UA50807C2 - Німесулідна гелева система для місцевого застосування і спосіб її отримання (варіанти) - Google Patents

Німесулідна гелева система для місцевого застосування і спосіб її отримання (варіанти)

Info

Publication number
UA50807C2
UA50807C2 UA99084652A UA99084652A UA50807C2 UA 50807 C2 UA50807 C2 UA 50807C2 UA 99084652 A UA99084652 A UA 99084652A UA 99084652 A UA99084652 A UA 99084652A UA 50807 C2 UA50807 C2 UA 50807C2
Authority
UA
Ukraine
Prior art keywords
local administration
gel formulation
topical gel
nimesulide
nimesulide topical
Prior art date
Application number
UA99084652A
Other languages
English (en)
Russian (ru)
Inventor
Стефано БАДЕР
Енріке Ейсерманн
Тіціана Монті
Original Assignee
Гелсінн Гелскер С.А.
Гелсинн Гелскер С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Гелсінн Гелскер С.А., Гелсинн Гелскер С.А. filed Critical Гелсінн Гелскер С.А.
Publication of UA50807C2 publication Critical patent/UA50807C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Цей винахід стосується німесулідної композиції для місцевого застосування, яка включає карбоксивініловий полімер, нейтралізований як речовина, що утворює гель, або поліакрил-ізопарафін і розчинник, вибраний з групи, яка містить етанол, ізопропанол і моноетиловий етер діетиленгліколю, а також способів їх приготування. Перевагами згаданої композиції є висока стабільність системи та біоспроможність активної речовини.
UA99084652A 1997-02-25 1998-02-20 Німесулідна гелева система для місцевого застосування і спосіб її отримання (варіанти) UA50807C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI000408A IT1289973B1 (it) 1997-02-25 1997-02-25 Sistemi gelificati di nimesulide per uso topico
PCT/EP1998/000990 WO1998037879A1 (en) 1997-02-25 1998-02-20 Nimesulide gel systems for topical use

Publications (1)

Publication Number Publication Date
UA50807C2 true UA50807C2 (uk) 2002-11-15

Family

ID=11376173

Family Applications (1)

Application Number Title Priority Date Filing Date
UA99084652A UA50807C2 (uk) 1997-02-25 1998-02-20 Німесулідна гелева система для місцевого застосування і спосіб її отримання (варіанти)

Country Status (33)

Country Link
US (2) US20020119997A1 (uk)
EP (1) EP0971708B1 (uk)
JP (1) JP2001513093A (uk)
KR (1) KR100413143B1 (uk)
CN (1) CN1148174C (uk)
AT (1) ATE210437T1 (uk)
AU (1) AU723843B2 (uk)
BG (1) BG64664B1 (uk)
BR (1) BR9807729A (uk)
CA (1) CA2279277A1 (uk)
CU (1) CU22836A3 (uk)
CZ (1) CZ293665B6 (uk)
DE (2) DE69802913T2 (uk)
DK (1) DK0971708T3 (uk)
EE (1) EE04041B1 (uk)
ES (1) ES2169506T3 (uk)
GE (1) GEP20022628B (uk)
HK (1) HK1025265A1 (uk)
HU (1) HU226122B1 (uk)
ID (1) ID22668A (uk)
IL (1) IL131128A (uk)
IS (1) IS2090B (uk)
IT (1) IT1289973B1 (uk)
MX (1) MXPA99007468A (uk)
NO (1) NO994040L (uk)
PL (1) PL190603B1 (uk)
PT (1) PT971708E (uk)
RS (1) RS49700B (uk)
RU (1) RU2181285C2 (uk)
SK (1) SK284809B6 (uk)
TR (1) TR199902034T2 (uk)
UA (1) UA50807C2 (uk)
WO (1) WO1998037879A1 (uk)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU718356B2 (en) * 1998-01-12 2000-04-13 Panacea Biotec Limited A parenteral water-miscible non-intensely coloured injectable composition of non-steroidal anit-inflammatory drugs
GB2340751B (en) * 1998-08-12 2003-11-05 Edko Trading Representation Pharmaceutical compositions
AU1888900A (en) * 1999-05-31 2000-12-18 Shashikant Prabhudas Kurani A novel formulation of n-(4-nitro-2-phenoxyphenyl)methanesulfonamide
US7198801B2 (en) 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
ES2222817B1 (es) * 2003-07-25 2007-03-01 Luis Ucelay Sanz Gel frio.
PL1670433T3 (pl) 2003-10-10 2013-03-29 Ferring Bv Przezskórna formulacja farmaceutyczna do zmniejszania pozostałości na skórze
WO2007124250A2 (en) 2006-04-21 2007-11-01 Antares Pharma Ipl Ag Methods of treating hot flashes with formulations for transdermal or transmucosal application
WO2006125642A1 (en) 2005-05-27 2006-11-30 Antares Pharma Ipl Ag Methods and apparatus for transdermal or transmucosal application of testosterone
TR200906775A1 (tr) * 2009-09-02 2011-03-21 Sanovel İlaç San.Ve Ti̇c.A.Ş. Nimesulid ve kas gevşetici kombinasyonları
CN102068404A (zh) * 2009-11-25 2011-05-25 中国人民武装警察部队医学院 一种尼美舒利温度敏感水凝胶及其制备方法
WO2016116909A2 (en) * 2015-01-23 2016-07-28 Dr. Reddy's Laboratories Limited Non-staining topical gel compositions of nimesulide
RU2593777C1 (ru) * 2015-04-20 2016-08-10 Общество с ограниченной ответственностью "Трейдсервис" Гелевая форма нимесулида, обладающая противовоспалительным и анальгетическим действием
CN108158993A (zh) * 2018-01-12 2018-06-15 连云港本草美汇医药科技有限公司 一种祛痘控油微乳凝胶剂及其制备方法与应用
IL305451A (en) * 2021-02-25 2023-10-01 Alphyn Biologics Llc A preparation for the treatment of local dermatological bacterial skin conditions
PL244577B1 (pl) 2021-12-16 2024-02-12 Univ Gdanski Sole nimesulidu i sposób otrzymywania kryształów soli nimesulidu

