Pharmaceuticals Inc Kombination af et sedativ og en neurotransmittermodulator og fremgangsmåder til forbedring af søvnkvaliteten og behandling af depression
WO2005082372A1 (en) * 2004-01-29 2005-09-09 Pfizer Products Inc. COMBINATION OF γ-AMINOBUTYRIC ACID MODULATORS AND 5-HT 1B RECEPTOR ANTAGONISTS
WO2005102366A2 (en) * 2004-04-19 2005-11-03 Philip Maxwell Satow Lithium combinations, and uses related thereto
BRPI0515154A (pt) * 2004-09-10 2008-07-08 Newron Pharm Spa uso de (halobenzilóxi)benzilamino-propanamidas para a fabricação de medicamentos ativos, compostos e composição farmacêutica
EP1937646A1 (en) 2005-09-23 2008-07-02 Janssen Pharmaceutica N.V. Tetrahydro-cyclopentyl pyrazole cannabinoid modulators
JP5162461B2 (ja) * 2005-09-23 2013-03-13 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヘキサヒドロシクロオクチルピラゾール系カンナビノイドモジュレーター
US8378096B2 (en) * 2005-09-23 2013-02-19 Janssen Pharmaceutica N.V. Hexahydro-cycloheptapyrazole cannabinoid modulators
US7825151B2 (en) * 2005-09-23 2010-11-02 Janssen Pharmaceutica Nv Hexahydro-cyclooctyl pyrazole cannabinoid modulators
US8378117B2 (en) * 2005-09-23 2013-02-19 Janssen Pharmaceutica N.V. Hexahydro-cycloheptapyrazole cannabinoid modulators
BRPI0616402A2 (pt) * 2005-09-23 2011-06-21 Janssen Pharmaceutica Nv moduladores de canabinóide de hexaidro-cicloeptapirazol
US20070117858A1 (en) * 2005-11-23 2007-05-24 Mingde Xia Substituted 5-heteroaryl-1-phenyl-pyrazole cannabinoid modulators
WO2007092456A2 (en) * 2006-02-03 2007-08-16 Rolls-Royce Corporation Gas turbine engine fuel system with fuel metering valve
US7795294B2 (en) * 2006-02-14 2010-09-14 Janssen Pharmaceutica N.V. Tetrahydro-2H-indazole pyrazole cannabinoid modulators
US20070254911A1 (en) * 2006-03-27 2007-11-01 Mingde Xia Tetrahydro-Pyrazolo[3,4-c]Pyridine Cannabinoid Modulators
WO2007112402A1 (en) * 2006-03-27 2007-10-04 Janssen Pharmaceutica N.V. Tetrahydro-1h-1,2,6-triaza-azulene cannabinoid modulators
WO2007122638A2 (en) * 2006-04-26 2007-11-01 Ratnamani Bio-Chemicals & Pharmaceuticals Pvt. Ltd. An improved process for preparation of lamotrigine intermediates
EP2024345B1 (en) * 2006-05-31 2009-12-16 Calaire Chimie SAS Method for preparing lamotrigine and its intermediate 2,3-dichlorobenzoyl chloride
GB0613836D0 (en) * 2006-07-13 2006-08-23 Univ Greenwich New medical use of triazine derivatives
US20120142919A1 (en) 2006-08-02 2012-06-07 Medichem, S.A. Method for synthesizing lamotrigine
US20100087638A1 (en) * 2006-08-14 2010-04-08 Jean-Paul Roduit Process for the preparation of lamotrigine
KR20090112722A (ko) 2007-01-24 2009-10-28 글락소 그룹 리미티드 3,5-디아미노-6-(2,3-디클로로페닐)-1,2,4-트리아진 또는 r(-)-2,4-디아미노-5-(2,3-디클로로페닐)-6-플루오로메틸 피리미딘 및 nk1을 포함하는 제약 조성물
US7943653B2 (en) * 2007-08-13 2011-05-17 Janssen Pharmaceutica N.V. Substituted 5-vinylphenyl-1-phenyl-pyrazole cannabinoid modulators
US20090076010A1 (en) * 2007-09-13 2009-03-19 Protia, Llc Deuterium-enriched lamotrigine
US8486927B2 (en) * 2007-11-09 2013-07-16 Thar Pharmaceuticals Crystalline forms of lamotrigine
GB0800741D0 (en) 2008-01-16 2008-02-20 Univ Greenwich Cyclic triazo and diazo sodium channel blockers
US20100190752A1 (en) 2008-09-05 2010-07-29 Gruenenthal Gmbh Pharmaceutical Combination
AU2010248943B2 (en) 2009-05-13 2015-05-21 Nektar Therapeutics Oligomer-containing substituted aromatic triazine compounds
US20100297195A1 (en) 2009-05-20 2010-11-25 Ranbaxy Laboratories Limited Controlled release lamotrigine formulations
GB2471713A (en) * 2009-07-08 2011-01-12 Univ Greenwich 1,2,4-triazine derivatives and their use as sodium channel blockers
GB2471729A (en) 2009-07-08 2011-01-12 Univ Greenwich 1,2,4-triazine derivatives and their use as sodium channel blockers
US20110052686A1 (en) * 2009-09-03 2011-03-03 Ranbaxy Laboratories Limited Modified release lamotrigine tablets
GB201111712D0 (en) 2011-07-08 2011-08-24 Gosforth Ct Holdings Pty Ltd Pharmaceutical compositions
WO2013183985A1 (en) 2012-06-05 2013-12-12 Erasmus University Medical Center Rotterdam Method of treating cognitive impairment and compounds for use therein
WO2015092819A2 (en) * 2013-12-21 2015-06-25 Nektar Therapeutics (India) Pvt. Ltd. Derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5- amine
US10576086B2 (en) 2015-06-12 2020-03-03 University Of Greenwich Triazine derivatives as interferon-gamma inhibitors
LT3554490T (lt) 2016-12-16 2022-04-25 Idorsia Pharmaceuticals Ltd Farmacinis derinys, apimantis t tipo kalcio kanalo blokatorių
TWI826531B (zh) 2018-09-21 2023-12-21 南韓商愛思開生物製藥股份有限公司 具有㗁二唑之化合物及包含該化合物之醫藥組合物
GB2641294A (en) 2024-05-24 2025-11-26 Novumgen Ltd An orodispersible tablet of Lamotrigine and its process of preparation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB759014A (en) * 1952-02-26 1956-10-10 Wellcome Found Improvements in triazines and their manufacture
AT190941B (de) * 1954-09-22 1957-07-25 Chemie Linz Ag Verfahren zur Herstellung neuer Guanylhydrazone
US2952677A (en) * 1956-10-01 1960-09-13 Ici Ltd Aminoguanadine compounds
BE663481A (cg-RX-API-DMAC10.html) * 1964-05-05
GB1204631A (en) * 1967-10-12 1970-09-09 Shell Int Research Pharmacologically active benzylideneamino guanidines and their use
GB1223492A (en) * 1967-10-13 1971-02-24 American Home Prod Guanidines
US3637688A (en) * 1970-01-09 1972-01-25 American Home Prod 6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines
EP0024351B1 (en) * 1979-08-16 1984-10-31 The Wellcome Foundation Limited Solid pharmaceutical formulation containing substitued phenyl-triazines

