UA51716C2 - Сполуки, що мають гіпотензивну, кардіопротекторну, анти-ішемічну та антиліполітичну властивості, фармацевтична композиція та способи лікування - Google Patents

Info

Publication number

UA51716C2

UA51716C2 UA99020643A UA99020643A UA51716C2 UA 51716 C2 UA51716 C2 UA 51716C2 UA 99020643 A UA99020643 A UA 99020643A UA 99020643 A UA99020643 A UA 99020643A UA 51716 C2 UA51716 C2 UA 51716C2

Authority

UA

Ukraine

Prior art keywords

ylamino

diol

purin

pyrrolidin

hydroxymethyl

Prior art date

1996-07-08

Links

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• 238000000034 method Methods 0.000 title claims abstract description 29
• 230000003243 anti-lipolytic effect Effects 0.000 title claims abstract description 22
• 230000003293 cardioprotective effect Effects 0.000 title abstract description 12
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• 230000001077 hypotensive effect Effects 0.000 title description 15
• 208000001953 Hypotension Diseases 0.000 title description 7
• 208000021822 hypotensive Diseases 0.000 title description 6
• 150000001875 compounds Chemical class 0.000 claims abstract description 107
• 206010020772 Hypertension Diseases 0.000 claims abstract description 22
• 208000031226 Hyperlipidaemia Diseases 0.000 claims abstract description 7
• VCVOSERVUCJNPR-UHFFFAOYSA-N cyclopentane-1,2-diol Chemical compound OC1CCCC1O VCVOSERVUCJNPR-UHFFFAOYSA-N 0.000 claims description 72
• 239000000203 mixture Substances 0.000 claims description 70
• 125000000217 alkyl group Chemical group 0.000 claims description 38
• 150000003839 salts Chemical class 0.000 claims description 37
• -1 purin-9-yl Cyclopentane Chemical compound 0.000 claims description 35
• 125000004545 purin-9-yl group Chemical group N1=CN=C2N(C=NC2=C1)* 0.000 claims description 35
• SSYDTHANSGMJTP-UHFFFAOYSA-N oxolane-3,4-diol Chemical compound OC1COCC1O SSYDTHANSGMJTP-UHFFFAOYSA-N 0.000 claims description 32
• 229910052739 hydrogen Inorganic materials 0.000 claims description 18
• 239000001257 hydrogen Substances 0.000 claims description 17
• 239000002253 acid Substances 0.000 claims description 16
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• 125000000623 heterocyclic group Chemical group 0.000 claims description 14
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• 208000031225 myocardial ischemia Diseases 0.000 claims description 11
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 10
• JBDSSBMEKXHSJF-UHFFFAOYSA-N cyclopentanecarboxylic acid Chemical compound OC(=O)C1CCCC1 JBDSSBMEKXHSJF-UHFFFAOYSA-N 0.000 claims description 10
• 125000003118 aryl group Chemical group 0.000 claims description 9
• 125000004432 carbon atom Chemical group C* 0.000 claims description 9
• 125000002252 acyl group Chemical group 0.000 claims description 7
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 6
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• 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 4
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• AYVGBNGTBQLJBG-UHFFFAOYSA-N [3-(hydroxymethyl)cyclopentyl]methanol Chemical compound OCC1CCC(CO)C1 AYVGBNGTBQLJBG-UHFFFAOYSA-N 0.000 claims description 3
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• 229910052799 carbon Inorganic materials 0.000 claims description 3
• 150000002009 diols Chemical class 0.000 claims description 3
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• DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 claims description 3
• 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims description 3
• 125000004974 2-butenyl group Chemical group C(C=CC)* 0.000 claims description 2
• 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 2
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• HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 25
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