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1251838B (it) * 1991-09-20 1995-05-26 Lpb Ist Farm Uso della nimesulide nel trattamento della cataratta
WO1997012608A1 (fr) * 1995-10-05 1997-04-10 Helsinn Healthcare S.A. Agent anti-inflammatoire externe
CN1080561C (zh) * 1994-10-05 2002-03-13 赫尔辛保健公司 外用抗炎剂
HUP9601442A3 (en) * 1995-07-25 1999-03-29 Panacea Biotec Ltd Nes antinflammatory and analgetic pharmaceutical compositions, containing nimesulid for transdermal use, and process for producing them
HUP9601443A3 (en) * 1996-05-29 1999-03-29 Panacea Biotec Ltd Injectable analgetic pharmaceutical compositions for intramuscular use containing nimesulid, and process for producing them
IT1291278B1 (it) * 1996-07-05 1999-01-07 Errekappa Euroterapici S P A Preparazione farmaceutica a base di nimesulide per uso topico

Also Published As

Publication number Publication date
EE9900355A (et) 2000-02-15
TR199902034T2 (xx) 1999-11-22
SK284809B6 (sk) 2005-11-03
WO1998037879A1 (en) 1998-09-03
CN1248165A (zh) 2000-03-22
IS5143A (is) 1999-07-30
IL131128A (en) 2003-11-23
KR100413143B1 (ko) 2003-12-31
IS2090B (is) 2006-03-15
US20020119997A1 (en) 2002-08-29
BR9807729A (pt) 2000-02-15
ID22668A (id) 1999-12-02
PL190603B1 (pl) 2005-12-30
JP2001513093A (ja) 2001-08-28
BG64664B1 (bg) 2005-11-30
IL131128A0 (en) 2001-01-28
US7186755B2 (en) 2007-03-06
CU22836A3 (es) 2003-01-29
ATE210437T1 (de) 2001-12-15
EP0971708A1 (en) 2000-01-19
YU38599A (sh) 2002-06-19
AU6499298A (en) 1998-09-18
GEP20022628B (en) 2002-02-25
DE971708T1 (de) 2000-08-17
DE69802913D1 (de) 2002-01-24
HUP0001486A2 (hu) 2000-10-28
PL335141A1 (en) 2000-04-10
EP0971708B1 (en) 2001-12-12
RS49700B (sr) 2007-12-31
RU2181285C2 (ru) 2002-04-20
BG103645A (en) 2000-04-28
IT1289973B1 (it) 1998-10-19
PT971708E (pt) 2002-05-31
HU226122B1 (en) 2008-04-28
DE69802913T2 (de) 2002-07-04
HK1025265A1 (en) 2000-11-10
HUP0001486A3 (en) 2002-11-28
AU723843B2 (en) 2000-09-07
KR20000075561A (ko) 2000-12-15
CZ298699A3 (cs) 2000-02-16
EE04041B1 (et) 2003-06-16
SK114199A3 (en) 2000-11-07
ES2169506T3 (es) 2002-07-01
DK0971708T3 (da) 2002-03-25
US20030036563A1 (en) 2003-02-20
CN1148174C (zh) 2004-05-05
CA2279277A1 (en) 1998-09-03
MXPA99007468A (es) 2004-05-05
CZ293665B6 (cs) 2004-06-16
ITMI970408A1 (it) 1998-08-25
NO994040D0 (no) 1999-08-20
NO994040L (no) 1999-10-20

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