Also Published As

Publication number Publication date
JPH0144706B2 (cg-RX-API-DMAC10.html) 1989-09-29
GR68380B (cg-RX-API-DMAC10.html) 1981-12-28
EP0021121B1 (en) 1983-05-11
IT1147087B (it) 1986-11-19
ES8104993A1 (es) 1981-05-16
CS234018B2 (en) 1985-03-14
EP0021121A1 (en) 1981-01-07
CA1112643A (en) 1981-11-17
BG60427B2 (bg) 1995-03-31
ZW12980A1 (en) 1982-01-06
US4602017A (en) 1986-07-22
ZA803250B (en) 1982-01-27
US4486354A (en) 1984-12-04
EP0059987B1 (en) 1985-08-14
NZ193890A (en) 1984-07-06
JPS6133163A (ja) 1986-02-17
ATA289680A (de) 1982-07-15
DD151309A5 (de) 1981-10-14
PL224633A1 (cg-RX-API-DMAC10.html) 1981-02-13
IE801126L (en) 1980-12-01
AU566870B2 (en) 1987-11-05
IT8048848A0 (it) 1980-05-30
ES491998A0 (es) 1981-05-16
AT370097B (de) 1983-02-25
DK233880A (da) 1980-12-02
FI67844C (fi) 1985-06-10
YU145680A (en) 1983-02-28
EP0059987A1 (en) 1982-09-15
FI801758A7 (fi) 1980-12-02
AR227521A1 (es) 1982-11-15
HU182086B (en) 1983-12-28
IL60201A (en) 1984-05-31
IE49823B1 (en) 1985-12-25
SU1055331A3 (ru) 1983-11-15
PL124029B1 (en) 1982-12-31
JPH0144179B2 (cg-RX-API-DMAC10.html) 1989-09-26
IL60201A0 (en) 1980-07-31
MX9202962A (es) 1992-07-01
DK153787C (da) 1989-01-16
CZ384891A3 (en) 1993-10-13
DK153787B (da) 1988-09-05
MY8500062A (en) 1985-12-31
JPS5625169A (en) 1981-03-10
NL950007I1 (nl) 1995-06-16
NL950007I2 (nl) 1997-02-03
FI67844B (fi) 1985-02-28
AU5890680A (en) 1980-12-04
AU530999B2 (en) 1983-08-04
GEP19960470B (en) 1996-08-29

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